Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128379 . T A CCDS8539.1:NM_000552.3:c.4205cAg>cTg_NP_000543.2:p.1402Q>L Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 GLN A:177 A:1402 62.0 0.344 H -70.9 -35.8 62.0 0.344 0.0 HOH
 2.702
 OE1
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 GLN A:144 A:639 72.0 0.4 H -68.6 -39.8 72.0 0.4 0.0 OMG
A2M
OMC
OMC
OMU
A2M
A2M
OMG
HOH
 8.473
5.194
3.054
4.079
8.034
3.730
7.188
7.677
2.724
 NE2
NE2
NE2
OE1
OE1
C
O
O
OE1
 O3'
O3'
OP2
OP2
OP2
N6
N6
O6
O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 GLN C:143 C:639 82.0 0.456 H -67.8 -44.0 52.0 0.289 0.167 A:2134244:0.167
 HOH
 3.144
 NE2
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 GLN A:143 A:639 34.0 0.189 H -64.8 -32.7 34.0 0.189 0.0 HOH
 3.888
 CG
 O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 GLN A:143 A:639 91.0 0.506 H -71.0 -36.4 91.0 0.506 0.0 DT
HOH
 9.937
3.136
 NE2
CG
 C7
O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 GLN A:166 A:166 77.0 0.428 H -67.4 -37.8 77.0 0.428 0.0 HOH
 2.940
 OE1
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 GLN A:142 A:639 74.0 0.411 H -71.9 -31.7 74.0 0.411 0.0 HOH
 3.547
 CB
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 GLN A:142 A:639 90.0 0.5 H -78.7 -41.5 14.0 0.078 0.422 B:P22029:0.422
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 GLN A:142 A:639 73.0 0.406 H -70.6 -54.3 73.0 0.406 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 GLN A:141 AAA:1402 61.0 0.339 H -73.7 -32.3 61.0 0.339 0.0 HOH
 3.145
 HB3
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 GLN A:140 A:639 64.0 0.356 H -69.1 -34.2 64.0 0.356 0.0 HOH
 2.598
 OE1
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 GLN A:140 A:639 73.0 0.406 H -71.8 -41.7 5.0 0.028 0.378 B:P22029:0.378
 HOH
 2.649
 NE2
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 GLN A:144 A:639 48.0 0.267 H -65.1 -42.5 48.0 0.267 0.0 HOH
 3.908
 CB
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 GLN A:140 A:1402 55.0 0.306 H -65.5 -38.1 55.0 0.306 0.0 HOH
 3.233
 CG
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 GLN C:133 A:639 78.0 0.433 H -72.6 -34.6 71.0 0.394 0.039 A:1890296:0.039
 HOH
 4.392
 OE1
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 GLN C:133 A:639 56.0 0.311 H -66.7 -38.4 56.0 0.311 0.0 HOH
 3.379
 CB
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 GLN A:140 A:1402 101.0 0.561 H -68.9 -36.0 101.0 0.561 0.0 HOH
 6.970
 N
 O
GLN B:140 B:1402 100.0 0.556 H -66.2 -36.5 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 GLN A:140 A:1402 60.0 0.333 H -71.0 -24.4 60.0 0.333 0.0
GLN C:140 C:1402 84.0 0.467 H -68.9 -27.7 NA NA NA
GLN E:140 E:1402 82.0 0.456 H -69.6 -39.0 NA NA NA
GLN G:140 G:1402 53.0 0.294 H -68.4 -30.7 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 GLN C:142 C:639 68.0 0.378 H -73.9 -36.3 9.0 0.05 0.328 A:P22029:0.328
 HOH
 6.253
 OE1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f2 1 P04275 99.93 0.0 GLN A:1202 A:1202 94.0 0.522 H -65.0 -36.4
af-p04275-f3 1 P04275 99.93 0.0 GLN A:1002 A:1002 90.0 0.5 H -64.9 -35.7
af-p04275-f6 1 P04275 100.0 0.0 GLN A:402 A:402 95.0 0.528 H -66.1 -36.0
af-p04275-f5 1 P04275 99.93 0.0 GLN A:602 A:602 93.0 0.517 H -65.0 -35.6
af-p04275-f8 1 P04275 100.0 0.0 GLN A:2 A:2 161.0 0.894 H -50.4 -37.2
af-p04275-f7 1 P04275 100.0 0.0 GLN A:202 A:202 89.0 0.494 H -65.4 -32.4
af-p04275-f4 1 P04275 99.93 0.0 GLN A:802 A:802 91.0 0.506 H -65.2 -36.9