Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 67169225 . T A CCDS8160.1:NM_002708.3:c.29gAc>gTc_NP_002699.1:p.10D>V Homo sapiens protein phosphatase 1 catalytic subunit alpha (PPP1CA), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1fjm 1 P08129 100.0 0.0 X-RAY
1996-06-20 ASP A:10 A:10 97.0 0.647 H -61.8 -34.0 97.0 0.647 0.0 HOH
2.683
OD1
O
ASP B:10 B:10 103.0 0.687 H -62.2 -39.1 NA NA NA
4g9j 1 P62136 100.0 0.0 X-RAY
2012-09-19 ASP A:11 A:10 106.0 0.707 H -80.3 -8.6 106.0 0.707 0.0 HOH
7.597
O
O
ASP B:11 B:10 101.0 0.673 H -48.8 -43.4 NA NA NA
6g0i 1 P62136 100.0 0.0 X-RAY
2018-11-21 ASP A:11 A:10 105.0 0.7 H -63.8 -32.4 105.0 0.7 0.0 HOH
3.558
N
O
6g0j 1 P62136 100.0 0.0 X-RAY
2018-11-21 ASP A:11 A:10 87.0 0.58 H -63.3 -29.5 87.0 0.58 0.0 HOH
6.581
CG
O
5zqv 1 P62137 99.7 0.0 X-RAY
2019-03-13 ASP A:10 A:10 90.0 0.6 H -66.8 -38.8 90.0 0.6 0.0
ASP B:10 B:10 83.0 0.553 H -62.6 -31.6 NA NA NA
ASP C:10 C:10 99.0 0.66 H -61.2 -40.2 99.0 0.66 0.0
ASP D:10 D:10 105.0 0.7 H -63.3 -33.6 NA NA NA
6dcx 1 P62136 100.0 0.0 X-RAY
2019-05-15 ASP A:19 A:10 105.0 0.7 H -60.4 -39.5 105.0 0.7 0.0
ASP B:19 B:10 103.0 0.687 H -61.0 -38.3 NA NA NA
6zk6 1 P62136 99.7 0.0 X-RAY
2020-11-18 ASP A:11 A:10 105.0 0.7 H -70.0 -34.7 105.0 0.7 0.0 HOH
5.305
OD1
O
3egg 1 P62136 100.0 0.0 X-RAY
2010-03-23 ASP A:9 A:10 100.0 0.667 H -66.8 -32.6 100.0 0.667 0.0 GOL
HOH
9.370
2.765
O
O
O3
O
ASP B:9 B:10 99.0 0.66 H -59.4 -42.4 NA NA NA
3egh 1 P62136 100.0 0.0 X-RAY
2010-03-23 ASP A:9 A:10 100.0 0.667 H -65.4 -31.1 100.0 0.667 0.0 GOL
HOH
9.827
2.731
O
OD2
O2
O
ASP B:9 B:10 95.0 0.633 H -61.7 -38.0 NA NA NA
3hvq 1 P62136 100.0 0.0 X-RAY
2010-03-23 ASP A:9 A:10 106.0 0.707 H -64.8 -29.0 106.0 0.707 0.0 HOH
2.463
O
O
ASP B:9 B:10 98.0 0.653 H -60.9 -38.6 98.0 0.653 0.0 GOL
HOH
6.371
2.711
O
OD1
O3
O
6ghm 1 P62136 100.0 0.0 X-RAY
2019-02-27 ASP A:9 A:10 107.0 0.713 H -61.6 -42.3 107.0 0.713 0.0 EDO
HOH
3.150
4.689
N
OD1
O2
O
ASP B:9 B:10 90.0 0.6 H -66.1 -44.5 NA NA NA
3v4y 1 P62136 100.0 0.0 X-RAY
2012-10-31 ASP A:9 A:10 95.0 0.633 H -64.7 -36.4 95.0 0.633 0.0 HOH
2.104
H
O
ASP C:9 C:10 92.0 0.613 H -70.6 -35.2 NA NA NA
ASP E:9 E:10 98.0 0.653 H -59.7 -42.2 NA NA NA
ASP G:9 G:10 76.0 0.507 H -62.3 -37.4 NA NA NA
3n5u 1 P62136 100.0 0.0 X-RAY
2010-08-11 ASP A:10 A:10 100.0 0.667 H -58.7 -42.8 100.0 0.667 0.0
ASP B:10 B:10 102.0 0.68 H -58.2 -42.5 102.0 0.68 0.0
