Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 85979560 . A C CCDS8273.1:NM_003797.3:c.923tAt>tCt_NP_003788.2:p.308Y>S Homo sapiens embryonic ectoderm development (EED), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6c23 4 O75530 100.0 0.0 EM
 2018-01-24 TYR D:308 L:308 82.0 0.357 -66.0 169.1 12.0 0.052 0.305 L:Q92833:0.083
K:Q15910:0.222
6c24 5 O75530 100.0 0.0 EM
 2018-01-24 TYR E:308 L:308 73.0 0.317 -61.3 179.0 60.0 0.261 0.056 B:Q92833:0.057
6wkr 3 O75530 100.0 0.0 EM
 2021-02-03 TYR C:308 L:308 71.0 0.309 -54.3 155.8 10.0 0.043 0.266 E:Q15910:0.217
F:Q92833:0.052
7kso 2 O75530 100.0 0.0 EM
 2021-02-03 TYR B:308 B:308 92.0 0.4 -67.6 152.4 92.0 0.4 0.0
7ksr 4 O75530 100.0 0.0 EM
 2021-02-03 TYR D:308 B:308 91.0 0.396 -67.4 152.0 91.0 0.396 0.0
7ktp 2 O75530 100.0 0.0 EM
 2021-02-03 TYR B:308 B:308 94.0 0.409 -67.5 151.2 94.0 0.409 0.0
5wg6 2 O75530 100.0 0.0 X-RAY
 2018-06-27 TYR B:309 B:308 37.0 0.161 -69.1 160.0 37.0 0.161 0.0
TYR D:309 D:308 42.0 0.183 -73.7 145.4 NA NA NA
3jpx 1 O75530 100.0 0.0 X-RAY
 2009-10-20 TYR A:269 A:308 70.0 0.304 -44.9 125.8 60.0 0.261 0.043 B:None:0.043
 HOH
 2.508
 OH
 O
3jzg 1 O75530 100.0 0.0 X-RAY
 2009-12-15 TYR A:269 A:308 69.0 0.3 -52.8 124.5 53.0 0.23 0.07 B:None:0.07
 HOH
 3.125
 OH
 O
3jzh 1 O75530 100.0 0.0 X-RAY
 2009-12-15 TYR A:269 A:308 67.0 0.291 -51.3 126.4 51.0 0.222 0.069 B:None:0.07
 HOH
 2.764
 OH
 O
7kxt 1 O75530 100.0 0.0 X-RAY
 2021-02-24 TYR A:269 A:308 22.0 0.096 -59.7 156.9 22.0 0.096 0.0 UNX
UNX
UNX
UNX
UNX
HOH
 9.542
6.875
2.678
6.856
4.962
4.316
 N
O
OH
N
OH
OH
 UNK
UNK
UNK
UNK
UNK
O
TYR B:269 B:308 22.0 0.096 -58.8 157.6 NA NA NA
5wp3 1 O75530 100.0 0.0 X-RAY
 2017-09-13 TYR A:235 A:308 55.0 0.239 -54.1 140.7 55.0 0.239 0.0 UNX
 7.488
 O
 UNK
5h13 1 O75530 99.19 0.0 X-RAY
 2017-01-25 TYR A:243 A:308 13.0 0.057 -52.2 152.6 13.0 0.057 0.0 LQA
HOH
 9.772
2.729
 CE1
OH
 C12
O
3jzn 1 O75530 100.0 0.0 X-RAY
 2009-12-15 TYR A:233 A:308 51.0 0.222 -36.3 120.0 51.0 0.222 0.0 HOH
 3.032
 OH
 O
3k26 1 O75530 100.0 0.0 X-RAY
 2009-12-15 TYR A:233 A:308 67.0 0.291 -56.1 131.7 67.0 0.291 0.0 HOH
 2.722
 OH
 O
3k27 1 O75530 100.0 0.0 X-RAY
 2009-12-15 TYR A:233 A:308 69.0 0.3 -55.4 131.8 34.0 0.148 0.152 B:None:0.152
 HOH
 3.037
 OH
 O
6sfb 1 O75530 100.0 0.0 X-RAY
 2019-09-25 TYR A:233 A:308 50.0 0.217 -52.7 128.6 50.0 0.217 0.0 L9K
HOH
 8.232
2.817
 CB
OH
 C16
O
