Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 67168247 . T A CCDS8160.1:NM_002708.3:c.331Aag>Tag_NP_002699.1:p.111K>* Homo sapiens protein phosphatase 1 catalytic subunit alpha (PPP1CA), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1fjm 1 P08129 100.0 0.0 X-RAY
 1996-06-20 LYS A:111 A:111 1.0 0.005 H -67.0 -44.2 1.0 0.005 0.0 HOH
 3.631
 NZ
 O
LYS B:111 B:111 2.0 0.01 H -62.5 -40.2 NA NA NA
4g9j 1 P62136 100.0 0.0 X-RAY
 2012-09-19 LYS A:112 A:111 1.0 0.005 H -59.5 -40.2 1.0 0.005 0.0
LYS B:112 B:111 1.0 0.005 H -70.3 -37.2 NA NA NA
6g0i 1 P62136 100.0 0.0 X-RAY
 2018-11-21 LYS A:112 A:111 1.0 0.005 H -67.6 -38.0 1.0 0.005 0.0 HOH
 3.755
 CE
 O
6g0j 1 P62136 100.0 0.0 X-RAY
 2018-11-21 LYS A:112 A:111 1.0 0.005 H -75.1 -32.1 1.0 0.005 0.0 HOH
 3.739
 CE
 O
5zqv 1 P62137 99.7 0.0 X-RAY
 2019-03-13 LYS A:111 A:111 1.0 0.005 H -64.2 -35.0 1.0 0.005 0.0
LYS B:111 B:111 1.0 0.005 H -62.3 -32.3 NA NA NA
LYS C:111 C:111 1.0 0.005 H -62.4 -29.7 1.0 0.005 0.0
LYS D:111 D:111 1.0 0.005 H -59.4 -27.4 NA NA NA
6dcx 1 P62136 100.0 0.0 X-RAY
 2019-05-15 LYS A:120 A:111 0.0 0.0 H -59.3 -38.9 0.0 0.0 0.0
LYS B:120 B:111 0.0 0.0 H -60.1 -38.3 NA NA NA
6zk6 1 P62136 99.7 0.0 X-RAY
 2020-11-18 LYS A:112 A:111 1.0 0.005 H -64.9 -38.5 1.0 0.005 0.0 HOH
 3.664
 CE
 O
3egg 1 P62136 100.0 0.0 X-RAY
 2010-03-23 LYS A:110 A:111 2.0 0.01 H -60.3 -42.8 2.0 0.01 0.0 GOL
HOH
 6.416
3.780
 NZ
CE
 C3
O
LYS B:110 B:111 1.0 0.005 H -58.6 -44.3 NA NA NA
3egh 1 P62136 100.0 0.0 X-RAY
 2010-03-23 LYS A:110 A:111 2.0 0.01 H -64.1 -43.4 2.0 0.01 0.0 GOL
HOH
 6.466
3.623
 NZ
CE
 C3
O
LYS B:110 B:111 1.0 0.005 H -57.3 -47.0 NA NA NA
3hvq 1 P62136 100.0 0.0 X-RAY
 2010-03-23 LYS A:110 A:111 1.0 0.005 H -60.7 -41.6 1.0 0.005 0.0 HOH
 3.696
 CE
 O
LYS B:110 B:111 1.0 0.005 H -67.6 -40.9 1.0 0.005 0.0 HOH
 3.532
 CE
 O
6ghm 1 P62136 100.0 0.0 X-RAY
 2019-02-27 LYS A:110 A:111 2.0 0.01 H -60.2 -41.8 2.0 0.01 0.0 EDO
HOH
 6.800
3.566
 NZ
NZ
 C2
O
