Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128562 . C A CCDS8539.1:NM_000552.3:c.4022cGg>cTg_NP_000543.2:p.1341R>L Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 ARG A:116 A:1341 44.0 0.196 H -66.8 -37.2 44.0 0.196 0.0 HOH
 2.705
 NH1
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 ARG A:83 A:578 75.0 0.333 H -68.3 -33.0 75.0 0.333 0.0 HOH
 5.047
 NH2
 O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 ARG C:82 C:578 32.0 0.142 H -58.4 -32.0 32.0 0.142 0.0
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:82 A:578 72.0 0.32 H -64.3 -38.5 72.0 0.32 0.0 HOH
 3.009
 NE
 O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:82 A:578 76.0 0.338 H -73.4 -31.6 76.0 0.338 0.0 HOH
 3.882
 CB
 O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 ARG A:105 A:105 45.0 0.2 H -65.8 -36.5 45.0 0.2 0.0 HOH
 2.860
 NH1
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 ARG A:81 A:578 44.0 0.196 H -60.8 -36.9 44.0 0.196 0.0 HOH
 2.750
 NH1
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 ARG A:81 A:578 58.0 0.258 H -70.6 -21.8 58.0 0.258 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 ARG A:81 A:578 85.0 0.378 H -27.1 -44.0 85.0 0.378 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 ARG A:80 AAA:1341 38.0 0.169 H -65.4 -41.4 38.0 0.169 0.0 HOH
 2.098
 HH11
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:79 A:578 41.0 0.182 H -65.1 -37.9 41.0 0.182 0.0 HOH
 2.581
 NH2
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:79 A:578 48.0 0.213 H -66.8 -34.2 48.0 0.213 0.0 HOH
 2.642
 NH2
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 ARG A:83 A:578 76.0 0.338 H -58.6 -36.4 76.0 0.338 0.0 HOH
 3.020
 NH2
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 ARG A:79 A:1341 84.0 0.373 H -65.0 -41.0 84.0 0.373 0.0 CA
HOH
 8.873
3.001
 CD
NE
 CA
O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 ARG C:72 A:578 64.0 0.284 H -65.0 -35.2 64.0 0.284 0.0 HOH
 3.113
 NH1
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 ARG C:72 A:578 79.0 0.351 H -65.4 -37.8 79.0 0.351 0.0 HOH
 2.902
 NE
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:79 A:1341 77.0 0.342 H -68.1 -34.2 77.0 0.342 0.0 HOH
 2.589
 NH1
 O
ARG B:79 B:1341 74.0 0.329 H -68.2 -33.5 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:79 A:1341 61.0 0.271 H -84.7 -31.4 61.0 0.271 0.0 MES
 3.203
 NH2
 O1S
ARG C:79 C:1341 57.0 0.253 H -84.2 -24.6 NA NA NA
ARG E:79 E:1341 60.0 0.267 H -80.0 -26.7 NA NA NA
ARG G:79 G:1341 54.0 0.24 H -80.4 -17.9 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 ARG C:81 C:578 64.0 0.284 H -68.5 -25.5 64.0 0.284 0.0 HOH
 3.844
 NH1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f1 1 P04275 99.93 0.0 ARG A:1341 A:1341 28.0 0.124 H -60.3 -41.2
af-p04275-f2 1 P04275 99.93 0.0 ARG A:1141 A:1141 51.0 0.227 H -60.7 -38.8
af-p04275-f3 1 P04275 99.93 0.0 ARG A:941 A:941 50.0 0.222 H -60.4 -41.6
af-p04275-f6 1 P04275 100.0 0.0 ARG A:341 A:341 42.0 0.187 H -61.7 -40.6
af-p04275-f5 1 P04275 99.93 0.0 ARG A:541 A:541 49.0 0.218 H -61.3 -40.0
af-p04275-f7 1 P04275 100.0 0.0 ARG A:141 A:141 29.0 0.129 H -61.0 -41.2
af-p04275-f4 1 P04275 99.93 0.0 ARG A:741 A:741 58.0 0.258 H -61.1 -40.2