Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12303796 . G A CCDS8647.1:NM_002336.2:c.2968Cga>Tga_NP_002327.2:p.990R>* Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 ARG A:363 A:990 36.0 0.16 E -121.6 173.0 36.0 0.16 0.0
ARG B:363 B:990 40.0 0.178 E -101.6 168.0 40.0 0.178 0.0
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 ARG A:363 A:990 30.0 0.133 E -97.2 162.7 30.0 0.133 0.0
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 ARG A:365 A:990 51.0 0.227 E -128.4 159.6 51.0 0.227 0.0 HOH
 3.310
 NH1
 O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 ARG B:360 B:990 39.0 0.173 E -101.6 168.0 39.0 0.173 0.0
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:361 A:990 54.0 0.24 E -127.0 148.7 54.0 0.24 0.0
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:361 A:990 66.0 0.293 E -112.2 168.3 26.0 0.116 0.177 C:None:0.178
 HOH
 3.275
 NH1
 O
ARG D:361 B:990 26.0 0.116 E -111.6 164.5 26.0 0.116 0.0 HOH
 8.305
 NH1
 O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:370 A:990 50.0 0.222 E -125.6 159.1 50.0 0.222 0.0
ARG B:370 B:990 56.0 0.249 E -132.5 156.0 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:370 A:990 60.0 0.267 E -121.5 154.6 60.0 0.267 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 ARG A:990 A:990 34.0 0.151 E -125.8 160.2