Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 114183068 . G A CCDS8368.1:NM_006169.2:c.664Gag>Aag_NP_006160.1:p.222E>K Homo sapiens nicotinamide N-methyltransferase (NNMT), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5yjf 1 P40261 98.86 0.0 X-RAY
 2018-03-21 GLU A:242 A:222 75.0 0.395 H -56.7 -50.4 75.0 0.395 0.0 HOH
 7.809
 OE2
 O
GLU B:242 B:222 49.0 0.258 H -51.4 -40.7 NA NA NA
GLU C:242 C:222 24.0 NA H -54.4 -44.9 NA NA NA
GLU D:242 D:222 1.0 NA H -52.1 -51.5 NA NA NA
2iip 1 P40261 98.86 0.0 X-RAY
 2006-10-10 GLU A:241 A:222 65.0 0.342 H -59.9 -44.0 65.0 0.342 0.0 HOH
 4.505
 OE2
 O
GLU B:241 B:222 54.0 0.284 H -59.6 -49.3 NA NA NA
GLU C:241 C:222 58.0 0.305 H -58.9 -53.7 NA NA NA
GLU D:241 D:222 90.0 0.474 H -56.0 -51.0 NA NA NA
3rod 1 P40261 98.86 0.0 X-RAY
 2011-09-07 GLU A:241 A:222 70.0 0.368 H -57.3 -42.7 70.0 0.368 0.0
GLU B:241 B:222 40.0 0.211 H -58.6 -55.8 NA NA NA
GLU C:241 C:222 40.0 0.211 H -58.9 -38.4 NA NA NA
GLU D:241 D:222 65.0 0.342 H -51.6 -68.1 NA NA NA
6b1a 1 P40261 98.86 0.0 X-RAY
 2018-01-31 GLU A:241 A:222 82.0 0.432 H -61.1 -43.4 82.0 0.432 0.0 HOH
 5.480
 OE2
 O
GLU B:241 B:222 76.0 0.4 H -54.6 -43.7 NA NA NA
GLU C:241 C:222 68.0 0.358 H -55.8 -46.8 NA NA NA
GLU D:241 D:222 82.0 0.432 H -67.1 -46.0 NA NA NA
6chh 1 P40261 98.86 0.0 X-RAY
 2018-06-13 GLU A:241 A:222 82.0 0.432 H -61.1 -43.4 46.0 0.242 0.19 D:P40261:0.189
 HOH
 5.523
 OE2
 O
GLU B:241 B:222 76.0 0.4 H -52.3 -44.0 NA NA NA
GLU C:241 C:222 67.0 0.353 H -54.9 -48.3 65.0 0.342 0.011 B:P40261:0.011
 HOH
 6.658
 OE2
 O
GLU D:241 D:222 82.0 0.432 H -67.9 -47.1 49.0 0.258 0.174 A:P40261:0.174
 HOH
 7.219
 O
 O
6orr 1 Q6FH49 98.86 0.0 X-RAY
 2019-10-23 GLU A:241 A:222 42.0 0.221 H -62.1 -40.7 42.0 0.221 0.0 GOL
GOL
HOH
 9.442
8.281
4.605
 C
O
OE1
 O2
C1
O
GLU B:241 B:222 63.0 0.332 H -63.2 -40.3 NA NA NA
GLU C:241 C:222 69.0 0.363 H -61.1 -38.8 NA NA NA
GLU D:241 D:222 45.0 0.237 H -62.5 -41.1 NA NA NA
6pve 1 Q6FH49 98.86 0.0 X-RAY
 2019-11-27 GLU A:241 A:222 82.0 0.432 H -58.4 -45.3 82.0 0.432 0.0 HOH
 4.446
 CB
 O
GLU B:241 B:222 48.0 0.253 H -59.1 -45.8 NA NA NA
GLU C:241 C:222 50.0 0.263 H -59.6 -46.7 NA NA NA
GLU D:241 D:222 65.0 0.342 H -58.4 -45.8 NA NA NA
6pvs 1 Q6FH49 98.86 0.0 X-RAY
 2019-11-27 GLU A:241 A:222 47.0 0.247 H -53.6 -44.7 47.0 0.247 0.0 HOH
 8.763
 O
 O
GLU B:241 B:222 73.0 0.384 H -53.4 -45.5 NA NA NA
GLU C:241 C:222 87.0 0.458 H -53.4 -46.1 NA NA NA
GLU D:241 D:222 104.0 0.547 H -52.4 -40.2 NA NA NA
