Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr11 | 114183174 | . | C | A | CCDS8368.1:NM_006169.2:c.770gCg>gAg_NP_006160.1:p.257A>E | Homo sapiens nicotinamide N-methyltransferase (NNMT), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 5yjf | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2018-03-21 | ALA | A:277 | A:257 | 0.0 | 0.0 | E | -124.4 | 160.1 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | B:277 | B:257 | 0.0 | 0.0 | E | -120.7 | 155.3 | NA | NA | NA | |||||||||||||
| ALA | C:277 | C:257 | 0.0 | 0.0 | E | -120.4 | 152.5 | NA | NA | NA | |||||||||||||
| ALA | D:277 | D:257 | 0.0 | 0.0 | E | -120.9 | 171.2 | NA | NA | NA | |||||||||||||
| 2iip | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2006-10-10 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -125.0 | 163.1 | 0.0 | 0.0 | 0.0 |
HOH |
8.237 |
CA |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -136.3 | 154.6 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -117.6 | 161.4 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -125.4 | 155.8 | NA | NA | NA | |||||||||||||
| 3rod | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2011-09-07 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -125.5 | 149.3 | 0.0 | 0.0 | 0.0 |
HOH |
9.155 |
CA |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -142.1 | 152.3 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -107.2 | 149.9 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -90.2 | 150.9 | NA | NA | NA | |||||||||||||
| 6b1a | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2018-01-31 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -132.9 | 165.1 | 0.0 | 0.0 | 0.0 |
HOH |
6.807 |
CB |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -135.2 | 167.2 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -128.3 | 159.6 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -130.5 | 157.3 | NA | NA | NA | |||||||||||||
| 6chh | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2018-06-13 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -131.1 | 163.9 | 0.0 | 0.0 | 0.0 |
HOH |
6.804 |
CB |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -134.4 | 167.8 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -126.9 | 162.4 | 0.0 | 0.0 | 0.0 |
HOH |
9.100 |
CA |
O |
|||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -127.8 | 157.1 | 0.0 | 0.0 | 0.0 |
HOH |
8.884 |
CB |
O |
|||||||||
| 6orr | 1 | Q6FH49 | 98.86 | 0.0 |
X-RAY |
2019-10-23 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -129.2 | 162.2 | 0.0 | 0.0 | 0.0 |
GOL HOH |
9.096 8.431 |
CB CB |
C1 O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -129.4 | 159.4 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -129.1 | 169.5 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -129.3 | 164.9 | NA | NA | NA | |||||||||||||
| 6pve | 1 | Q6FH49 | 98.86 | 0.0 |
X-RAY |
2019-11-27 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -130.0 | 165.9 | 0.0 | 0.0 | 0.0 |
HOH |
9.340 |
O |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -129.7 | 166.5 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -129.8 | 166.7 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -129.2 | 166.7 | NA | NA | NA | |||||||||||||
| 6pvs | 1 | Q6FH49 | 98.86 | 0.0 |
X-RAY |
2019-11-27 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -129.4 | 162.9 | 0.0 | 0.0 | 0.0 |
HOH |
7.950 |
C |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -130.7 | 162.2 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -132.3 | 164.5 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -128.7 | 163.1 | NA | NA | NA | |||||||||||||