LYS B:110 B:111 2.0 0.01 H -62.6 -42.2 NA NA NA
3v4y 1 P62136 100.0 0.0 X-RAY
 2012-10-31 LYS A:110 A:111 1.0 0.005 H -62.3 -41.1 1.0 0.005 0.0 GOL
GOL
HOH
 7.510
4.515
2.778
 HZ1
HZ3
HE2
 H2
H31
O
LYS C:110 C:111 1.0 0.005 H -59.9 -39.4 NA NA NA
LYS E:110 E:111 2.0 0.01 H -63.6 -40.5 NA NA NA
LYS G:110 G:111 1.0 0.005 H -61.8 -45.5 NA NA NA
3n5u 1 P62136 100.0 0.0 X-RAY
 2010-08-11 LYS A:111 A:111 1.0 0.005 H -66.2 -29.5 1.0 0.005 0.0
LYS B:111 B:111 0.0 0.0 H -66.8 -28.7 0.0 0.0 0.0
6obn 1 P62136 100.0 0.0 X-RAY
 2019-09-18 LYS A:116 A:111 1.0 0.005 H -61.4 -41.9 1.0 0.005 0.0 MPD
HOH
 9.272
3.803
 C
NZ
 C1
O
LYS B:116 B:111 1.0 0.005 H -61.4 -40.6 NA NA NA
6obp 1 P62136 100.0 0.0 X-RAY
 2019-09-18 LYS A:116 A:111 2.0 0.01 H -65.2 -38.4 2.0 0.01 0.0 CL
HOH
 6.623
6.512
 O
NZ
 CL
O
6zej 1 P62136,Q4VY12 100.0 0.0 X-RAY
 2020-09-30 LYS A:110 D:110 1.0 0.005 H -71.9 -35.7 1.0 0.005 0.0 HOH
 2.742
 HE2
 O
LYS B:110 A:110 1.0 0.005 H -67.1 -38.2 NA NA NA
LYS C:110 F:110 1.0 0.005 H -67.7 -37.9 NA NA NA
LYS D:110 I:110 2.0 0.01 H -67.7 -37.8 NA NA NA
LYS E:110 L:110 1.0 0.005 H -63.3 -41.2 NA NA NA
LYS F:110 O:110 1.0 0.005 H -61.3 -40.1 NA NA NA
6zeh 1 P62136,Q13813 100.0 0.0 X-RAY
 2020-09-30 LYS A:110 A:111 2.0 0.01 H -64.0 -43.0 2.0 0.01 0.0 HOH
 2.914
 HE2
 O
LYS C:110 B:111 1.0 0.005 H -59.5 -44.5 NA NA NA
1it6 1 P36873 90.66 0.0 X-RAY
 2002-05-22 LYS A:111 A:111 2.0 0.01 H -65.2 -38.5 2.0 0.01 0.0 HOH
 3.574
 CE
 O
LYS B:111 B:111 1.0 0.005 H -58.6 -44.6 NA NA NA
1jk7 1 P36873 90.66 0.0 X-RAY
 2001-08-15 LYS A:111 A:111 1.0 0.005 H -62.7 -41.7 1.0 0.005 0.0 HOH
 3.648
 CE
 O
2bcd 1 P36873 90.66 0.0 X-RAY
 2006-01-17 LYS A:111 A:111 2.0 0.01 H -60.8 -40.6 2.0 0.01 0.0 HOH
 3.650
 CE
 O
2bdx 1 P36873 90.66 0.0 X-RAY
 2006-01-17 LYS A:111 A:111 2.0 0.01 H -65.0 -40.5 2.0 0.01 0.0 HOH
 3.540
 CE
 O
4ut2 1 P36873 90.66 0.0 X-RAY
 2015-07-22 LYS A:111 A:111 2.0 0.01 H -64.4 -41.8 2.0 0.01 0.0 HOH
 3.532
 NZ
 O
LYS B:111 B:111 2.0 0.01 H -64.5 -41.2 NA NA NA
