Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 109998849 . T A CCDS9131.1:NM_052845.3:c.580Aga>Tga_NP_443077.1:p.194R>* Homo sapiens methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2idx 1 Q96EY8 99.49 4e-145 X-RAY
 2007-02-06 ARG A:140 A:194 134.0 0.596 H -53.2 -30.0 11.0 0.049 0.547 C:Q96EY8:0.547
 CL
MG
ATP
HOH
 6.590
9.491
2.844
2.687
 NH2
N
NH1
O
 CL
MG
N1
O
ARG B:140 B:194 134.0 0.596 H -60.2 -28.3 39.0 0.173 0.423 A:Q96EY8:0.422
 CL
HOH
 6.493
2.735
 NH2
NH1
 CL
O
ARG C:140 C:194 137.0 0.609 H -58.4 -29.5 11.0 0.049 0.56 B:Q96EY8:0.56
 CL
ATP
MG
HOH
 6.559
3.013
9.725
2.530
 NH2
NH1
N
NH2
 CL
N1
MG
O
6d5k 1 Q96EY8 99.49 4e-145 X-RAY
 2018-10-10 ARG A:140 A:194 144.0 0.64 H -63.1 -30.1 16.0 0.071 0.569 C:Q96EY8:0.569
 5AD
B12
EPE
HOH
 2.908
6.815
9.109
6.747
 NH1
NH1
CG
NH2
 N1
C47
O2S
O
ARG B:140 B:194 130.0 0.578 H -73.5 -26.8 23.0 0.102 0.476 A:Q96EY8:0.476
 B12
5AD
HOH
 6.985
3.193
2.836
 NH1
NH1
NH2
 C47
N1
O
ARG C:140 C:194 135.0 0.6 H -62.6 -30.3 15.0 0.067 0.533 B:Q96EY8:0.533
 ATP
MG
HOH
 3.101
9.529
4.720
 NH1
N
NH2
 N1
MG
O
6d5x 1 Q96EY8 99.49 4e-145 X-RAY
 2018-10-10 ARG A:140 A:194 138.0 0.613 H -61.5 -33.5 14.0 0.062 0.551 C:Q96EY8:0.551
 5AD
B12
MG
3PO
HOH
 2.790
7.016
9.405
9.377
2.624
 NH1
NH1
N
CG
O
 N1
C47
MG
O2B
O
ARG B:140 B:194 137.0 0.609 H -62.7 -29.5 46.0 0.204 0.405 A:Q96EY8:0.404
 5AD
B12
HOH
 2.940
6.856
2.829
 NH1
NH1
NH2
 N1
C47
O
ARG C:140 C:194 138.0 0.613 H -62.8 -29.3 14.0 0.062 0.551 B:Q96EY8:0.551
 ATP
MG
HOH
 2.976
9.626
2.844
 NH1
N
NH2
 N1
MG
O
7ruv 1 Q96EY8 98.98 2e-144 X-RAY
 2021-11-24 ARG A:140 A:194 133.0 0.591 H -64.5 -34.7 36.0 0.16 0.431 A:Q96EY8:0.431
 K
B12
5AD
K
K
HOH
 6.533
7.003
2.787
6.533
6.533
2.810
 NH2
NH1
NH1
NH2
NH2
NH2
 K
C46
N1
K
K
O
ARG B:140 B:194 135.0 0.6 H -59.4 -34.0 NA NA NA
ARG C:140 C:194 129.0 0.573 H -62.7 -33.7 NA NA NA
ARG D:140 D:194 135.0 0.6 H -60.8 -37.6 NA NA NA
7rut 1 Q96EY8 98.98 2e-143 X-RAY
 2021-11-24 ARG A:140 E:194 136.0 0.604 H -63.4 -29.4 12.0 0.053 0.551 E:Q96EY8:0.551
 K
K
MG
ATP
HOH
 6.597
6.586
9.701
2.904
2.726
 NH2
NH2
N
NH1
O
 K
K
MG
N1
O
ARG B:140 C:194 133.0 0.591 H -63.6 -30.8 NA NA NA
ARG C:140 F:194 131.0 0.582 H -61.9 -29.5 NA NA NA
ARG D:140 B:194 134.0 0.596 H -61.5 -31.5 NA NA NA
ARG E:140 A:194 134.0 0.596 H -59.8 -31.7 NA NA NA
ARG F:140 D:194 133.0 0.591 H -59.8 -31.3 12.0 0.053 0.538 A:Q96EY8:0.538
 K
ATP
MG
K
HOH
 4.745
2.898
9.689
6.569
2.735
 NH2
NH1
N
NH2
O
 K
N1
MG
K
O
7ruu 1 Q96EY8 98.98 2e-143 X-RAY
 2021-11-24 ARG A:140 A:194 135.0 0.6 H -60.3 -32.8 44.0 0.196 0.404 A:Q96EY8:0.404
 K
5AD
B12
K
K
HOH
 6.409
2.883
6.944
6.409
6.409
2.768
 NH2
NH1
NH1
NH2
NH2
NH2
 K
N1
C46
K
K
O
ARG B:140 B:194 135.0 0.6 H -65.0 -29.7 NA NA NA
ARG C:140 C:194 138.0 0.613 H -62.8 -29.6 NA NA NA
ARG D:140 D:194 138.0 0.613 H -63.0 -30.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q96ey8-f1 1 Q96EY8 100.0 0.0 ARG A:194 A:194 132.0 0.587 H -63.0 -24.7