6obn 1 P62136 100.0 0.0 X-RAY
2019-09-18 ASP A:15 A:10 56.0 0.373 H -67.2 -32.3 56.0 0.373 0.0 MPD
HOH
6.992
4.331
N
OD2
O2
O
ASP B:15 B:10 104.0 0.693 H -65.8 -35.2 NA NA NA
6obp 1 P62136 100.0 0.0 X-RAY
2019-09-18 ASP A:15 A:10 70.0 0.467 H -65.2 -31.5 70.0 0.467 0.0 HOH
7.638
N
O
6zej 1 P62136,Q4VY12 100.0 0.0 X-RAY
2020-09-30 ASP A:9 D:9 103.0 0.687 H -64.5 -36.0 103.0 0.687 0.0 HOH
2.607
OD2
O
ASP B:9 A:9 100.0 0.667 H -59.7 -35.6 NA NA NA
ASP C:9 F:9 101.0 0.673 H -61.7 -41.0 NA NA NA
ASP D:9 I:9 103.0 0.687 H -62.5 -36.7 NA NA NA
ASP E:9 L:9 96.0 0.64 H -62.5 -32.6 NA NA NA
ASP F:9 O:9 93.0 0.62 H -65.5 -35.6 NA NA NA
6zeh 1 P62136,Q13813 100.0 0.0 X-RAY
2020-09-30 ASP A:9 A:10 95.0 0.633 H -67.0 -34.5 95.0 0.633 0.0 HOH
2.131
H
O
ASP C:9 B:10 96.0 0.64 H -62.5 -37.4 NA NA NA
1it6 1 P36873 90.66 0.0 X-RAY
2002-05-22 ASP A:10 A:10 72.0 0.48 H -63.9 -34.5 72.0 0.48 0.0 HOH
4.376
O
O
ASP B:10 B:10 82.0 0.547 H -53.3 -38.4 NA NA NA
1jk7 1 P36873 90.66 0.0 X-RAY
2001-08-15 ASP A:10 A:10 98.0 0.653 H -64.2 -33.8 98.0 0.653 0.0 HOH
2.614
OD2
O
2bcd 1 P36873 90.66 0.0 X-RAY
2006-01-17 ASP A:10 A:10 94.0 0.627 H -58.6 -34.7 94.0 0.627 0.0 HOH
3.030
O
O
2bdx 1 P36873 90.66 0.0 X-RAY
2006-01-17 ASP A:10 A:10 94.0 0.627 H -63.2 -30.9 94.0 0.627 0.0 HOH
4.930
N
O
4ut2 1 P36873 90.66 0.0 X-RAY
2015-07-22 ASP A:10 A:10 92.0 0.613 H -59.2 -43.3 92.0 0.613 0.0 HOH
2.768
OD1
O
ASP B:10 B:10 93.0 0.62 H -59.1 -43.3 NA NA NA
4ut3 1 P36873 90.66 0.0 X-RAY
2015-07-22 ASP A:10 A:10 93.0 0.62 H -56.7 -47.6 93.0 0.62 0.0
4ut3 2 P36873 90.66 0.0 X-RAY
2015-07-22 ASP B:10 B:10 93.0 0.62 H -56.3 -47.5 NA NA NA
4v0u 2 P63087 90.66 0.0 X-RAY
2015-03-25 ASP D:10 D:10 77.0 0.513 H -62.2 -44.3 NA NA NA
ASP F:10 F:10 74.0 0.493 H -62.2 -44.2 NA NA NA
ASP H:10 H:10 76.0 0.507 H -62.2 -44.3 NA NA NA
ASP J:10 J:10 77.0 0.513 H -62.4 -44.2 77.0 0.513 0.0
ASP N:10 N:10 76.0 0.507 H -62.2 -44.2 NA NA NA
2o8a 1 P63088 90.63 0.0 X-RAY
2007-07-17 ASP A:16 A:10 96.0 0.64 H -59.6 -36.2 96.0 0.64 0.0 HOH
2.878
O
O
ASP C:16 B:10 89.0 0.593 H -59.2 -38.4 NA NA NA
2o8g 1 P63088 90.63 0.0 X-RAY
2007-07-17 ASP A:16 A:10 96.0 0.64 H -62.0 -36.9 96.0 0.64 0.0 HOH
2.864
N
O
ASP C:16 B:10 90.0 0.6 H -59.5 -40.6 NA NA NA
6zeg 1 P62136,Q9UQB8 100.0 0.0 X-RAY
2020-09-30 ASP A:9 A:10 105.0 0.7 H -66.0 -35.4 105.0 0.7 0.0 HOH
2.105
H
O
