Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 79842728 . T A CCDS9017.1:NM_001135805.1:c.1093Tat>Aat_NP_001129277.1:p.365Y>N Homo sapiens synaptotagmin 1 (SYT1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5w5c 6 P21707 100.0 0.0 X-RAY
 2017-08-23 TYR F:225 F:364 113.0 0.491 G -65.2 -28.1 113.0 0.491 0.0 HOH
 2.654
 OH
 O
5ccg 5 P21707 100.0 0.0 X-RAY
 2015-08-12 TYR E:224 E:364 96.0 0.417 -83.2 121.9 96.0 0.417 0.0 CA
CA
 2.491
5.740
 O
O
 CA
CA
TYR F:224 F:364 105.0 0.457 -82.7 124.5 105.0 0.457 0.0 CA
 2.505
 O
 CA
TYR K:224 K:364 81.0 0.352 -82.9 120.0 NA NA NA
5cch 5 P21707 100.0 0.0 X-RAY
 2015-08-12 TYR E:224 E:364 70.0 0.304 -71.7 156.6 70.0 0.304 0.0 CA
CA
 2.888
5.045
 O
O
 CA
CA
TYR F:224 F:364 113.0 0.491 -69.5 128.6 113.0 0.491 0.0 CA
CA
 2.446
3.180
 O
O
 CA
CA
5cci 5 P21707 100.0 0.0 X-RAY
 2015-08-12 TYR E:224 E:364 69.0 0.3 -113.9 110.2 69.0 0.3 0.0 MG
 3.227
 O
 MG
TYR F:224 F:364 98.0 0.426 -113.2 111.6 98.0 0.426 0.0 MG
 5.013
 O
 MG
6mti 2 P21707 100.0 0.0 EM
 2019-04-24 TYR B:224 2:645 70.0 0.304 -113.9 110.3 70.0 0.304 0.0 MG
 3.228
 O
 MG
TYR C:224 3:645 70.0 0.304 -113.9 110.2 70.0 0.304 0.0 MG
 3.228
 O
 MG
TYR D:224 4:645 69.0 0.3 -113.9 110.2 69.0 0.3 0.0 MG
 3.226
 O
 MG
TYR E:224 5:645 71.0 0.309 -114.0 110.3 71.0 0.309 0.0 MG
 3.228
 O
 MG
2r83 1 P21579 99.65 0.0 X-RAY
 2008-02-12 TYR A:227 A:364 58.0 0.252 -77.1 132.2 58.0 0.252 0.0 HOH
 2.476
 O
 O
TYR B:227 B:364 58.0 0.252 -77.2 132.2 58.0 0.252 0.0 HOH
 2.464
 O
 O
5kj7 5 P21707 100.0 0.0 X-RAY
 2016-10-19 TYR E:224 E:364 92.0 0.4 -84.9 126.6 92.0 0.4 0.0 CA
CA
 2.605
5.741
 O
O
 CA
CA
TYR F:224 F:364 107.0 0.465 -85.1 132.0 NA NA NA
TYR K:224 K:364 80.0 0.348 -83.6 124.1 NA NA NA
5kj8 5 P21707 100.0 0.0 X-RAY
 2016-10-19 TYR E:224 E:364 92.0 0.4 -79.7 124.2 92.0 0.4 0.0 CA
CA
 2.458
5.206
 O
O
 CA
CA
TYR F:224 F:364 106.0 0.461 -79.2 124.3 NA NA NA
TYR K:224 K:364 76.0 0.33 -81.4 122.2 NA NA NA
2lha 1 P21579 100.0 4e-96 NMR
 2012-05-02 TYR A:95 A:364 82.0 0.357 -110.9 73.6 82.0 0.357 0.0 IHP
 1.823
 HH
 H5
5w5d 6 P21707 100.0 4e-96 X-RAY
 2017-08-23 TYR F:95 F:364 96.0 0.417 G -61.6 -22.9 96.0 0.417 0.0 HOH
 2.217
 OH
 O
5t0s 1 P46096 100.0 2e-95 X-RAY
 2017-06-14 TYR A:94 A:364 82.0 0.357 -75.3 129.3 82.0 0.357 0.0 CD
HOH
 2.560
3.158
 O
CD1
 CD
