Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 85977218 . A C CCDS8273.1:NM_003797.3:c.820Att>Ctt_NP_003788.2:p.274I>L Homo sapiens embryonic ectoderm development (EED), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6c23 4 O75530 100.0 0.0 EM
 2018-01-24 ILE D:274 L:274 18.0 0.103 H -58.1 -48.4 18.0 0.103 0.0
6c24 5 O75530 100.0 0.0 EM
 2018-01-24 ILE E:274 L:274 19.0 0.109 H -63.5 -45.0 19.0 0.109 0.0
6wkr 3 O75530 100.0 0.0 EM
 2021-02-03 ILE C:274 L:274 30.0 0.171 H -60.5 -51.2 30.0 0.171 0.0
7kso 2 O75530 100.0 0.0 EM
 2021-02-03 ILE B:274 B:274 19.0 0.109 H -64.6 -36.8 19.0 0.109 0.0
7ksr 4 O75530 100.0 0.0 EM
 2021-02-03 ILE D:274 B:274 21.0 0.12 H -65.0 -38.8 21.0 0.12 0.0
7ktp 2 O75530 100.0 0.0 EM
 2021-02-03 ILE B:274 B:274 18.0 0.103 H -64.5 -37.3 18.0 0.103 0.0
5wg6 2 O75530 100.0 0.0 X-RAY
 2018-06-27 ILE B:275 B:274 32.0 0.183 H -61.2 -36.5 32.0 0.183 0.0
ILE D:275 D:274 27.0 0.154 H -74.4 -31.9 NA NA NA
3jpx 1 O75530 100.0 0.0 X-RAY
 2009-10-20 ILE A:235 A:274 27.0 0.154 H -63.5 -48.1 27.0 0.154 0.0 HOH
 3.761
 CB
 O
3jzg 1 O75530 100.0 0.0 X-RAY
 2009-12-15 ILE A:235 A:274 28.0 0.16 H -62.2 -44.9 28.0 0.16 0.0 HOH
 3.672
 CG2
 O
3jzh 1 O75530 100.0 0.0 X-RAY
 2009-12-15 ILE A:235 A:274 26.0 0.149 H -65.0 -46.1 26.0 0.149 0.0 HOH
 3.749
 CG2
 O
7kxt 1 O75530 100.0 0.0 X-RAY
 2021-02-24 ILE A:235 A:274 20.0 0.114 H -62.9 -42.5 20.0 0.114 0.0 UNX
HOH
 7.932
5.957
 N
N
 UNK
O
ILE B:235 B:274 18.0 0.103 H -63.3 -41.1 NA NA NA
5wp3 1 O75530 100.0 0.0 X-RAY
 2017-09-13 ILE A:201 A:274 18.0 0.103 H -62.1 -51.2 18.0 0.103 0.0 UNX
 6.426
 CD1
 UNK
5h13 1 O75530 99.19 0.0 X-RAY
 2017-01-25 ILE A:209 A:274 20.0 0.114 H -66.4 -42.7 20.0 0.114 0.0 HOH
 3.802
 CG2
 O
3jzn 1 O75530 100.0 0.0 X-RAY
 2009-12-15 ILE A:199 A:274 26.0 0.149 H -56.4 -46.5 26.0 0.149 0.0 HOH
 5.741
 N
 O
3k26 1 O75530 100.0 0.0 X-RAY
 2009-12-15 ILE A:199 A:274 25.0 0.143 H -60.2 -45.5 25.0 0.143 0.0 HOH
 3.777
 CD1
 O
3k27 1 O75530 100.0 0.0 X-RAY
 2009-12-15 ILE A:199 A:274 26.0 0.149 H -61.7 -43.4 26.0 0.149 0.0 HOH
 3.728
 CG2
 O
6sfb 1 O75530 100.0 0.0 X-RAY
 2019-09-25 ILE A:199 A:274 28.0 0.16 H -64.1 -45.1 28.0 0.16 0.0 HOH
 3.765
 CD1
 O
ILE B:199 B:274 20.0 0.114 H -63.3 -45.4 NA NA NA
