Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr11 | 85988967 | . | C | A | CCDS8273.1:NM_003797.3:c.1133gCa>gAa_NP_003788.2:p.378A>E | Homo sapiens embryonic ectoderm development (EED), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6c23 | 4 | O75530 | 100.0 | 0.0 |
EM |
2018-01-24 | ALA | D:378 | L:378 | 0.0 | 0.0 | -96.2 | -178.8 | 0.0 | 0.0 | 0.0 | |||||||
| 6c24 | 5 | O75530 | 100.0 | 0.0 |
EM |
2018-01-24 | ALA | E:378 | L:378 | 0.0 | 0.0 | E | -104.8 | 125.2 | 0.0 | 0.0 | 0.0 | ||||||
| 6wkr | 3 | O75530 | 100.0 | 0.0 |
EM |
2021-02-03 | ALA | C:378 | L:378 | 1.0 | 0.009 | E | -121.2 | 150.1 | 1.0 | 0.009 | 0.0 | ||||||
| 7kso | 2 | O75530 | 100.0 | 0.0 |
EM |
2021-02-03 | ALA | B:378 | B:378 | 0.0 | 0.0 | E | -130.3 | 147.2 | 0.0 | 0.0 | 0.0 | ||||||
| 7ksr | 4 | O75530 | 100.0 | 0.0 |
EM |
2021-02-03 | ALA | D:378 | B:378 | 0.0 | 0.0 | E | -124.3 | 150.0 | 0.0 | 0.0 | 0.0 | ||||||
| 7ktp | 2 | O75530 | 100.0 | 0.0 |
EM |
2021-02-03 | ALA | B:378 | B:378 | 0.0 | 0.0 | E | -128.7 | 150.5 | 0.0 | 0.0 | 0.0 | ||||||
| 5wg6 | 2 | O75530 | 100.0 | 0.0 |
X-RAY |
2018-06-27 | ALA | B:379 | B:378 | 0.0 | 0.0 | E | -120.0 | 129.5 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | D:379 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3jpx | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2009-10-20 | ALA | A:339 | A:378 | 0.0 | 0.0 | E | -121.0 | 141.0 | 0.0 | 0.0 | 0.0 |
HOH |
4.711 |
O |
O |
||
| 3jzg | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2009-12-15 | ALA | A:339 | A:378 | 0.0 | 0.0 | E | -125.8 | 132.1 | 0.0 | 0.0 | 0.0 |
HOH |
4.784 |
O |
O |
||
| 3jzh | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2009-12-15 | ALA | A:339 | A:378 | 0.0 | 0.0 | E | -122.6 | 139.0 | 0.0 | 0.0 | 0.0 |
HOH |
4.778 |
O |
O |
||
| 7kxt | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-02-24 | ALA | A:339 | A:378 | 0.0 | 0.0 | E | -122.1 | 138.8 | 0.0 | 0.0 | 0.0 |
UNX HOH |
9.213 4.166 |
N O |
UNK O |
||
| ALA | B:339 | B:378 | 0.0 | 0.0 | E | -123.4 | 138.6 | NA | NA | NA | |||||||||||||
| 5wp3 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-09-13 | ALA | A:305 | A:378 | 0.0 | 0.0 | E | -123.9 | 146.1 | 0.0 | 0.0 | 0.0 | ||||||
| 5h13 | 1 | O75530 | 99.19 | 0.0 |
X-RAY |
2017-01-25 | ALA | A:313 | A:378 | 0.0 | 0.0 | E | -135.5 | 146.5 | 0.0 | 0.0 | 0.0 |
HOH |
5.301 |
O |
O |
||
| 3jzn | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2009-12-15 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -127.0 | 138.0 | 0.0 | 0.0 | 0.0 |
HOH |
4.987 |
O |
O |
||
| 3k26 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2009-12-15 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -124.1 | 143.1 | 0.0 | 0.0 | 0.0 |
HOH |
3.719 |
O |
O |
||
| 3k27 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2009-12-15 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -126.3 | 142.2 | 0.0 | 0.0 | 0.0 |
HOH |
4.719 |
O |
O |
||
| 6sfb | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2019-09-25 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -131.3 | 145.3 | 0.0 | 0.0 | 0.0 |
HOH |
3.981 |
O |
O |
||
| ALA | B:303 | B:378 | 0.0 | 0.0 | E | -127.1 | 143.5 | NA | NA | NA | |||||||||||||
| 6sfc | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2019-09-25 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -135.3 | 144.2 | 0.0 | 0.0 | 0.0 |
HOH |
3.980 |
O |
O |
||
