Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 114182909 . G A CCDS8368.1:NM_006169.2:c.505Gcc>Acc_NP_006160.1:p.169A>T Homo sapiens nicotinamide N-methyltransferase (NNMT), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5yjf 1 P40261 98.86 0.0 X-RAY
 2018-03-21 ALA A:189 A:169 11.0 0.096 H -83.8 -24.9 11.0 0.096 0.0 SAH
8WO
HOH
 3.358
7.587
6.247
 CB
N
N
 N7
N2
O
ALA B:189 B:169 11.0 0.096 H -95.8 -18.6 NA NA NA
ALA C:189 C:169 12.0 0.104 H -101.9 -21.9 NA NA NA
ALA D:189 D:169 8.0 0.07 H -110.2 0.1 NA NA NA
2iip 1 P40261 98.86 0.0 X-RAY
 2006-10-10 ALA A:188 A:169 11.0 0.096 H -97.5 -20.4 11.0 0.096 0.0 SAH
HOH
 3.651
2.781
 CB
O
 C5
O
ALA B:188 B:169 11.0 0.096 H -79.9 -25.8 NA NA NA
ALA C:188 C:169 11.0 0.096 H -89.5 -17.4 NA NA NA
ALA D:188 D:169 11.0 0.096 H -86.4 -15.4 NA NA NA
3rod 1 P40261 98.86 0.0 X-RAY
 2011-09-07 ALA A:188 A:169 12.0 0.104 H -82.8 -20.0 12.0 0.104 0.0 SAH
NCA
HOH
 3.152
7.782
9.644
 CB
N
N
 N7
N7
O
ALA B:188 B:169 9.0 0.078 H -94.2 -13.7 NA NA NA
ALA C:188 C:169 9.0 0.078 G -117.6 40.6 NA NA NA
ALA D:188 D:169 7.0 0.061 T -118.5 -9.0 NA NA NA
6b1a 1 P40261 98.86 0.0 X-RAY
 2018-01-31 ALA A:188 A:169 9.0 0.078 H -94.8 -21.0 9.0 0.078 0.0 C8J
HOH
 3.575
2.683
 CB
O
 C5
O
ALA B:188 B:169 10.0 0.087 H -97.9 -21.4 NA NA NA
ALA C:188 C:169 15.0 0.13 H -93.4 -19.3 NA NA NA
ALA D:188 D:169 15.0 0.13 H -91.3 -26.1 NA NA NA
6chh 1 P40261 98.86 0.0 X-RAY
 2018-06-13 ALA A:188 A:169 10.0 0.087 H -96.6 -20.7 10.0 0.087 0.0 F0P
HOH
 3.598
2.733
 CB
O
 C5
O
ALA B:188 B:169 10.0 0.087 H -99.3 -20.7 NA NA NA
ALA C:188 C:169 15.0 0.13 H -93.4 -19.9 15.0 0.13 0.0 F0P
HOH
 3.519
2.728
 CB
O
 N7
O
ALA D:188 D:169 15.0 0.13 H -92.6 -25.0 15.0 0.13 0.0 F0P
HOH
 3.415
2.507
 CB
O
 N7
O
6orr 1 Q6FH49 98.86 0.0 X-RAY
 2019-10-23 ALA A:188 A:169 33.0 0.287 H -96.5 -11.4 33.0 0.287 0.0 N37
HOH
 3.497
4.499
 CB
CA
 C4
O
ALA B:188 B:169 38.0 0.33 H -95.8 -11.1 NA NA NA
ALA C:188 C:169 35.0 0.304 H -103.9 -11.0 NA NA NA
ALA D:188 D:169 35.0 0.304 H -95.3 -10.1 NA NA NA
6pve 1 Q6FH49 98.86 0.0 X-RAY
 2019-11-27 ALA A:188 A:169 36.0 0.313 H -95.4 -24.0 36.0 0.313 0.0 OZP
HOH
 3.414
2.888
 CB
O
 N7
O
ALA B:188 B:169 34.0 0.296 H -95.6 -23.7 NA NA NA
ALA C:188 C:169 36.0 0.313 H -93.2 -21.1 NA NA NA
ALA D:188 D:169 36.0 0.313 H -93.3 -21.3 NA NA NA
6pvs 1 Q6FH49 98.86 0.0 X-RAY
 2019-11-27 ALA A:188 A:169 34.0 0.296 H -92.0 -22.4 34.0 0.296 0.0 P0V
HOH
 3.790
3.321
 CB
O
 H171
O
ALA B:188 B:169 35.0 0.304 H -91.6 -21.6 NA NA NA
ALA C:188 C:169 38.0 0.33 H -90.0 -15.1 NA NA NA
ALA D:188 D:169 41.0 0.357 H -92.8 -18.9 NA NA NA
7bkg 1 P40261 98.86 0.0 X-RAY
