Variant
Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr12 | 50453643 | . | G | A | CCDS8796.1:NM_020039.3:c.464cGt>cAt_NP_064423.2:p.155R>H | Homo sapiens acid sensing ion channel subunit 1 (ASIC1), transcript variant 1, mRNA. |
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PDB
Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
7rnn | 2 | P78348 | 91.46 | 0.0 |
EM |
2021-08-11 | ARG | B:155 | D:155 | 82.0 | 0.364 | H | -59.1 | -43.5 | 82.0 | 0.364 | 0.0 | ||||||
6ave | 1 | Q1XA76 | 82.06 | 0.0 |
EM |
2018-03-21 | LEU | A:156 | A:156 | 57.0 | 0.335 | H | -76.5 | -30.6 | 57.0 | 0.335 | 0.0 | ||||||
LEU | B:156 | B:156 | 58.0 | 0.341 | H | -76.6 | -30.7 | 58.0 | 0.341 | 0.0 | |||||||||||||
LEU | C:156 | C:156 | 58.0 | 0.341 | H | -76.6 | -30.7 | 58.0 | 0.341 | 0.0 | |||||||||||||
6vtk | 1 | Q1XA76 | 82.06 | 0.0 |
EM |
2020-03-11 | LEU | A:156 | A:156 | 46.0 | 0.271 | H | -68.9 | -32.6 | 46.0 | 0.271 | 0.0 | ||||||
LEU | B:156 | C:156 | 47.0 | 0.276 | H | -68.9 | -32.7 | 47.0 | 0.276 | 0.0 | |||||||||||||
LEU | C:156 | B:156 | 46.0 | 0.271 | H | -68.9 | -32.7 | 46.0 | 0.271 | 0.0 | |||||||||||||
6vtl | 1 | Q1XA76 | 82.06 | 0.0 |
EM |
2020-03-11 | LEU | A:156 | A:156 | 46.0 | 0.271 | H | -71.6 | -36.6 | 46.0 | 0.271 | 0.0 | ||||||
LEU | B:156 | C:156 | 47.0 | 0.276 | H | -71.6 | -36.6 | 47.0 | 0.276 | 0.0 | |||||||||||||
LEU | C:156 | B:156 | 47.0 | 0.276 | H | -71.5 | -36.7 | 47.0 | 0.276 | 0.0 | |||||||||||||
7cfs | 1 | P78348 | 91.05 | 0.0 |
EM |
2020-10-21 | ARG | A:164 | A:155 | 103.0 | 0.458 | H | -70.3 | -33.8 | 103.0 | 0.458 | 0.0 | ||||||
ARG | B:164 | B:155 | 101.0 | 0.449 | H | -70.3 | -33.8 | 101.0 | 0.449 | 0.0 | |||||||||||||
ARG | C:164 | C:155 | 101.0 | 0.449 | H | -70.3 | -33.9 | 101.0 | 0.449 | 0.0 | |||||||||||||
7cft | 1 | P78348 | 91.05 | 0.0 |
EM |
2020-10-21 | ARG | A:164 | A:155 | 83.0 | 0.369 | H | -64.3 | -33.6 | 83.0 | 0.369 | 0.0 | ||||||
ARG | B:164 | B:155 | 85.0 | 0.378 | H | -64.2 | -33.7 | 85.0 | 0.378 | 0.0 | |||||||||||||
ARG | C:164 | C:155 | 84.0 | 0.373 | H | -64.3 | -33.6 | 84.0 | 0.373 | 0.0 | |||||||||||||
6l6i | 1 | P78348 | 90.0 | 0.0 |
X-RAY |
2020-11-04 | ARG | A:145 | A:155 | 80.0 | 0.356 | H | -54.7 | -49.3 | 80.0 | 0.356 | 0.0 | ||||||
ARG | B:145 | B:155 | 80.0 | 0.356 | H | -54.0 | -50.5 | 80.0 | 0.356 | 0.0 | |||||||||||||
ARG | C:145 | C:155 | 81.0 | 0.36 | H | -54.1 | -50.9 | 81.0 | 0.36 | 0.0 | |||||||||||||
6l6n | 1 | P78348 | 90.0 | 0.0 |
X-RAY |
2021-01-13 | ARG | A:145 | A:155 | 80.0 | 0.356 | H | -59.2 | -47.8 | 80.0 | 0.356 | 0.0 | ||||||
ARG | B:145 | B:155 | 78.0 | 0.347 | H | -60.6 | -46.5 | 78.0 | 0.347 | 0.0 | |||||||||||||
ARG | C:145 | C:155 | 82.0 | 0.364 | H | -59.9 | -46.3 | 82.0 | 0.364 | 0.0 |
HOH |
7.125 |
NH2 |
O |
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4nyk | 1 | Q1XA76 | 81.29 | 0.0 |
