Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 85977170 . C A CCDS8273.1:NM_003797.3:c.772Cat>Aat_NP_003788.2:p.258H>N Homo sapiens embryonic ectoderm development (EED), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6c23 4 O75530 100.0 0.0 EM
 2018-01-24 HIS D:258 L:258 55.0 0.282 S 62.4 32.9 12.0 0.062 0.22 K:Q15910:0.221
6c24 5 O75530 100.0 0.0 EM
 2018-01-24 HIS E:258 L:258 53.0 0.272 S 65.0 17.2 53.0 0.272 0.0
6wkr 3 O75530 100.0 0.0 EM
 2021-02-03 HIS C:258 L:258 51.0 0.262 S 59.3 15.9 14.0 0.072 0.19 E:Q15910:0.19
7kso 2 O75530 100.0 0.0 EM
 2021-02-03 HIS B:258 B:258 61.0 0.313 S 61.6 36.7 61.0 0.313 0.0
7ksr 4 O75530 100.0 0.0 EM
 2021-02-03 HIS D:258 B:258 63.0 0.323 S 61.8 41.1 63.0 0.323 0.0
7ktp 2 O75530 100.0 0.0 EM
 2021-02-03 HIS B:258 B:258 62.0 0.318 S 62.2 40.9 62.0 0.318 0.0
5wg6 2 O75530 100.0 0.0 X-RAY
 2018-06-27 HIS B:259 B:258 54.0 0.277 S 64.5 15.0 54.0 0.277 0.0
HIS D:259 D:258 47.0 0.241 S 59.5 22.3 NA NA NA
3jpx 1 O75530 100.0 0.0 X-RAY
 2009-10-20 HIS A:219 A:258 45.0 0.231 S 71.9 1.1 45.0 0.231 0.0 HOH
 2.528
 O
 O
3jzg 1 O75530 100.0 0.0 X-RAY
 2009-12-15 HIS A:219 A:258 49.0 0.251 S 75.0 -5.5 49.0 0.251 0.0 HOH
 2.567
 O
 O
3jzh 1 O75530 100.0 0.0 X-RAY
 2009-12-15 HIS A:219 A:258 47.0 0.241 S 74.7 -0.5 47.0 0.241 0.0 HOH
 2.586
 O
 O
7kxt 1 O75530 100.0 0.0 X-RAY
 2021-02-24 HIS A:219 A:258 71.0 0.364 S 72.3 1.3 71.0 0.364 0.0 UNX
UNX
UNX
UNX
HOH
 6.425
7.547
9.100
7.548
2.737
 CD2
CD2
O
NE2
O
 UNK
UNK
UNK
UNK
O
HIS B:219 B:258 71.0 0.364 S 73.9 -0.9 NA NA NA
5wp3 1 O75530 100.0 0.0 X-RAY
 2017-09-13 HIS A:185 A:258 25.0 NA S 75.1 0.5 25.0 NA NA UNX
 9.560
 O
 UNK
5h13 1 O75530 99.19 0.0 X-RAY
 2017-01-25 HIS A:193 A:258 51.0 0.262 S 68.9 10.4 51.0 0.262 0.0 HOH
 2.794
 O
 O
3jzn 1 O75530 100.0 0.0 X-RAY
 2009-12-15 HIS A:183 A:258 49.0 0.251 S 77.2 1.0 49.0 0.251 0.0 HOH
 2.468
 O
 O
3k26 1 O75530 100.0 0.0 X-RAY
 2009-12-15 HIS A:183 A:258 47.0 0.241 S 73.4 2.0 47.0 0.241 0.0 HOH
 2.695
 O
 O
3k27 1 O75530 100.0 0.0 X-RAY
 2009-12-15 HIS A:183 A:258 49.0 0.251 S 72.5 5.6 49.0 0.251 0.0 HOH
 2.602
 O
 O
6sfb 1 O75530 100.0 0.0 X-RAY
 2019-09-25 HIS A:183 A:258 49.0 0.251 S 71.6 2.6 49.0 0.251 0.0 HOH
