Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12300324 . G A CCDS8647.1:NM_002336.2:c.3373Cga>Tga_NP_002327.2:p.1125R>* Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 ARG A:498 A:1125 49.0 0.218 E -167.1 153.2 49.0 0.218 0.0
ARG B:498 B:1125 58.0 0.258 E -161.9 153.6 58.0 0.258 0.0 HOH
 2.588
 NH1
 O
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 ARG A:498 A:1125 56.0 0.249 E -161.6 163.9 56.0 0.249 0.0
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 ARG A:500 A:1125 54.0 0.24 E -156.2 165.2 54.0 0.24 0.0 CL
HOH
 8.925
2.830
 NH2
NH1
 CL
O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 ARG B:495 B:1125 57.0 0.253 E -161.9 153.7 57.0 0.253 0.0
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:496 A:1125 39.0 0.173 E -158.4 171.7 39.0 0.173 0.0
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:496 A:1125 54.0 0.24 E -157.4 164.4 54.0 0.24 0.0 CL
HOH
 6.535
2.790
 NH1
NE
 CL
O
ARG D:496 B:1125 55.0 0.244 E -160.7 163.3 55.0 0.244 0.0 HOH
 7.968
 CB
 O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:505 A:1125 45.0 0.2 E -162.4 164.3 45.0 0.2 0.0
ARG B:505 B:1125 50.0 0.222 E -140.5 165.8 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:505 A:1125 55.0 0.244 E -152.8 149.0 55.0 0.244 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 ARG A:1125 A:1125 55.0 0.244 E -149.0 157.4