X-RAY |
2014-02-12 | LEU | A:160 | A:156 | 44.0 | 0.259 | H | -62.9 | -44.2 | 44.0 | 0.259 | 0.0 |
HOH |
3.538 |
CG |
O |
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3ij4 | 1 | Q1XA76 | 81.29 | 0.0 |
X-RAY |
2009-11-10 | LEU | A:155 | A:156 | 45.0 | 0.265 | H | -61.5 | -43.4 | 45.0 | 0.265 | 0.0 |
HOH |
3.344 |
CD2 |
O |
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4fz0 | 1 | Q1XA76 | 81.89 | 0.0 |
X-RAY |
2012-08-01 | LEU | A:143 | A:156 | 42.0 | 0.247 | H | -55.3 | -49.4 | 42.0 | 0.247 | 0.0 |
HOH |
9.851 |
O |
O |
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LEU | B:143 | B:156 | 44.0 | 0.259 | H | -56.8 | -49.7 | 44.0 | 0.259 | 0.0 |
HOH |
6.033 |
CB |
O |
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LEU | C:143 | C:156 | 50.0 | 0.294 | H | -54.6 | -49.8 | 50.0 | 0.294 | 0.0 |
GOL HOH |
5.287 3.761 |
N CD2 |
O2 O |
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4fz1 | 1 | Q1XA76 | 81.89 | 0.0 |
X-RAY |
2012-08-01 | LEU | A:143 | A:156 | 41.0 | 0.241 | H | -66.8 | -50.7 | 41.0 | 0.241 | 0.0 | ||||||
4ntw | 1 | Q1XA76 | 81.89 | 0.0 |
X-RAY |
2014-02-19 | LEU | A:143 | A:156 | 40.0 | 0.235 | H | -67.2 | -42.0 | 40.0 | 0.235 | 0.0 |
HOH |
3.745 |
CD2 |
O |
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4ntx | 1 | Q1XA76 | 81.89 | 0.0 |
X-RAY |
2014-02-19 | LEU | A:143 | A:156 | 40.0 | 0.235 | H | -66.4 | -45.3 | 40.0 | 0.235 | 0.0 |
HOH |
5.067 |
N |
O |
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4nty | 1 | Q1XA76 | 81.89 | 0.0 |
X-RAY |
2014-02-19 | LEU | A:143 | A:156 | 39.0 | 0.229 | H | -67.3 | -38.3 | 39.0 | 0.229 | 0.0 |
CS HOH |
3.917 4.005 |
CD2 CG |
CS O |
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6cmc | 1 | Q1XA76 | 81.89 | 0.0 |
X-RAY |
2018-08-08 | LEU | A:143 | A:156 | 44.0 | 0.259 | H | -62.5 | -43.7 | 44.0 | 0.259 | 0.0 | ||||||
5wku | 1 | Q1XA76 | 81.52 | 0.0 |
X-RAY |
2018-03-14 | LEU | A:132 | A:156 | 33.0 | 0.194 | H | -73.7 | -35.6 | 33.0 | 0.194 | 0.0 | ||||||
LEU | B:132 | C:156 | 23.0 | 0.135 | H | -74.1 | -32.3 | 23.0 | 0.135 | 0.0 | |||||||||||||
LEU | C:132 | B:156 | 27.0 | 0.159 | H | -72.1 | -35.8 | 27.0 | 0.159 | 0.0 | |||||||||||||
5wkv | 1 | Q1XA76 | 81.52 | 0.0 |
X-RAY |
2018-03-14 | LEU | A:132 | A:156 | 32.0 | 0.188 | H | -73.1 | -35.2 | 32.0 | 0.188 | 0.0 | ||||||
LEU | B:132 | C:156 | 23.0 | 0.135 | H | -74.0 | -32.1 | 23.0 | 0.135 | 0.0 | |||||||||||||
LEU | C:132 | B:156 | 24.0 | 0.141 | H | -71.8 | -35.1 | 24.0 | 0.141 | 0.0 | |||||||||||||
5wkx | 1 | Q1XA76 | 81.52 | 0.0 |
X-RAY |
2018-08-08 | LEU | A:132 | A:156 | 33.0 | 0.194 | H | -73.8 | -35.6 | 33.0 | 0.194 | 0.0 | ||||||
LEU | B:132 | C:156 | 23.0 | 0.135 | H | -74.1 | -32.4 | 23.0 | 0.135 | 0.0 | |||||||||||||
