Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 111160464 . C A CCDS58279.1:NM_001244974.1:c.560cGg>cTg_NP_001231903.1:p.187R>L Homo sapiens protein phosphatase 1 catalytic subunit gamma (PPP1CC), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1it6 1 P36873 100.0 0.0 X-RAY
 2002-05-22 ARG A:187 A:187 99.0 0.44 H -62.9 -23.7 99.0 0.44 0.0 HOH
 2.812
 NE
 O
ARG B:187 B:187 103.0 0.458 H -66.7 -23.0 NA NA NA
1jk7 1 P36873 100.0 0.0 X-RAY
 2001-08-15 ARG A:187 A:187 88.0 0.391 H -58.4 -32.2 88.0 0.391 0.0 HOH
 2.888
 NH2
 O
2bcd 1 P36873 100.0 0.0 X-RAY
 2006-01-17 ARG A:187 A:187 101.0 0.449 H -63.5 -32.1 101.0 0.449 0.0 MN
HOH
 4.420
4.407
 NH1
C
 MN
O
2bdx 1 P36873 100.0 0.0 X-RAY
 2006-01-17 ARG A:187 A:187 89.0 0.396 H -59.9 -29.8 89.0 0.396 0.0 HOH
 9.048
 NE
 O
4ut2 1 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG A:187 A:187 107.0 0.476 H -62.9 -25.9 107.0 0.476 0.0 HOH
 2.716
 NH1
 O
ARG B:187 B:187 105.0 0.467 H -62.3 -25.9 NA NA NA
4ut3 1 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG A:187 A:187 107.0 0.476 H -63.8 -24.5 107.0 0.476 0.0 HOH
 2.485
 NE
 O
4ut3 2 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG B:187 B:187 110.0 0.489 H -65.0 -24.7 NA NA NA
4v0u 2 P63087 99.69 0.0 X-RAY
 2015-03-25 ARG D:187 D:187 123.0 0.547 H -63.0 -27.5 NA NA NA
ARG F:187 F:187 124.0 0.551 H -63.0 -27.5 NA NA NA
ARG H:187 H:187 123.0 0.547 H -62.9 -27.5 NA NA NA
ARG J:187 J:187 124.0 0.551 H -63.0 -27.5 124.0 0.551 0.0
ARG N:187 N:187 123.0 0.547 H -63.0 -27.5 NA NA NA
2o8a 1 P63088 99.69 0.0 X-RAY
 2007-07-17 ARG A:193 A:187 107.0 0.476 H -51.6 -28.1 101.0 0.449 0.027 B:Q9DCL8:0.027
 HOH
 5.261
 O
 O
ARG C:193 B:187 94.0 0.418 H -51.2 -28.0 NA NA NA
2o8g 1 P63088 99.69 0.0 X-RAY
 2007-07-17 ARG A:193 A:187 90.0 0.4 H -56.5 -29.8 87.0 0.387 0.013 B:Q9DCL8:0.013
 HOH
 3.299
 CG
 O
ARG C:193 B:187 89.0 0.396 H -53.0 -33.8 NA NA NA
5inb 1 P36873 100.0 0.0 X-RAY
 2016-10-05 ARG A:184 A:187 102.0 0.453 H -61.1 -28.7 102.0 0.453 0.0 GOL
NA
HOH
 8.056
3.844
2.708
 NE
NH2
O
 O3
NA
O
5j28 1 P36873 100.0 0.0 X-RAY
 2016-10-05 ARG A:184 A:187 94.0 0.418 H -65.3 -31.5 94.0 0.418 0.0 NA
HOH
 3.832
2.992
 NH2
NE
 NA
O
ARG B:184 B:187 122.0 0.542 H -62.7 -38.7 NA NA NA
1fjm 1 P08129 90.66 0.0 X-RAY
 1996-06-20 ARG A:187 A:187 111.0 0.493 H -56.4 -29.0 111.0 0.493 0.0 HOH
 4.931
 O
 O
ARG B:187 B:187 95.0 0.422 H -56.8 -33.7 NA NA NA
4g9j 1 P62136 90.66 0.0 X-RAY
 2012-09-19 ARG A:188 A:187 80.0 0.356 H -74.7 -16.5 80.0 0.356 0.0 HOH
 2.640
 NH2
 O
ARG B:188 B:187 100.0 0.444 H -65.9 -31.3 NA NA NA
6g0i 1 P62136 90.66 0.0 X-RAY
