Variant
Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr12 | 13828685 | . | C | A | CCDS8662.1:NM_000834.3:c.1119tgG>tgT_NP_000825.2:p.373W>C | Homo sapiens glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B), mRNA. |
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PDB
Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
7eu8 | 2 | Q13224 | 100.0 | 0.0 |
EM |
2021-07-28 | TRP | B:373 | B:373 | 92.0 | 0.361 | E | -129.1 | 141.2 | 92.0 | 0.361 | 0.0 | ||||||
TRP | D:373 | D:373 | 121.0 | 0.475 | -68.6 | 145.1 | 121.0 | 0.475 | 0.0 | ||||||||||||||
6wi1 | 2 | ? | 99.28 | 0.0 |
EM |
2020-07-15 | TRP | B:404 | B:373 | 24.0 | 0.094 | E | -76.6 | 98.7 | 24.0 | 0.094 | 0.0 | ||||||
TRP | D:404 | D:373 | 22.0 | 0.086 | E | -76.6 | 98.7 | 22.0 | 0.086 | 0.0 | |||||||||||||
5fxg | 2 | Q00960 | 98.91 | 0.0 |
EM |
2016-05-11 | TRP | B:348 | B:373 | 47.0 | NA | E | -66.2 | 160.3 | 47.0 | NA | NA | ||||||
TRP | D:348 | D:373 | 52.0 | NA | E | -66.2 | 160.4 | 52.0 | NA | NA | |||||||||||||
5fxh | 2 | Q00960 | 98.91 | 0.0 |
EM |
2016-05-11 | TRP | B:348 | B:373 | 73.0 | NA | E | -59.6 | 123.8 | 73.0 | NA | NA | ||||||
TRP | D:348 | D:373 | 71.0 | NA | E | -59.7 | 123.9 | 71.0 | NA | NA | |||||||||||||
5fxi | 2 | Q00960 | 98.91 | 0.0 |
EM |
2016-05-11 | TRP | B:348 | B:373 | 51.0 | NA | E | -61.1 | 123.9 | 51.0 | NA | NA | ||||||
TRP | D:348 | D:373 | 51.0 | NA | E | -61.1 | 123.8 | 51.0 | NA | NA | |||||||||||||
5fxj | 2 | Q00960 | 98.91 | 0.0 |
EM |
2016-05-25 | TRP | B:348 | B:373 | 69.0 | NA | -89.4 | 110.8 | 69.0 | NA | NA | |||||||
TRP | D:348 | D:373 | 71.0 | NA | -89.4 | 110.8 | 71.0 | NA | NA | ||||||||||||||
5fxk | 2 | Q00960 | 98.91 | 0.0 |
EM |
2016-05-11 | TRP | B:348 | B:373 | 52.0 | NA | E | -79.8 | 117.4 | 52.0 | NA | NA | ||||||
TRP | D:348 | D:373 | 53.0 | NA | E | -79.8 | 117.5 | 53.0 | NA | NA | |||||||||||||
6whr | 2 | Q00960 | 98.91 | 0.0 |
EM |
2020-08-05 | TRP | B:404 | B:373 | 55.0 | 0.216 | E | -93.9 | 114.8 | 55.0 | 0.216 | 0.0 | ||||||
TRP | D:404 | D:373 | 53.0 | 0.208 | E | -93.8 | 114.8 | 53.0 | 0.208 | 0.0 | |||||||||||||
6whs | 2 | Q00960 | 98.91 | 0.0 |
EM |
2020-08-05 | TRP | B:404 | B:373 | 47.0 | 0.184 | E | -104.9 | 94.5 | 47.0 | 0.184 | 0.0 | ||||||
TRP | D:404 | D:373 | 47.0 | 0.184 | E | -104.9 | 94.4 | 47.0 | 0.184 | 0.0 | |||||||||||||
6wht | 2 | Q00960 | 98.91 | 0.0 |
EM |
2020-08-05 | TRP | B:404 | B:373 | 55.0 | 0.216 | -165.9 | -176.1 | 55.0 | 0.216 | 0.0 | |||||||
TRP | D:404 | D:373 | 59.0 | 0.231 | -166.0 | -176.1 | 59.0 | 0.231 | 0.0 | ||||||||||||||
6whu | 2 | Q00960 | 98.91 | 0.0 |
EM |
2020-08-05 | TRP | B:404 | B:373 | 23.0 | 0.09 | E | -107.6 | 126.1 | 23.0 | 0.09 | 0.0 | ||||||
TRP | D:404 | D:373 | 23.0 | 0.09 | E | -107.6 | 126.1 | 23.0 | 0.09 | 0.0 | |||||||||||||
6whv | 2 | Q00960 | 98.91 | 0.0 |
EM |
2020-08-05 | TRP | B:404 | B:373 | 22.0 | 0.086 | -162.7 | 135.7 | 22.0 | 0.086 | 0.0 | |||||||