 2.732
 O
 O
HIS B:183 B:258 48.0 0.246 S 71.8 1.9 NA NA NA
6sfc 1 O75530 100.0 0.0 X-RAY
 2019-09-25 HIS A:183 A:258 48.0 0.246 S 71.6 1.4 48.0 0.246 0.0 HOH
 2.600
 O
 O
HIS B:183 B:258 44.0 0.226 S 72.1 0.5 NA NA NA
6yvi 1 O75530 100.0 0.0 X-RAY
 2021-05-12 HIS A:183 A:258 46.0 0.236 S 75.8 -12.7 46.0 0.236 0.0 HOH
 2.714
 O
 O
HIS B:183 B:258 46.0 0.236 S 75.2 -11.4 NA NA NA
6yvj 1 O75530 100.0 0.0 X-RAY
 2021-05-12 HIS A:183 A:258 48.0 0.246 S 70.7 4.1 48.0 0.246 0.0 HOH
 2.737
 O
 O
HIS B:183 B:258 48.0 0.246 S 71.9 3.4 NA NA NA
7p3c 1 O75530 100.0 0.0 X-RAY
 2021-12-08 HIS A:183 A:258 46.0 0.236 S 71.9 5.0 46.0 0.236 0.0 HOH
 2.701
 O
 O
HIS B:183 B:258 46.0 0.236 S 72.6 4.5 NA NA NA
7p3g 1 O75530 100.0 0.0 X-RAY
 2021-12-08 HIS A:183 A:258 44.0 0.226 S 80.1 -7.7 44.0 0.226 0.0 HOH
 2.608
 O
 O
HIS B:183 B:258 45.0 0.231 S 80.6 -8.8 NA NA NA
7p3j 1 O75530 100.0 0.0 X-RAY
 2021-12-08 HIS A:183 A:258 51.0 0.262 S 70.3 4.0 51.0 0.262 0.0 HOH
 2.693
 O
 O
HIS B:183 B:258 50.0 0.256 S 70.4 3.7 NA NA NA
5gsa 1 O75530 100.0 0.0 X-RAY
 2017-02-01 HIS A:184 A:258 44.0 0.226 S 65.0 1.6 44.0 0.226 0.0 HOH
 2.792
 O
 O
HIS B:184 B:258 49.0 0.251 S 70.5 0.6 NA NA NA
5h14 1 O75530 100.0 0.0 X-RAY
 2017-01-25 HIS A:184 A:258 64.0 0.328 S 72.4 5.7 64.0 0.328 0.0 HOH
 2.722
 O
 O
HIS B:184 B:258 50.0 0.256 S 70.5 2.1 NA NA NA
5h15 1 O75530 100.0 0.0 X-RAY
 2017-01-25 HIS A:184 A:258 61.0 0.313 S 75.6 1.6 61.0 0.313 0.0 HOH
 2.698
 O
 O
HIS B:184 B:258 37.0 0.19 S 69.8 6.5 NA NA NA
5h17 1 O75530 100.0 0.0 X-RAY
 2017-01-25 HIS A:184 A:258 59.0 0.303 S 74.3 -6.1 59.0 0.303 0.0 HOH
 2.807
 O
 O
5h19 1 O75530 100.0 0.0 X-RAY
 2017-01-25 HIS A:184 A:258 51.0 0.262 S 69.3 2.8 51.0 0.262 0.0 HOH
 2.691
 O
 O
5h24 1 O75530 100.0 0.0 X-RAY
 2017-01-25 HIS A:184 A:258 44.0 0.226 S 68.9 4.9 44.0 0.226 0.0 HOH
 4.103
 CE1
 O
HIS B:184 B:258 61.0 0.313 S 71.8 -0.8 NA NA NA
5h25 1 O75530 100.0 0.0 X-RAY
 2017-01-25 HIS A:184 A:258 47.0 0.241 S 69.1 -3.7 47.0 0.241 0.0
HIS B:184 B:258 46.0 0.236 S 72.0 -7.3 NA NA NA
5ttw 1 O75530 100.0 0.0 X-RAY
 2017-01-11 HIS A:184 A:258 36.0 0.185 S 48.1 36.2 36.0 0.185 0.0 UNX
HOH
 7.063
3.372
 O