ASP C:9 B:10 96.0 0.64 H -63.6 -35.3 NA NA NA
6zei 1 P62136,Q9UQB8 100.0 0.0 X-RAY
2020-09-30 ASP A:9 A:10 105.0 0.7 H -66.2 -35.3 105.0 0.7 0.0 HOH
2.300
H
O
ASP C:9 B:10 103.0 0.687 H -62.8 -37.5 NA NA NA
3e7a 1 P62136 99.66 0.0 X-RAY
2008-11-04 ASP A:9 A:10 93.0 0.62 H -65.8 -35.6 93.0 0.62 0.0 HOH
2.545
OD2
O
ASP B:9 B:10 94.0 0.627 H -63.4 -37.7 NA NA NA
3e7b 1 P62136 99.66 0.0 X-RAY
2008-11-04 ASP A:9 A:10 96.0 0.64 H -66.0 -36.4 96.0 0.64 0.0 HOH
2.373
OD2
O
ASP B:9 B:10 92.0 0.613 H -63.6 -38.9 NA NA NA
4mov 1 P62136 99.66 0.0 X-RAY
2014-03-26 ASP A:9 A:10 94.0 0.627 H -71.4 -32.9 94.0 0.627 0.0 CL
HOH
4.613
2.523
OD2
OD2
CL
O
ASP B:9 B:10 94.0 0.627 H -68.7 -31.9 NA NA NA
4moy 1 P62136 99.66 0.0 X-RAY
2014-03-26 ASP A:9 A:10 98.0 0.653 H -61.0 -40.3 98.0 0.653 0.0 HOH
2.799
O
O
4mp0 1 P62136 99.66 0.0 X-RAY
2014-03-26 ASP A:9 A:10 96.0 0.64 H -68.4 -33.3 96.0 0.64 0.0 HOH
2.514
OD1
O
ASP B:9 C:10 97.0 0.647 H -67.4 -33.2 NA NA NA
4xpn 1 P62136 99.66 0.0 X-RAY
2015-07-01 ASP A:9 A:10 99.0 0.66 H -66.7 -35.1 99.0 0.66 0.0 HOH
3.164
OD2
O
ASP C:9 C:10 97.0 0.647 H -65.7 -36.5 NA NA NA
5ioh 1 P62136 99.66 0.0 X-RAY
2016-10-05 ASP A:9 A:10 98.0 0.653 H -68.4 -32.5 98.0 0.653 0.0
ASP C:9 C:10 96.0 0.64 H -68.8 -32.5 NA NA NA
6alz 1 P62136 99.66 0.0 X-RAY
2017-11-29 ASP A:9 A:10 96.0 0.64 H -69.4 -38.2 96.0 0.64 0.0 HOH
2.471
OD2
O
ASP B:9 B:10 97.0 0.647 H -69.8 -32.7 NA NA NA
6czo 1 P62136 99.66 0.0 X-RAY
2019-01-23 ASP A:9 A:10 100.0 0.667 H -64.5 -36.5 100.0 0.667 0.0 HOH
3.495
OD2
O
ASP C:9 C:10 97.0 0.647 H -60.3 -33.9 NA NA NA
6dno 1 P62136 99.66 0.0 X-RAY
2019-01-23 ASP A:9 A:10 99.0 0.66 H -63.0 -34.4 99.0 0.66 0.0 HOH
2.538
O
O
6zee 1 P62136 99.66 0.0 X-RAY
2020-09-30 ASP A:9 P:10 95.0 0.633 H -64.9 -36.9 9.0 0.06 0.573 B:P62136:0.573
EDO
SO4
EDO
HOH
5.160
9.326
8.140
2.436
OD1
O
OD2
OD2
HO1
O2
HO1
O
ASP B:9 Q:10 102.0 0.68 H -59.8 -35.0 102.0 0.68 0.0 EDO
HOH
9.327
2.241
O
OD2
HO2
O
ASP C:9 B:10 103.0 0.687 H -63.4 -33.2 103.0 0.687 0.0 EDO
HOH
4.809
2.033
OD1
H
HO1
O
ASP D:9 A:10 102.0 0.68 H -66.2 -36.4 102.0 0.68 0.0 EDO
HOH
5.200
3.137
OD1
H
HO2
O
ASP E:9 I:10 106.0 0.707 H -59.7 -32.2 106.0 0.707 0.0 EDO
HOH
9.544
6.637
O
C
H22
O
ASP F:9 K:10 98.0 0.653 H -64.0 -33.3 9.0 0.06 0.593 E:P62136:0.593
EDO
EDO
EDO
HOH
6.562
9.469
9.490
2.153
C
O
OD2
H
O1
H12
O1
O
6zef 1 P62136 99.66 0.0 X-RAY