TYR B:233 B:308 53.0 0.23 -53.6 134.8 NA NA NA
6sfc 1 O75530 100.0 0.0 X-RAY
 2019-09-25 TYR A:233 A:308 49.0 0.213 -48.8 123.2 49.0 0.213 0.0 L9W
HOH
 8.123
2.731
 CB
OH
 C15
O
TYR B:233 B:308 51.0 0.222 -47.5 128.8 NA NA NA
6yvi 1 O75530 100.0 0.0 X-RAY
 2021-05-12 TYR A:233 A:308 50.0 0.217 -47.7 131.3 50.0 0.217 0.0 L9W
HOH
 8.621
4.338
 CB
OH
 C15
O
TYR B:233 B:308 50.0 0.217 -48.8 132.0 NA NA NA
6yvj 1 O75530 100.0 0.0 X-RAY
 2021-05-12 TYR A:233 A:308 53.0 0.23 -51.3 127.1 53.0 0.23 0.0 L9W
HOH
 8.677
2.749
 CB
OH
 C15
O
TYR B:233 B:308 53.0 0.23 -52.1 128.4 NA NA NA
7p3c 1 O75530 100.0 0.0 X-RAY
 2021-12-08 TYR A:233 A:308 49.0 0.213 -54.8 131.8 49.0 0.213 0.0 L9W
HOH
 8.389
2.709
 CB
OH
 C15
O
TYR B:233 B:308 51.0 0.222 -54.6 133.7 NA NA NA
7p3g 1 O75530 100.0 0.0 X-RAY
 2021-12-08 TYR A:233 A:308 50.0 0.217 -57.8 122.4 50.0 0.217 0.0 L9W
HOH
 8.270
2.954
 CB
O
 C15
O
TYR B:233 B:308 51.0 0.222 -56.0 130.1 NA NA NA
7p3j 1 O75530 100.0 0.0 X-RAY
 2021-12-08 TYR A:233 A:308 48.0 0.209 -50.5 125.6 48.0 0.209 0.0 L9W
HOH
 8.363
2.730
 CB
OH
 C15
O
TYR B:233 B:308 47.0 0.204 -51.3 126.2 NA NA NA
5gsa 1 O75530 100.0 0.0 X-RAY
 2017-02-01 TYR A:234 A:308 64.0 0.278 -53.0 152.1 64.0 0.278 0.0 73K
HOH
 8.728
3.098
 CB
OH
 C15
O
TYR B:234 B:308 73.0 0.317 -46.9 145.6 NA NA NA
5h14 1 O75530 100.0 0.0 X-RAY
 2017-01-25 TYR A:234 A:308 66.0 0.287 -49.1 142.6 66.0 0.287 0.0 LQB
HOH
 8.770
4.546
 CB
OH
 C25
O
TYR B:234 B:308 71.0 0.309 -47.2 145.7 NA NA NA
5h15 1 O75530 100.0 0.0 X-RAY
 2017-01-25 TYR A:234 A:308 48.0 0.209 -46.5 129.8 48.0 0.209 0.0 LQD
HOH
 6.994
3.485
 CD2
CE1
 C20
O
TYR B:234 B:308 48.0 0.209 -45.8 128.2 NA NA NA
5h17 1 O75530 100.0 0.0 X-RAY
 2017-01-25 TYR A:234 A:308 52.0 0.226 -46.8 130.7 52.0 0.226 0.0 LQE
HOH
 7.032
5.185
 CE2
CE1
 C17
O
5h19 1 O75530 100.0 0.0 X-RAY
 2017-01-25 TYR A:234 A:308 73.0 0.317 -48.7 143.2 73.0 0.317 0.0 LQF
HOH
 8.954
3.598
 CB
CE1
 C21
O
5h24 1 O75530 100.0 0.0 X-RAY
 2017-01-25 TYR A:234 A:308 72.0 0.313 -52.8 140.3 72.0 0.313 0.0 LQG
HOH
 8.982
4.345
 CB
CE1
 C10
O
TYR B:234 B:308 69.0 0.3 -53.8 143.6 NA NA NA
5h25 1 O75530 100.0 0.0 X-RAY
 2017-01-25 TYR A:234 A:308 65.0 0.283 -55.3 146.3 65.0 0.283 0.0 LQH
 9.388
 CE2
 C9
TYR B:234 B:308 63.0 0.274 -54.2 143.9 NA NA NA
5ttw 1 O75530 100.0 0.0 X-RAY
 2017-01-11 TYR A:234 A:308 72.0 0.313 -54.0 127.4 56.0 0.243 0.07 B:None:0.07
 HOH
 2.720
 OH
 O
