Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 21531247 . A C CCDS8688.1:NM_000415.2:c.157Agc>Cgc_NP_000406.1:p.53S>R Homo sapiens islet amyloid polypeptide (IAPP), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6ucj 1 P10997 100.0 3e-45 NMR
 2020-02-26 SER A:31 A:31 62.0 0.539 H -63.1 -37.1 62.0 0.539 0.0
6uck 1 P10997 100.0 3e-45 NMR
 2020-02-26 SER A:31 A:31 74.0 0.643 H -53.6 -51.7 74.0 0.643 0.0
6vw2 1 Q12306,P10997 86.96 1e-22 EM
 2020-06-10 SER A:138 A:20 104.0 0.904 68.6 42.3 45.0 0.391 0.513 D:Q12306+P10997:0.252
E:Q12306+P10997:0.252
SER B:138 B:20 101.0 0.878 68.6 42.3 46.0 0.4 0.478 F:Q12306+P10997:0.235
C:Q12306+P10997:0.243
SER C:138 C:20 101.0 0.878 68.6 42.3 46.0 0.4 0.478 G:Q12306+P10997:0.243
B:Q12306+P10997:0.235
SER D:138 D:20 106.0 0.922 68.6 42.3 46.0 0.4 0.522 H:Q12306+P10997:0.261
A:Q12306+P10997:0.261
SER E:138 E:20 104.0 0.904 68.6 42.3 45.0 0.391 0.513 I:Q12306+P10997:0.261
A:Q12306+P10997:0.252
SER F:138 F:20 102.0 0.887 68.6 42.3 45.0 0.391 0.496 J:Q12306+P10997:0.235
B:Q12306+P10997:0.261
SER G:138 G:20 103.0 0.896 68.6 42.3 75.0 0.652 0.244 C:Q12306+P10997:0.243
SER H:138 H:20 105.0 0.913 68.6 42.3 75.0 0.652 0.261 D:Q12306+P10997:0.261
SER I:138 I:20 104.0 0.904 68.7 42.3 75.0 0.652 0.252 E:Q12306+P10997:0.252
SER J:138 J:20 101.0 0.878 68.6 42.3 72.0 0.626 0.252 F:Q12306+P10997:0.252
2g48 2 P10997 100.0 2e-20 X-RAY
 2006-10-24 SER C:20 C:20 115.0 NA -78.3 -25.6 85.0 NA NA A:Q5T5N2:NA
 HOH
 6.363
 N
 O
SER D:20 D:20 98.0 0.852 -106.5 150.7 NA NA NA
3hgz 2 P10997 100.0 2e-20 X-RAY
 2009-12-08 SER C:20 NA:NA DO NA DO DO DO NA NA NA
SER D:20 NA:NA DO NA DO DO DO NA NA NA
5k5g 1 P10997 100.0 2e-20 NMR
 2016-10-26 SER A:20 A:20 103.0 0.896 T -69.8 -56.3 66.0 0.574 0.322 B:None:0.322
6y1a 1 P10997 100.0 2e-20 EM
 2020-03-04 SER A:20 A:20 98.0 0.852 S -153.8 103.3 82.0 0.713 0.139 C:P10997:0.139
 NH2
 8.192
 C
 N
SER B:20 B:20 95.0 0.826 S -153.8 103.3 80.0 0.696 0.13 D:P10997:0.13
 NH2
NH2
 5.851
7.875
 O
C
 N
N
SER C:20 C:20 97.0 0.843 S -154.0 103.3 41.0 0.357 0.486 A:P10997:0.348
E:P10997:0.139
 NH2
NH2
 6.255
8.031
 O
C
 N
N
SER D:20 D:20 97.0 0.843 S -153.9 103.3 40.0 0.348 0.495 F:P10997:0.139
