Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 79842738 . T A CCDS9017.1:NM_001135805.1:c.1103aTt>aAt_NP_001129277.1:p.368I>N Homo sapiens synaptotagmin 1 (SYT1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5w5c 6 P21707 100.0 0.0 X-RAY
 2017-08-23 ILE F:228 F:367 96.0 0.549 T -56.9 140.6 96.0 0.549 0.0 HOH
 3.475
 CA
 O
5ccg 5 P21707 100.0 0.0 X-RAY
 2015-08-12 ILE E:227 E:367 165.0 0.943 S -124.1 129.1 165.0 0.943 0.0 CA
CA
 7.229
7.647
 N
O
 CA
CA
ILE F:227 F:367 68.0 NA S -123.3 128.4 68.0 NA NA CA
 6.983
 N
 CA
ILE K:227 K:367 164.0 0.937 S -124.4 129.8 NA NA NA
5cch 5 P21707 100.0 0.0 X-RAY
 2015-08-12 ILE E:227 E:367 151.0 0.863 S -107.8 132.1 151.0 0.863 0.0 CA
CA
 8.079
7.775
 O
O
 CA
CA
ILE F:227 NA:NA DO NA DO DO DO NA NA NA
5cci 5 P21707 100.0 0.0 X-RAY
 2015-08-12 ILE E:227 E:367 66.0 NA S -88.8 123.1 66.0 NA NA MG
 8.659
 N
 MG
ILE F:227 NA:NA DO NA DO DO DO NA NA NA
6mti 2 P21707 100.0 0.0 EM
 2019-04-24 ILE B:227 2:648 66.0 NA S -88.6 123.1 66.0 NA NA MG
 8.659
 N
 MG
ILE C:227 3:648 67.0 NA S -88.8 123.2 67.0 NA NA MG
 8.658
 N
 MG
ILE D:227 4:648 67.0 NA S -88.8 123.1 67.0 NA NA MG
 8.659
 N
 MG
ILE E:227 5:648 67.0 NA S -88.7 123.1 67.0 NA NA MG
 8.659
 N
 MG
2r83 1 P21579 99.65 0.0 X-RAY
 2008-02-12 ILE A:230 A:367 155.0 0.886 S -95.9 84.1 155.0 0.886 0.0 HOH
 5.588
 N
 O
ILE B:230 B:367 156.0 0.891 S -96.2 83.7 156.0 0.891 0.0 HOH
 7.216
 N
 O
5kj7 5 P21707 100.0 0.0 X-RAY
 2016-10-19 ILE E:227 E:367 163.0 0.931 S -126.6 132.6 163.0 0.931 0.0 CA
CA
 7.338
7.551
 N
O
 CA
CA
ILE F:227 F:367 69.0 NA S -116.1 131.4 NA NA NA
ILE K:227 K:367 164.0 0.937 S -128.4 134.3 NA NA NA
5kj8 5 P21707 100.0 0.0 X-RAY
 2016-10-19 ILE E:227 E:367 166.0 0.949 S -122.3 128.6 166.0 0.949 0.0 CA
CA
 8.104
7.940
 N
O
 CA
CA
ILE F:227 F:367 68.0 NA S -122.3 129.3 NA NA NA
ILE K:227 K:367 166.0 0.949 S -122.8 130.7 NA NA NA
2lha 1 P21579 100.0 4e-96 NMR
 2012-05-02 ILE A:98 A:367 130.0 0.743 G 64.0 35.3 130.0 0.743 0.0 IHP
 2.857
 HG21
 O22
5w5d 6 P21707 100.0 4e-96 X-RAY
 2017-08-23 ILE F:98 F:367 96.0 0.549 T -59.1 138.9 96.0 0.549 0.0 HOH
 3.417
 CB
 O
5t0s 1 P46096 100.0 2e-95 X-RAY
 2017-06-14 ILE A:97 A:367 151.0 0.863 T -56.3 133.5 151.0 0.863 0.0 CD
HOH
 9.848
3.805
 N
CA
 CD
O
