Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 111168531 . C A CCDS58279.1:NM_001244974.1:c.221cGa>cTa_NP_001231903.1:p.74R>L Homo sapiens protein phosphatase 1 catalytic subunit gamma (PPP1CC), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1it6 1 P36873 100.0 0.0 X-RAY
 2002-05-22 ARG A:74 A:74 50.0 0.222 H -64.1 -36.6 50.0 0.222 0.0 HOH
 3.909
 NH2
 O
ARG B:74 B:74 54.0 0.24 H -63.1 -33.8 NA NA NA
1jk7 1 P36873 100.0 0.0 X-RAY
 2001-08-15 ARG A:74 A:74 55.0 0.244 H -61.7 -39.4 55.0 0.244 0.0 HOH
 3.020
 NH2
 O
2bcd 1 P36873 100.0 0.0 X-RAY
 2006-01-17 ARG A:74 A:74 104.0 0.462 H -57.6 -36.8 104.0 0.462 0.0 HOH
 3.325
 CG
 O
2bdx 1 P36873 100.0 0.0 X-RAY
 2006-01-17 ARG A:74 A:74 102.0 0.453 H -62.2 -37.3 102.0 0.453 0.0
4ut2 1 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG A:74 A:74 39.0 0.173 H -60.4 -49.8 39.0 0.173 0.0 HOH
 2.722
 NH2
 O
ARG B:74 B:74 40.0 0.178 H -60.8 -49.6 NA NA NA
4ut3 1 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG A:74 A:74 44.0 0.196 H -50.4 -51.3 44.0 0.196 0.0 HOH
 4.604
 N
 O
4ut3 2 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG B:74 B:74 44.0 0.196 H -50.6 -51.1 NA NA NA
4v0u 2 P63087 99.69 0.0 X-RAY
 2015-03-25 ARG D:74 D:74 93.0 0.413 H -69.6 -39.0 NA NA NA
ARG F:74 F:74 92.0 0.409 H -69.4 -39.2 NA NA NA
ARG H:74 H:74 91.0 0.404 H -69.4 -39.3 NA NA NA
ARG J:74 J:74 93.0 0.413 H -69.5 -39.2 49.0 0.218 0.195 K:Q5SWA1:0.196
ARG N:74 N:74 92.0 0.409 H -69.5 -39.2 NA NA NA
2o8a 1 P63088 99.69 0.0 X-RAY
 2007-07-17 ARG A:80 A:74 63.0 0.28 H -60.1 -38.3 63.0 0.28 0.0 HOH
 4.383
 N
 O
ARG C:80 B:74 61.0 0.271 H -57.3 -38.6 NA NA NA
2o8g 1 P63088 99.69 0.0 X-RAY
 2007-07-17 ARG A:80 A:74 62.0 0.276 H -64.8 -36.3 62.0 0.276 0.0 HOH
 3.204
 NH2
 O
ARG C:80 B:74 63.0 0.28 H -59.3 -33.0 NA NA NA
5inb 1 P36873 100.0 0.0 X-RAY
 2016-10-05 ARG A:71 A:74 107.0 0.476 H -67.4 -37.0 13.0 0.058 0.418 B:Q69YH5:0.418
 HOH
 2.885
 O
 O
5j28 1 P36873 100.0 0.0 X-RAY
 2016-10-05 ARG A:71 A:74 106.0 0.471 H -62.8 -36.8 6.0 0.027 0.444 C:P46013:0.444
 HOH
 2.855
 NE
 O
ARG B:71 B:74 111.0 0.493 H -67.3 -33.9 NA NA NA
1fjm 1 P08129 90.66 0.0 X-RAY
 1996-06-20 ARG A:74 A:74 105.0 0.467 H -67.1 -35.8 105.0 0.467 0.0 HOH
 2.760
 NH2
 O
ARG B:74 B:74 74.0 0.329 H -66.3 -42.3 NA NA NA
4g9j 1 P62136 90.66 0.0 X-RAY
 2012-09-19 ARG A:75 A:74 60.0 0.267 H -63.4 -41.6 55.0 0.244 0.023 C:None:0.022
 HOH
 2.640
 NE
 O
ARG B:75 B:74 67.0 0.298 H -64.2 -26.4 NA NA NA
6g0i 1 P62136 90.66 0.0 X-RAY
 2018-11-21 ARG A:75 A:74 56.0 0.249 H -51.3 -50.4 56.0 0.249 0.0 HOH
 4.914
 N
 O
6g0j 1 P62136 90.66 0.0 X-RAY
