Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12315224 . G A CCDS8647.1:NM_002336.2:c.2182Cga>Tga_NP_002327.2:p.728R>* Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 ARG A:101 A:728 43.0 0.191 E -144.8 142.8 43.0 0.191 0.0 HOH
 8.804
 CA
 O
ARG B:101 B:728 37.0 0.164 E -144.1 140.0 37.0 0.164 0.0 HOH
 9.680
 CA
 O
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 ARG A:101 A:728 31.0 0.138 E -142.6 138.1 31.0 0.138 0.0
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 ARG A:103 A:728 43.0 0.191 E -137.1 142.6 43.0 0.191 0.0 EDO
HOH
 7.971
2.735
 CA
NE
 O2
O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 ARG B:98 B:728 39.0 0.173 E -144.2 139.9 39.0 0.173 0.0
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:99 A:728 53.0 0.236 E -156.3 146.9 53.0 0.236 0.0
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:99 A:728 43.0 0.191 E -144.9 143.3 43.0 0.191 0.0 CL
HOH
 9.370
2.352
 NH2
NH1
 CL
O
ARG D:99 B:728 42.0 0.187 E -141.6 144.3 42.0 0.187 0.0 CL
HOH
 3.681
4.086
 NH1
CZ
 CL
O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:108 A:728 36.0 0.16 E -143.0 136.1 36.0 0.16 0.0
ARG B:108 B:728 36.0 0.16 E -130.5 142.1 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:108 A:728 50.0 0.222 E -143.4 145.9 50.0 0.222 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 ARG A:728 A:728 41.0 0.182 E -128.0 140.8