Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 111169635 . G A CCDS58279.1:NM_001244974.1:c.127Cgt>Tgt_NP_001231903.1:p.43R>C Homo sapiens protein phosphatase 1 catalytic subunit gamma (PPP1CC), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1it6 1 P36873 100.0 0.0 X-RAY
 2002-05-22 ARG A:43 A:43 68.0 0.302 H -56.8 -44.2 68.0 0.302 0.0 HOH
 5.487
 O
 O
ARG B:43 B:43 64.0 0.284 H -57.6 -43.5 NA NA NA
1jk7 1 P36873 100.0 0.0 X-RAY
 2001-08-15 ARG A:43 A:43 73.0 0.324 H -53.6 -47.2 73.0 0.324 0.0 HOH
 2.597
 NH2
 O
2bcd 1 P36873 100.0 0.0 X-RAY
 2006-01-17 ARG A:43 A:43 79.0 0.351 H -56.9 -41.8 79.0 0.351 0.0 HOH
 7.356
 O
 O
2bdx 1 P36873 100.0 0.0 X-RAY
 2006-01-17 ARG A:43 A:43 70.0 0.311 H -54.8 -47.4 70.0 0.311 0.0 HOH
 7.390
 O
 O
4ut2 1 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG A:43 A:43 72.0 0.32 H -54.0 -46.7 72.0 0.32 0.0 HOH
 2.584
 NH1
 O
ARG B:43 B:43 58.0 0.258 H -53.7 -46.8 NA NA NA
4ut3 1 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG A:43 A:43 79.0 0.351 H -58.9 -40.5 79.0 0.351 0.0 HOH
 2.574
 NH2
 O
4ut3 2 P36873 100.0 0.0 X-RAY
 2015-07-22 ARG B:43 B:43 79.0 0.351 H -58.4 -41.7 NA NA NA
4v0u 2 P63087 99.69 0.0 X-RAY
 2015-03-25 ARG D:43 D:43 78.0 0.347 H -56.5 -44.9 NA NA NA
ARG F:43 F:43 81.0 0.36 H -56.5 -44.8 NA NA NA
ARG H:43 H:43 82.0 0.364 H -56.5 -44.9 NA NA NA
ARG J:43 J:43 80.0 0.356 H -56.4 -44.9 80.0 0.356 0.0
ARG N:43 N:43 80.0 0.356 H -56.5 -44.9 NA NA NA
2o8a 1 P63088 99.69 0.0 X-RAY
 2007-07-17 ARG A:49 A:43 69.0 0.307 H -54.2 -44.5 69.0 0.307 0.0 HOH
 7.208
 O
 O
ARG C:49 B:43 63.0 0.28 H -51.5 -46.0 NA NA NA
2o8g 1 P63088 99.69 0.0 X-RAY
 2007-07-17 ARG A:49 A:43 64.0 0.284 H -55.0 -43.6 64.0 0.284 0.0 HOH
 3.894
 CD
 O
ARG C:49 B:43 68.0 0.302 H -51.0 -52.3 NA NA NA
5inb 1 P36873 100.0 0.0 X-RAY
 2016-10-05 ARG A:40 A:43 68.0 0.302 H -57.0 -44.7 68.0 0.302 0.0 HOH
 2.677
 NH1
 O
5j28 1 P36873 100.0 0.0 X-RAY
 2016-10-05 ARG A:40 A:43 78.0 0.347 H -53.7 -42.9 78.0 0.347 0.0 HOH
 4.693
 O
 O
ARG B:40 B:43 52.0 0.231 H -56.5 -45.3 NA NA NA
1fjm 1 P08129 90.66 0.0 X-RAY
 1996-06-20 ARG A:43 A:43 76.0 0.338 H -57.9 -42.5 76.0 0.338 0.0 HOH
 2.929
 NH2
 O
ARG B:43 B:43 78.0 0.347 H -58.3 -41.6 NA NA NA
4g9j 1 P62136 90.66 0.0 X-RAY
 2012-09-19 ARG A:44 A:43 50.0 0.222 H -57.1 -45.3 50.0 0.222 0.0
ARG B:44 B:43 53.0 0.236 H -48.7 -45.3 NA NA NA
6g0i 1 P62136 90.66 0.0 X-RAY
 2018-11-21 ARG A:44 A:43 73.0 0.324 H -57.2 -46.0 73.0 0.324 0.0 HOH
 2.972
 NH2
 O
6g0j 1 P62136 90.66 0.0 X-RAY