 2018-11-21 ARG A:75 A:74 57.0 0.253 H -54.4 -47.1 57.0 0.253 0.0 HOH
 4.687
 NH1
 O
6dcx 1 P62136 90.66 0.0 X-RAY
 2019-05-15 ARG A:83 A:74 87.0 0.387 H -64.7 -36.5 87.0 0.387 0.0
ARG B:83 B:74 75.0 0.333 H -64.2 -36.8 NA NA NA
6zk6 1 P62136 90.36 0.0 X-RAY
 2020-11-18 ARG A:75 A:74 57.0 0.253 H -56.2 -45.2 57.0 0.253 0.0 HOH
 3.146
 NE
 O
5zqv 1 P62137 91.95 0.0 X-RAY
 2019-03-13 ARG A:74 A:74 136.0 0.604 H -65.2 -35.6 89.0 0.396 0.208 E:Q16821:0.209
ARG B:74 B:74 121.0 0.538 H -64.0 -33.7 NA NA NA
ARG C:74 C:74 146.0 0.649 H -61.8 -32.4 84.0 0.373 0.276 H:Q16821:0.276
ARG D:74 D:74 127.0 0.564 H -65.2 -37.2 NA NA NA
4v0v 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:69 A:74 93.0 0.413 H -69.9 -38.8 48.0 0.213 0.2 B:Q5SWA1:0.2
 HOH
 2.995
 NE
 O
ARG C:69 C:74 115.0 0.511 H -68.1 -39.4 NA NA NA
4v0w 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:69 A:74 88.0 0.391 H -65.4 -37.6 55.0 0.244 0.147 B:Q5SWA1:0.147
 HOH
 3.009
 NE
 O
ARG C:69 C:74 111.0 0.493 H -65.2 -38.4 NA NA NA
4v0x 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:69 A:74 100.0 0.444 H -63.5 -37.5 30.0 0.133 0.311 B:Q5SWA1:0.311
 HOH
 2.932
 HE
 O
3egg 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:73 A:74 114.0 0.507 H -69.2 -36.6 7.0 0.031 0.476 C:O35274:0.476
 GOL
HOH
 9.207
3.100
 N
NH1
 O1
O
ARG B:73 B:74 112.0 0.498 H -67.3 -38.9 NA NA NA
3egh 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:73 A:74 114.0 0.507 H -67.9 -41.9 6.0 0.027 0.48 C:O35274:0.48
 GOL
HOH
 9.363
2.941
 N
NH1
 C1
O
ARG B:73 B:74 111.0 0.493 H -67.3 -37.7 NA NA NA
3hvq 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:73 A:74 151.0 0.671 H -62.6 -43.9 41.0 0.182 0.489 C:O35867:0.489
 HOH
 2.997
 NH2
 O
ARG B:73 B:74 123.0 0.547 H -59.6 -43.8 11.0 0.049 0.498 D:O35867:0.498
 HOH
 2.571
 NH1
 O
6ghm 1 P62136 90.58 0.0 X-RAY
 2019-02-27 ARG A:73 A:74 65.0 0.289 H -61.1 -41.5 65.0 0.289 0.0 EDO
HOH
 9.746
3.391
 N
NH1
 O2
O
ARG B:73 B:74 86.0 0.382 H -56.6 -44.5 NA NA NA
3n5u 1 P62136 96.67 0.0 X-RAY
 2010-08-11 ARG A:74 A:74 81.0 0.36 H -52.5 -33.1 81.0 0.36 0.0
ARG B:74 B:74 79.0 0.351 H -52.0 -33.1 79.0 0.351 0.0
6obn 1 P62136 96.67 0.0 X-RAY
 2019-09-18 ARG A:79 A:74 59.0 0.262 H -66.5 -35.6 59.0 0.262 0.0 PO4
 9.112
 NH2
 O1
ARG B:79 B:74 64.0 0.284 H -68.9 -36.0 NA NA NA
6obp 1 P62136 96.67 0.0 X-RAY
 2019-09-18 ARG A:79 A:74 61.0 0.271 H -75.0 -38.4 61.0 0.271 0.0
6zej 1 P62136,Q4VY12 94.46 0.0 X-RAY
 2020-09-30 ARG A:73 D:73 66.0 0.293 H -64.3 -33.4 66.0 0.293 0.0 HOH
 2.360
 HD2
 O
ARG B:73 A:73 66.0 0.293 H -68.1 -37.7 NA NA NA
ARG C:73 F:73 67.0 0.298 H -67.2 -35.4 NA NA NA