 2021-03-17 ALA A:188 A:169 10.0 0.087 H -91.2 -30.0 10.0 0.087 0.0 SAH
U0Z
HOH
 3.605
6.456
2.615
 CB
N
O
 N7
C13
O
ALA B:188 B:169 11.0 0.096 H -88.8 -25.8 NA NA NA
ALA C:188 C:169 12.0 0.104 H -81.7 -23.4 NA NA NA
ALA D:188 D:169 11.0 0.096 H -79.3 -18.2 NA NA NA
7ble 1 P40261 98.86 0.0 X-RAY
 2021-03-17 ALA A:188 A:169 10.0 0.087 H -84.3 -36.4 10.0 0.087 0.0 SAH
U1W
HOH
 3.685
6.301
4.924
 CB
N
O
 C5
C14
O
ALA B:188 B:169 11.0 0.096 H -88.0 -36.7 NA NA NA
ALA C:188 C:169 10.0 0.087 H -77.2 -28.1 NA NA NA
ALA D:188 D:169 10.0 0.087 H -85.3 -24.7 NA NA NA
7nbj 1 P40261 98.86 0.0 X-RAY
 2021-03-17 ALA A:188 A:169 35.0 0.304 H -93.8 -27.1 35.0 0.304 0.0 U7H
HOH
 3.590
2.613
 CB
O
 C29
O
ALA B:188 B:169 35.0 0.304 H -90.0 -24.4 NA NA NA
ALA C:188 C:169 35.0 0.304 H -96.6 -18.7 NA NA NA
ALA D:188 D:169 37.0 0.322 H -94.3 -20.3 NA NA NA
7nbm 1 P40261 98.86 0.0 X-RAY
 2021-03-17 ALA A:188 A:169 29.0 0.252 H -69.4 -42.2 29.0 0.252 0.0 U7K
HOH
 3.650
6.534
 CB
O
 C20
O
ALA B:188 B:169 32.0 0.278 H -95.5 -27.5 NA NA NA
ALA C:188 C:169 37.0 0.322 H -89.7 -28.2 NA NA NA
ALA D:188 D:169 34.0 0.296 H -98.3 -25.9 NA NA NA
7nbq 1 P40261 98.86 0.0 X-RAY
 2021-03-17 ALA A:188 A:169 11.0 0.096 H -99.7 -16.7 11.0 0.096 0.0 SAH
U72
HOH
 3.637
6.415
2.718
 CB
N
O
 N7
C15
O
ALA B:188 B:169 11.0 0.096 H -90.4 -25.3 NA NA NA
ALA C:188 C:169 13.0 0.113 H -89.5 -24.2 NA NA NA
ALA D:188 D:169 12.0 0.104 H -89.2 -14.3 NA NA NA
7egu 1 P40261 99.61 0.0 X-RAY
 2021-12-15 ALA A:168 A:169 45.0 0.391 T -88.6 -21.8 37.0 0.322 0.069 B:None:0.07
 HOH
 2.689
 O
 O
7ehz 1 P40261 99.61 0.0 X-RAY
 2021-12-15 ALA A:168 A:169 44.0 0.383 H -74.9 -25.7 14.0 0.122 0.261 B:None:0.261
 HOH
 5.074
 N
 O
5xvq 1 F7ERX8 96.97 0.0 X-RAY
 2017-08-02 ALA A:189 A:169 11.0 0.096 H -82.5 -26.6 11.0 0.096 0.0 SAH
8GC
HOH
 3.662
7.173
2.731
 CB
N
O
 C5
N3
O
ALA B:189 B:169 11.0 0.096 H -80.2 -22.9 NA NA NA
2i62 1 O55239 85.5 7e-168 X-RAY
 2006-09-12 ALA A:170 A:170 15.0 0.13 H -87.2 -8.3 15.0 0.13 0.0 SAH
HOH
 3.624
2.784
 CB
O
 N7
O
ALA B:170 B:170 15.0 0.13 H -89.6 -7.5 NA NA NA
ALA C:170 C:170 5.0 0.043 H -86.7 -14.8 NA NA NA
ALA D:170 D:170 6.0 0.052 H -77.7 -8.1 NA NA NA
5xvk 1 O55239 85.5 2e-167 X-RAY
 2017-08-02 ALA A:189 A:169 14.0 0.122 H -93.0 -10.5 14.0 0.122 0.0 SAH
8GC
HOH
 3.548
7.203
2.775
 CB
N
O
 N7
N3
O
ALA B:189 B:169 14.0 0.122 H -93.3 -11.4 NA NA NA
5yji 1 O55239 85.5 2e-167 X-RAY
 2018-03-21 ALA A:189 A:169 13.0 0.113 H -92.4 -11.8 13.0 0.113 0.0 SAH
8WO
HOH
 3.625
7.305
2.848
 CB
N
O
 N7
N2
O
ALA B:189 B:169 15.0 0.13 H -101.5 -14.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40261-f1 1 P40261 100.0 0.0 ALA A:169 A:169 27.0 0.235 H -90.8 -15.6