Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 50474306 . T A CCDS8796.1:NM_020039.3:c.1231Ttc>Atc_NP_064423.2:p.411F>I Homo sapiens acid sensing ion channel subunit 1 (ASIC1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7rnn 2 P78348 91.46 0.0 EM
 2021-08-11 PHE B:411 D:411 17.0 0.081 E -154.9 164.3 17.0 0.081 0.0
6ave 1 Q1XA76 82.06 0.0 EM
 2018-03-21 PHE A:410 A:410 23.0 0.11 E -157.0 155.5 7.0 0.033 0.077 B:Q1XA76:0.076
PHE B:410 B:410 22.0 0.105 E -156.9 155.5 6.0 0.029 0.076 C:Q1XA76:0.076
PHE C:410 C:410 22.0 0.105 E -157.0 155.5 6.0 0.029 0.076 A:Q1XA76:0.076
6vtk 1 Q1XA76 82.06 0.0 EM
 2020-03-11 PHE A:410 A:410 26.0 0.124 E -149.2 174.8 8.0 0.038 0.086 C:Q1XA76:0.086
PHE B:410 C:410 25.0 0.119 E -149.2 174.8 7.0 0.033 0.086 A:Q1XA76:0.086
PHE C:410 B:410 24.0 0.114 E -149.3 174.8 6.0 0.029 0.085 B:Q1XA76:0.086
6vtl 1 Q1XA76 82.06 0.0 EM
 2020-03-11 PHE A:410 A:410 12.0 0.057 E -148.2 -168.8 1.0 0.005 0.052 C:Q1XA76:0.052
PHE B:410 C:410 12.0 0.057 E -148.2 -168.7 2.0 0.01 0.047 A:Q1XA76:0.048
PHE C:410 B:410 12.0 0.057 E -148.2 -168.8 2.0 0.01 0.047 B:Q1XA76:0.048
7cfs 1 P78348 91.05 0.0 EM
 2020-10-21 PHE A:420 A:411 18.0 0.086 E -151.5 176.9 13.0 0.062 0.024 C:P78348:0.024
PHE B:420 B:411 18.0 0.086 E -151.5 176.9 13.0 0.062 0.024 A:P78348:0.024
PHE C:420 C:411 17.0 0.081 E -151.5 176.9 13.0 0.062 0.019 B:P78348:0.019
7cft 1 P78348 91.05 0.0 EM
 2020-10-21 PHE A:420 A:411 24.0 0.114 E -155.7 150.3 16.0 0.076 0.038 B:P78348:0.038
PHE B:420 B:411 25.0 0.119 E -155.8 150.4 16.0 0.076 0.043 C:P78348:0.043
PHE C:420 C:411 23.0 0.11 E -155.8 150.4 15.0 0.071 0.039 A:P78348:0.038
6l6i 1 P78348 90.0 0.0 X-RAY
 2020-11-04 PHE A:401 A:411 20.0 0.095 E -164.0 169.7 6.0 0.029 0.066 B:P78348:0.067
 HOH
 9.163
 CE1
 O
PHE B:401 B:411 19.0 0.09 E -163.4 167.9 6.0 0.029 0.061 C:P78348:0.062
 HOH
 8.420
 CE2
 O
PHE C:401 C:411 18.0 0.086 E -163.8 168.7 7.0 0.033 0.053 A:P78348:0.052
 HOH
 9.373
 CE2
 O
6l6n 1 P78348 90.0 0.0 X-RAY
 2021-01-13 PHE A:401 A:411 16.0 0.076 E -161.5 163.4 1.0 0.005 0.071 B:P78348:0.071
PHE B:401 B:411 20.0 0.095 E -163.5 164.3 3.0 0.014 0.081 C:P78348:0.081
 CL
HOH
 8.024
3.635
 CB
CB
 CL
O
PHE C:401 C:411 18.0 0.086 E -162.2 163.2 2.0 0.01 0.076 A:P78348:0.076
 HOH
 7.724
 CB
 O
4nyk 1 Q1XA76 81.29 0.0 X-RAY
 2014-02-12 PHE A:414 A:410 24.0 0.114 E -157.6 -178.0 4.0 0.019 0.095 A:Q1XA76:0.095
 HOH
 3.543
 CB
 O
3ij4 1 Q1XA76 81.29 0.0 X-RAY
 2009-11-10 PHE A:409 A:410 22.0 0.105 E -156.9 172.1 2.0 0.01 0.095 A:Q1XA76:0.095
 HOH
 3.593
 CB
 O
4fz0 1 Q1XA76 81.89 0.0 X-RAY
 2012-08-01 PHE A:397 A:410 24.0 0.114 E -152.8 175.1 2.0 0.01 0.104 C:Q1XA76:0.105
 HOH
 5.121
 CZ
 O
PHE B:397 B:410 24.0 0.114 E -149.4 175.8 3.0 0.014 0.1 A:Q1XA76:0.1
 HOH
 5.344
 CZ
 O
PHE C:397 C:410 24.0 0.114 E -149.3 176.3 1.0 0.005 0.109 B:Q1XA76:0.11
 HOH
 3.909
 CZ
 O
4fz1 1 Q1XA76 81.89 0.0 X-RAY
 2012-08-01 PHE A:397 A:410 23.0 0.11 E -156.2 174.9 4.0 0.019 0.091 A:Q1XA76:0.09