6sfc 1 O75530 100.0 0.0 X-RAY
 2019-09-25 ILE A:199 A:274 26.0 0.149 H -65.8 -45.1 26.0 0.149 0.0 HOH
 3.693
 CB
 O
ILE B:199 B:274 19.0 0.109 H -64.9 -49.7 NA NA NA
6yvi 1 O75530 100.0 0.0 X-RAY
 2021-05-12 ILE A:199 A:274 24.0 0.137 H -63.2 -44.1 24.0 0.137 0.0 HOH
 3.486
 CB
 O
ILE B:199 B:274 17.0 0.097 H -64.0 -45.8 NA NA NA
6yvj 1 O75530 100.0 0.0 X-RAY
 2021-05-12 ILE A:199 A:274 27.0 0.154 H -64.2 -45.9 27.0 0.154 0.0 HOH
 3.730
 CD1
 O
ILE B:199 B:274 28.0 0.16 H -63.8 -45.4 NA NA NA
7p3c 1 O75530 100.0 0.0 X-RAY
 2021-12-08 ILE A:199 A:274 27.0 0.154 H -63.4 -44.7 27.0 0.154 0.0 HOH
 3.678
 CD1
 O
ILE B:199 B:274 18.0 0.103 H -62.9 -45.4 NA NA NA
7p3g 1 O75530 100.0 0.0 X-RAY
 2021-12-08 ILE A:199 A:274 29.0 0.166 H -64.6 -48.6 29.0 0.166 0.0 HOH
 4.475
 CD1
 O
ILE B:199 B:274 21.0 0.12 H -64.7 -48.3 NA NA NA
7p3j 1 O75530 100.0 0.0 X-RAY
 2021-12-08 ILE A:199 A:274 26.0 0.149 H -64.3 -48.2 26.0 0.149 0.0 HOH
 3.652
 CG2
 O
ILE B:199 B:274 22.0 0.126 H -63.1 -49.3 NA NA NA
5gsa 1 O75530 100.0 0.0 X-RAY
 2017-02-01 ILE A:200 A:274 25.0 0.143 H -62.6 -44.0 25.0 0.143 0.0 HOH
 6.414
 N
 O
ILE B:200 B:274 24.0 0.137 H -68.3 -50.3 NA NA NA
5h14 1 O75530 100.0 0.0 X-RAY
 2017-01-25 ILE A:200 A:274 24.0 0.137 H -64.0 -45.5 24.0 0.137 0.0 GOL
HOH
 3.676
3.776
 CD1
CG2
 C2
O
ILE B:200 B:274 24.0 0.137 H -68.7 -43.2 NA NA NA
5h15 1 O75530 100.0 0.0 X-RAY
 2017-01-25 ILE A:200 A:274 26.0 0.149 H -64.3 -48.0 26.0 0.149 0.0 HOH
 4.055
 CG2
 O
ILE B:200 B:274 25.0 0.143 H -63.8 -43.2 NA NA NA
5h17 1 O75530 100.0 0.0 X-RAY
 2017-01-25 ILE A:200 A:274 27.0 0.154 H -66.7 -49.9 27.0 0.154 0.0 HOH
 3.826
 CG2
 O
5h19 1 O75530 100.0 0.0 X-RAY
 2017-01-25 ILE A:200 A:274 23.0 0.131 H -65.2 -47.2 23.0 0.131 0.0 HOH
 3.780
 CG2
 O
5h24 1 O75530 100.0 0.0 X-RAY
 2017-01-25 ILE A:200 A:274 24.0 0.137 H -67.7 -43.4 24.0 0.137 0.0 HOH
 4.694
 CD1
 O
ILE B:200 B:274 24.0 0.137 H -66.4 -46.0 NA NA NA
5h25 1 O75530 100.0 0.0 X-RAY
 2017-01-25 ILE A:200 A:274 24.0 0.137 H -61.9 -53.2 24.0 0.137 0.0
ILE B:200 B:274 24.0 0.137 H -62.4 -53.0 NA NA NA
5ttw 1 O75530 100.0 0.0 X-RAY
 2017-01-11 ILE A:200 A:274 17.0 0.097 H -62.3 -45.2 17.0 0.097 0.0 HOH
 3.683
 CD1
 O
