Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 12317329 . G A CCDS8647.1:NM_002336.2:c.1930Cga>Tga_NP_002327.2:p.644R>* Homo sapiens LDL receptor related protein 6 (LRP6), mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3s2k 1 O75581 99.84 0.0 X-RAY
 2011-11-02 ARG A:17 A:644 74.0 0.329 E -133.9 132.9 74.0 0.329 0.0 FUC
 8.731
 NH1
 O3
ARG B:17 B:644 101.0 0.449 E -125.7 140.0 101.0 0.449 0.0 FUC
HOH
 9.905
4.913
 NH1
NH2
 O3
O
5fww 1 O75581 99.84 0.0 X-RAY
 2016-07-20 ARG A:17 A:644 103.0 0.458 E -115.6 142.6 103.0 0.458 0.0
4a0p 1 O75581 100.0 0.0 X-RAY
 2011-10-26 ARG A:19 A:644 75.0 0.333 E -122.0 128.5 75.0 0.333 0.0 HOH
 3.006
 NE
 O
5gje 2 O75581 99.84 0.0 EM
 2017-01-18 ARG B:14 B:644 100.0 0.444 E -125.7 140.1 100.0 0.444 0.0 FUC
 9.907
 NH1
 O3
6h16 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:15 A:644 46.0 0.204 E -120.9 132.5 46.0 0.204 0.0 NAG
 9.338
 NH2
 C8
6h15 1 O75581 100.0 0.0 X-RAY
 2019-01-30 ARG A:15 A:644 70.0 0.311 E -117.8 131.5 70.0 0.311 0.0 HOH
 8.595
 N
 O
ARG D:15 B:644 53.0 0.236 E -127.1 134.7 53.0 0.236 0.0 HOH
 7.891
 N
 O
3s8v 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:24 A:644 68.0 0.302 E -131.7 127.6 68.0 0.302 0.0
ARG B:24 B:644 51.0 0.227 E -117.6 134.8 NA NA NA
3s8z 1 O75581 99.84 0.0 X-RAY
 2011-10-26 ARG A:24 A:644 69.0 0.307 E -105.5 134.9 69.0 0.307 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o75581-f1 1 O75581 100.0 0.0 ARG A:644 A:644 48.0 0.213 E -117.8 145.3