Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12291316 . G A CCDS8647.1:NM_002336.2:c.3550Cga>Tga_NP_002327.2:p.1184R>* Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
pdb_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 ARG A:557 A:1184 215.0 0.956 58.1 61.5 159.0 0.707 0.249 C:O94907:0.249
ARG B:557 B:1184 227.0 1.0 52.5 51.9 136.0 0.604 0.396 C:O94907:0.404
 HOH
 6.854
 C
 O
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 ARG A:557 A:1184 226.0 1.0 63.1 29.3 155.0 0.689 0.311 C:O94907:0.316
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 ARG A:559 A:1184 211.0 0.938 59.0 40.9 211.0 0.938 0.0 HOH
 2.697
 N
 O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 ARG B:554 B:1184 228.0 1.0 52.4 51.9 137.0 0.609 0.391 C:O94907:0.404
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:555 A:1184 198.0 0.88 59.8 71.7 198.0 0.88 0.0
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:555 A:1184 218.0 0.969 59.8 43.7 218.0 0.969 0.0 CL
HOH
 5.334
6.383
 N
C
 CL
O
ARG D:555 B:1184 207.0 0.92 60.3 43.4 207.0 0.92 0.0 HOH
 9.065
 O
 O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:564 A:1184 218.0 0.969 S 53.7 51.4 186.0 0.827 0.142 C:O94907:0.142
ARG B:564 B:1184 220.0 0.978 S 64.1 46.9 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:564 A:1184 219.0 0.973 68.3 8.4 219.0 0.973 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 ARG A:1184 A:1184 216.0 0.96 66.0 24.4