ILE C:200 C:274 26.0 0.149 H -73.6 -44.8 NA NA NA
5u5h 1 O75530 100.0 0.0 X-RAY
 2017-01-11 ILE A:200 A:274 25.0 0.143 H -59.5 -47.3 25.0 0.143 0.0 HOH
 3.762
 CD1
 O
5u5k 1 O75530 100.0 0.0 X-RAY
 2017-01-11 ILE A:200 A:274 28.0 0.16 H -67.8 -43.6 28.0 0.16 0.0 HOH
 3.524
 CG2
 O
5u5t 1 O75530 100.0 0.0 X-RAY
 2017-01-11 ILE A:200 A:274 24.0 0.137 H -68.0 -45.6 24.0 0.137 0.0 HOH
 3.553
 CG2
 O
ILE B:200 B:274 26.0 0.149 H -59.9 -47.0 NA NA NA
5u62 1 O75530 100.0 0.0 X-RAY
 2017-01-11 ILE A:200 A:274 25.0 0.143 H -67.5 -49.8 25.0 0.143 0.0 YT3
HOH
 9.727
3.506
 N
CG2
 Y
O
ILE B:200 B:274 25.0 0.143 H -64.1 -44.7 NA NA NA
6lo2 1 O75530 100.0 0.0 X-RAY
 2021-07-07 ILE A:200 A:274 25.0 0.143 H -62.1 -51.4 25.0 0.143 0.0 HOH
 3.854
 CG2
 O
ILE B:200 B:274 24.0 0.137 H -68.3 -43.8 NA NA NA
6v3x 1 O75530 100.0 0.0 X-RAY
 2021-05-26 ILE A:200 A:274 25.0 0.143 H -65.5 -43.4 25.0 0.143 0.0 HOH
 3.839
 CB
 O
4x3e 1 O75530 100.0 0.0 X-RAY
 2015-01-21 ILE A:200 A:274 26.0 0.149 H -63.0 -41.3 26.0 0.149 0.0 HOH
 3.487
 CG2
 O
5hyn 2 O75530 100.0 0.0 X-RAY
 2016-05-11 ILE B:200 B:274 19.0 0.109 H -59.5 -47.5 19.0 0.109 0.0
ILE G:200 G:274 18.0 0.103 H -60.4 -46.8 NA NA NA
ILE L:200 L:274 18.0 0.103 H -59.6 -49.3 NA NA NA
ILE Q:200 R:274 22.0 0.126 H -61.8 -45.7 NA NA NA
5ls6 2 O75530 100.0 0.0 X-RAY
 2017-02-22 ILE B:200 B:274 19.0 0.109 H -62.7 -49.9 19.0 0.109 0.0
ILE E:200 E:274 15.0 0.086 H -72.6 -45.4 NA NA NA
ILE H:200 H:274 17.0 0.097 H -60.4 -54.3 NA NA NA
ILE K:200 K:274 19.0 0.109 H -58.8 -48.4 NA NA NA
5u69 1 O75530 100.0 0.0 X-RAY
 2017-03-15 ILE A:202 A:274 28.0 0.16 H -64.8 -45.4 28.0 0.16 0.0 HOH
 3.700
 CG2
 O
5u6d 1 O75530 100.0 0.0 X-RAY
 2017-03-15 ILE A:202 A:274 27.0 0.154 H -63.5 -43.6 27.0 0.154 0.0 HOH
 3.821
 CG2
 O
5u8a 1 O75530 100.0 0.0 X-RAY
 2017-03-15 ILE A:202 A:274 27.0 0.154 H -63.0 -45.3 27.0 0.154 0.0 HOH
 3.745
 CD1
 O
5u8f 1 O75530 100.0 0.0 X-RAY
 2017-03-15 ILE A:202 A:274 27.0 0.154 H -64.0 -45.2 27.0 0.154 0.0 HOH
 3.666
 CG2
 O
3iiw 1 O75530 100.0 0.0 X-RAY
 2009-09-15 ILE A:198 A:274 28.0 0.16 H -58.0 -45.6 28.0 0.16 0.0 HOH
 3.653
 CG2
 O
5k0m 1 O75530 100.0 0.0 X-RAY
 2017-01-25 ILE A:205 A:274 27.0 0.154 H -65.0 -45.0 27.0 0.154 0.0 HOH
 3.690
 CD1
 O
5wuk 1 O75530 99.73 0.0 X-RAY