TRP | D:404 | D:373 | 35.0 | 0.137 | B | -95.7 | 142.8 | 35.0 | 0.137 | 0.0 | |||||||||||||
6whw | 2 | ? | 98.91 | 0.0 |
EM |
2020-07-15 | TRP | B:404 | B:373 | 40.0 | 0.157 | E | -86.8 | 123.2 | 40.0 | 0.157 | 0.0 | ||||||
TRP | D:404 | D:373 | 40.0 | 0.157 | E | -86.8 | 123.3 | 40.0 | 0.157 | 0.0 | |||||||||||||
6whx | 2 | ? | 98.91 | 0.0 |
EM |
2020-07-15 | TRP | B:404 | B:373 | 44.0 | 0.173 | E | -67.2 | 127.8 | 44.0 | 0.173 | 0.0 | ||||||
TRP | D:404 | D:373 | 47.0 | 0.184 | B | -129.2 | 115.7 | 47.0 | 0.184 | 0.0 | |||||||||||||
6why | 2 | ? | 98.91 | 0.0 |
EM |
2020-07-15 | TRP | B:404 | B:373 | 29.0 | 0.114 | E | -109.5 | 152.1 | 29.0 | 0.114 | 0.0 | ||||||
TRP | D:404 | D:373 | 30.0 | 0.118 | E | -109.5 | 152.1 | 30.0 | 0.118 | 0.0 | |||||||||||||
6wi0 | 2 | Q00960 | 98.91 | 0.0 |
EM |
2020-07-15 | TRP | B:404 | B:373 | 41.0 | 0.161 | E | -108.7 | 150.6 | 41.0 | 0.161 | 0.0 | ||||||
TRP | D:404 | D:373 | 42.0 | 0.165 | E | -108.7 | 150.6 | 42.0 | 0.165 | 0.0 | |||||||||||||
4pe5 | 2 | Q00960 | 97.82 | 0.0 |
X-RAY |
2014-06-04 | TRP | B:347 | B:373 | 33.0 | 0.129 | E | -87.6 | 125.7 | 33.0 | 0.129 | 0.0 | ||||||
TRP | D:347 | D:373 | 34.0 | 0.133 | E | -82.7 | 127.1 | 34.0 | 0.133 | 0.0 | |||||||||||||
6cna | 2 | Q00960 | 99.14 | 0.0 |
EM |
2018-10-03 | TRP | B:340 | B:373 | 54.0 | 0.212 | E | -68.2 | 160.1 | 54.0 | 0.212 | 0.0 | ||||||
TRP | D:340 | D:373 | 56.0 | 0.22 | E | -68.2 | 160.1 | 56.0 | 0.22 | 0.0 | |||||||||||||
5uow | 3 | A7XY94 | 86.86 | 0.0 |
EM |
2017-03-22 | TRP | D:368 | D:368 | 40.0 | 0.157 | E | -94.6 | 108.0 | 40.0 | 0.157 | 0.0 | ||||||
5up2 | 3 | A7XY94 | 86.86 | 0.0 |
EM |
2017-03-22 | TRP | D:368 | D:368 | 42.0 | 0.165 | E | -94.6 | 108.0 | 42.0 | 0.165 | 0.0 | ||||||
5iou | 2 | A7XY94 | 85.78 | 0.0 |
EM |
2016-04-20 | TRP | C:368 | B:368 | 57.0 | NA | E | -73.9 | 113.5 | 57.0 | NA | NA | ||||||
TRP | D:368 | D:368 | 62.0 | NA | E | -72.0 | 111.3 | 62.0 | NA | NA | |||||||||||||
5iov | 2 | A7XY94 | 85.78 | 0.0 |
EM |
2016-04-20 | TRP | C:368 | B:368 | 70.0 | NA | E | -74.0 | 103.0 | 70.0 | NA | NA | ||||||
TRP | D:368 | D:368 | 63.0 | NA | E | -72.0 | 109.4 | 63.0 | NA | NA | |||||||||||||
5ipq | 2 | A7XY94 | 85.78 | 0.0 |
EM |
2016-04-20 | TRP | B:368 | B:368 | 77.0 | NA | E | -101.7 | 109.1 | 77.0 | NA | NA | ||||||
TRP | D:368 | D:368 | 77.0 | NA | E | -102.2 | 110.1 | 77.0 | NA | NA | |||||||||||||
5ipr | 2 | A7XY94 | 85.78 | 0.0 |
EM |
2016-04-20 | TRP | B:368 | B:368 | 77.0 | NA | E | -101.8 | 109.1 | 77.0 | NA | NA | ||||||
TRP | D:368 | D:368 | 76.0 | NA | E | -102.3 | 110.1 | 76.0 | NA | NA | |||||||||||||
5ips | 2 | A7XY94 | 85.78 | 0.0 |
EM |
2016-04-20 | TRP | B:368 | B:368 | 77.0 | NA | E | -101.8 | 109.1 | 77.0 | NA | NA | ||||||
TRP | D:368 | D:368 | 77.0 | NA | E | -102.3 | 110.1 | 77.0 | NA | NA | |||||||||||||
5ipt | 2 | A7XY94 | 85.78 | 0.0 |
EM |