4ut3 1 P36873 90.66 0.0 X-RAY
 2015-07-22 LYS A:111 A:111 3.0 0.015 H -64.6 -38.9 3.0 0.015 0.0 HOH
 3.676
 CE
 O
4ut3 2 P36873 90.66 0.0 X-RAY
 2015-07-22 LYS B:111 B:111 2.0 0.01 H -64.6 -39.3 NA NA NA
4v0u 2 P63087 90.66 0.0 X-RAY
 2015-03-25 LYS D:111 D:111 2.0 0.01 H -59.7 -41.5 NA NA NA
LYS F:111 F:111 3.0 0.015 H -59.7 -41.5 NA NA NA
LYS H:111 H:111 2.0 0.01 H -59.6 -41.6 NA NA NA
LYS J:111 J:111 2.0 0.01 H -59.6 -41.6 2.0 0.01 0.0
LYS N:111 N:111 2.0 0.01 H -59.6 -41.5 NA NA NA
2o8a 1 P63088 90.63 0.0 X-RAY
 2007-07-17 LYS A:117 A:111 1.0 0.005 H -66.4 -46.3 1.0 0.005 0.0 HOH
 3.642
 NZ
 O
LYS C:117 B:111 2.0 0.01 H -68.2 -45.5 NA NA NA
2o8g 1 P63088 90.63 0.0 X-RAY
 2007-07-17 LYS A:117 A:111 2.0 0.01 H -60.0 -48.0 2.0 0.01 0.0 HOH
 3.808
 CE
 O
LYS C:117 B:111 2.0 0.01 H -63.6 -46.2 NA NA NA
6zeg 1 P62136,Q9UQB8 100.0 0.0 X-RAY
 2020-09-30 LYS A:110 A:111 1.0 0.005 H -61.9 -41.6 1.0 0.005 0.0 HOH
 2.794
 HE2
 O
LYS C:110 B:111 1.0 0.005 H -59.4 -43.6 NA NA NA
6zei 1 P62136,Q9UQB8 100.0 0.0 X-RAY
 2020-09-30 LYS A:110 A:111 2.0 0.01 H -60.5 -41.5 2.0 0.01 0.0 HOH
 2.950
 HE2
 O
LYS C:110 B:111 1.0 0.005 H -61.8 -42.1 NA NA NA
3e7a 1 P62136 99.66 0.0 X-RAY
 2008-11-04 LYS A:110 A:111 2.0 0.01 H -62.2 -40.3 2.0 0.01 0.0 GOL
HOH
 5.910
3.629
 NZ
NZ
 C3
O
LYS B:110 B:111 2.0 0.01 H -57.6 -44.5 NA NA NA
3e7b 1 P62136 99.66 0.0 X-RAY
 2008-11-04 LYS A:110 A:111 2.0 0.01 H -61.5 -41.0 2.0 0.01 0.0 GOL
NA
HOH
 5.956
7.718
3.479
 NZ
N
NZ
 O2
NA
O
LYS B:110 B:111 2.0 0.01 H -63.0 -42.0 NA NA NA
4mov 1 P62136 99.66 0.0 X-RAY
 2014-03-26 LYS A:110 A:111 2.0 0.01 H -62.1 -40.6 2.0 0.01 0.0 CL
HOH
 9.666
3.500
 O
NZ
 CL
O
LYS B:110 B:111 2.0 0.01 H -61.4 -41.6 NA NA NA
4moy 1 P62136 99.66 0.0 X-RAY
 2014-03-26 LYS A:110 A:111 2.0 0.01 H -62.9 -43.6 2.0 0.01 0.0 GOL
HOH
 6.258
3.510
 NZ
CE
 O2
O
4mp0 1 P62136 99.66 0.0 X-RAY
 2014-03-26 LYS A:110 A:111 1.0 0.005 H -63.5 -44.1 1.0 0.005 0.0 GOL
HOH
 6.331
3.729
 NZ
CE
 O2
O