ARG D:73 I:73 52.0 0.231 H -68.3 -37.0 NA NA NA
ARG E:73 L:73 65.0 0.289 H -69.1 -37.8 NA NA NA
ARG F:73 O:73 63.0 0.28 H -63.8 -37.8 NA NA NA
6zeh 1 P62136,Q13813 96.33 0.0 X-RAY
 2020-09-30 ARG A:73 A:74 107.0 0.476 H -64.4 -40.0 47.0 0.209 0.267 B:Q4VY12:0.267
 HOH
 2.378
 HH12
 O
ARG C:73 B:74 111.0 0.493 H -66.8 -36.6 NA NA NA
3v4y 1 P62136 96.33 0.0 X-RAY
 2012-10-31 ARG A:73 A:74 124.0 0.551 H -65.7 -40.4 88.0 0.391 0.16 B:Q12972:0.16
 HOH
 1.723
 HH22
 O
ARG C:73 C:74 118.0 0.524 H -65.3 -36.9 NA NA NA
ARG E:73 E:74 116.0 0.516 H -66.5 -34.0 NA NA NA
ARG G:73 G:74 109.0 0.484 H -66.8 -30.0 NA NA NA
6zei 1 P62136,Q9UQB8 96.32 0.0 X-RAY
 2020-09-30 ARG A:73 A:74 113.0 0.502 H -63.3 -39.7 48.0 0.213 0.289 B:Q4VY12:0.289
 HOH
 2.312
 HD3
 O
ARG C:73 B:74 106.0 0.471 H -68.1 -37.3 NA NA NA
6zeg 1 P62136,Q9UQB8 96.32 0.0 X-RAY
 2020-09-30 ARG A:73 A:74 100.0 0.444 H -65.8 -38.0 48.0 0.213 0.231 B:Q4VY12:0.231
 HOH
 2.879
 HG2
 O
ARG C:73 B:74 109.0 0.484 H -66.2 -38.6 NA NA NA
3e7a 1 P62136 96.63 0.0 X-RAY
 2008-11-04 ARG A:73 A:74 80.0 0.356 H -64.4 -39.5 80.0 0.356 0.0 IOD
HOH
 8.214
2.815
 NH2
NH2
 I
O
ARG B:73 B:74 58.0 0.258 H -63.5 -41.9 NA NA NA
3e7b 1 P62136 96.63 0.0 X-RAY
 2008-11-04 ARG A:73 A:74 81.0 0.36 H -62.4 -41.0 81.0 0.36 0.0 HOH
 2.826
 NH2
 O
ARG B:73 B:74 92.0 0.409 H -65.7 -39.8 NA NA NA
4mov 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:73 A:74 75.0 0.333 H -65.7 -38.9 75.0 0.333 0.0 HOH
 2.878
 NH1
 O
ARG B:73 B:74 96.0 0.427 H -67.8 -39.2 NA NA NA
4moy 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:73 A:74 130.0 0.578 H -59.0 -44.8 60.0 0.267 0.311 B:O55000:0.311
 HOH
 2.995
 NE
 O
4mp0 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:73 A:74 109.0 0.484 H -66.3 -38.9 38.0 0.169 0.315 C:O55000:0.316
 HOH
 2.830
 NE
 O
ARG B:73 C:74 108.0 0.48 H -66.4 -39.9 NA NA NA
4xpn 1 P62136 96.63 0.0 X-RAY
 2015-07-01 ARG A:73 A:74 47.0 0.209 H -62.2 -40.5 17.0 0.076 0.133 B:O75807:0.133
 HOH
 3.803
 N
 O
ARG C:73 C:74 47.0 0.209 H -61.2 -40.0 NA NA NA
5ioh 1 P62136 96.63 0.0 X-RAY
 2016-10-05 ARG A:73 A:74 105.0 0.467 H -69.9 -35.2 10.0 0.044 0.423 B:Q69YH5:0.422
 HOH
 2.760
 O
 O
ARG C:73 C:74 104.0 0.462 H -69.8 -35.2 NA NA NA
6alz 1 P62136 96.63 0.0 X-RAY
 2017-11-29 ARG A:73 A:74 73.0 0.324 H -65.1 -37.5 73.0 0.324 0.0 CL
CL
HOH
 9.341
8.537
2.920
 NH2
O
NH1
 CL
CL
O
ARG B:73 B:74 76.0 0.338 H -65.5 -37.2 NA NA NA
6czo 1 P62136 96.63 0.0 X-RAY
 2019-01-23 ARG A:73 A:74 89.0 0.396 H -66.9 -37.9 57.0 0.253 0.143 B:Q05C46:0.142
ARG C:73 C:74 50.0 0.222 H -67.1 -37.1 NA NA NA
6dno 1 P62136 96.63 0.0 X-RAY