B:P10997:0.357
 NH2
NH2
NH2
 7.107
5.884
7.925
 O
O
C
 N
N
N
SER E:20 E:20 96.0 0.835 S -153.8 103.2 41.0 0.357 0.478 C:P10997:0.348
G:P10997:0.13
 NH2
NH2
NH2
 7.302
5.998
7.952
 O
O
C
 N
N
N
SER F:20 F:20 99.0 0.861 S -153.9 103.2 40.0 0.348 0.513 H:P10997:0.148
D:P10997:0.374
 NH2
NH2
NH2
 6.961
5.865
7.915
 O
O
C
 N
N
N
SER G:20 G:20 96.0 0.835 S -153.9 103.3 40.0 0.348 0.487 I:P10997:0.13
E:P10997:0.365
 NH2
NH2
NH2
 7.085
5.938
7.953
 O
O
C
 N
N
N
SER H:20 H:20 97.0 0.843 S -153.9 103.3 39.0 0.339 0.504 F:P10997:0.357
J:P10997:0.148
 NH2
NH2
NH2
 6.967
5.894
8.054
 O
O
C
 N
N
N
SER I:20 I:20 95.0 0.826 S -153.9 103.3 38.0 0.33 0.496 G:P10997:0.365
K:P10997:0.13
 NH2
NH2
NH2
 6.957
5.870
7.912
 O
O
C
 N
N
N
SER J:20 J:20 96.0 0.835 S -153.8 103.2 39.0 0.339 0.496 H:P10997:0.365
L:P10997:0.139
 NH2
NH2
NH2
 6.931
6.014
7.963
 O
O
C
 N
N
N
SER K:20 K:20 97.0 0.843 S -153.9 103.3 40.0 0.348 0.495 I:P10997:0.365
M:P10997:0.139
 NH2
NH2
NH2
 6.958
5.863
8.020
 O
O
C
 N
N
N
SER L:20 L:20 96.0 0.835 S -153.9 103.3 40.0 0.348 0.487 J:P10997:0.357
N:P10997:0.13
 NH2
NH2
NH2
 7.035
5.884
7.933
 O
O
C
 N
N
N
SER M:20 M:20 98.0 0.852 S -153.9 103.3 40.0 0.348 0.504 O:P10997:0.13
K:P10997:0.374
 NH2
NH2
NH2
 6.964
5.994
7.869
 O
O
C
 N
N
N
SER N:20 N:20 95.0 0.826 S -153.9 103.3 41.0 0.357 0.469 L:P10997:0.348
P:P10997:0.122
 NH2
NH2
NH2
 7.062
5.952
8.039
 O
O
C
 N
N
N
SER O:20 O:20 96.0 0.835 S -153.8 103.3 56.0 0.487 0.348 M:P10997:0.348
 NH2
NH2
NH2
 7.364
6.005
8.012
 O
O
C
 N
N
N
SER P:20 P:20 95.0 0.826 S -154.0 103.3 55.0 0.478 0.348 N:P10997:0.348
 NH2
NH2
 7.251
6.157
 O
O
 N
N
2l86 1 P10997 100.0 3e-20 NMR
 2011-07-13 SER A:20 A:20 91.0 0.791 T -55.9 -33.9 91.0 0.791 0.0
7m61 1 P10997 100.0 3e-20 EM
 2021-09-22 SER A:20 A:20 121.0 1.0 S -100.4 -59.2 46.0 0.4 0.6 G:P10997:0.278
I:P10997:0.365
SER B:20 B:20 101.0 0.878 58.1 65.1 40.0 0.348 0.53 H:P10997:0.322
J:P10997:0.209
SER C:20 C:20 122.0 1.0 S -100.4 -59.2 79.0 0.687 0.313 E:P10997:0.374
SER D:20 D:20 102.0 0.887 58.0 65.0 80.0 0.696 0.191 F:P10997:0.191
SER E:20 E:20 122.0 1.0 S -100.4 -59.2 44.0 0.383 0.617 C:P10997:0.287
G:P10997:0.383
