Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr12 | 109994870 | . | A | C | CCDS9131.1:NM_052845.3:c.716aTg>aGg_NP_443077.1:p.239M>R | Homo sapiens methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2idx | 1 | Q96EY8 | 99.49 | 4e-145 |
X-RAY |
2007-02-06 | MET | A:185 | A:239 | 170.0 | 0.919 | -149.8 | 128.4 | 146.0 | 0.789 | 0.13 |
C:Q96EY8:0.13 |
HOH |
8.723 |
N |
O |
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| MET | B:185 | B:239 | 172.0 | 0.93 | -130.1 | 135.5 | 131.0 | 0.708 | 0.222 |
A:Q96EY8:0.222 |
HOH |
5.065 |
N |
O |
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| MET | C:185 | C:239 | 156.0 | 0.843 | -120.9 | -169.4 | 135.0 | 0.73 | 0.113 |
B:Q96EY8:0.114 |
HOH |
3.587 |
O |
O |
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| 6d5k | 1 | Q96EY8 | 99.49 | 4e-145 |
X-RAY |
2018-10-10 | MET | A:185 | A:239 | 138.0 | 0.746 | -148.3 | 127.6 | 132.0 | 0.714 | 0.032 |
C:Q96EY8:0.032 |
B12 HOH |
3.311 7.024 |
CE N |
O5 O |
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| MET | B:185 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| MET | C:185 | C:239 | 135.0 | 0.73 | -135.8 | 120.9 | 114.0 | 0.616 | 0.114 |
B:Q96EY8:0.114 |
HOH |
8.134 |
C |
O |
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| 6d5x | 1 | Q96EY8 | 99.49 | 4e-145 |
X-RAY |
2018-10-10 | MET | A:185 | A:239 | 178.0 | 0.962 | -110.2 | 360.0 | 178.0 | 0.962 | 0.0 |
B12 HOH |
6.266 4.345 |
SD SD |
O4 O |
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| MET | B:185 | B:239 | 201.0 | 1.0 | -130.0 | 360.0 | 124.0 | 0.67 | 0.33 |
A:Q96EY8:0.416 |
B12 HOH |
8.249 8.873 |
N CA |
O4 O |
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| MET | C:185 | C:239 | 141.0 | 0.762 | -143.1 | 131.9 | 105.0 | 0.568 | 0.194 |
B:Q96EY8:0.195 |
HOH |
7.210 |
O |
O |
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| 7ruv | 1 | Q96EY8 | 98.98 | 2e-144 |
X-RAY |
2021-11-24 | MET | A:185 | A:239 | 196.0 | 1.0 | -117.0 | 360.0 | 196.0 | 1.0 | 0.0 |
B12 HOH |
6.310 4.858 |
SD SD |
O4 O |
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| MET | B:185 | B:239 | 187.0 | 1.0 | -143.8 | 360.0 | NA | NA | NA | ||||||||||||||
| MET | C:185 | C:239 | 207.0 | 1.0 | -117.1 | 360.0 | NA | NA | NA | ||||||||||||||
| MET | D:185 | D:239 | 129.0 | NA | -110.7 | 360.0 | NA | NA | NA | ||||||||||||||
| 7rut | 1 | Q96EY8 | 98.98 | 2e-143 |
X-RAY |
2021-11-24 | MET | A:185 | E:239 | 76.0 | NA | -138.2 | 138.6 | 59.0 | NA | NA |
E:Q96EY8:NA |
HOH |
3.102 |
O |
O |
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| MET | B:185 | C:239 | 147.0 | 0.795 | -133.2 | 136.3 | NA | NA | NA | ||||||||||||||
| MET | C:185 | F:239 | 144.0 | 0.778 | -147.2 | 142.4 | NA | NA | NA | ||||||||||||||
| MET | D:185 | B:239 | 170.0 | 0.919 | -130.8 | 161.0 | NA | NA | NA | ||||||||||||||
| MET | E:185 | A:239 | 81.0 | NA | -127.7 | 126.2 | NA | NA | NA | ||||||||||||||
| MET | F:185 | D:239 | 158.0 | 0.854 | -135.6 | 140.8 | 135.0 | 0.73 | 0.124 |
A:Q96EY8:0.124 |
HOH |
3.130 |
O |
O |
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| 7ruu | 1 | Q96EY8 | 98.98 | 2e-143 |
X-RAY |
2021-11-24 | MET | A:185 | A:239 | 84.0 | NA | -127.1 | -60.1 | 80.0 | NA | NA |
A:Q96EY8:NA |
B12 HOH |
6.319 4.702 |
O O |
O4 O |
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| MET | B:185 | B:239 | 88.0 | NA | -138.6 | 120.6 | NA | NA | NA | ||||||||||||||
| MET | C:185 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| MET | D:185 | D:239 | 154.0 | 0.832 | -127.1 | 129.1 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
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| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q96ey8-f1 | 1 | Q96EY8 | 100.0 | 0.0 | MET | A:239 | A:239 | 161.0 | 0.87 | -102.7 | 124.0 | ||