2016-04-20 | TRP | B:368 | B:368 | 77.0 | NA | E | -101.8 | 109.1 | 77.0 | NA | NA | ||||||
TRP | D:368 | D:368 | 77.0 | NA | E | -102.3 | 110.2 | 77.0 | NA | NA | |||||||||||||
5ipu | 2 | A7XY94 | 85.78 | 0.0 |
EM |
2016-04-20 | TRP | B:368 | B:368 | 76.0 | NA | E | -101.8 | 109.1 | 76.0 | NA | NA | ||||||
TRP | D:368 | D:368 | 77.0 | NA | E | -102.3 | 110.1 | 77.0 | NA | NA | |||||||||||||
5ipv | 2 | A7XY94 | 85.78 | 0.0 |
EM |
2016-04-20 | TRP | B:368 | B:368 | 78.0 | NA | E | -102.3 | 110.3 | 78.0 | NA | NA | ||||||
TRP | D:368 | D:368 | 79.0 | NA | E | -102.2 | 110.3 | 79.0 | NA | NA | |||||||||||||
4tll | 2 | A7XY94 | 87.47 | 0.0 |
X-RAY |
2014-07-02 | TRP | B:349 | B:368 | 33.0 | 0.129 | E | -79.4 | 119.3 | 33.0 | 0.129 | 0.0 | ||||||
TRP | D:349 | D:368 | 31.0 | 0.122 | E | -79.0 | 119.7 | 31.0 | 0.122 | 0.0 | |||||||||||||
4tlm | 2 | A7XY94 | 87.47 | 0.0 |
X-RAY |
2014-07-02 | TRP | B:349 | B:368 | 43.0 | 0.169 | E | -101.8 | 109.0 | 43.0 | 0.169 | 0.0 | ||||||
TRP | D:349 | D:368 | 47.0 | 0.184 | E | -102.3 | 110.1 | 47.0 | 0.184 | 0.0 | |||||||||||||
5ewj | 2 | Q13224 | 99.73 | 0.0 |
X-RAY |
2016-03-02 | TRP | B:343 | B:373 | 26.0 | 0.102 | E | -79.2 | 122.2 | 26.0 | 0.102 | 0.0 |
HOH |
2.694 |
NE1 |
O |
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TRP | D:343 | D:373 | 26.0 | 0.102 | E | -77.9 | 120.3 | NA | NA | NA | |||||||||||||
5ewl | 2 | Q13224 | 99.73 | 0.0 |
X-RAY |
2016-03-02 | TRP | B:343 | B:373 | 28.0 | 0.11 | E | -81.6 | 127.8 | 28.0 | 0.11 | 0.0 |
HOH |
3.085 |
N |
O |
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TRP | D:343 | D:373 | 28.0 | 0.11 | E | -79.7 | 126.8 | NA | NA | NA | |||||||||||||
5ewm | 2 | Q13224 | 99.73 | 0.0 |
X-RAY |
2016-03-02 | TRP | B:343 | B:373 | 29.0 | 0.114 | E | -74.0 | 132.6 | 29.0 | 0.114 | 0.0 |
HOH |
2.775 |
NE1 |
O |
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TRP | D:343 | D:373 | 28.0 | 0.11 | E | -73.9 | 132.5 | NA | NA | NA | |||||||||||||
3qel | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2011-06-15 | TRP | B:343 | B:373 | 35.0 | 0.137 | E | -82.9 | 127.6 | 35.0 | 0.137 | 0.0 |
HOH |
2.642 |
NE1 |
O |
||
TRP | D:343 | D:373 | 32.0 | 0.125 | E | -80.0 | 127.6 | 32.0 | 0.125 | 0.0 |
HOH |
2.498 |
NE1 |
O |
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3qem | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2011-06-15 | TRP | B:343 | B:373 | 35.0 | 0.137 | E | -93.1 | 114.8 | 35.0 | 0.137 | 0.0 | ||||||
TRP | D:343 | D:373 | 34.0 | 0.133 | E | -85.4 | 128.3 | NA | NA | NA | |||||||||||||
5b3j | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2016-05-11 | TRP | C:343 | C:373 | 55.0 | 0.216 | -77.0 | 124.2 | 55.0 | 0.216 | 0.0 | |||||||
TRP | E:343 | D:373 | 55.0 | 0.216 | E | -78.1 | 128.4 | NA | NA | NA | |||||||||||||
3jpw | 1 | Q00960 | 99.45 | 0.0 |
X-RAY |
2009-12-08 | TRP | A:342 | A:373 | 22.0 | 0.086 | E | -75.3 | 135.7 | 22.0 | 0.086 | 0.0 |