| 7bkg | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -118.7 | 168.4 | 0.0 | 0.0 | 0.0 |
HOH |
7.123 |
CB |
O |
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| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -130.9 | 161.0 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -121.6 | 165.0 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -118.0 | 166.5 | NA | NA | NA | |||||||||||||
| 7ble | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -102.8 | 163.6 | 0.0 | 0.0 | 0.0 |
HOH |
7.887 |
N |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -109.7 | 178.4 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -100.1 | 163.2 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -123.1 | 158.8 | NA | NA | NA | |||||||||||||
| 7nbj | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -127.0 | 165.3 | 0.0 | 0.0 | 0.0 |
HOH |
7.302 |
N |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -125.8 | 166.0 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -129.6 | 165.8 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -125.5 | 160.3 | NA | NA | NA | |||||||||||||
| 7nbm | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -130.9 | -177.8 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -128.7 | 163.5 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 1.0 | 0.009 | E | -102.9 | 154.6 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -114.3 | 150.5 | NA | NA | NA | |||||||||||||
| 7nbq | 1 | P40261 | 98.86 | 0.0 |
X-RAY |
2021-03-17 | ALA | A:276 | A:257 | 0.0 | 0.0 | E | -124.3 | 162.3 | 0.0 | 0.0 | 0.0 |
HOH |
7.324 |
CB |
O |
||
| ALA | B:276 | B:257 | 0.0 | 0.0 | E | -128.4 | 158.1 | NA | NA | NA | |||||||||||||
| ALA | C:276 | C:257 | 0.0 | 0.0 | E | -123.4 | 159.8 | NA | NA | NA | |||||||||||||
| ALA | D:276 | D:257 | 0.0 | 0.0 | E | -124.3 | 159.3 | NA | NA | NA | |||||||||||||
| 7egu | 1 | P40261 | 99.61 | 0.0 |
X-RAY |
2021-12-15 | ALA | A:256 | A:257 | 0.0 | 0.0 | E | -137.3 | 159.7 | 0.0 | 0.0 | 0.0 |
HOH |
7.349 |
N |
O |
||
| 7ehz | 1 | P40261 | 99.61 | 0.0 |
X-RAY |
2021-12-15 | ALA | A:256 | A:257 | 0.0 | 0.0 | E | -129.3 | 157.8 | 0.0 | 0.0 | 0.0 | ||||||
| 5xvq | 1 | F7ERX8 | 96.97 | 0.0 |
X-RAY |
2017-08-02 | GLY | A:277 | A:257 | 0.0 | 0.0 | E | -133.9 | 157.8 | 0.0 | 0.0 | 0.0 |
GOL HOH |
9.114 6.971 |
O N |
O1 O |
||
| GLY | B:277 | B:257 | 0.0 | 0.0 | E | -120.4 | 163.6 | NA | NA | NA | |||||||||||||
| 2i62 | 1 | O55239 | 85.5 | 7e-168 |
X-RAY |
2006-09-12 | GLY | A:258 | A:258 | 0.0 | 0.0 | E | -116.3 | 165.8 | 0.0 | 0.0 | 0.0 |
HOH |
7.414 |
N |
O |
||
| GLY | B:258 | B:258 | 0.0 | 0.0 | E | -114.4 | 133.3 | NA | NA | NA | |||||||||||||
| GLY | C:258 | C:258 | 0.0 | 0.0 | E | -122.1 | 147.0 | NA | NA | NA | |||||||||||||
| GLY | D:258 | D:258 | 0.0 | 0.0 | E | -119.4 | 145.0 | NA | NA | NA | |||||||||||||
| 5xvk | 1 | O55239 | 85.5 | 2e-167 |
X-RAY |
2017-08-02 | GLY | A:277 | A:257 | 0.0 | 0.0 | E | -115.9 | 151.8 | 0.0 | 0.0 | 0.0 |
HOH |
6.407 |
C |
O |
||
| GLY | B:277 | B:257 | 0.0 | 0.0 | E | -115.7 | 152.0 | NA | NA | NA | |||||||||||||
| 5yji | 1 | O55239 | 85.5 | 2e-167 |
X-RAY |
2018-03-21 | GLY | A:277 | A:257 | 0.0 | 0.0 | E | -115.8 | 157.5 | 0.0 | 0.0 | 0.0 |
HOH |
6.468 |
C |
O |
||
| GLY | B:277 | B:257 | 0.0 | 0.0 | E | -119.2 | 155.4 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p40261-f1 | 1 | P40261 | 100.0 | 0.0 | ALA | A:257 | A:257 | 0.0 | 0.0 | E | -129.4 | 147.5 | |