TYR C:234 C:308 73.0 0.317 -44.9 125.5 NA NA NA
5u5h 1 O75530 100.0 0.0 X-RAY
 2017-01-11 TYR A:234 A:308 55.0 0.239 -54.4 129.3 55.0 0.239 0.0 7VV
HOH
 5.684
2.719
 CD2
OH
 H43
O
5u5k 1 O75530 100.0 0.0 X-RAY
 2017-01-11 TYR A:234 A:308 49.0 0.213 -56.8 122.0 49.0 0.213 0.0 7VY
HOH
 8.077
2.917
 CD2
O
 N12
O
5u5t 1 O75530 100.0 0.0 X-RAY
 2017-01-11 TYR A:234 A:308 51.0 0.222 -52.8 131.8 51.0 0.222 0.0 7W7
HOH
 7.710
2.733
 CE2
OH
 N18
O
TYR B:234 B:308 47.0 0.204 -51.1 130.6 NA NA NA
5u62 1 O75530 100.0 0.0 X-RAY
 2017-01-11 TYR A:234 A:308 52.0 0.226 -50.0 127.9 52.0 0.226 0.0 7WD
HOH
 7.024
2.664
 CE2
OH
 N20
O
TYR B:234 B:308 47.0 0.204 -51.3 131.1 NA NA NA
6lo2 1 O75530 100.0 0.0 X-RAY
 2021-07-07 TYR A:234 A:308 70.0 0.304 -47.4 135.9 70.0 0.304 0.0 EJU
HOH
 9.122
3.900
 CB
OH
 C23
O
TYR B:234 B:308 70.0 0.304 -51.8 141.6 NA NA NA
6v3x 1 O75530 100.0 0.0 X-RAY
 2021-05-26 TYR A:234 A:308 68.0 0.296 -47.3 129.9 68.0 0.296 0.0 HOH
 4.851
 OH
 O
4x3e 1 O75530 100.0 0.0 X-RAY
 2015-01-21 TYR A:234 A:308 67.0 0.291 -43.1 122.9 29.0 0.126 0.165 B:None:0.165
 HOH
 2.964
 OH
 O
5hyn 2 O75530 100.0 0.0 X-RAY
 2016-05-11 TYR B:234 B:308 75.0 0.326 -54.6 136.1 0.0 0.0 0.326 A:Q15910:0.261
E:None:0.109
TYR G:234 G:308 79.0 0.343 -53.4 132.9 NA NA NA
TYR L:234 L:308 75.0 0.326 -54.5 131.5 NA NA NA
TYR Q:234 R:308 74.0 0.322 -54.9 132.0 NA NA NA
5ls6 2 O75530 100.0 0.0 X-RAY
 2017-02-22 TYR B:234 B:308 86.0 0.374 -59.8 140.5 2.0 0.009 0.365 M:None:0.148
A:Q15910:0.257
 74D
 8.781
 OH
 FBI
TYR E:234 E:308 77.0 0.335 -54.7 137.3 NA NA NA
TYR H:234 H:308 79.0 0.343 -38.8 119.7 NA NA NA
TYR K:234 K:308 79.0 0.343 -57.5 135.0 NA NA NA
5u69 1 O75530 100.0 0.0 X-RAY
 2017-03-15 TYR A:236 A:308 47.0 0.204 -54.2 129.5 47.0 0.204 0.0 LQD
HOH
 6.481
2.651
 CE2
OH
 C21
O
5u6d 1 O75530 100.0 0.0 X-RAY
 2017-03-15 TYR A:236 A:308 43.0 0.187 -55.2 128.5 43.0 0.187 0.0 7XG
HOH
 6.604
2.708
 CE2
OH
 C22
O
5u8a 1 O75530 100.0 0.0 X-RAY
 2017-03-15 TYR A:236 A:308 47.0 0.204 -55.9 132.2 47.0 0.204 0.0 82D
HOH
 6.568
2.708
 CE2
OH
 C28
O
5u8f 1 O75530 100.0 0.0 X-RAY
 2017-03-15 TYR A:236 A:308 48.0 0.209 -54.9 129.7 48.0 0.209 0.0 82G
HOH
 6.516
2.697
 CE2
OH
 C23
O
3iiw 1 O75530 100.0 0.0 X-RAY
 2009-09-15 TYR A:232 A:308 69.0 0.3 -58.4 140.1 53.0 0.23 0.07 B:None:0.07
 HOH
 3.038
 OH
 O
5k0m 1 O75530 100.0 0.0 X-RAY
 2017-01-25 TYR A:239 A:308 43.0 0.187 -56.7 130.4 43.0 0.187 0.0 6PU
