Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12300317 . T A CCDS8647.1:NM_002336.2:c.3380gAa>gTa_NP_002327.2:p.1127E>V Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 GLU A:500 A:1127 5.0 0.026 E -118.2 166.0 5.0 0.026 0.0
GLU B:500 B:1127 4.0 0.021 E -115.4 162.0 4.0 0.021 0.0 HOH
 3.240
 OE2
 O
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 GLU A:500 A:1127 5.0 0.026 E -110.6 169.3 5.0 0.026 0.0
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 GLU A:502 A:1127 5.0 0.026 E -125.1 166.8 5.0 0.026 0.0 CL
HOH
 8.585
2.632
 OE2
OE1
 CL
O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 GLU B:497 B:1127 3.0 0.016 E -115.4 162.0 3.0 0.016 0.0
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 GLU A:498 A:1127 2.0 0.011 E -131.4 159.6 2.0 0.011 0.0
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 GLU A:498 A:1127 4.0 0.021 E -122.2 170.4 4.0 0.021 0.0 CL
HOH
 6.150
2.734
 OE1
OE2
 CL
O
GLU D:498 B:1127 3.0 0.016 E -117.3 169.6 3.0 0.016 0.0 HOH
 8.321
 OE1
 O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 GLU A:507 A:1127 8.0 0.042 E -115.9 155.2 8.0 0.042 0.0
GLU B:507 B:1127 3.0 0.016 E -115.6 149.5 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 GLU A:507 A:1127 0.0 0.0 E -118.6 164.1 0.0 0.0 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 GLU A:1127 A:1127 3.0 0.016 E -124.2 161.8