CE1
 UNK
O
HIS C:184 C:258 41.0 0.21 S 48.3 29.3 NA NA NA
5u5h 1 O75530 100.0 0.0 X-RAY
 2017-01-11 HIS A:184 A:258 46.0 0.236 S 79.6 -3.9 46.0 0.236 0.0 HOH
 2.608
 O
 O
5u5k 1 O75530 100.0 0.0 X-RAY
 2017-01-11 HIS A:184 A:258 54.0 0.277 S 74.4 6.7 54.0 0.277 0.0 HOH
 2.685
 NE2
 O
5u5t 1 O75530 100.0 0.0 X-RAY
 2017-01-11 HIS A:184 A:258 45.0 0.231 S 72.3 2.5 45.0 0.231 0.0 HOH
 2.632
 O
 O
HIS B:184 B:258 53.0 0.272 S 72.7 3.0 NA NA NA
5u62 1 O75530 100.0 0.0 X-RAY
 2017-01-11 HIS A:184 A:258 66.0 0.338 S 70.5 5.2 66.0 0.338 0.0 HOH
 2.570
 O
 O
HIS B:184 B:258 40.0 0.205 S 76.0 0.6 NA NA NA
6lo2 1 O75530 100.0 0.0 X-RAY
 2021-07-07 HIS A:184 A:258 45.0 0.231 S 67.7 9.4 45.0 0.231 0.0 HOH
 2.704
 O
 O
HIS B:184 B:258 41.0 0.21 S 67.5 0.6 NA NA NA
6v3x 1 O75530 100.0 0.0 X-RAY
 2021-05-26 HIS A:184 A:258 49.0 0.251 S 68.8 6.9 49.0 0.251 0.0 HOH
 2.673
 O
 O
4x3e 1 O75530 100.0 0.0 X-RAY
 2015-01-21 HIS A:184 A:258 46.0 0.236 S 78.4 0.1 46.0 0.236 0.0 HOH
 2.618
 O
 O
5hyn 2 O75530 100.0 0.0 X-RAY
 2016-05-11 HIS B:184 B:258 61.0 0.313 S 81.3 4.4 5.0 0.026 0.287 A:Q15910:0.287
HIS G:184 G:258 58.0 0.297 S 77.1 6.7 NA NA NA
HIS L:184 L:258 61.0 0.313 S 76.7 8.9 NA NA NA
HIS Q:184 R:258 60.0 0.308 S 77.6 5.9 NA NA NA
5ls6 2 O75530 100.0 0.0 X-RAY
 2017-02-22 HIS B:184 B:258 61.0 0.313 S 81.3 1.6 2.0 0.01 0.303 A:Q15910:0.303
HIS E:184 E:258 61.0 0.313 S 74.4 8.3 NA NA NA
HIS H:184 H:258 62.0 0.318 S 73.0 6.0 NA NA NA
HIS K:184 K:258 59.0 0.303 S 69.6 7.6 NA NA NA
5u69 1 O75530 100.0 0.0 X-RAY
 2017-03-15 HIS A:186 A:258 46.0 0.236 S 75.9 4.1 46.0 0.236 0.0 HOH
 2.686
 O
 O
5u6d 1 O75530 100.0 0.0 X-RAY
 2017-03-15 HIS A:186 A:258 48.0 0.246 S 77.0 1.9 48.0 0.246 0.0 HOH
 2.628
 O
 O
5u8a 1 O75530 100.0 0.0 X-RAY
 2017-03-15 HIS A:186 A:258 47.0 0.241 S 75.4 3.8 47.0 0.241 0.0 HOH
 2.671
 O
 O
5u8f 1 O75530 100.0 0.0 X-RAY
 2017-03-15 HIS A:186 A:258 48.0 0.246 S 75.6 4.3 48.0 0.246 0.0 HOH
 2.675
 O
 O
3iiw 1 O75530 100.0 0.0 X-RAY
 2009-09-15 HIS A:182 A:258 47.0 0.241 S 71.9 4.3 47.0 0.241 0.0 HOH
 2.598
 O
 O
5k0m 1 O75530 100.0 0.0 X-RAY
 2017-01-25 HIS A:189 A:258 45.0 0.231 S 72.8 7.4 45.0 0.231 0.0 HOH
 2.671
 O
 O
