Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 12958749 . T A CCDS7810.2:NM_021961.5:c.1261Tac>Aac_NP_068780.2:p.421Y>N Homo sapiens TEA domain transcription factor 1 (TEAD1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7cmm 1 P28347 99.55 1e-167 X-RAY
 2021-02-03 TYR A:225 A:421 48.0 0.209 E -124.5 158.4 48.0 0.209 0.0
TYR B:225 B:421 28.0 0.122 E -132.8 162.2 NA NA NA
TYR C:225 C:421 58.0 0.252 E -124.3 158.0 NA NA NA
TYR D:225 D:421 67.0 0.291 E -132.6 163.8 NA NA NA
4re1 1 P28347 99.54 3e-166 X-RAY
 2014-11-19 TYR A:215 A:406 44.0 0.191 E -123.9 142.9 2.0 0.009 0.182 D:P46937:0.183
 HOH
 5.693
 N
 O
TYR B:215 B:406 44.0 0.191 E -123.5 144.8 NA NA NA
3kys 1 P28347 100.0 4e-166 X-RAY
 2010-02-23 TYR A:214 A:406 44.0 0.191 E -127.1 141.2 0.0 0.0 0.191 B:P46937:0.191
TYR C:214 C:406 44.0 0.191 E -129.5 139.2 NA NA NA
6im5 1 P28347 99.55 3e-165 X-RAY
 2019-02-06 TYR A:228 A:421 40.0 0.174 E -128.7 148.5 40.0 0.174 0.0 HOH
 2.657
 OH
 O
TYR B:228 B:421 39.0 0.17 E -123.7 150.5 NA NA NA
6hil 1 P28347 99.54 4e-165 X-RAY
 2019-04-03 HIS A:214 A:406 33.0 0.169 E -128.1 141.5 1.0 0.005 0.164 B:P46937:0.164
 HOH
 8.943
 CE1
 O
HIS C:214 D:406 30.0 0.154 E -125.5 137.5 NA NA NA
HIS E:214 B:406 30.0 0.154 E -129.4 135.9 NA NA NA
HIS G:214 C:406 29.0 0.149 E -132.2 146.6 NA NA NA
7li5 1 E9PKB7 100.0 5e-164 X-RAY
 2022-02-02 TYR A:217 A:421 56.0 0.243 E -126.8 153.3 56.0 0.243 0.0 HOH
 2.472
 OH
 O
TYR B:217 B:421 60.0 0.261 E -125.1 157.3 NA NA NA
6ge3 1 Q15561 81.74 5e-136 X-RAY
 2018-09-19 TYR A:214 A:429 41.0 0.178 E -124.4 148.9 1.0 0.004 0.174 B:P46937:0.174
 HOH
 3.665
 CE1
 O
6gec 1 Q15561 81.74 5e-136 X-RAY
 2018-09-19 TYR A:214 A:429 46.0 0.2 E -127.3 154.4 5.0 0.022 0.178 B:P46937:0.178
 HOH
 2.590
 OH
 O
4ln0 1 Q62296 82.19 5e-136 X-RAY
 2014-02-26 TYR A:217 A:422 43.0 0.187 E -131.0 146.6 43.0 0.187 0.0 GOL
HOH
 7.239
4.917
 OH
CD1
 O2
O
TYR B:217 B:422 46.0 0.2 E -129.2 147.0 46.0 0.2 0.0 GOL
 3.829
 OH
 O1
6l9f 1 Q62296 82.19 5e-136 X-RAY
 2019-12-11 TYR A:217 A:422 46.0 0.2 E -124.5 148.0 2.0 0.009 0.191 B:Q8N9Y4:0.191
 HOH
 3.958
 CE1
 O
TYR C:217 B:422 42.0 0.183 E -115.5 147.4 NA NA NA
6sba 1 Q62296 82.19 1e-135 X-RAY
 2020-09-30 TYR A:216 A:422 47.0 0.204 E -131.8 151.3 47.0 0.204 0.0 GOL
GOL
HOH
 3.891
6.979
3.570
 OH
HE2
HA
 O3
HO1
O
6ge5 1 Q15561 81.28 2e-135 X-RAY
 2018-09-19 PHE A:214 A:429 39.0 0.186 E -121.5 149.8 0.0 0.0 0.186 B:P46937:0.186
 HOH
 4.223
 CD1
 O
6geg 1 Q15561 81.28 2e-135 X-RAY
 2018-09-19 PHE A:214 A:429 40.0 0.19 E -121.0 153.9 0.0 0.0 0.19 B:P46937:0.19
 HOH
 4.175
 CD1
 O
6gek 1 Q15561 81.28 2e-135 X-RAY
 2018-09-19 PHE A:214 A:429 39.0 0.186 E -126.9 153.4 0.0 0.0 0.186 B:P46937:0.186
