Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 114182895 . T A CCDS8368.1:NM_006169.2:c.491cTg>cAg_NP_006160.1:p.164L>Q Homo sapiens nicotinamide N-methyltransferase (NNMT), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5yjf 1 P40261 98.86 0.0 X-RAY
 2018-03-21 LEU A:184 A:164 17.0 0.1 S 51.6 33.7 17.0 0.1 0.0 SAH
8WO
HOH
 3.439
3.208
3.046
 O
O
N
 C5'
C8
O
LEU B:184 B:164 17.0 0.1 S 48.3 33.2 NA NA NA
LEU C:184 C:164 19.0 0.112 S 44.4 40.6 NA NA NA
LEU D:184 D:164 19.0 0.112 S 62.5 27.0 NA NA NA
2iip 1 P40261 98.86 0.0 X-RAY
 2006-10-10 LEU A:183 A:164 13.0 0.076 S 48.2 32.8 13.0 0.076 0.0 SAH
HOH
 3.279
2.597
 O
O
 CG
O
LEU B:183 B:164 12.0 0.071 S 67.0 23.6 NA NA NA
LEU C:183 C:164 15.0 0.088 S 62.3 28.4 NA NA NA
LEU D:183 D:164 12.0 0.071 S 58.9 26.7 NA NA NA
3rod 1 P40261 98.86 0.0 X-RAY
 2011-09-07 LEU A:183 A:164 17.0 0.1 S 42.9 39.4 17.0 0.1 0.0 SAH
NCA
HOH
 3.297
3.458
6.064
 O
O
CD1
 C5'
C2
O
LEU B:183 B:164 15.0 0.088 S 68.2 26.9 NA NA NA
LEU C:183 C:164 13.0 0.076 S 39.3 32.0 NA NA NA
LEU D:183 D:164 20.0 0.118 S 40.7 48.4 NA NA NA
6b1a 1 P40261 98.86 0.0 X-RAY
 2018-01-31 LEU A:183 A:164 0.0 0.0 S 56.5 33.8 0.0 0.0 0.0 C8J
HOH
 3.044
2.714
 O
O
 CE
O
LEU B:183 B:164 0.0 0.0 S 53.3 38.2 NA NA NA
LEU C:183 C:164 0.0 0.0 S 55.3 27.1 NA NA NA
LEU D:183 D:164 1.0 0.006 S 53.3 33.1 NA NA NA
6chh 1 P40261 98.86 0.0 X-RAY
 2018-06-13 LEU A:183 A:164 0.0 0.0 S 57.5 35.0 0.0 0.0 0.0 F0P
HOH
 3.024
2.823
 O
O
 CG
O
LEU B:183 B:164 0.0 0.0 S 53.6 40.0 NA NA NA
LEU C:183 C:164 0.0 0.0 S 55.9 29.0 0.0 0.0 0.0 F0P
HOH
 2.990
2.724
 O
O
 CE
O
LEU D:183 D:164 1.0 0.006 S 53.9 33.7 1.0 0.006 0.0 F0P
HOH
 3.003
2.849
 O
O
 CE
O
6orr 1 Q6FH49 98.86 0.0 X-RAY
 2019-10-23 LEU A:183 A:164 32.0 0.188 S 61.9 36.0 32.0 0.188 0.0 N37
HOH
 3.055
2.975
 O
O
 C16
O
LEU B:183 B:164 33.0 0.194 S 61.3 35.5 NA NA NA
LEU C:183 C:164 32.0 0.188 S 59.0 38.7 NA NA NA
LEU D:183 D:164 34.0 0.2 S 61.4 35.8 NA NA NA
6pve 1 Q6FH49 98.86 0.0 X-RAY
 2019-11-27 LEU A:183 A:164 36.0 0.212 S 63.9 29.3 36.0 0.212 0.0 OZP
HOH
 3.096
2.936
 O
O
 C25
O
LEU B:183 B:164 33.0 0.194 S 62.5 30.2 NA NA NA
LEU C:183 C:164 35.0 0.206 S 64.0 30.6 NA NA NA
LEU D:183 D:164 34.0 0.2 S 64.3 30.4 NA NA NA
6pvs 1 Q6FH49 98.86 0.0 X-RAY
 2019-11-27 LEU A:183 A:164 37.0 0.218 S 62.3 20.9 37.0 0.218 0.0 P0V
HOH
 3.087
6.811
 CD1
CD2
 H321
O
LEU B:183 B:164 33.0 0.194 S 66.4 24.3 NA NA NA
LEU C:183 C:164 34.0 0.2 S 65.3 24.6 NA NA NA
LEU D:183 D:164 28.0 0.165 S 62.7 22.7 NA NA NA
7bkg 1 P40261 98.86 0.0 X-RAY
 2021-03-17 LEU A:183 A:164 19.0 0.112 S 53.8 33.3 19.0 0.112 0.0 SAH