 2017-05-03 ILE A:199 A:274 25.0 0.143 H -62.1 -49.2 25.0 0.143 0.0 HOH
 3.661
 CD1
 O
6u4y 2 O75530 100.0 0.0 X-RAY
 2020-07-08 ILE D:199 D:274 27.0 0.154 H -64.3 -44.9 27.0 0.154 0.0
ILE E:199 E:274 25.0 0.143 H -67.0 -38.6 25.0 0.143 0.0
ILE F:199 F:274 26.0 0.149 H -70.8 -33.8 26.0 0.149 0.0
6w7f 1 O75530 99.73 0.0 X-RAY
 2020-07-08 ILE A:201 A:274 25.0 0.143 H -65.3 -45.5 25.0 0.143 0.0 Q3D
HOH
 3.094
5.451
 CD1
O
 H2
O
6w7g 1 O75530 99.73 0.0 X-RAY
 2020-07-08 ILE A:201 A:274 25.0 0.143 H -62.4 -46.9 25.0 0.143 0.0 Q3A
HOH
 3.080
5.367
 CD1
O
 H9
O
7msb 1 O75530 99.73 0.0 X-RAY
 2021-10-20 ILE A:201 A:274 27.0 0.154 H -64.8 -44.9 27.0 0.154 0.0 HOH
 3.832
 CG2
 O
7msd 1 O75530 99.73 0.0 X-RAY
 2021-10-20 ILE A:201 A:274 26.0 0.149 H -64.8 -42.6 26.0 0.149 0.0 HOH
 3.748
 CG2
 O
3iiy 1 O75530 99.73 0.0 X-RAY
 2009-09-15 ILE A:198 A:274 26.0 0.149 H -67.6 -40.2 26.0 0.149 0.0 HOH
 4.240
 CG2
 O
3ij0 1 O75530 99.73 0.0 X-RAY
 2009-09-15 ILE A:198 A:274 28.0 0.16 H -61.3 -44.2 28.0 0.16 0.0 HOH
 3.917
 CG2
 O
3ij1 1 O75530 99.73 0.0 X-RAY
 2009-09-15 ILE A:198 A:274 28.0 0.16 H -60.4 -46.0 28.0 0.16 0.0 HOH
 3.543
 CG2
 O
3ijc 1 O75530 99.73 0.0 X-RAY
 2009-09-15 ILE A:198 A:274 29.0 0.166 H -63.6 -45.7 29.0 0.166 0.0 HOH
 3.773
 CD1
 O
2qxv 1 Q921E6 100.0 0.0 X-RAY
 2007-08-28 ILE A:194 A:273 21.0 0.12 H -59.7 -46.1 21.0 0.12 0.0 HOH
 3.573
 CG2
 O
4w2r 2 O75530 100.0 0.0 X-RAY
 2017-12-27 ILE C:195 E:260 23.0 0.131 H -66.9 -43.4 NA NA NA
ILE D:195 F:260 23.0 0.131 H -71.8 -48.1 23.0 0.131 0.0
5ij7 2 O75530 100.0 0.0 X-RAY
 2016-05-04 ILE C:195 E:260 24.0 0.137 H -62.7 -48.1 24.0 0.137 0.0
ILE D:195 F:260 24.0 0.137 H -62.9 -48.1 NA NA NA
5ij8 2 O75530 100.0 0.0 X-RAY
 2016-05-04 ILE C:195 E:260 25.0 0.143 H -64.9 -43.0 NA NA NA
ILE D:195 F:260 25.0 0.143 H -65.3 -42.8 25.0 0.143 0.0
6b3w 2 O75530 100.0 0.0 X-RAY
 2017-12-27 ILE C:195 E:260 22.0 0.126 H -65.0 -56.6 NA NA NA
ILE D:195 F:260 23.0 0.131 H -67.1 -57.7 23.0 0.131 0.0
6v3y 1 O75530 100.0 0.0 X-RAY
 2021-05-26 ILE A:194 A:274 26.0 0.149 H -65.3 -41.8 26.0 0.149 0.0 HOH
 3.891
 CG2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75530-f1 1 O75530 100.0 0.0 ILE A:274 A:274 26.0 0.149 H -61.5 -48.3