 2018-11-21 ARG A:44 A:43 76.0 0.338 H -53.0 -40.5 76.0 0.338 0.0 HOH
 4.663
 NH2
 O
6dcx 1 P62136 90.66 0.0 X-RAY
 2019-05-15 ARG A:52 A:43 73.0 0.324 H -56.1 -41.3 73.0 0.324 0.0
ARG B:52 B:43 69.0 0.307 H -56.1 -42.7 NA NA NA
6zk6 1 P62136 90.36 0.0 X-RAY
 2020-11-18 ARG A:44 A:43 59.0 0.262 H -54.7 -48.2 59.0 0.262 0.0 HOH
 3.816
 CD
 O
5zqv 1 P62137 91.95 0.0 X-RAY
 2019-03-13 ARG A:43 A:43 71.0 0.316 H -55.9 -34.2 71.0 0.316 0.0
ARG B:43 B:43 72.0 0.32 H -60.7 -34.9 NA NA NA
ARG C:43 C:43 74.0 0.329 H -58.1 -38.6 74.0 0.329 0.0
ARG D:43 D:43 67.0 0.298 H -58.2 -31.7 NA NA NA
4v0v 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:38 A:43 79.0 0.351 H -55.3 -44.9 79.0 0.351 0.0 HOH
 2.714
 NE
 O
ARG C:38 C:43 56.0 0.249 H -56.2 -44.3 NA NA NA
4v0w 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:38 A:43 80.0 0.356 H -55.6 -44.6 80.0 0.356 0.0 HOH
 2.845
 NE
 O
ARG C:38 C:43 55.0 0.244 H -54.5 -46.2 NA NA NA
4v0x 1 P63087 100.0 0.0 X-RAY
 2015-03-25 ARG A:38 A:43 61.0 0.271 H -56.8 -42.0 61.0 0.271 0.0 HOH
 2.549
 HH12
 O
3egg 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:42 A:43 72.0 0.32 H -56.5 -46.0 72.0 0.32 0.0 HOH
 3.639
 CD
 O
ARG B:42 B:43 84.0 0.373 H -57.3 -44.7 NA NA NA
3egh 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:42 A:43 70.0 0.311 H -55.5 -41.2 70.0 0.311 0.0 HOH
 2.358
 NH2
 O
ARG B:42 B:43 83.0 0.369 H -56.5 -45.4 NA NA NA
3hvq 1 P62136 90.58 0.0 X-RAY
 2010-03-23 ARG A:42 A:43 59.0 0.262 H -56.4 -47.3 59.0 0.262 0.0 HOH
 3.079
 NH1
 O
ARG B:42 B:43 80.0 0.356 H -57.7 -41.5 8.0 0.036 0.32 C:O35867:0.32
 HOH
 2.731
 NH2
 O
6ghm 1 P62136 90.58 0.0 X-RAY
 2019-02-27 ARG A:42 A:43 55.0 0.244 H -55.4 -45.2 55.0 0.244 0.0 HOH
 3.098
 NH1
 O
ARG B:42 B:43 72.0 0.32 H -56.5 -48.6 NA NA NA
3n5u 1 P62136 96.67 0.0 X-RAY
 2010-08-11 ARG A:43 A:43 76.0 0.338 H -51.2 -39.7 76.0 0.338 0.0
ARG B:43 B:43 75.0 0.333 H -51.2 -40.6 75.0 0.333 0.0
6obn 1 P62136 96.67 0.0 X-RAY
 2019-09-18 ARG A:48 A:43 66.0 0.293 H -59.3 -40.2 22.0 0.098 0.195 C:Q15435:0.196
 CL
MPD
HOH
 8.535
8.989
4.734
 O
N
NH2
 CL
C1
O
ARG B:48 B:43 64.0 0.284 H -57.5 -39.8 NA NA NA
6obp 1 P62136 96.67 0.0 X-RAY
 2019-09-18 ARG A:48 A:43 73.0 0.324 H -63.4 -39.5 25.0 0.111 0.213 B:Q15435:0.213
 CL
HOH
 3.333
2.869
 NH1
NH2
 CL
O
6zej 1 P62136,Q4VY12 94.46 0.0 X-RAY
 2020-09-30 ARG A:42 D:42 38.0 0.169 H -55.9 -42.9 38.0 0.169 0.0 HOH
 2.165
 HH21
 O
ARG B:42 A:42 43.0 0.191 H -52.7 -47.2 NA NA NA
ARG C:42 F:42 45.0 0.2 H -51.5 -41.7 NA NA NA