 2018-11-21 ARG A:188 A:187 95.0 0.422 H -59.3 -25.9 95.0 0.422 0.0 HOH
 3.416
 NH2
 O
6g0j 1 P62136 90.66 0.0 X-RAY
 2018-11-21 ARG A:188 A:187 106.0 0.471 H -54.5 -26.5 106.0 0.471 0.0 HOH
 3.329
 CG
 O
6dcx 1 P62136 90.66 0.0 X-RAY
 2019-05-15 ARG A:196 A:187 101.0 0.449 H -62.6 -30.5 101.0 0.449 0.0
ARG B:196 B:187 103.0 0.458 H -63.1 -31.7 NA NA NA
6zk6 1 P62136 90.36 0.0 X-RAY
 2020-11-18 ARG A:188 A:187 108.0 0.48 H -60.0 -24.8 108.0 0.48 0.0 HOH
 3.123
 NE
 O
5zqv 1 P62137 91.95 0.0 X-RAY
 2019-03-13 ARG A:187 A:187 96.0 0.427 H -66.7 -25.1 96.0 0.427 0.0
ARG B:187 B:187 82.0 0.364 H -66.8 -16.7 NA NA NA
ARG C:187 C:187 112.0 0.498 H -73.5 -27.7 112.0 0.498 0.0
ARG D:187 D:187 94.0 0.418 H -74.1 -23.7 NA NA NA
4v0v 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:182 A:187 97.0 0.431 H -62.5 -26.3 97.0 0.431 0.0 HOH
 2.472
 NE
 O
ARG C:182 C:187 84.0 0.373 H -59.1 -30.8 NA NA NA
4v0w 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:182 A:187 97.0 0.431 H -61.0 -28.7 97.0 0.431 0.0 HOH
 2.461
 NE
 O
ARG C:182 C:187 92.0 0.409 H -60.7 -28.9 NA NA NA
4v0x 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:182 A:187 87.0 0.387 H -59.2 -30.1 87.0 0.387 0.0 HOH
 4.368
 O
 O
3egg 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:186 A:187 98.0 0.436 H -60.0 -30.8 98.0 0.436 0.0 HOH
 2.635
 O
 O
ARG B:186 B:187 99.0 0.44 H -61.7 -31.2 NA NA NA
3egh 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:186 A:187 99.0 0.44 H -59.2 -27.9 99.0 0.44 0.0 HOH
 2.317
 NH1
 O
ARG B:186 B:187 101.0 0.449 H -60.4 -27.2 NA NA NA
3hvq 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:186 A:187 95.0 0.422 H -52.4 -30.6 95.0 0.422 0.0 HOH
 2.788
 NH2
 O
ARG B:186 B:187 94.0 0.418 H -55.3 -28.7 94.0 0.418 0.0 HOH
 2.520
 NH1
 O
6ghm 1 P62136 90.58 0.0 X-RAY
 2019-02-27 ARG A:186 A:187 95.0 0.422 H -58.9 -28.9 95.0 0.422 0.0 EDO
HOH
 8.774
2.894
 NE
NE
 O1
O
ARG B:186 B:187 107.0 0.476 H -69.3 -26.4 NA NA NA
3n5u 1 P62136 96.67 0.0 X-RAY
 2010-08-11 ARG A:187 A:187 88.0 0.391 H -65.5 -22.1 88.0 0.391 0.0
ARG B:187 B:187 89.0 0.396 H -64.9 -21.8 89.0 0.396 0.0
6obn 1 P62136 96.67 0.0 X-RAY
 2019-09-18 ARG A:192 A:187 104.0 0.462 H -63.9 -24.5 104.0 0.462 0.0 CL
CL
HOH
 6.250
6.722
2.981
 NH1
O
NE
 CL
CL
O
ARG B:192 B:187 107.0 0.476 H -64.1 -23.8 NA NA NA
6obp 1 P62136 96.67 0.0 X-RAY
 2019-09-18 ARG A:192 A:187 82.0 0.364 H -66.8 -25.9 82.0 0.364 0.0 CL
HOH
 6.504
2.975
 NH1
NE
 CL
O
6zej 1 P62136,Q4VY12 94.46 0.0 X-RAY
 2020-09-30 ARG A:186 D:186 94.0 0.418 H -62.5 -38.5 94.0 0.418 0.0 HOH
 2.586
 O
 O
ARG B:186 A:186 80.0 0.356 H -62.9 -28.8 NA NA NA
ARG C:186 F:186 93.0 0.413 H -62.0 -31.0 NA NA NA