 2019-01-23 ARG A:73 A:74 106.0 0.471 H -64.9 -38.3 30.0 0.133 0.338 B:Q00756:0.338
 HOH
 3.543
 NH1
 O
6zee 1 P62136 96.63 0.0 X-RAY
 2020-09-30 ARG A:73 P:74 125.0 0.556 H -62.2 -38.8 68.0 0.302 0.254 G:Q4VY12:0.253
 HOH
 2.698
 HG2
 O
ARG B:73 Q:74 136.0 0.604 H -66.3 -36.3 55.0 0.244 0.36 L:Q4VY12:0.36
 EDO
HOH
 1.991
5.731
 HD3
HH11
 HO1
O
ARG C:73 B:74 149.0 0.662 H -65.1 -36.1 63.0 0.28 0.382 I:Q4VY12:0.382
 HOH
 8.857
 O
 O
ARG D:73 A:74 117.0 0.52 H -64.1 -35.4 56.0 0.249 0.271 J:Q4VY12:0.271
 HOH
 2.599
 HG2
 O
ARG E:73 I:74 27.0 NA H -64.4 -40.0 10.0 NA NA K:Q4VY12:NA
 HOH
 7.379
 HA
 O
ARG F:73 K:74 152.0 0.676 H -57.7 -42.2 75.0 0.333 0.343 H:Q4VY12:0.342
 GOL
HOH
 2.658
2.595
 HE
HG2
 HO3
O
6zef 1 P62136 96.63 0.0 X-RAY
 2020-09-30 ARG A:73 A:74 149.0 0.662 H -71.8 -33.4 66.0 0.293 0.369 C:Q4VY12:0.369
 HOH
 2.743
 HB2
 O
ARG B:73 B:74 153.0 0.68 H -71.6 -37.7 NA NA NA
1u32 1 P36873 98.29 0.0 X-RAY
 2004-08-17 ARG A:69 A:74 88.0 0.391 H -65.9 -35.9 88.0 0.391 0.0 HOH
 5.016
 NH2
 O
5zt0 1 P62137 97.28 0.0 X-RAY
 2019-03-13 ARG A:68 A:74 100.0 0.444 H -65.7 -32.9 97.0 0.431 0.013 G:Q86XI6:0.013
ARG B:68 B:74 105.0 0.467 H -69.3 -34.7 NA NA NA
ARG C:68 C:74 104.0 0.462 H -64.9 -34.4 NA NA NA
ARG D:68 D:74 106.0 0.471 H -65.3 -31.9 NA NA NA
ARG E:68 E:74 103.0 0.458 H -73.3 -29.3 NA NA NA
ARG F:68 F:74 106.0 0.471 H -74.2 -30.6 NA NA NA
6obr 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:73 A:74 73.0 0.324 H -63.6 -41.9 73.0 0.324 0.0 HOH
 2.927
 NH1
 O
ARG B:73 B:74 94.0 0.418 H -63.2 -41.7 NA NA NA
6obq 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:73 A:74 71.0 0.316 H -65.7 -38.5 71.0 0.316 0.0 HOH
 2.790
 NH1
 O
ARG B:73 B:74 84.0 0.373 H -66.6 -38.4 NA NA NA
6obs 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:73 A:74 73.0 0.324 H -65.8 -37.2 73.0 0.324 0.0 HOH
 2.781
 NH2
 O
ARG B:73 B:74 91.0 0.404 H -67.3 -37.0 NA NA NA
6obu 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:73 A:74 73.0 0.324 H -63.2 -41.2 73.0 0.324 0.0 GOL
HOH
 7.746
2.832
 NE
NH2
 O1
O
ARG B:73 B:74 47.0 0.209 H -61.6 -41.4 NA NA NA
7nzm 2 P62139 97.28 0.0 EM
 2021-09-29 ARG B:68 B:74 129.0 0.573 H -66.2 -37.7 67.0 0.298 0.275 E:O75807+P0AEX9:0.276
1s70 1 P62140 89.06 0.0 X-RAY
 2004-06-22 ARG A:76 A:74 55.0 0.244 H -64.8 -33.6 44.0 0.196 0.048 B:Q90624:0.049
 PGE
HOH
 3.905
5.209
 CG
NH2
 O1
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p36873-f1 1 P36873 100.0 0.0 ARG A:74 A:74 70.0 0.311 H -65.5 -36.6
af-p62136-f1 1 P62136 90.66 0.0 ARG A:74 A:74 74.0 0.329 H -63.3 -36.9
af-p62140-f1 1 P62140 89.06 0.0 ARG A:73 A:73 61.0 0.271 H -65.1 -37.3