Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12291343 . G A CCDS8647.1:NM_002336.2:c.3523Cga>Tga_NP_002327.2:p.1175R>* Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
pdb_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 ARG A:548 A:1175 210.0 0.933 S -116.1 -28.8 210.0 0.933 0.0
ARG B:548 B:1175 223.0 0.991 S -66.2 -50.4 223.0 0.991 0.0 HOH
 4.363
 CB
 O
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 ARG A:548 A:1175 199.0 0.884 S -78.6 -56.8 199.0 0.884 0.0
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 ARG A:550 A:1175 195.0 0.867 S -86.6 -44.9 195.0 0.867 0.0 HOH
 3.366
 NH2
 O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 ARG B:545 B:1175 221.0 0.982 S -66.1 -50.5 221.0 0.982 0.0
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:546 A:1175 207.0 0.92 S -106.0 -66.1 207.0 0.92 0.0
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:546 A:1175 196.0 0.871 S -79.8 -50.3 196.0 0.871 0.0 HOH
 6.315
 C
 O
ARG D:546 B:1175 159.0 0.707 S -68.1 -46.5 159.0 0.707 0.0 HOH
 3.426
 NH2
 O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:555 NA:NA DO NA DO DO DO NA NA NA
ARG B:555 B:1175 196.0 0.871 S -111.3 -58.8 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:555 A:1175 202.0 0.898 -46.3 132.6 202.0 0.898 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 ARG A:1175 A:1175 214.0 0.951 S -86.6 -40.2