ARG D:186 I:186 64.0 NA H -63.7 -28.7 NA NA NA
ARG E:186 L:186 70.0 NA H -59.6 -33.7 NA NA NA
ARG F:186 O:186 92.0 0.409 H -60.9 -31.2 NA NA NA
6zeh 1 P62136,Q13813 96.33 0.0 X-RAY
 2020-09-30 ARG A:186 A:187 115.0 0.511 H -63.5 -25.9 115.0 0.511 0.0 HOH
 1.900
 HH12
 O
ARG C:186 B:187 96.0 0.427 H -63.1 -25.2 NA NA NA
3v4y 1 P62136 96.33 0.0 X-RAY
 2012-10-31 ARG A:186 A:187 104.0 0.462 H -69.0 -19.0 104.0 0.462 0.0 GOL
HOH
 7.157
1.987
 HE
HH12
 HO1
O
ARG C:186 C:187 98.0 0.436 H -64.7 -19.9 NA NA NA
ARG E:186 E:187 102.0 0.453 H -71.3 -9.9 NA NA NA
ARG G:186 G:187 100.0 0.444 H -68.4 -16.0 NA NA NA
6zei 1 P62136,Q9UQB8 96.32 0.0 X-RAY
 2020-09-30 ARG A:186 A:187 96.0 0.427 H -60.5 -27.2 96.0 0.427 0.0 HOH
 2.037
 HE
 O
ARG C:186 B:187 94.0 0.418 H -61.2 -29.2 NA NA NA
6zeg 1 P62136,Q9UQB8 96.32 0.0 X-RAY
 2020-09-30 ARG A:186 A:187 106.0 0.471 H -61.5 -27.2 106.0 0.471 0.0 EDO
HOH
 2.322
1.645
 O
HH11
 HO2
O
ARG C:186 B:187 138.0 0.613 H -60.4 -27.9 NA NA NA
3e7a 1 P62136 96.63 0.0 X-RAY
 2008-11-04 ARG A:186 A:187 99.0 0.44 H -57.8 -31.2 99.0 0.44 0.0 GOL
HOH
 8.724
2.679
 NE
O
 O1
O
ARG B:186 B:187 80.0 0.356 H -61.1 -29.7 NA NA NA
3e7b 1 P62136 96.63 0.0 X-RAY
 2008-11-04 ARG A:186 A:187 99.0 0.44 H -59.6 -30.4 99.0 0.44 0.0 GOL
AZI
HOH
 8.349
6.707
3.003
 NE
O
NH2
 O1
N3
O
ARG B:186 B:187 94.0 0.418 H -60.0 -28.1 NA NA NA
4mov 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:186 A:187 102.0 0.453 H -57.5 -27.9 102.0 0.453 0.0 HOH
 2.462
 NH2
 O
ARG B:186 B:187 113.0 0.502 H -58.6 -28.0 NA NA NA
4moy 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:186 A:187 98.0 0.436 H -55.7 -35.7 98.0 0.436 0.0 GOL
HOH
 8.985
3.102
 NE
NE
 O3
O
4mp0 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:186 A:187 142.0 0.631 H -61.7 -24.4 142.0 0.631 0.0 GOL
HOH
 9.166
2.758
 CD
O
 O3
O
ARG B:186 C:187 140.0 0.622 H -62.1 -25.5 NA NA NA
4xpn 1 P62136 96.63 0.0 X-RAY
 2015-07-01 ARG A:186 A:187 85.0 0.378 H -57.4 -27.5 85.0 0.378 0.0 GOL
HOH
 8.551
2.741
 NE
NE
 O3
O
ARG C:186 C:187 95.0 0.422 H -58.8 -27.3 NA NA NA
5ioh 1 P62136 96.63 0.0 X-RAY
 2016-10-05 ARG A:186 A:187 120.0 0.533 H -64.4 -28.7 120.0 0.533 0.0 HOH
 4.944
 O
 O
ARG C:186 C:187 109.0 0.484 H -64.5 -27.9 NA NA NA
6alz 1 P62136 96.63 0.0 X-RAY
 2017-11-29 ARG A:186 A:187 103.0 0.458 H -64.7 -24.3 103.0 0.458 0.0 DMS
HOH
 8.970
3.489
 NE
NE
 C1
O
ARG B:186 B:187 99.0 0.44 H -64.5 -22.7 NA NA NA
6czo 1 P62136 96.63 0.0 X-RAY
 2019-01-23 ARG A:186 A:187 95.0 0.422 H -64.1 -24.9 95.0 0.422 0.0 HOH
 5.129
 O
 O
ARG C:186 C:187 103.0 0.458 H -61.1 -30.5 NA NA NA
6dno 1 P62136 96.63 0.0 X-RAY