4ntw 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 PHE A:397 A:410 24.0 0.114 E -153.8 172.8 24.0 0.114 0.0 HOH
 3.595
 CB
 O
4ntx 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 PHE A:397 A:410 25.0 0.119 E -158.8 167.3 25.0 0.119 0.0 HOH
 3.613
 CB
 O
4nty 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 PHE A:397 A:410 26.0 0.124 E -155.1 166.7 6.0 0.029 0.095 A:Q1XA76:0.095
 HOH
 3.726
 CZ
 O
6cmc 1 Q1XA76 81.89 0.0 X-RAY
 2018-08-08 PHE A:397 A:410 25.0 0.119 E -157.4 -177.5 2.0 0.01 0.109 A:Q1XA76:0.11
5wku 1 Q1XA76 81.52 0.0 X-RAY
 2018-03-14 PHE A:386 A:410 15.0 0.071 E -159.0 168.5 3.0 0.014 0.057 C:Q1XA76:0.057
PHE B:386 C:410 15.0 0.071 E -159.4 167.4 4.0 0.019 0.052 A:Q1XA76:0.052
PHE C:386 B:410 14.0 0.067 E -159.5 167.8 3.0 0.014 0.053 B:Q1XA76:0.052
5wkv 1 Q1XA76 81.52 0.0 X-RAY
 2018-03-14 PHE A:386 A:410 17.0 0.081 E -158.9 168.6 3.0 0.014 0.067 C:Q1XA76:0.067
 CA
 8.586
 CE1
 CA
PHE B:386 C:410 14.0 0.067 E -159.1 167.9 3.0 0.014 0.053 A:Q1XA76:0.052
 CA
 8.587
 CE1
 CA
PHE C:386 B:410 13.0 0.062 E -159.6 167.5 1.0 0.005 0.057 B:Q1XA76:0.057
 CA
 8.735
 CE1
 CA
5wkx 1 Q1XA76 81.52 0.0 X-RAY
 2018-08-08 PHE A:386 A:410 15.0 0.071 E -159.0 168.5 4.0 0.019 0.052 C:Q1XA76:0.052
PHE B:386 C:410 15.0 0.071 E -159.4 167.4 4.0 0.019 0.052 A:Q1XA76:0.052
PHE C:386 B:410 14.0 0.067 E -159.4 167.8 3.0 0.014 0.053 B:Q1XA76:0.052
5wky 1 Q1XA76 81.52 0.0 X-RAY
 2018-08-08 PHE A:386 A:410 15.0 0.071 E -159.0 168.5 4.0 0.019 0.052 C:Q1XA76:0.052
PHE B:386 C:410 16.0 0.076 E -159.4 167.4 5.0 0.024 0.052 A:Q1XA76:0.052
PHE C:386 B:410 14.0 0.067 E -159.5 167.8 3.0 0.014 0.053 B:Q1XA76:0.052
2qts 1 Q1XA76 81.48 0.0 X-RAY
 2007-09-25 PHE A:385 A:410 22.0 0.105 E -150.0 179.1 4.0 0.019 0.086 B:Q1XA76:0.086
 HOH
 3.516
 CB
 O
PHE B:385 B:410 23.0 0.11 E -150.6 -179.2 2.0 0.01 0.1 C:Q1XA76:0.1
 HOH
 3.435
 CB
 O
PHE C:385 C:410 24.0 0.114 E -148.0 179.9 4.0 0.019 0.095 A:Q1XA76:0.095
 HOH
 3.381
 CB
 O
PHE D:385 D:410 23.0 0.11 E -153.5 -180.0 NA NA NA
PHE E:385 E:410 20.0 0.095 E -152.2 179.4 NA NA NA
PHE F:385 F:410 21.0 0.1 E -152.4 -179.3 NA NA NA
6x9h 1 Q1XA76 81.48 0.0 X-RAY
 2020-12-30 PHE A:385 A:410 11.0 0.052 E -161.3 173.1 6.0 0.029 0.023 C:Q1XA76:0.024
PHE B:385 B:410 16.0 0.076 E -159.0 175.7 8.0 0.038 0.038 A:Q1XA76:0.038
PHE C:385 C:410 16.0 0.076 E -161.7 170.6 5.0 0.024 0.052 B:Q1XA76:0.052
3s3w 1 Q1XA76 81.48 0.0 X-RAY
 2012-05-23 PHE A:406 A:410 24.0 0.114 E -149.9 178.3 4.0 0.019 0.095 B:Q1XA76:0.095
 HOH
 3.631
 CB
 O
PHE B:406 B:410 23.0 0.11 E -150.2 178.5 3.0 0.014 0.096 C:Q1XA76:0.095
 HOH
 3.356
 CB
 O
PHE C:406 C:410 23.0 0.11 E -150.1 178.7 4.0 0.019 0.091 A:Q1XA76:0.09
 HOH
 3.742
 CD1
 O
3s3x 1 Q1XA76 81.48 0.0 X-RAY
 2012-05-23 PHE A:406 A:410 25.0 0.119 E -156.7 178.3 4.0 0.019 0.1 B:Q1XA76:0.1
PHE B:406 B:410 24.0 0.114 E -156.4 178.5 4.0 0.019 0.095 C:Q1XA76:0.095
PHE C:406 C:410 25.0 0.119 E -156.3 178.0 4.0 0.019 0.1 A:Q1XA76:0.1

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p78348-f1 1 P78348 91.99 0.0 PHE A:411 A:411 24.0 0.114 E -146.7 163.8