LYS B:110 C:111 2.0 0.01 H -63.5 -44.6 NA NA NA
4xpn 1 P62136 99.66 0.0 X-RAY
 2015-07-01 LYS A:110 A:111 1.0 0.005 H -61.2 -40.8 1.0 0.005 0.0 GOL
HOH
 6.263
3.640
 NZ
CE
 O2
O
LYS C:110 C:111 2.0 0.01 H -62.4 -41.3 NA NA NA
5ioh 1 P62136 99.66 0.0 X-RAY
 2016-10-05 LYS A:110 A:111 1.0 0.005 H -64.4 -41.5 1.0 0.005 0.0 HOH
 3.745
 CE
 O
LYS C:110 C:111 2.0 0.01 H -64.2 -41.3 NA NA NA
6alz 1 P62136 99.66 0.0 X-RAY
 2017-11-29 LYS A:110 A:111 2.0 0.01 H -63.8 -36.9 2.0 0.01 0.0 DMS
HOH
 6.607
3.603
 NZ
NZ
 C2
O
LYS B:110 B:111 1.0 0.005 H -65.5 -37.8 NA NA NA
6czo 1 P62136 99.66 0.0 X-RAY
 2019-01-23 LYS A:110 A:111 1.0 0.005 H -65.2 -34.3 1.0 0.005 0.0 HOH
 3.444
 NZ
 O
LYS C:110 C:111 2.0 0.01 H -64.2 -33.9 NA NA NA
6dno 1 P62136 99.66 0.0 X-RAY
 2019-01-23 LYS A:110 A:111 1.0 0.005 H -62.0 -41.7 1.0 0.005 0.0 HOH
 3.738
 CE
 O
6zee 1 P62136 99.66 0.0 X-RAY
 2020-09-30 LYS A:110 P:111 1.0 0.005 H -67.4 -36.6 1.0 0.005 0.0 EDO
HOH
 9.040
2.928
 N
HE2
 HO1
O
LYS B:110 Q:111 1.0 0.005 H -70.2 -40.2 1.0 0.005 0.0 HOH
 3.027
 HZ1
 O
LYS C:110 B:111 1.0 0.005 H -65.2 -39.7 1.0 0.005 0.0 EDO
HOH
 9.122
3.134
 N
HE2
 H21
O
LYS D:110 A:111 1.0 0.005 H -64.6 -40.4 1.0 0.005 0.0 EDO
EDO
HOH
 8.836
5.053
2.843
 N
HZ3
HE2
 HO2
H11
O
LYS E:110 I:111 2.0 0.01 H -67.0 -38.5 2.0 0.01 0.0 HOH
 2.856
 HE2
 O
LYS F:110 K:111 2.0 0.01 H -58.4 -41.6 2.0 0.01 0.0 EDO
HOH
 4.718
2.928
 HZ1
HE2
 H11
O
6zef 1 P62136 99.66 0.0 X-RAY
 2020-09-30 LYS A:110 A:111 1.0 0.005 H -64.0 -38.7 1.0 0.005 0.0 EDO
EDO
EDO
HOH
 7.156
4.939
8.885
3.110
 HZ3
HZ2
N
HZ1
 H21
H22
HO1
O
LYS B:110 B:111 2.0 0.01 H -62.1 -39.1 NA NA NA
5zt0 1 P62137 99.66 0.0 X-RAY
 2019-03-13 LYS A:105 A:111 0.0 0.0 H -54.5 -54.6 0.0 0.0 0.0
LYS B:105 B:111 0.0 0.0 H -60.6 -51.7 NA NA NA
LYS C:105 C:111 0.0 0.0 H -58.6 -40.0 NA NA NA
LYS D:105 D:111 0.0 0.0 H -61.9 -53.3 NA NA NA
LYS E:105 E:111 0.0 0.0 H -53.0 -49.8 NA NA NA
LYS F:105 F:111 0.0 0.0 H -58.8 -46.3 NA NA NA
7nzm 2 P62139 99.66 0.0 EM