 2019-01-23 ARG A:186 A:187 114.0 0.507 H -63.2 -26.0 114.0 0.507 0.0 HOH
 2.672
 NE
 O
6zee 1 P62136 96.63 0.0 X-RAY
 2020-09-30 ARG A:186 P:187 111.0 0.493 H -58.6 -44.5 111.0 0.493 0.0 EDO
EDO
HOH
 7.892
2.607
2.036
 C
HH22
HE
 HO1
HO1
O
ARG B:186 Q:187 81.0 0.36 H -66.0 -30.2 81.0 0.36 0.0 EDO
HOH
 2.057
1.996
 HH12
HE
 HO1
O
ARG C:186 B:187 104.0 0.462 H -60.9 -31.3 104.0 0.462 0.0 EDO
HOH
 2.967
1.782
 HH11
HE
 O1
O
ARG D:186 A:187 87.0 0.387 H -62.7 -30.3 87.0 0.387 0.0 EDO
16P
EDO
EDO
HOH
 2.143
2.328
5.952
9.236
2.144
 HH11
HA
HG2
HH21
HH21
 O1
H42
H12
HO2
O
ARG E:186 I:187 133.0 0.591 H -65.7 -26.3 133.0 0.591 0.0 HOH
 2.602
 HG2
 O
ARG F:186 K:187 62.0 NA H -59.7 -31.0 62.0 NA NA EDO
GOL
HOH
 9.402
3.380
4.430
 HG2
O
O
 HO2
HO3
O
6zef 1 P62136 96.63 0.0 X-RAY
 2020-09-30 ARG A:186 A:187 144.0 0.64 H -68.8 -25.4 144.0 0.64 0.0 EDO
EDO
CL
HOH
 2.007
8.014
5.742
2.430
 HH21
HE
O
HH22
 O2
HO1
CL
O
ARG B:186 B:187 143.0 0.636 H -67.3 -24.9 NA NA NA
1u32 1 P36873 98.29 0.0 X-RAY
 2004-08-17 ARG A:182 A:187 93.0 0.413 H -52.0 -26.1 93.0 0.413 0.0 HOH
 3.608
 O
 O
5zt0 1 P62137 97.28 0.0 X-RAY
 2019-03-13 ARG A:181 A:187 112.0 0.498 H -63.4 -29.7 112.0 0.498 0.0
ARG B:181 B:187 111.0 0.493 H -62.9 -19.8 NA NA NA
ARG C:181 C:187 107.0 0.476 H -57.6 -30.2 NA NA NA
ARG D:181 D:187 106.0 0.471 H -56.9 -34.0 NA NA NA
ARG E:181 E:187 115.0 0.511 H -62.3 -29.2 NA NA NA
ARG F:181 F:187 108.0 0.48 H -64.3 -33.7 NA NA NA
6obr 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:186 A:187 98.0 0.436 H -62.3 -26.1 98.0 0.436 0.0 HOH
 3.227
 NE
 O
ARG B:186 B:187 91.0 0.404 H -62.4 -25.2 NA NA NA
6obq 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:186 A:187 86.0 0.382 H -66.3 -26.1 86.0 0.382 0.0 HOH
 3.017
 NE
 O
ARG B:186 B:187 80.0 0.356 H -67.0 -25.7 NA NA NA
6obs 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:186 A:187 93.0 0.413 H -63.6 -27.2 93.0 0.413 0.0 HOH
 3.041
 NE
 O
ARG B:186 B:187 92.0 0.409 H -63.0 -26.5 NA NA NA
6obu 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:186 A:187 94.0 0.418 H -61.4 -26.3 94.0 0.418 0.0 GOL
HOH
 7.708
2.878
 NH2
NH2
 O1
O
ARG B:186 B:187 98.0 0.436 H -60.6 -26.3 NA NA NA
7nzm 2 P62139 97.28 0.0 EM
 2021-09-29 ARG B:181 B:187 98.0 0.436 H -57.7 -28.0 98.0 0.436 0.0
1s70 1 P62140 89.06 0.0 X-RAY
 2004-06-22 ARG A:189 A:187 109.0 0.484 H -55.6 -34.4 109.0 0.484 0.0 HOH
 3.372
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p36873-f1 1 P36873 100.0 0.0 ARG A:187 A:187 108.0 0.48 H -59.1 -29.8
af-p62136-f1 1 P62136 90.66 0.0 ARG A:187 A:187 98.0 0.436 H -58.5 -29.8
af-p62140-f1 1 P62140 89.06 0.0 ARG A:186 A:186 100.0 0.444 H -58.8 -28.9