HOH
 6.653
2.661
 CE2
OH
 C1
O
5wuk 1 O75530 99.73 0.0 X-RAY
 2017-05-03 TYR A:233 A:308 3.0 0.013 -44.5 146.4 3.0 0.013 0.0 GOL
73K
HOH
 9.106
7.851
2.923
 CB
CD1
OH
 C3
C15
O
6u4y 2 O75530 100.0 0.0 X-RAY
 2020-07-08 TYR D:233 D:308 77.0 0.335 -59.7 144.6 77.0 0.335 0.0
TYR E:233 E:308 76.0 0.33 -62.2 141.8 76.0 0.33 0.0
TYR F:233 F:308 72.0 0.313 -51.5 132.8 72.0 0.313 0.0
6w7f 1 O75530 99.73 0.0 X-RAY
 2020-07-08 TYR A:235 A:308 54.0 0.235 -52.5 126.3 54.0 0.235 0.0 Q3D
HOH
 7.894
2.739
 O
OH
 H
O
6w7g 1 O75530 99.73 0.0 X-RAY
 2020-07-08 TYR A:235 A:308 52.0 0.226 -52.7 129.3 52.0 0.226 0.0 Q3A
HOH
 7.770
2.736
 CB
OH
 H14
O
7msb 1 O75530 99.73 0.0 X-RAY
 2021-10-20 TYR A:235 A:308 50.0 0.217 -51.9 127.0 50.0 0.217 0.0 ZNG
HOH
 8.355
2.836
 CB
OH
 C19
O
7msd 1 O75530 99.73 0.0 X-RAY
 2021-10-20 TYR A:235 A:308 72.0 0.313 -51.6 133.4 72.0 0.313 0.0 ZMY
HOH
 8.018
6.767
 CB
O
 H18
O
3iiy 1 O75530 99.73 0.0 X-RAY
 2009-09-15 TYR A:232 A:308 70.0 0.304 -49.7 126.4 57.0 0.248 0.056 B:None:0.057
 HOH
 2.814
 OH
 O
3ij0 1 O75530 99.73 0.0 X-RAY
 2009-09-15 TYR A:232 A:308 69.0 0.3 -50.8 119.4 55.0 0.239 0.061 B:None:0.061
 HOH
 2.594
 OH
 O
3ij1 1 O75530 99.73 0.0 X-RAY
 2009-09-15 TYR A:232 A:308 66.0 0.287 -49.8 125.1 33.0 0.143 0.144 B:None:0.143
 HOH
 2.433
 OH
 O
3ijc 1 O75530 99.73 0.0 X-RAY
 2009-09-15 TYR A:232 A:308 67.0 0.291 -43.0 133.7 67.0 0.291 0.0 NDS
HOH
 7.711
3.606
 CE2
CE1
 C4
O
2qxv 1 Q921E6 100.0 0.0 X-RAY
 2007-08-28 TYR A:228 A:300 69.0 0.3 -54.7 145.6 69.0 0.3 0.0 HOH
 2.555
 OH
 O
4w2r 2 O75530 100.0 0.0 X-RAY
 2017-12-27 TYR C:229 E:294 22.0 0.096 -52.4 148.4 NA NA NA
TYR D:229 F:294 22.0 0.096 -59.4 147.4 22.0 0.096 0.0
5ij7 2 O75530 100.0 0.0 X-RAY
 2016-05-04 TYR C:229 E:294 23.0 0.1 -59.3 144.6 23.0 0.1 0.0 HOH
 6.609
 OH
 O
TYR D:229 F:294 23.0 0.1 -58.1 143.4 NA NA NA
5ij8 2 O75530 100.0 0.0 X-RAY
 2016-05-04 TYR C:229 E:294 17.0 0.074 -59.7 151.3 NA NA NA
TYR D:229 F:294 17.0 0.074 -60.2 153.0 17.0 0.074 0.0
6b3w 2 O75530 100.0 0.0 X-RAY
 2017-12-27 TYR C:229 E:294 22.0 0.096 -50.7 147.5 NA NA NA
TYR D:229 F:294 23.0 0.1 -48.9 145.8 23.0 0.1 0.0
6v3y 1 O75530 100.0 0.0 X-RAY
 2021-05-26 TYR A:228 A:308 67.0 0.291 -50.1 129.6 53.0 0.23 0.061 B:None:0.061
 HOH
 2.800
 OH
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75530-f1 1 O75530 100.0 0.0 TYR A:308 A:308 26.0 0.113 -46.9 144.0