 HOH
 4.324
 CD2
 O
PHE C:214 B:429 40.0 0.19 E -127.4 148.3 NA NA NA
3jua 1 Q62296 82.11 4e-135 X-RAY
 2010-02-23 TYR A:215 A:422 47.0 0.204 E -126.7 135.3 1.0 0.004 0.2 B:P46938:0.2
 HOH
 3.869
 CE1
 O
TYR C:215 C:422 45.0 0.196 E -133.5 147.1 NA NA NA
TYR E:215 E:422 46.0 0.2 E -128.5 149.7 NA NA NA
TYR G:215 G:422 49.0 0.213 E -117.9 135.1 NA NA NA
5xjd 1 Q62296 82.11 4e-135 X-RAY
 2018-01-24 TYR A:215 A:422 45.0 0.196 E -125.9 153.4 45.0 0.196 0.0 HOH
 4.290
 CD2
 O
TYR B:215 B:422 53.0 0.23 E -123.1 150.5 53.0 0.23 0.0 HOH
 4.814
 CD1
 O
6ge4 1 Q15561 81.28 4e-135 X-RAY
 2018-09-19 TYR A:214 A:429 59.0 0.257 E -124.4 149.7 3.0 0.013 0.244 B:P46937:0.243
 HOH
 3.440
 CE1
 O
6gee 1 Q15561 81.28 4e-135 X-RAY
 2018-09-19 TYR A:214 A:429 62.0 0.27 E -128.6 154.8 12.0 0.052 0.218 B:P46937:0.217
 HOH
 2.579
 OH
 O
6hik 1 Q15561 81.28 4e-135 X-RAY
 2019-04-03 HIS A:214 A:429 36.0 0.185 E -129.4 146.8 4.0 0.021 0.164 B:P46937:0.164
 HOH
 5.668
 N
 O
5gn0 1 Q62296 82.11 6e-135 X-RAY
 2017-05-31 TYR A:220 A:422 45.0 0.196 E -129.1 155.2 0.0 0.0 0.196 E:Q9EPK5:0.196
 HOH
 6.773
 N
 O
TYR B:220 B:422 42.0 0.183 E -134.7 151.1 NA NA NA
TYR C:220 C:422 42.0 0.183 E -138.3 154.7 NA NA NA
TYR D:220 D:422 44.0 0.191 E -129.1 158.3 NA NA NA
5oaq 1 Q15561 81.65 7e-135 X-RAY
 2017-10-11 TYR A:215 A:429 42.0 0.183 E -121.0 150.0 1.0 0.004 0.179 B:P46937:0.178
 HOH
 4.161
 CD1
 O
6q2x 1 Q15561 81.65 7e-135 X-RAY
 2019-07-03 TYR A:215 A:429 43.0 0.187 E -121.3 150.3 1.0 0.004 0.183 B:P46937:0.183
 HOH
 3.536
 CE1
 O
6q36 1 Q15561 81.65 7e-135 X-RAY
 2019-07-03 TYR A:215 A:429 45.0 0.196 E -127.1 144.1 0.0 0.0 0.196 C:None:0.196
 HOH
 3.598
 CE1
 O
TYR B:215 B:429 44.0 0.191 E -128.7 145.5 0.0 0.0 0.191 D:None:0.191
 HOH
 3.842
 CE1
 O
5z2q 4 Q62296 82.49 1e-134 X-RAY
 2018-01-31 TYR D:224 B:422 45.0 0.196 E -119.9 153.7 45.0 0.196 0.0
5z2q 3 Q62296 82.49 1e-134 X-RAY
 2018-01-31 TYR C:222 A:422 48.0 0.209 E -116.0 154.0 NA NA NA
6ge6 1 Q15561 80.82 2e-134 X-RAY
 2018-09-19 PHE A:214 A:429 45.0 0.214 E -127.7 147.7 0.0 0.0 0.214 B:P46937:0.214
 HOH
 4.044
 CD2
 O
6gei 1 Q15561 80.82 2e-134 X-RAY
 2018-09-19 PHE A:214 A:429 47.0 0.224 E -123.4 150.7 0.0 0.0 0.224 B:P46937:0.224
 HOH
 3.891
 CD1
 O
6sen 1 Q15561 81.19 4e-134 X-RAY
 2019-11-20 TYR A:215 A:429 41.0 0.178 E -124.3 155.1 2.0 0.009 0.169 C:Q8N9Y4:0.17
 HOH
 3.884
 CE1
 O
TYR B:215 B:429 39.0 0.17 E -126.1 153.4 NA NA NA
6seo 1 Q15561 81.19 4e-134 X-RAY
 2019-11-20 TYR A:215 A:429 43.0 0.187 E -125.2 143.8 0.0 0.0 0.187 B:A6NEQ2:0.187
 HOH
 4.280
 CD1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p28347-f1 1 P28347 100.0 0.0 TYR A:421 A:421 49.0 0.213 E -124.8 148.5