2020-09-30 ASP A:9 A:10 103.0 0.687 H -62.7 -37.9 103.0 0.687 0.0 EDO
HOH
5.216
3.299
OD1
H
HO1
O
ASP B:9 B:10 95.0 0.633 H -71.1 -36.1 NA NA NA
5zt0 1 P62137 99.66 0.0 X-RAY
2019-03-13 ASP A:4 A:10 95.0 0.633 H -58.2 -26.0 95.0 0.633 0.0
ASP B:4 B:10 97.0 0.647 H -57.7 -21.3 NA NA NA
ASP C:4 C:10 105.0 0.7 H -63.0 -20.7 NA NA NA
ASP D:4 D:10 95.0 0.633 H -57.0 -22.3 NA NA NA
ASP E:4 E:10 110.0 0.733 H -59.9 -24.2 NA NA NA
ASP F:4 F:10 87.0 0.58 H -60.5 -19.8 NA NA NA
7nzm 2 P62139 99.66 0.0 EM
2021-09-29 ASP B:4 B:10 96.0 0.64 H -70.2 -32.5 96.0 0.64 0.0
6obq 1 P62136 99.66 0.0 X-RAY
2019-09-18 ASP A:9 A:10 101.0 0.673 H -66.1 -35.9 101.0 0.673 0.0 HOH
2.477
OD2
O
ASP B:9 B:10 90.0 0.6 H -67.2 -36.5 NA NA NA
6obr 1 P62136 99.32 0.0 X-RAY
2019-09-18 ASP A:9 A:10 96.0 0.64 H -67.5 -34.1 96.0 0.64 0.0 HOH
2.602
OD2
O
ASP B:9 B:10 91.0 0.607 H -67.6 -35.8 NA NA NA
6obs 1 P62136 99.66 0.0 X-RAY
2019-09-18 ASP A:9 A:10 95.0 0.633 H -70.4 -31.0 95.0 0.633 0.0 HOH
2.486
OD2
O
ASP B:9 B:10 92.0 0.613 H -68.8 -32.3 NA NA NA
6obu 1 P62136 99.66 0.0 X-RAY
2019-09-18 ASP A:9 A:10 94.0 0.627 H -66.4 -37.7 94.0 0.627 0.0 DMS
HOH
3.008
2.737
OD2
OD1
C2
O
ASP B:9 B:10 99.0 0.66 H -66.2 -38.4 NA NA NA
1s70 1 P62140 88.79 0.0 X-RAY
2004-06-22 ASP A:12 A:10 74.0 0.493 H -48.3 -44.3 74.0 0.493 0.0 HOH
2.859
OD1
O
5inb 1 P36873 97.31 0.0 X-RAY
2016-10-05 ASP A:7 A:10 80.0 0.533 H -63.2 -40.6 80.0 0.533 0.0 HOH
2.868
O
O
5j28 1 P36873 97.31 0.0 X-RAY
2016-10-05 ASP A:7 A:10 77.0 0.513 H -63.3 -42.4 77.0 0.513 0.0 HOH
3.008
O
O
ASP B:7 B:10 87.0 0.58 H -57.5 -35.6 NA NA NA
4v0v 1 P63087 97.62 0.0 X-RAY
2015-03-25 ASP A:5 A:10 76.0 0.507 H -63.6 -43.0 76.0 0.507 0.0 HOH
3.403
O
O
ASP C:5 C:10 75.0 0.5 H -62.3 -43.0 NA NA NA
4v0w 1 P63087 97.62 0.0 X-RAY
2015-03-25 ASP A:5 A:10 68.0 0.453 H -65.8 -43.4 68.0 0.453 0.0 HOH
2.328
OD2
O
ASP C:5 C:10 77.0 0.513 H -62.1 -43.7 NA NA NA
4v0x 1 P63087 97.62 0.0 X-RAY
2015-03-25 ASP A:5 A:10 89.0 0.593 H -56.1 -43.3 89.0 0.593 0.0 HOH
3.216
OD2
O
1u32 1 P36873 96.25 0.0 X-RAY
2004-08-17 ASP A:5 A:10 96.0 0.64 H -61.7 -35.5 96.0 0.64 0.0 HOH
2.562
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p62136-f1 1 P62136 100.0 0.0 ASP A:10 A:10 93.0 0.62 H -67.1 -36.4
af-p36873-f1 1 P36873 90.66 0.0 ASP A:10 A:10 87.0 0.58 H -64.2 -41.4
af-p62140-f1 1 P62140 88.79 0.0 ASP A:9 A:9 82.0 0.547 H -66.1 -42.0