Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12291280 . C A CCDS8647.1:NM_002336.2:c.3586Gag>Tag_NP_002327.2:p.1196E>* Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 GLU A:569 A:1196 117.0 0.616 -58.0 134.8 117.0 0.616 0.0
GLU B:569 B:1196 123.0 0.647 -61.5 130.8 123.0 0.647 0.0 HOH
 7.537
 OE1
 O
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 GLU A:569 A:1196 113.0 0.595 -68.2 135.5 113.0 0.595 0.0
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 GLU A:571 A:1196 131.0 0.689 -71.3 131.3 131.0 0.689 0.0 HOH
 3.909
 O
 O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 GLU B:566 B:1196 122.0 0.642 -61.4 130.7 122.0 0.642 0.0
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 GLU A:567 A:1196 124.0 0.653 -66.2 134.8 124.0 0.653 0.0
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 GLU A:567 A:1196 117.0 0.616 -59.0 130.3 117.0 0.616 0.0 HOH
 6.057
 OE2
 O
GLU D:567 B:1196 107.0 0.563 -58.2 135.5 107.0 0.563 0.0 HOH
 8.395
 N
 O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 GLU A:576 A:1196 115.0 0.605 -61.9 118.5 115.0 0.605 0.0
GLU B:576 B:1196 102.0 0.537 -70.7 119.8 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 GLU A:576 A:1196 108.0 0.568 -49.0 124.1 108.0 0.568 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 GLU A:1196 A:1196 129.0 0.679 -68.3 123.3