Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 114183014 . T A CCDS8368.1:NM_006169.2:c.610Tac>Aac_NP_006160.1:p.204Y>N Homo sapiens nicotinamide N-methyltransferase (NNMT), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5yjf 1 P40261 98.86 0.0 X-RAY
 2018-03-21 TYR A:224 A:204 27.0 0.117 E -138.2 153.3 27.0 0.117 0.0 SAH
8WO
HOH
 4.019
3.405
5.444
 OH
CD2
CE2
 C5'
C2
O
TYR B:224 B:204 25.0 0.109 E -142.6 152.0 NA NA NA
TYR C:224 C:204 30.0 0.13 E -147.2 154.3 NA NA NA
TYR D:224 D:204 27.0 0.117 E -142.2 147.1 NA NA NA
2iip 1 P40261 98.86 0.0 X-RAY
 2006-10-10 TYR A:223 A:204 23.0 0.1 E -137.8 142.3 23.0 0.1 0.0 SAH
HOH
 3.863
3.643
 OH
CE2
 SD
O
TYR B:223 B:204 22.0 0.096 E -138.4 152.4 NA NA NA
TYR C:223 C:204 24.0 0.104 E -135.0 151.9 NA NA NA
TYR D:223 D:204 22.0 0.096 E -144.7 153.4 NA NA NA
3rod 1 P40261 98.86 0.0 X-RAY
 2011-09-07 TYR A:223 A:204 21.0 0.091 E -161.3 154.3 21.0 0.091 0.0 SAH
NCA
HOH
 3.916
3.395
8.255
 OH
CE1
N
 C5'
N1
O
TYR B:223 B:204 20.0 0.087 E -153.1 141.1 NA NA NA
TYR C:223 C:204 22.0 0.096 -159.3 133.3 NA NA NA
TYR D:223 D:204 26.0 0.113 E -155.2 134.2 NA NA NA
6b1a 1 P40261 98.86 0.0 X-RAY
 2018-01-31 TYR A:223 A:204 0.0 0.0 E -137.5 151.2 0.0 0.0 0.0 C8J
HOH
 3.466
4.558
 CD1
CE1
 C13
O
TYR B:223 B:204 0.0 0.0 E -132.1 157.9 NA NA NA
TYR C:223 C:204 16.0 0.07 E -138.0 150.0 NA NA NA
TYR D:223 D:204 15.0 0.065 E -137.2 156.8 NA NA NA
6chh 1 P40261 98.86 0.0 X-RAY
 2018-06-13 TYR A:223 A:204 0.0 0.0 E -137.5 149.9 0.0 0.0 0.0 F0P
HOH
 3.458
4.557
 CD1
CE1
 C13
O
TYR B:223 B:204 0.0 0.0 E -135.4 155.6 NA NA NA
TYR C:223 C:204 16.0 0.07 E -138.8 148.4 16.0 0.07 0.0 F0P
HOH
 3.463
3.252
 CD1
OH
 C13
O
TYR D:223 D:204 15.0 0.065 E -137.2 155.8 15.0 0.065 0.0 F0P
HOH
 3.436
3.808
 CD1
OH
 C13
O
6orr 1 Q6FH49 98.86 0.0 X-RAY
 2019-10-23 TYR A:223 A:204 34.0 0.148 E -143.2 152.3 34.0 0.148 0.0 N37
HOH
 3.415
4.612
 CD1
CE1
 C23
O
TYR B:223 B:204 32.0 0.139 E -143.2 151.2 NA NA NA
TYR C:223 C:204 35.0 0.152 E -137.9 153.6 NA NA NA
TYR D:223 D:204 32.0 0.139 E -143.4 151.3 NA NA NA
6pve 1 Q6FH49 98.86 0.0 X-RAY
 2019-11-27 TYR A:223 A:204 30.0 0.13 E -137.9 156.3 30.0 0.13 0.0 OZP
HOH
 3.289
4.364
 CD1
CE1
 C28
O
TYR B:223 B:204 30.0 0.13 E -137.4 155.2 NA NA NA
TYR C:223 C:204 32.0 0.139 E -139.4 155.7 NA NA NA
TYR D:223 D:204 32.0 0.139 E -139.5 155.4 NA NA NA
6pvs 1 Q6FH49 98.86 0.0 X-RAY
 2019-11-27 TYR A:223 A:204 34.0 0.148 E -136.2 153.2 34.0 0.148 0.0 P0V
HOH
 2.738
7.666
 CD1
CD1
 H281
O
TYR B:223 B:204 34.0 0.148 E -135.0 154.3 NA NA NA
TYR C:223 C:204 34.0 0.148 E -138.6 154.8 NA NA NA
TYR D:223 D:204 37.0 0.161 E -137.3 154.5 NA NA NA
7bkg 1 P40261 98.86 0.0 X-RAY