| ALA | B:303 | B:378 | 0.0 | 0.0 | E | -131.4 | 143.8 | NA | NA | NA | |||||||||||||
| 6yvi | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-05-12 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -133.2 | 137.1 | 0.0 | 0.0 | 0.0 |
HOH |
3.650 |
O |
O |
||
| ALA | B:303 | B:378 | 0.0 | 0.0 | E | -132.9 | 137.9 | NA | NA | NA | |||||||||||||
| 6yvj | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-05-12 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -131.6 | 145.2 | 0.0 | 0.0 | 0.0 |
HOH |
3.964 |
O |
O |
||
| ALA | B:303 | B:378 | 0.0 | 0.0 | E | -131.0 | 143.8 | NA | NA | NA | |||||||||||||
| 7p3c | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-12-08 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -130.6 | 146.7 | 0.0 | 0.0 | 0.0 |
HOH |
3.939 |
O |
O |
||
| ALA | B:303 | B:378 | 0.0 | 0.0 | E | -130.4 | 144.1 | NA | NA | NA | |||||||||||||
| 7p3g | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-12-08 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -131.5 | 142.3 | 0.0 | 0.0 | 0.0 |
HOH |
4.025 |
O |
O |
||
| ALA | B:303 | B:378 | 0.0 | 0.0 | E | -127.1 | 142.0 | NA | NA | NA | |||||||||||||
| 7p3j | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-12-08 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -127.9 | 143.3 | 0.0 | 0.0 | 0.0 |
HOH |
3.931 |
O |
O |
||
| ALA | B:303 | B:378 | 0.0 | 0.0 | E | -127.8 | 142.2 | NA | NA | NA | |||||||||||||
| 5gsa | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-02-01 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -132.7 | 140.2 | 0.0 | 0.0 | 0.0 |
HOH |
3.797 |
O |
O |
||
| ALA | B:304 | B:378 | 0.0 | 0.0 | E | -129.9 | 145.4 | NA | NA | NA | |||||||||||||
| 5h14 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-25 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -127.8 | 147.5 | 0.0 | 0.0 | 0.0 |
HOH |
3.998 |
O |
O |
||
| ALA | B:304 | B:378 | 0.0 | 0.0 | E | -139.7 | 144.8 | NA | NA | NA | |||||||||||||
| 5h15 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-25 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -131.7 | 149.0 | 0.0 | 0.0 | 0.0 |
HOH |
4.197 |
O |
O |
||
| ALA | B:304 | B:378 | 0.0 | 0.0 | E | -125.4 | 147.7 | NA | NA | NA | |||||||||||||
| 5h17 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-25 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -134.2 | 144.5 | 0.0 | 0.0 | 0.0 |
HOH |
3.908 |
O |
O |
||
| 5h19 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-25 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -128.9 | 145.2 | 0.0 | 0.0 | 0.0 |
HOH |
4.019 |
O |
O |
||
| 5h24 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-25 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -129.0 | 142.8 | 0.0 | 0.0 | 0.0 |
HOH |
3.978 |
O |
O |
||
| ALA | B:304 | B:378 | 0.0 | 0.0 | E | -148.7 | 137.2 | NA | NA | NA | |||||||||||||
| 5h25 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-25 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -109.6 | 149.7 | 0.0 | 0.0 | 0.0 |
HOH |
5.620 |
O |
O |
||
| ALA | B:304 | B:378 | 0.0 | 0.0 | E | -131.0 | 143.9 | NA | NA | NA | |||||||||||||
| 5ttw | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-11 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -122.9 | 135.0 | 0.0 | 0.0 | 0.0 |
HOH |
3.812 |
O |
O |
||
| ALA | C:304 | C:378 | 0.0 | 0.0 | E | -124.5 | 138.9 | NA | NA | NA | |||||||||||||