ARG D:42 I:42 46.0 0.204 H -41.6 -53.2 NA NA NA
ARG E:42 L:42 43.0 0.191 H -51.1 -48.6 NA NA NA
ARG F:42 O:42 39.0 0.173 H -60.8 -39.0 NA NA NA
6zeh 1 P62136,Q13813 96.33 0.0 X-RAY
 2020-09-30 ARG A:42 A:43 73.0 0.324 H -59.9 -42.0 47.0 0.209 0.115 B:Q4VY12:0.116
 HOH
 2.047
 HE
 O
ARG C:42 B:43 67.0 0.298 H -54.8 -45.6 NA NA NA
3v4y 1 P62136 96.33 0.0 X-RAY
 2012-10-31 ARG A:42 A:43 73.0 0.324 H -58.8 -43.7 50.0 0.222 0.102 B:Q12972:0.102
 HOH
 1.978
 HH21
 O
ARG C:42 C:43 81.0 0.36 H -59.0 -42.4 NA NA NA
ARG E:42 E:43 70.0 0.311 H -52.9 -47.9 NA NA NA
ARG G:42 G:43 72.0 0.32 H -54.2 -51.6 NA NA NA
6zei 1 P62136,Q9UQB8 96.32 0.0 X-RAY
 2020-09-30 ARG A:42 A:43 71.0 0.316 H -57.4 -45.2 46.0 0.204 0.112 B:Q4VY12:0.111
 HOH
 2.028
 HH21
 O
ARG C:42 B:43 65.0 0.289 H -54.2 -41.7 NA NA NA
6zeg 1 P62136,Q9UQB8 96.32 0.0 X-RAY
 2020-09-30 ARG A:42 A:43 72.0 0.32 H -57.8 -43.4 63.0 0.28 0.04 B:Q4VY12:0.04
 EDO
HOH
 8.443
2.013
 HH22
HH21
 HO1
O
ARG C:42 B:43 65.0 0.289 H -55.6 -44.8 NA NA NA
3e7a 1 P62136 96.63 0.0 X-RAY
 2008-11-04 ARG A:42 A:43 76.0 0.338 H -50.5 -48.7 76.0 0.338 0.0 HOH
 5.088
 O
 O
ARG B:42 B:43 89.0 0.396 H -56.2 -45.6 NA NA NA
3e7b 1 P62136 96.63 0.0 X-RAY
 2008-11-04 ARG A:42 A:43 74.0 0.329 H -54.3 -47.3 74.0 0.329 0.0 AZI
HOH
 7.936
2.658
 O
NH1
 N1
O
ARG B:42 B:43 84.0 0.373 H -54.7 -48.2 NA NA NA
4mov 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:42 A:43 72.0 0.32 H -58.6 -41.4 72.0 0.32 0.0 HOH
 2.469
 NH2
 O
ARG B:42 B:43 75.0 0.333 H -58.5 -42.5 NA NA NA
4moy 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:42 A:43 64.0 0.284 H -52.2 -48.0 64.0 0.284 0.0 HOH
 2.745
 NH1
 O
4mp0 1 P62136 96.63 0.0 X-RAY
 2014-03-26 ARG A:42 A:43 53.0 0.236 H -58.6 -43.7 53.0 0.236 0.0 HOH
 2.879
 NH1
 O
ARG B:42 C:43 50.0 0.222 H -58.4 -44.3 NA NA NA
4xpn 1 P62136 96.63 0.0 X-RAY
 2015-07-01 ARG A:42 A:43 56.0 0.249 H -54.8 -43.9 56.0 0.249 0.0 HOH
 2.846
 NH1
 O
ARG C:42 C:43 56.0 0.249 H -54.8 -43.9 NA NA NA
5ioh 1 P62136 96.63 0.0 X-RAY
 2016-10-05 ARG A:42 A:43 68.0 0.302 H -61.5 -38.8 68.0 0.302 0.0 HOH
 2.581
 NH1
 O
ARG C:42 C:43 63.0 0.28 H -61.7 -38.7 NA NA NA
6alz 1 P62136 96.63 0.0 X-RAY
 2017-11-29 ARG A:42 A:43 72.0 0.32 H -59.8 -42.1 72.0 0.32 0.0 HOH
 2.400
 NH2
 O
ARG B:42 B:43 69.0 0.307 H -62.1 -40.4 NA NA NA
6czo 1 P62136 96.63 0.0 X-RAY
 2019-01-23 ARG A:42 A:43 51.0 0.227 H -61.2 -39.0 51.0 0.227 0.0 HOH
 7.517
 O
 O
ARG C:42 C:43 51.0 0.227 H -63.4 -36.3 NA NA NA
6dno 1 P62136 96.63 0.0 X-RAY
