Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr11 | 114168833 | . | T | A | CCDS8368.1:NM_006169.2:c.315ttT>ttA_NP_006160.1:p.105F>L | Homo sapiens nicotinamide N-methyltransferase (NNMT), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 5yjf | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2018-03-21 | PHE | A:125 | A:105 | 9.0 | 0.043 | -55.5 | 143.8 | 9.0 | 0.043 | 0.0 |
HOH |
3.660 |
CE2 |
O |
|||
| PHE | B:125 | B:105 | 7.0 | 0.033 | -67.4 | 137.7 | NA | NA | NA | ||||||||||||||
| PHE | C:125 | C:105 | 9.0 | 0.043 | -76.7 | 147.1 | NA | NA | NA | ||||||||||||||
| PHE | D:125 | D:105 | 5.0 | 0.024 | -69.7 | 147.4 | NA | NA | NA | ||||||||||||||
| 2iip | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2006-10-10 | PHE | A:124 | A:105 | 30.0 | 0.143 | -69.9 | 142.7 | 30.0 | 0.143 | 0.0 |
HOH |
3.330 |
N |
O |
|||
| PHE | B:124 | B:105 | 29.0 | 0.138 | -56.2 | 142.4 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 34.0 | 0.162 | -67.2 | 148.4 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 33.0 | 0.157 | -62.3 | 142.6 | NA | NA | NA | ||||||||||||||
| 3rod | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2011-09-07 | PHE | A:124 | A:105 | 33.0 | 0.157 | -53.4 | 147.7 | 33.0 | 0.157 | 0.0 |
HOH |
2.943 |
O |
O |
|||
| PHE | B:124 | B:105 | 38.0 | 0.181 | -65.5 | 157.8 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 36.0 | 0.171 | -46.6 | 161.0 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 26.0 | 0.124 | -58.1 | 160.4 | NA | NA | NA | ||||||||||||||
| 6b1a | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2018-01-31 | PHE | A:124 | A:105 | 41.0 | 0.195 | -55.7 | 145.7 | 41.0 | 0.195 | 0.0 |
HOH |
3.480 |
N |
O |
|||
| PHE | B:124 | B:105 | 41.0 | 0.195 | -69.6 | 147.6 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 33.0 | 0.157 | -60.3 | 141.9 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 28.0 | 0.133 | -63.8 | 142.4 | NA | NA | NA | ||||||||||||||
| 6chh | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2018-06-13 | PHE | A:124 | A:105 | 41.0 | 0.195 | -54.6 | 145.9 | 41.0 | 0.195 | 0.0 |
HOH |
3.487 |
N |
O |
|||
| PHE | B:124 | B:105 | 42.0 | 0.2 | -69.9 | 145.6 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 34.0 | 0.162 | -59.8 | 142.2 | 34.0 | 0.162 | 0.0 |
HOH |
3.372 |
N |
O |
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| PHE | D:124 | D:105 | 28.0 | 0.133 | -62.5 | 141.5 | 28.0 | 0.133 | 0.0 |
HOH |
3.981 |
CB |
O |
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| 6orr | 1 | Q6FH49 | 98.86 | 0.0 |
X-RAY |
2019-10-23 | PHE | A:124 | A:105 | 7.0 | 0.033 | -68.3 | 149.1 | 7.0 | 0.033 | 0.0 |
HOH |
3.244 |
O |
O |
|||
| PHE | B:124 | B:105 | 24.0 | 0.114 | -70.3 | 150.7 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 27.0 | 0.129 | -66.9 | 146.5 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 26.0 | 0.124 | -67.4 | 149.6 | NA | NA | NA | ||||||||||||||
| 6pve | 1 | Q6FH49 | 98.86 | 0.0 |
X-RAY |
2019-11-27 | PHE | A:124 | A:105 | 39.0 | 0.186 | -67.1 | 148.2 | 39.0 | 0.186 | 0.0 |
HOH |
2.816 |
N |
O |
|||
| PHE | B:124 | B:105 | 23.0 | 0.11 | -67.0 | 146.8 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 35.0 | 0.167 | -69.9 | 148.4 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 23.0 | 0.11 | -66.0 | 146.1 | NA | NA | NA | ||||||||||||||
| 6pvs | 1 | Q6FH49 | 98.86 | 0.0 |
X-RAY |
2019-11-27 | PHE | A:124 | A:105 | 28.0 | 0.133 | -70.3 | 147.8 | 28.0 | 0.133 | 0.0 |
HOH |
4.306 |
CB |
O |
|||
| PHE | B:124 | B:105 | 42.0 | 0.2 | -69.1 | 150.1 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 32.0 | 0.152 | -70.4 | 152.7 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 20.0 | 0.095 | -65.0 | 148.7 | NA | NA | NA | ||||||||||||||
