Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12291339 . T A CCDS8647.1:NM_002336.2:c.3527gAg>gTg_NP_002327.2:p.1176E>V Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 GLU A:549 A:1176 134.0 0.705 S -110.2 -14.0 134.0 0.705 0.0
GLU B:549 B:1176 126.0 0.663 S -98.7 168.8 126.0 0.663 0.0 HOH
 2.958
 OE2
 O
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 GLU A:549 A:1176 118.0 0.621 S -105.3 154.2 118.0 0.621 0.0
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 GLU A:551 A:1176 125.0 0.658 S -102.2 156.5 125.0 0.658 0.0 HOH
 2.682
 O
 O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 GLU B:546 B:1176 125.0 0.658 S -98.6 168.9 125.0 0.658 0.0
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 GLU A:547 A:1176 142.0 0.747 S -81.6 -31.2 142.0 0.747 0.0
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 GLU A:547 A:1176 130.0 0.684 S -101.1 165.7 130.0 0.684 0.0 HOH
 2.866
 O
 O
GLU D:547 B:1176 111.0 0.584 S -105.1 168.8 111.0 0.584 0.0 HOH
 8.065
 OE2
 O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 GLU A:556 A:1176 184.0 0.968 360.0 -26.5 184.0 0.968 0.0
GLU B:556 B:1176 104.0 0.547 S -91.1 160.4 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 GLU A:556 A:1176 150.0 0.789 -98.1 -5.2 150.0 0.789 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 GLU A:1176 A:1176 118.0 0.621 S -109.7 150.3