O
2yoa 1 P21707 100.0 3e-95 X-RAY
 2013-03-20 TYR A:95 A:364 80.0 0.348 -68.7 133.8 80.0 0.348 0.0 CA
CA
CA
SEP
CA
SCN
HOH
 2.340
5.103
6.607
3.454
3.624
3.993
2.590
 O
O
C
O
CD2
CD1
OH
 CA
CA
CA
O
CA
S
O
TYR B:95 B:364 84.0 0.365 -68.9 135.0 NA NA NA
6tz3 1 P21579 100.0 3e-95 X-RAY
 2020-05-13 TYR A:100 A:365 71.0 0.309 -76.9 134.0 71.0 0.309 0.0 SO4
HOH
 5.765
1.912
 HD1
HH
 O4
O
1tjm 1 P21707 100.0 4e-95 X-RAY
 2004-09-28 TYR A:102 A:364 74.0 0.322 -76.2 140.1 74.0 0.322 0.0 SR
HOH
 2.493
1.856
 O
OH
 SR
H2
1tjx 1 P21707 100.0 4e-95 X-RAY
 2004-11-23 TYR A:102 A:364 65.0 0.283 -71.1 133.4 65.0 0.283 0.0 CA
CA
HOH
 5.117
2.406
2.125
 O
O
HE2
 CA
CA
H2
1uov 1 P21707 100.0 4e-95 X-RAY
 2004-09-09 TYR A:102 A:364 65.0 0.283 -70.2 128.9 65.0 0.283 0.0 CA
CA
CA
HOH
 5.132
2.355
5.816
3.129
 O
O
O
OH
 CA
CA
CA
O
1uow 1 P21707 100.0 4e-95 X-RAY
 2004-09-16 TYR A:102 A:364 67.0 0.291 -70.7 133.6 67.0 0.291 0.0 CA
CA
HOH
 5.120
2.415
3.441
 O
O
OH
 CA
CA
O
4v11 1 P21579 100.0 2e-94 X-RAY
 2015-02-25 TYR A:93 A:365 74.0 0.322 -63.1 130.8 74.0 0.322 0.0 CA
CA
HOH
 2.316
5.035
2.673
 O
O
OH
 CA
CA
O
6u4w 1 P21579 99.34 2e-94 X-RAY
 2020-05-13 TYR A:100 A:365 81.0 0.352 -74.2 134.9 81.0 0.352 0.0 SO4
HOH
 6.269
2.748
 HD1
O
 O1
O
6u4u 1 P21579 99.34 2e-94 X-RAY
 2020-05-13 TYR A:100 A:365 73.0 0.317 -79.2 135.7 73.0 0.317 0.0 SO4
HOH
 5.882
2.665
 HD1
HE1
 O4
O
6u41 1 P21579 99.34 3e-94 X-RAY
 2020-05-13 TYR A:100 A:365 76.0 0.33 -85.3 130.7 76.0 0.33 0.0 SO4
HOH
 5.319
2.706
 HD1
HD2
 O4
O
5vff 1 P46096 99.34 5e-94 X-RAY
 2018-04-11 TYR A:94 A:364 60.0 0.261 -68.9 125.2 60.0 0.261 0.0 PB
HOH
 2.778
2.969
 O
O
 PB
O
5vfg 1 P46096 99.34 5e-94 X-RAY
 2018-04-11 TYR A:94 A:364 71.0 0.309 -80.1 131.0 71.0 0.309 0.0 PB
HOH
 2.644
2.988
 O
OH
 PB
O
2n1t 5 P21579 100.0 3e-93 NMR
 2015-06-03 TYR E:102 E:364 118.0 0.513 -107.1 105.4 27.0 0.117 0.396 B:P32851:0.396
A:P63045:0.039
5ccj 1 P21707 96.69 7e-91 X-RAY
 2015-08-12 TYR A:95 A:364 51.0 0.222 -84.8 129.1 51.0 0.222 0.0 GOL
SO4
HOH
 4.109
6.767
2.606
 CD1
CD1
O
 C1
O3
O
TYR B:95 B:364 84.0 0.365 -77.0 131.8 NA NA NA
TYR C:95 C:364 56.0 0.243 -79.5 126.8 NA NA NA
TYR D:95 D:364 70.0 0.304 -85.2 133.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p21579-f1 1 P21579 100.0 0.0 TYR A:365 A:365 84.0 0.365 -99.3 98.5