7bkg 1 P40261 98.86 0.0 X-RAY
 2021-03-17 GLU A:241 A:222 54.0 0.284 H -59.2 -44.4 54.0 0.284 0.0 HOH
 5.321
 OE2
 O
GLU B:241 B:222 86.0 0.453 H -60.3 -39.2 NA NA NA
GLU C:241 C:222 80.0 0.421 H -60.0 -46.6 NA NA NA
GLU D:241 D:222 89.0 0.468 H -55.2 -46.6 NA NA NA
7ble 1 P40261 98.86 0.0 X-RAY
 2021-03-17 GLU A:241 A:222 62.0 0.326 H -49.2 -54.3 62.0 0.326 0.0 HOH
 4.633
 OE2
 O
GLU B:241 B:222 65.0 0.342 H -53.5 -48.9 NA NA NA
GLU C:241 C:222 61.0 0.321 H -54.3 -41.8 NA NA NA
GLU D:241 D:222 58.0 0.305 H -51.7 -50.4 NA NA NA
7nbj 1 P40261 98.86 0.0 X-RAY
 2021-03-17 GLU A:241 A:222 52.0 0.274 H -65.8 -47.7 52.0 0.274 0.0 HOH
 6.590
 O
 O
GLU B:241 B:222 59.0 0.311 H -62.8 -38.9 NA NA NA
GLU C:241 C:222 60.0 0.316 H -61.4 -41.0 NA NA NA
GLU D:241 D:222 66.0 0.347 H -59.5 -44.8 NA NA NA
7nbm 1 P40261 98.86 0.0 X-RAY
 2021-03-17 GLU A:241 A:222 61.0 0.321 H -57.9 -45.8 61.0 0.321 0.0 HOH
 4.395
 OE2
 O
GLU B:241 B:222 73.0 0.384 H -56.1 -45.2 NA NA NA
GLU C:241 C:222 39.0 0.205 H -53.2 -47.8 NA NA NA
GLU D:241 D:222 70.0 0.368 H -58.5 -34.3 NA NA NA
7nbq 1 P40261 98.86 0.0 X-RAY
 2021-03-17 GLU A:241 A:222 52.0 0.274 H -50.3 -54.0 52.0 0.274 0.0 HOH
 5.296
 OE2
 O
GLU B:241 B:222 91.0 0.479 H -53.7 -47.6 NA NA NA
GLU C:241 C:222 31.0 0.163 H -61.0 -45.2 NA NA NA
GLU D:241 D:222 61.0 0.321 H -55.4 -49.0 NA NA NA
7egu 1 P40261 99.61 0.0 X-RAY
 2021-12-15 GLU A:221 A:222 35.0 0.184 H -61.0 -40.9 35.0 0.184 0.0 HOH
 2.660
 OE2
 O
7ehz 1 P40261 99.61 0.0 X-RAY
 2021-12-15 GLU A:221 A:222 28.0 0.147 H -54.8 -39.3 28.0 0.147 0.0
5xvq 1 F7ERX8 96.97 0.0 X-RAY
 2017-08-02 GLU A:242 A:222 47.0 0.247 H -64.7 -43.7 47.0 0.247 0.0 HOH
 2.512
 OE2
 O
GLU B:242 B:222 44.0 0.232 H -59.6 -41.5 NA NA NA
2i62 1 O55239 85.5 7e-168 X-RAY
 2006-09-12 ARG A:223 A:223 77.0 0.342 H -57.1 -47.2 77.0 0.342 0.0 HOH
 2.792
 NH2
 O
ARG B:223 B:223 76.0 0.338 H -46.6 -55.9 NA NA NA
ARG C:223 C:223 81.0 0.36 H -48.8 -51.3 NA NA NA
ARG D:223 D:223 77.0 0.342 H -49.8 -51.5 NA NA NA
5xvk 1 O55239 85.5 2e-167 X-RAY
 2017-08-02 ARG A:242 A:222 78.0 0.347 H -50.8 -53.7 78.0 0.347 0.0 HOH
 5.397
 CD
 O
ARG B:242 B:222 84.0 0.373 H -53.5 -48.8 NA NA NA
5yji 1 O55239 85.5 2e-167 X-RAY
 2018-03-21 ARG A:242 A:222 81.0 0.36 H -50.7 -50.0 81.0 0.36 0.0 HOH
 2.618
 NH2
 O
ARG B:242 B:222 86.0 0.382 H -50.5 -51.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40261-f1 1 P40261 100.0 0.0 GLU A:222 A:222 39.0 0.205 H -60.2 -42.0