U0Z
HOH
 3.073
3.049
3.503
 O
O
CD1
 CG
C8
O
LEU B:183 B:164 19.0 0.112 S 51.5 39.9 NA NA NA
LEU C:183 C:164 19.0 0.112 S 47.2 34.5 NA NA NA
LEU D:183 D:164 19.0 0.112 S 50.5 37.5 NA NA NA
7ble 1 P40261 98.86 0.0 X-RAY
 2021-03-17 LEU A:183 A:164 15.0 0.088 S 39.1 44.6 15.0 0.088 0.0 SAH
U1W
HOH
 3.159
2.835
3.917
 O
O
N
 CG
N13
O
LEU B:183 B:164 21.0 0.124 S 43.3 44.1 NA NA NA
LEU C:183 C:164 21.0 0.124 S 54.2 35.9 NA NA NA
LEU D:183 D:164 20.0 0.118 S 57.5 39.3 NA NA NA
7nbj 1 P40261 98.86 0.0 X-RAY
 2021-03-17 LEU A:183 A:164 38.0 0.224 S 51.4 39.0 38.0 0.224 0.0 U7H
HOH
 3.122
3.154
 O
O
 C1
O
LEU B:183 B:164 34.0 0.2 S 52.9 32.5 NA NA NA
LEU C:183 C:164 38.0 0.224 S 54.1 32.3 NA NA NA
LEU D:183 D:164 38.0 0.224 S 52.2 41.6 NA NA NA
7nbm 1 P40261 98.86 0.0 X-RAY
 2021-03-17 LEU A:183 A:164 39.0 0.229 S 49.9 58.0 39.0 0.229 0.0 U7K
HOH
 3.340
3.503
 O
CD1
 C8
O
LEU B:183 B:164 47.0 0.276 S 46.9 41.6 NA NA NA
LEU C:183 C:164 41.0 0.241 S 60.4 59.5 NA NA NA
LEU D:183 D:164 40.0 0.235 S 49.9 86.7 NA NA NA
7nbq 1 P40261 98.86 0.0 X-RAY
 2021-03-17 LEU A:183 A:164 19.0 0.112 S 47.3 40.0 19.0 0.112 0.0 SAH
U72
HOH
 3.140
3.131
3.620
 O
O
N
 CG
C14
O
LEU B:183 B:164 21.0 0.124 S 42.4 40.8 NA NA NA
LEU C:183 C:164 21.0 0.124 S 52.0 32.0 NA NA NA
LEU D:183 D:164 23.0 0.135 S 57.7 36.0 NA NA NA
7egu 1 P40261 99.61 0.0 X-RAY
 2021-12-15 LEU A:163 A:164 54.0 0.318 S 50.7 52.2 1.0 0.006 0.312 B:None:0.312
 HOH
 3.140
 N
 O
7ehz 1 P40261 99.61 0.0 X-RAY
 2021-12-15 LEU A:163 A:164 71.0 0.418 S 53.9 36.5 1.0 0.006 0.412 B:None:0.412
 HOH
 3.031
 C
 O
5xvq 1 F7ERX8 96.97 0.0 X-RAY
 2017-08-02 LEU A:184 A:164 19.0 0.112 S 52.4 39.2 19.0 0.112 0.0 SAH
8GC
HOH
 3.344
3.303
2.879
 O
O
O
 C5'
C9
O
LEU B:184 B:164 20.0 0.118 S 50.5 37.5 NA NA NA
2i62 1 O55239 85.5 7e-168 X-RAY
 2006-09-12 LEU A:165 A:165 15.0 0.088 S 55.0 36.7 15.0 0.088 0.0 SAH
HOH
 3.082
2.866
 O
O
 CG
O
LEU B:165 B:165 16.0 0.094 S 55.9 33.4 NA NA NA
LEU C:165 C:165 17.0 0.1 S 56.3 38.3 NA NA NA
LEU D:165 D:165 15.0 0.088 S 55.7 36.6 NA NA NA
5xvk 1 O55239 85.5 2e-167 X-RAY
 2017-08-02 LEU A:184 A:164 17.0 0.1 S 56.8 31.8 17.0 0.1 0.0 SAH
8GC
HOH
 3.358
3.276
2.863
 O
O
O
 C5'
C9
O
LEU B:184 B:164 16.0 0.094 S 56.7 31.3 NA NA NA
5yji 1 O55239 85.5 2e-167 X-RAY
 2018-03-21 LEU A:184 A:164 18.0 0.106 S 57.4 28.7 18.0 0.106 0.0 SAH
8WO
HOH
 3.466
3.271
2.834
 O
O
O
 C5'
C8
O
LEU B:184 B:164 18.0 0.106 S 58.2 32.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40261-f1 1 P40261 100.0 0.0 LEU A:164 A:164 31.0 0.182 S 54.8 39.7