| 5u5h | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-11 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -129.0 | 140.7 | 0.0 | 0.0 | 0.0 |
7VV HOH |
9.945 3.875 |
O O |
H47 O |
||
| 5u5k | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-11 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -120.9 | 140.7 | 0.0 | 0.0 | 0.0 |
HOH |
4.031 |
O |
O |
||
| 5u5t | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-11 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -129.5 | 142.1 | 0.0 | 0.0 | 0.0 |
HOH |
3.929 |
CB |
O |
||
| ALA | B:304 | B:378 | 0.0 | 0.0 | E | -125.7 | 142.6 | NA | NA | NA | |||||||||||||
| 5u62 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-11 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -127.6 | 143.5 | 0.0 | 0.0 | 0.0 |
HOH |
4.036 |
O |
O |
||
| ALA | B:304 | B:378 | 0.0 | 0.0 | E | -127.4 | 142.8 | NA | NA | NA | |||||||||||||
| 6lo2 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-07-07 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -128.2 | 145.3 | 0.0 | 0.0 | 0.0 |
HOH |
4.106 |
O |
O |
||
| ALA | B:304 | B:378 | 0.0 | 0.0 | E | -140.2 | 142.6 | NA | NA | NA | |||||||||||||
| 6v3x | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-05-26 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -126.0 | 140.5 | 0.0 | 0.0 | 0.0 |
HOH |
4.983 |
O |
O |
||
| 4x3e | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2015-01-21 | ALA | A:304 | A:378 | 0.0 | 0.0 | E | -125.7 | 136.8 | 0.0 | 0.0 | 0.0 |
HOH |
3.888 |
O |
O |
||
| 5hyn | 2 | O75530 | 100.0 | 0.0 |
X-RAY |
2016-05-11 | ALA | B:304 | B:378 | 0.0 | 0.0 | E | -134.0 | 131.9 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | G:304 | G:378 | 0.0 | 0.0 | E | -134.5 | 131.5 | NA | NA | NA | |||||||||||||
| ALA | L:304 | L:378 | 1.0 | 0.009 | E | -137.5 | 133.8 | NA | NA | NA | |||||||||||||
| ALA | Q:304 | R:378 | 0.0 | 0.0 | E | -137.2 | 134.9 | NA | NA | NA | |||||||||||||
| 5ls6 | 2 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-02-22 | ALA | B:304 | B:378 | 0.0 | 0.0 | E | -122.4 | 122.1 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | E:304 | E:378 | 0.0 | 0.0 | E | -125.9 | 124.8 | NA | NA | NA | |||||||||||||
| ALA | H:304 | H:378 | 0.0 | 0.0 | E | -143.6 | 132.1 | NA | NA | NA | |||||||||||||
| ALA | K:304 | K:378 | 0.0 | 0.0 | E | -132.4 | 157.9 | NA | NA | NA | |||||||||||||
| 5u69 | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-03-15 | ALA | A:306 | A:378 | 0.0 | 0.0 | E | -131.3 | 143.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.808 |
O |
O |
||
| 5u6d | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-03-15 | ALA | A:306 | A:378 | 0.0 | 0.0 | E | -127.9 | 142.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.767 |
O |
O |
||
| 5u8a | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-03-15 | ALA | A:306 | A:378 | 0.0 | 0.0 | E | -128.5 | 143.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.888 |
O |
O |
||
| 5u8f | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-03-15 | ALA | A:306 | A:378 | 0.0 | 0.0 | E | -129.4 | 144.6 | 0.0 | 0.0 | 0.0 |
HOH |
3.785 |
O |
O |
||
| 3iiw | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2009-09-15 | ALA | A:302 | A:378 | 0.0 | 0.0 | E | -127.4 | 138.5 | 0.0 | 0.0 | 0.0 |
HOH |
4.868 |
O |
O |
||
| 5k0m | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-01-25 | ALA | A:309 | A:378 | 0.0 | 0.0 | E | -134.2 | 144.0 | 0.0 | 0.0 | 0.0 |
HOH |