2yoa 1 P21707 100.0 3e-95 X-RAY
 2013-03-20 ILE A:98 A:367 155.0 0.886 S -124.0 131.8 155.0 0.886 0.0 CA
CA
CA
SEP
CA
HOH
 7.643
6.952
4.614
4.682
8.304
2.608
 O
O
O
N
N
O
 CA
CA
CA
OXT
CA
O
ILE B:98 B:367 156.0 0.891 S -123.5 129.6 NA NA NA
6tz3 1 P21579 100.0 3e-95 X-RAY
 2020-05-13 ILE A:103 A:368 136.0 0.777 S -128.0 131.0 136.0 0.777 0.0 SO4
HOH
 9.199
2.402
 C
H
 O4
O
1tjm 1 P21707 100.0 4e-95 X-RAY
 2004-09-28 ILE A:105 A:367 126.0 0.72 S -127.5 139.1 126.0 0.72 0.0 SR
HOH
 7.891
2.159
 H
O
 SR
H2
1tjx 1 P21707 100.0 4e-95 X-RAY
 2004-11-23 ILE A:105 A:367 152.0 0.869 S -127.6 132.3 152.0 0.869 0.0 CA
CA
HOH
 7.193
7.511
1.785
 O
H
H
 CA
CA
H2
1uov 1 P21707 100.0 4e-95 X-RAY
 2004-09-09 ILE A:105 A:367 148.0 0.846 S -121.7 130.1 148.0 0.846 0.0 CA
CA
HOH
 7.045
7.730
2.402
 O
O
O
 CA
CA
O
1uow 1 P21707 100.0 4e-95 X-RAY
 2004-09-16 ILE A:105 A:367 152.0 0.869 S -128.0 132.0 152.0 0.869 0.0 CA
CA
HOH
 7.198
7.915
2.657
 O
O
O
 CA
CA
O
4v11 1 P21579 100.0 2e-94 X-RAY
 2015-02-25 ILE A:96 A:368 146.0 0.834 S -117.3 120.2 146.0 0.834 0.0 CA
CA
HOH
 7.198
6.109
2.890
 O
O
O
 CA
CA
O
6u4w 1 P21579 99.34 2e-94 X-RAY
 2020-05-13 ILE A:103 A:368 135.0 0.771 S -128.7 130.7 135.0 0.771 0.0 SO4
HOH
 9.616
2.416
 C
H
 O1
O
6u4u 1 P21579 99.34 2e-94 X-RAY
 2020-05-13 THR A:103 A:368 120.0 0.857 S -130.8 130.1 120.0 0.857 0.0 SO4
HOH
 9.540
2.295
 C
H
 O4
O
6u41 1 P21579 99.34 3e-94 X-RAY
 2020-05-13 ILE A:103 A:368 148.0 0.846 S -105.9 138.1 148.0 0.846 0.0 SO4
HOH
 8.929
2.562
 C
O
 O4
O
5vff 1 P46096 99.34 5e-94 X-RAY
 2018-04-11 ILE A:97 A:367 147.0 0.84 S -111.2 98.1 147.0 0.84 0.0 PB
HOH
 7.900
3.332
 N
C
 PB
O
5vfg 1 P46096 99.34 5e-94 X-RAY
 2018-04-11 ILE A:97 A:367 147.0 0.84 S -114.2 115.7 147.0 0.84 0.0 PB
HOH
 7.782
2.884
 O
N
 PB
O
2n1t 5 P21579 100.0 3e-93 NMR
 2015-06-03 ILE E:105 E:367 143.0 0.817 S -62.6 -36.4 133.0 0.76 0.057 B:P32851:0.057
5ccj 1 P21707 96.69 7e-91 X-RAY
 2015-08-12 ILE A:98 A:367 163.0 0.931 T -101.9 7.2 163.0 0.931 0.0 HOH
 3.153
 N
 O
ILE B:98 B:367 148.0 0.846 S -122.2 140.2 NA NA NA
ILE C:98 C:367 139.0 0.794 S -91.3 103.5 NA NA NA
ILE D:98 D:367 144.0 0.823 S -97.2 129.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p21579-f1 1 P21579 100.0 0.0 ILE A:368 A:368 160.0 0.914 S -130.5 123.9