 2021-09-29 LYS B:105 B:111 4.0 0.02 H -61.4 -40.1 4.0 0.02 0.0
6obq 1 P62136 99.66 0.0 X-RAY
 2019-09-18 LYS A:110 A:111 3.0 0.015 H -62.6 -40.0 3.0 0.015 0.0 HOH
 3.702
 CE
 O
LYS B:110 B:111 2.0 0.01 H -61.9 -40.5 NA NA NA
6obr 1 P62136 99.32 0.0 X-RAY
 2019-09-18 LYS A:110 A:111 2.0 0.01 H -62.2 -41.2 2.0 0.01 0.0 HOH
 3.569
 NZ
 O
LYS B:110 B:111 2.0 0.01 H -61.3 -41.3 NA NA NA
6obs 1 P62136 99.66 0.0 X-RAY
 2019-09-18 LYS A:110 A:111 2.0 0.01 H -63.8 -43.0 2.0 0.01 0.0 HOH
 3.585
 CE
 O
LYS B:110 B:111 1.0 0.005 H -62.0 -42.4 NA NA NA
6obu 1 P62136 99.66 0.0 X-RAY
 2019-09-18 LYS A:110 A:111 2.0 0.01 H -62.1 -41.2 2.0 0.01 0.0 GOL
GOL
DMS
HOH
 8.564
6.315
9.048
3.647
 NZ
NZ
O
NZ
 C3
C3
O
O
LYS B:110 B:111 2.0 0.01 H -62.4 -40.8 NA NA NA
1s70 1 P62140 88.79 0.0 X-RAY
 2004-06-22 LYS A:113 A:111 1.0 0.005 H -64.7 -33.9 1.0 0.005 0.0 HOH
 3.285
 NZ
 O
5inb 1 P36873 97.31 0.0 X-RAY
 2016-10-05 LYS A:108 A:111 1.0 0.005 H -63.0 -39.9 1.0 0.005 0.0 GOL
HOH
 6.049
3.619
 NZ
CE
 C1
O
5j28 1 P36873 97.31 0.0 X-RAY
 2016-10-05 LYS A:108 A:111 0.0 0.0 H -66.6 -47.2 0.0 0.0 0.0 HOH
 3.868
 CE
 O
LYS B:108 B:111 1.0 0.005 H -67.7 -40.4 NA NA NA
4v0v 1 P63087 97.62 0.0 X-RAY
 2015-03-25 LYS A:106 A:111 2.0 0.01 H -59.9 -41.1 2.0 0.01 0.0 HOH
 3.435
 NZ
 O
LYS C:106 C:111 2.0 0.01 H -60.0 -40.9 NA NA NA
4v0w 1 P63087 97.62 0.0 X-RAY
 2015-03-25 LYS A:106 A:111 2.0 0.01 H -60.8 -40.6 2.0 0.01 0.0 HOH
 3.449
 NZ
 O
LYS C:106 C:111 2.0 0.01 H -60.9 -40.4 NA NA NA
4v0x 1 P63087 97.62 0.0 X-RAY
 2015-03-25 LYS A:106 A:111 2.0 0.01 H -62.2 -41.5 2.0 0.01 0.0 HOH
 2.870
 HZ1
 O
1u32 1 P36873 96.25 0.0 X-RAY
 2004-08-17 LYS A:106 A:111 1.0 0.005 H -64.3 -40.3 1.0 0.005 0.0 HOH
 3.633
 CE
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p62136-f1 1 P62136 100.0 0.0 LYS A:111 A:111 1.0 0.005 H -59.4 -39.2
af-p36873-f1 1 P36873 90.66 0.0 LYS A:111 A:111 1.0 0.005 H -59.0 -39.5
af-p62140-f1 1 P62140 88.79 0.0 LYS A:110 A:110 1.0 0.005 H -59.9 -39.6