3.766 |
O |
O |
||
| 5wuk | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2017-05-03 | ALA | A:303 | A:378 | 0.0 | 0.0 | E | -136.3 | 146.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.935 |
O |
O |
||
| 6u4y | 2 | O75530 | 100.0 | 0.0 |
X-RAY |
2020-07-08 | ALA | D:303 | D:378 | 0.0 | 0.0 | E | -125.2 | 140.6 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | E:303 | E:378 | 0.0 | 0.0 | E | -127.9 | 139.3 | 0.0 | 0.0 | 0.0 | |||||||||||||
| ALA | F:303 | F:378 | 0.0 | 0.0 | E | -126.8 | 140.8 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6w7f | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2020-07-08 | ALA | A:305 | A:378 | 0.0 | 0.0 | E | -134.0 | 143.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.716 |
O |
O |
||
| 6w7g | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2020-07-08 | ALA | A:305 | A:378 | 0.0 | 0.0 | E | -130.9 | 143.7 | 0.0 | 0.0 | 0.0 |
HOH |
3.795 |
O |
O |
||
| 7msb | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2021-10-20 | ALA | A:305 | A:378 | 0.0 | 0.0 | E | -133.6 | 144.3 | 0.0 | 0.0 | 0.0 |
HOH |
3.857 |
O |
O |
||
| 7msd | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2021-10-20 | ALA | A:305 | A:378 | 0.0 | 0.0 | E | -129.7 | 147.0 | 0.0 | 0.0 | 0.0 |
HOH |
3.670 |
O |
O |
||
| 3iiy | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2009-09-15 | ALA | A:302 | A:378 | 0.0 | 0.0 | E | -118.1 | 138.3 | 0.0 | 0.0 | 0.0 |
HOH |
4.817 |
O |
O |
||
| 3ij0 | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2009-09-15 | ALA | A:302 | A:378 | 0.0 | 0.0 | E | -122.3 | 134.9 | 0.0 | 0.0 | 0.0 |
HOH |
4.743 |
O |
O |
||
| 3ij1 | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2009-09-15 | ALA | A:302 | A:378 | 0.0 | 0.0 | E | -124.0 | 139.4 | 0.0 | 0.0 | 0.0 |
HOH |
4.697 |
O |
O |
||
| 3ijc | 1 | O75530 | 99.73 | 0.0 |
X-RAY |
2009-09-15 | ALA | A:302 | A:378 | 0.0 | 0.0 | E | -126.4 | 132.9 | 0.0 | 0.0 | 0.0 |
HOH |
6.655 |
CB |
O |
||
| 2qxv | 1 | Q921E6 | 100.0 | 0.0 |
X-RAY |
2007-08-28 | ALA | A:298 | A:370 | 0.0 | 0.0 | E | -132.6 | 146.5 | 0.0 | 0.0 | 0.0 |
HOH |
3.888 |
O |
O |
||
| 4w2r | 2 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-12-27 | ALA | C:299 | E:364 | 0.0 | 0.0 | E | -124.1 | 135.9 | NA | NA | NA | ||||||
| ALA | D:299 | F:364 | 0.0 | 0.0 | E | -129.0 | 128.6 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 5ij7 | 2 | O75530 | 100.0 | 0.0 |
X-RAY |
2016-05-04 | ALA | C:299 | E:364 | 0.0 | 0.0 | E | -133.8 | 144.0 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | D:299 | F:364 | 0.0 | 0.0 | E | -125.8 | 143.8 | NA | NA | NA | |||||||||||||
| 5ij8 | 2 | O75530 | 100.0 | 0.0 |
X-RAY |
2016-05-04 | ALA | C:299 | E:364 | 0.0 | 0.0 | E | -120.7 | 144.8 | NA | NA | NA | ||||||
| ALA | D:299 | F:364 | 0.0 | 0.0 | E | -132.7 | 144.0 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6b3w | 2 | O75530 | 100.0 | 0.0 |
X-RAY |
2017-12-27 | ALA | C:299 | E:364 | 0.0 | 0.0 | E | -116.6 | 137.8 | NA | NA | NA | ||||||
| ALA | D:299 | F:364 | 0.0 | 0.0 | E | -123.9 | 130.0 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6v3y | 1 | O75530 | 100.0 | 0.0 |
X-RAY |
2021-05-26 | ALA | A:298 | A:378 | 0.0 | 0.0 | E | -126.7 | 140.8 | 0.0 | 0.0 | 0.0 |
HOH |
4.921 |
O |
O |
||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-o75530-f1 | 1 | O75530 | 100.0 | 0.0 | ALA | A:378 | A:378 | 0.0 | 0.0 | E | -127.1 | 138.6 | |