5wuk 1 O75530 99.73 0.0 X-RAY
 2017-05-03 HIS A:183 A:258 45.0 0.231 S 63.5 16.6 45.0 0.231 0.0 HOH
 2.648
 O
 O
6u4y 2 O75530 100.0 0.0 X-RAY
 2020-07-08 HIS D:183 D:258 59.0 0.303 S 72.2 -2.3 59.0 0.303 0.0
HIS E:183 E:258 57.0 0.292 S 68.5 5.5 57.0 0.292 0.0
HIS F:183 F:258 60.0 0.308 S 74.0 2.8 60.0 0.308 0.0
6w7f 1 O75530 99.73 0.0 X-RAY
 2020-07-08 HIS A:185 A:258 51.0 0.262 S 74.8 -2.7 51.0 0.262 0.0 HOH
 2.705
 O
 O
6w7g 1 O75530 99.73 0.0 X-RAY
 2020-07-08 HIS A:185 A:258 47.0 0.241 S 71.0 6.5 47.0 0.241 0.0 HOH
 2.735
 O
 O
7msb 1 O75530 99.73 0.0 X-RAY
 2021-10-20 HIS A:185 A:258 48.0 0.246 S 69.3 7.8 48.0 0.246 0.0 HOH
 2.753
 O
 O
7msd 1 O75530 99.73 0.0 X-RAY
 2021-10-20 HIS A:185 A:258 45.0 0.231 S 71.6 0.8 45.0 0.231 0.0 HOH
 2.625
 O
 O
3iiy 1 O75530 99.73 0.0 X-RAY
 2009-09-15 HIS A:182 A:258 49.0 0.251 S 67.4 2.9 49.0 0.251 0.0 HOH
 2.476
 O
 O
3ij0 1 O75530 99.73 0.0 X-RAY
 2009-09-15 HIS A:182 A:258 43.0 0.221 S 71.7 -2.2 43.0 0.221 0.0 HOH
 2.440
 O
 O
3ij1 1 O75530 99.73 0.0 X-RAY
 2009-09-15 HIS A:182 A:258 44.0 0.226 S 74.2 0.4 32.0 0.164 0.062 B:None:0.062
 HOH
 2.537
 O
 O
3ijc 1 O75530 99.73 0.0 X-RAY
 2009-09-15 HIS A:182 A:258 46.0 0.236 S 67.9 1.9 46.0 0.236 0.0 HOH
 2.490
 NE2
 O
2qxv 1 Q921E6 100.0 0.0 X-RAY
 2007-08-28 HIS A:178 A:257 42.0 0.215 S 68.2 3.5 42.0 0.215 0.0 HOH
 2.698
 NE2
 O
4w2r 2 O75530 100.0 0.0 X-RAY
 2017-12-27 HIS C:179 E:244 42.0 0.215 S 79.6 6.3 NA NA NA
HIS D:179 F:244 42.0 0.215 S 80.9 6.2 42.0 0.215 0.0
5ij7 2 O75530 100.0 0.0 X-RAY
 2016-05-04 HIS C:179 E:244 39.0 0.2 S 77.4 3.8 39.0 0.2 0.0 6BN
 9.214
 N
 O35
HIS D:179 F:244 40.0 0.205 S 75.4 5.6 NA NA NA
5ij8 2 O75530 100.0 0.0 X-RAY
 2016-05-04 HIS C:179 E:244 44.0 0.226 S 73.2 9.7 NA NA NA
HIS D:179 F:244 44.0 0.226 S 73.2 9.6 44.0 0.226 0.0 6BN
 9.069
 N
 O35
6b3w 2 O75530 100.0 0.0 X-RAY
 2017-12-27 HIS C:179 E:244 51.0 0.262 S 82.1 1.3 NA NA NA
HIS D:179 F:244 53.0 0.272 S 85.7 0.2 53.0 0.272 0.0
6v3y 1 O75530 100.0 0.0 X-RAY
 2021-05-26 HIS A:178 A:258 47.0 0.241 S 71.9 6.2 47.0 0.241 0.0 HOH
 2.616
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75530-f1 1 O75530 100.0 0.0 HIS A:258 A:258 52.0 0.267 S 64.8 6.3