LEU | C:132 | B:156 | 27.0 | 0.159 | H | -72.2 | -35.8 | 27.0 | 0.159 | 0.0 | |||||||||||||
5wky | 1 | Q1XA76 | 81.52 | 0.0 |
X-RAY |
2018-08-08 | LEU | A:132 | A:156 | 33.0 | 0.194 | H | -73.8 | -35.6 | 33.0 | 0.194 | 0.0 | ||||||
LEU | B:132 | C:156 | 23.0 | 0.135 | H | -74.1 | -32.4 | 23.0 | 0.135 | 0.0 | |||||||||||||
LEU | C:132 | B:156 | 26.0 | 0.153 | H | -72.1 | -35.8 | 26.0 | 0.153 | 0.0 | |||||||||||||
2qts | 1 | Q1XA76 | 81.48 | 0.0 |
X-RAY |
2007-09-25 | LEU | A:131 | A:156 | 38.0 | 0.224 | H | -61.8 | -47.4 | 38.0 | 0.224 | 0.0 |
HOH |
3.780 |
CD2 |
O |
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LEU | B:131 | B:156 | 44.0 | 0.259 | H | -63.4 | -47.4 | 44.0 | 0.259 | 0.0 |
HOH |
3.817 |
CB |
O |
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LEU | C:131 | C:156 | 41.0 | 0.241 | H | -66.6 | -47.8 | 41.0 | 0.241 | 0.0 |
HOH |
3.890 |
CD2 |
O |
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LEU | D:131 | D:156 | 41.0 | 0.241 | H | -64.4 | -45.7 | NA | NA | NA | |||||||||||||
LEU | E:131 | E:156 | 42.0 | 0.247 | H | -63.0 | -45.3 | NA | NA | NA | |||||||||||||
LEU | F:131 | F:156 | 47.0 | 0.276 | H | -62.5 | -52.2 | NA | NA | NA | |||||||||||||
6x9h | 1 | Q1XA76 | 81.48 | 0.0 |
X-RAY |
2020-12-30 | LEU | A:131 | A:156 | 41.0 | 0.241 | H | -64.5 | -42.1 | 41.0 | 0.241 | 0.0 |
UZG |
5.061 |
N |
C01 |
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LEU | B:131 | B:156 | 49.0 | 0.288 | H | -65.0 | -42.8 | 49.0 | 0.288 | 0.0 |
UZG |
5.465 |
N |
C01 |
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LEU | C:131 | C:156 | 47.0 | 0.276 | H | -63.0 | -39.7 | 47.0 | 0.276 | 0.0 |
UZG |
5.394 |
N |
C01 |
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3s3w | 1 | Q1XA76 | 81.48 | 0.0 |
X-RAY |
2012-05-23 | LEU | A:152 | A:156 | 37.0 | 0.218 | H | -65.1 | -48.2 | 37.0 | 0.218 | 0.0 |
HOH |
4.936 |
N |
O |
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LEU | B:152 | B:156 | 39.0 | 0.229 | H | -64.9 | -48.1 | 39.0 | 0.229 | 0.0 |
HOH |
4.872 |
N |
O |
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LEU | C:152 | C:156 | 36.0 | 0.212 | H | -64.8 | -47.8 | 36.0 | 0.212 | 0.0 |
HOH |
5.017 |
CD2 |
O |
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3s3x | 1 | Q1XA76 | 81.48 | 0.0 |
X-RAY |
2012-05-23 | LEU | A:152 | A:156 | 46.0 | 0.271 | H | -52.6 | -39.1 | 46.0 | 0.271 | 0.0 | ||||||
LEU | B:152 | B:156 | 47.0 | 0.276 | H | -52.7 | -39.1 | 47.0 | 0.276 | 0.0 | |||||||||||||
LEU | C:152 | C:156 | 53.0 | 0.312 | H | -53.1 | -38.7 | 53.0 | 0.312 | 0.0 |
HOH |
6.805 |
N |
O |
AlphaFold DB
Entity | Residue | Monomer | View | ||||||||||
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ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
af-p78348-f1 | 1 | P78348 | 91.99 | 0.0 | ARG | A:155 | A:155 | 91.0 | 0.404 | H | -62.3 | -42.9 |