CL CL HOH |
4.267 9.057 2.959 |
O N NE1 |
CL CL O |
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3jpy | 1 | Q00960 | 99.45 | 0.0 |
X-RAY |
2009-12-08 | TRP | A:342 | A:373 | 36.0 | 0.141 | E | -104.4 | 125.8 | 36.0 | 0.141 | 0.0 |
HOH |
8.441 |
CZ3 |
O |
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6e7r | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2019-01-30 | TRP | B:342 | B:373 | 20.0 | 0.078 | E | -74.2 | 134.1 | 20.0 | 0.078 | 0.0 |
HOH |
2.823 |
N |
O |
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TRP | D:342 | D:373 | 21.0 | 0.082 | E | -78.3 | 124.9 | NA | NA | NA | |||||||||||||
6e7s | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2019-01-30 | TRP | B:342 | B:373 | 21.0 | 0.082 | E | -76.1 | 132.2 | 21.0 | 0.082 | 0.0 |
HOH |
2.719 |
NE1 |
O |
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TRP | D:342 | D:373 | 21.0 | 0.082 | E | -78.9 | 125.3 | NA | NA | NA | |||||||||||||
6e7t | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2019-01-30 | TRP | B:342 | B:373 | 21.0 | 0.082 | E | -77.9 | 132.9 | 21.0 | 0.082 | 0.0 |
HOH |
2.782 |
N |
O |
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TRP | D:342 | D:373 | 22.0 | 0.086 | E | -77.4 | 130.2 | NA | NA | NA | |||||||||||||
6e7u | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2019-01-30 | TRP | B:342 | B:373 | 25.0 | 0.098 | E | -77.0 | 130.6 | 25.0 | 0.098 | 0.0 |
HOH |
2.826 |
N |
O |
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TRP | D:342 | D:373 | 35.0 | 0.137 | E | -79.6 | 129.0 | NA | NA | NA | |||||||||||||
6e7v | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2019-01-30 | TRP | B:342 | B:373 | 21.0 | 0.082 | E | -75.2 | 135.6 | 21.0 | 0.082 | 0.0 |
HOH |
2.826 |
NE1 |
O |
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TRP | D:342 | D:373 | 20.0 | 0.078 | E | -70.8 | 126.4 | NA | NA | NA | |||||||||||||
6e7w | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2019-01-30 | TRP | B:342 | B:373 | 23.0 | 0.09 | E | -76.9 | 127.0 | 23.0 | 0.09 | 0.0 |
HOH |
2.626 |
N |
O |
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TRP | D:342 | D:373 | 32.0 | 0.125 | E | -75.0 | 123.6 | NA | NA | NA | |||||||||||||
6e7x | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2019-01-30 | TRP | B:342 | B:373 | 22.0 | 0.086 | E | -78.0 | 132.9 | 22.0 | 0.086 | 0.0 |
HOH |
2.991 |
NE1 |
O |
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TRP | D:342 | D:373 | 21.0 | 0.082 | E | -73.4 | 126.3 | NA | NA | NA | |||||||||||||
5tpz | 2 | Q00960 | 99.45 | 0.0 |
X-RAY |
2016-12-14 | TRP | B:342 | D:373 | 38.0 | 0.149 | E | -92.8 | 122.7 | 38.0 | 0.149 | 0.0 |
AlphaFold DB
Entity | Residue | Monomer | View | ||||||||||
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ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
af-q13224-f1 | 1 | Q13224 | 100.0 | 0.0 | TRP | A:373 | A:373 | 23.0 | 0.09 | E | -73.2 | 117.9 |