 2021-03-17 TYR A:223 A:204 25.0 0.109 E -150.9 144.4 25.0 0.109 0.0 SAH
U0Z
HOH
 3.948
3.545
4.512
 OH
CE2
CE2
 C5'
C8
O
TYR B:223 B:204 25.0 0.109 E -149.9 147.8 NA NA NA
TYR C:223 C:204 29.0 0.126 E -144.5 142.4 NA NA NA
TYR D:223 D:204 30.0 0.13 E -147.2 143.6 NA NA NA
7ble 1 P40261 98.86 0.0 X-RAY
 2021-03-17 TYR A:223 A:204 26.0 0.113 E -149.0 142.5 26.0 0.113 0.0 SAH
U1W
HOH
 3.836
3.417
8.333
 OH
CD2
O
 C5'
C14
O
TYR B:223 B:204 28.0 0.122 E -150.6 145.8 NA NA NA
TYR C:223 C:204 30.0 0.13 E -141.5 135.9 NA NA NA
TYR D:223 D:204 28.0 0.122 E -150.4 139.0 NA NA NA
7nbj 1 P40261 98.86 0.0 X-RAY
 2021-03-17 TYR A:223 A:204 38.0 0.165 E -146.0 155.5 38.0 0.165 0.0 U7H
HOH
 2.721
4.501
 OH
CE2
 O12
O
TYR B:223 B:204 38.0 0.165 E -144.3 154.2 NA NA NA
TYR C:223 C:204 39.0 0.17 E -140.6 158.0 NA NA NA
TYR D:223 D:204 38.0 0.165 E -145.4 153.3 NA NA NA
7nbm 1 P40261 98.86 0.0 X-RAY
 2021-03-17 TYR A:223 A:204 40.0 0.174 E -153.8 141.9 40.0 0.174 0.0 U7K
HOH
 2.526
8.045
 OH
CE1
 O16
O
TYR B:223 B:204 39.0 0.17 E -144.8 149.6 NA NA NA
TYR C:223 C:204 38.0 0.165 E -151.4 148.7 NA NA NA
TYR D:223 D:204 41.0 0.178 E -152.9 136.5 NA NA NA
7nbq 1 P40261 98.86 0.0 X-RAY
 2021-03-17 TYR A:223 A:204 29.0 0.126 E -143.3 154.2 29.0 0.126 0.0 SAH
U72
HOH
 3.950
3.590
4.735
 OH
CE2
CE2
 C5'
C14
O
TYR B:223 B:204 27.0 0.117 E -148.0 142.4 NA NA NA
TYR C:223 C:204 29.0 0.126 E -146.0 153.0 NA NA NA
TYR D:223 D:204 32.0 0.139 E -144.6 147.9 NA NA NA
7egu 1 P40261 99.61 0.0 X-RAY
 2021-12-15 TYR A:203 A:204 55.0 0.239 E -84.9 120.3 55.0 0.239 0.0 HOH
 2.787
 OH
 O
7ehz 1 P40261 99.61 0.0 X-RAY
 2021-12-15 TYR A:203 A:204 240.0 1.0 T 55.1 18.8 240.0 1.0 0.0
5xvq 1 F7ERX8 96.97 0.0 X-RAY
 2017-08-02 TYR A:224 A:204 27.0 0.117 E -137.2 159.2 27.0 0.117 0.0 SAH
8GC
HOH
 4.305
3.455
4.662
 OH
CD1
CE1
 C5'
C10
O
TYR B:224 B:204 26.0 0.113 E -136.9 158.3 NA NA NA
2i62 1 O55239 85.5 7e-168 X-RAY
 2006-09-12 TYR A:205 A:205 21.0 0.091 E -137.1 150.5 21.0 0.091 0.0 SAH
HOH
 3.840
4.217
 OH
CD2
 C5'
O
TYR B:205 B:205 23.0 0.1 E -140.5 151.4 NA NA NA
TYR C:205 C:205 22.0 0.096 E -142.2 154.3 NA NA NA
TYR D:205 D:205 22.0 0.096 E -140.1 155.8 NA NA NA
5xvk 1 O55239 85.5 2e-167 X-RAY
 2017-08-02 TYR A:224 A:204 23.0 0.1 E -142.2 149.9 23.0 0.1 0.0 SAH
8GC
GOL
HOH
 3.910
3.357
7.511
4.506
 OH
CD2
N
CE2
 C5'
C10
O1
O
TYR B:224 B:204 23.0 0.1 E -144.8 148.9 NA NA NA
5yji 1 O55239 85.5 2e-167 X-RAY
 2018-03-21 TYR A:224 A:204 27.0 0.117 E -140.7 157.1 27.0 0.117 0.0 SAH
8WO
HOH
 4.092
3.244
4.499
 OH
CD2
CE2
 C5'
C2
O
TYR B:224 B:204 29.0 0.126 E -142.1 151.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40261-f1 1 P40261 100.0 0.0 TYR A:204 A:204 32.0 0.139 E -139.0 161.7