 2019-01-23 ARG A:42 A:43 53.0 0.236 H -58.2 -43.2 53.0 0.236 0.0 HOH
 2.731
 NH1
 O
6zee 1 P62136 96.63 0.0 X-RAY
 2020-09-30 ARG A:42 P:43 70.0 0.311 H -54.2 -43.4 44.0 0.196 0.115 G:Q4VY12:0.116
 HOH
 2.270
 HH11
 O
ARG B:42 Q:43 74.0 0.329 H -53.4 -46.0 48.0 0.213 0.116 L:Q4VY12:0.116
 HOH
 5.045
 O
 O
ARG C:42 B:43 76.0 0.338 H -52.7 -43.2 47.0 0.209 0.129 I:Q4VY12:0.129
 HOH
 2.020
 HE
 O
ARG D:42 A:43 69.0 0.307 H -53.9 -43.3 42.0 0.187 0.12 J:Q4VY12:0.12
 16P
EDO
HOH
 7.126
9.587
1.718
 O
O
HH22
 H102
HO1
O
ARG E:42 I:43 73.0 0.324 H -54.2 -48.5 63.0 0.28 0.044 K:Q4VY12:0.044
 HOH
 2.659
 HD3
 O
ARG F:42 K:43 78.0 0.347 H -47.7 -51.5 49.0 0.218 0.129 H:Q4VY12:0.129
 GOL
HOH
 8.152
2.003
 O
HH21
 H2
O
6zef 1 P62136 96.63 0.0 X-RAY
 2020-09-30 ARG A:42 A:43 80.0 0.356 H -57.0 -43.9 77.0 0.342 0.014 C:Q4VY12:0.013
 CL
HOH
 9.175
2.254
 O
HE
 CL
O
ARG B:42 B:43 81.0 0.36 H -58.8 -42.3 NA NA NA
1u32 1 P36873 98.29 0.0 X-RAY
 2004-08-17 ARG A:38 A:43 73.0 0.324 H -54.5 -46.9 73.0 0.324 0.0 HOH
 3.098
 NH2
 O
5zt0 1 P62137 97.28 0.0 X-RAY
 2019-03-13 ARG A:37 A:43 54.0 0.24 H -60.1 -39.7 54.0 0.24 0.0
ARG B:37 B:43 49.0 0.218 H -61.7 -39.6 NA NA NA
ARG C:37 C:43 50.0 0.222 H -60.4 -37.0 NA NA NA
ARG D:37 D:43 51.0 0.227 H -61.8 -41.7 NA NA NA
ARG E:37 E:43 52.0 0.231 H -62.5 -36.9 NA NA NA
ARG F:37 F:43 50.0 0.222 H -61.9 -38.9 NA NA NA
6obr 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:42 A:43 73.0 0.324 H -58.8 -42.9 73.0 0.324 0.0 HOH
 2.563
 NH1
 O
ARG B:42 B:43 74.0 0.329 H -63.3 -41.4 NA NA NA
6obq 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:42 A:43 75.0 0.333 H -56.2 -43.5 75.0 0.333 0.0 HOH
 2.762
 NH2
 O
ARG B:42 B:43 73.0 0.324 H -58.3 -41.9 NA NA NA
6obs 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:42 A:43 78.0 0.347 H -57.3 -43.4 78.0 0.347 0.0 HOH
 2.410
 NH1
 O
ARG B:42 B:43 77.0 0.342 H -57.6 -43.7 NA NA NA
6obu 1 P62136 96.3 0.0 X-RAY
 2019-09-18 ARG A:42 A:43 74.0 0.329 H -56.7 -45.0 74.0 0.329 0.0 HOH
 2.562
 NH2
 O
ARG B:42 B:43 73.0 0.324 H -57.9 -43.7 NA NA NA
7nzm 2 P62139 97.28 0.0 EM
 2021-09-29 ARG B:37 B:43 87.0 0.387 H -83.0 5.2 87.0 0.387 0.0
1s70 1 P62140 89.06 0.0 X-RAY
 2004-06-22 ARG A:45 A:43 67.0 0.298 H -48.4 -37.2 67.0 0.298 0.0 HOH
 7.114
 NH1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p36873-f1 1 P36873 100.0 0.0 ARG A:43 A:43 71.0 0.316 H -57.1 -43.6
af-p62136-f1 1 P62136 90.66 0.0 ARG A:43 A:43 76.0 0.338 H -55.4 -43.5
af-p62140-f1 1 P62140 89.06 0.0 ARG A:42 A:42 82.0 0.364 H -57.9 -43.1