| 7bkg | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | PHE | A:124 | A:105 | 33.0 | 0.157 | -66.3 | 144.6 | 33.0 | 0.157 | 0.0 |
HOH |
3.121 |
N |
O |
|||
| PHE | B:124 | B:105 | 30.0 | 0.143 | -61.7 | 142.5 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 18.0 | 0.086 | -74.5 | 147.1 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 14.0 | 0.067 | -63.2 | 139.7 | NA | NA | NA | ||||||||||||||
| 7ble | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | PHE | A:124 | A:105 | 27.0 | 0.129 | -66.6 | 141.4 | 27.0 | 0.129 | 0.0 |
HOH |
3.553 |
CD1 |
O |
|||
| PHE | B:124 | B:105 | 35.0 | 0.167 | -53.3 | 144.4 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 23.0 | 0.11 | -78.3 | 148.5 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 25.0 | 0.119 | -57.0 | 137.0 | NA | NA | NA | ||||||||||||||
| 7nbj | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | PHE | A:124 | A:105 | 28.0 | 0.133 | -63.5 | 143.2 | 28.0 | 0.133 | 0.0 |
HOH |
3.071 |
N |
O |
|||
| PHE | B:124 | B:105 | 32.0 | 0.152 | -66.7 | 139.6 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 30.0 | 0.143 | -66.5 | 144.2 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 12.0 | 0.057 | -65.1 | 138.4 | NA | NA | NA | ||||||||||||||
| 7nbm | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | PHE | A:124 | A:105 | 30.0 | 0.143 | -52.7 | 148.0 | 30.0 | 0.143 | 0.0 |
HOH |
3.246 |
N |
O |
|||
| PHE | B:124 | B:105 | 19.0 | 0.09 | -55.3 | 143.6 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 32.0 | 0.152 | -74.7 | 145.7 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 19.0 | 0.09 | -56.4 | 139.7 | NA | NA | NA | ||||||||||||||
| 7nbq | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | PHE | A:124 | A:105 | 33.0 | 0.157 | -62.9 | 143.1 | 33.0 | 0.157 | 0.0 |
HOH |
2.892 |
N |
O |
|||
| PHE | B:124 | B:105 | 32.0 | 0.152 | -75.6 | 145.8 | NA | NA | NA | ||||||||||||||
| PHE | C:124 | C:105 | 24.0 | 0.114 | -72.7 | 145.4 | NA | NA | NA | ||||||||||||||
| PHE | D:124 | D:105 | 17.0 | 0.081 | -67.7 | 135.6 | NA | NA | NA | ||||||||||||||
| 7egu | 1 | P40261 | 99.61 | 0.0 |
X-RAY |
2021-12-15 | PHE | A:104 | A:105 | 5.0 | 0.024 | -59.4 | 142.7 | 5.0 | 0.024 | 0.0 |
HOH |
2.851 |
O |
O |
|||
| 7ehz | 1 | P40261 | 99.61 | 0.0 |
X-RAY |
2021-12-15 | PHE | A:104 | A:105 | 4.0 | 0.019 | -49.5 | 138.4 | 4.0 | 0.019 | 0.0 |
HOH |
3.385 |
N |
O |
|||
| 5xvq | 1 | F7ERX8 | 96.97 | 0.0 |
X-RAY |
2017-08-02 | PHE | A:125 | A:105 | 7.0 | 0.033 | -58.5 | 144.2 | 7.0 | 0.033 | 0.0 |
HOH |
3.066 |
O |
O |
|||
| PHE | B:125 | B:105 | 11.0 | 0.052 | -55.2 | 143.8 | NA | NA | NA | ||||||||||||||
| 2i62 | 1 | O55239 | 85.5 | 7e-168 |
X-RAY |
2006-09-12 | PHE | A:106 | A:106 | 24.0 | 0.114 | -65.3 | 146.5 | 24.0 | 0.114 | 0.0 |
HOH |
2.974 |
N |
O |
|||
| PHE | B:106 | B:106 | 17.0 | 0.081 | -72.7 | 141.4 | NA | NA | NA | ||||||||||||||
| PHE | C:106 | C:106 | 20.0 | 0.095 | -60.7 | 143.0 | NA | NA | NA | ||||||||||||||
| PHE | D:106 | D:106 | 15.0 | 0.071 | -61.0 | 143.2 | NA | NA | NA | ||||||||||||||
| 5xvk | 1 | O55239 | 85.5 | 2e-167 |
X-RAY |
2017-08-02 | PHE | A:125 | A:105 | 15.0 | 0.071 | -58.0 | 139.4 | 15.0 | 0.071 | 0.0 |
HOH |
2.975 |
O |
O |
|||
| PHE | B:125 | B:105 | 23.0 | 0.11 | -61.1 | 141.6 | NA | NA | NA | ||||||||||||||
| 5yji | 1 | O55239 | 85.5 | 2e-167 |
X-RAY |
2018-03-21 | PHE | A:125 | A:105 | 23.0 | 0.11 | -61.8 | 141.4 | 23.0 | 0.11 | 0.0 |
HOH |
3.110 |
N |
O |
|||
| PHE | B:125 | B:105 | 27.0 | 0.129 | -63.1 | 141.7 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p40261-f1 | 1 | P40261 | 100.0 | 0.0 | PHE | A:105 | A:105 | 12.0 | 0.057 | -62.5 | 137.1 | ||