SER F:20 F:20 101.0 0.878 58.1 65.0 40.0 0.348 0.53 H:P10997:0.2
D:P10997:0.322
SER G:20 G:20 121.0 1.0 S -100.3 -59.3 45.0 0.391 0.609 A:P10997:0.383
E:P10997:0.278
SER H:20 H:20 100.0 0.87 58.0 65.1 40.0 0.348 0.522 F:P10997:0.313
B:P10997:0.209
SER I:20 I:20 122.0 1.0 S -100.4 -59.2 89.0 0.774 0.226 A:P10997:0.287
SER J:20 J:20 98.0 0.852 58.1 65.0 61.0 0.53 0.322 B:P10997:0.322
7m62 1 P10997 100.0 3e-20 EM
 2021-09-22 SER A:20 A:20 73.0 0.635 -140.6 84.7 0.0 0.0 0.635 F:P10997:0.104
G:P10997:0.087
D:P10997:0.53
SER B:20 B:20 73.0 0.635 -140.5 84.7 0.0 0.0 0.635 H:P10997:0.096
C:P10997:0.539
E:P10997:0.104
SER C:20 C:20 74.0 0.643 -140.6 84.8 0.0 0.0 0.643 H:P10997:0.548
B:P10997:0.104
SER D:20 D:20 73.0 0.635 -140.6 84.8 0.0 0.0 0.635 G:P10997:0.53
A:P10997:0.113
SER E:20 E:20 72.0 0.626 -140.6 84.7 0.0 0.0 0.626 C:P10997:0.096
J:P10997:0.104
B:P10997:0.539
SER F:20 F:20 74.0 0.643 -140.6 84.7 0.0 0.0 0.643 I:P10997:0.104
D:P10997:0.087
A:P10997:0.548
SER G:20 G:20 73.0 0.635 -140.6 84.7 61.0 0.53 0.105 D:P10997:0.104
SER H:20 H:20 74.0 0.643 -140.6 84.7 62.0 0.539 0.104 C:P10997:0.104
SER I:20 I:20 74.0 0.643 -140.6 84.7 11.0 0.096 0.547 F:P10997:0.548
A:P10997:0.087
SER J:20 J:20 73.0 0.635 -140.6 84.6 10.0 0.087 0.548 E:P10997:0.548
B:P10997:0.096
7m64 1 P10997 100.0 3e-20 EM
 2021-09-22 SER A:20 A:20 88.0 0.765 S -132.7 114.1 39.0 0.339 0.426 D:P10997:0.13
E:P10997:0.287
SER B:20 B:20 91.0 0.791 S -132.7 114.1 39.0 0.339 0.452 F:P10997:0.148
C:P10997:0.304
SER C:20 C:20 89.0 0.774 S -132.8 114.1 39.0 0.339 0.435 G:P10997:0.296
B:P10997:0.139
SER D:20 D:20 89.0 0.774 S -132.7 114.1 39.0 0.339 0.435 H:P10997:0.139
A:P10997:0.287
SER E:20 E:20 90.0 0.783 S -132.7 114.2 39.0 0.339 0.444 I:P10997:0.296
A:P10997:0.139
SER F:20 F:20 91.0 0.791 S -132.7 114.1 39.0 0.339 0.452 J:P10997:0.148
B:P10997:0.313
SER G:20 G:20 89.0 0.774 S -132.7 114.1 74.0 0.643 0.131 C:P10997:0.13
SER H:20 H:20 89.0 0.774 S -132.7 114.2 56.0 0.487 0.287 D:P10997:0.287
SER I:20 I:20 91.0 0.791 S -132.8 114.1 74.0 0.643 0.148 E:P10997:0.148
SER J:20 J:20 88.0 0.765 S -132.8 114.1 55.0 0.478 0.287 F:P10997:0.287
7m65 1 P10997 100.0 3e-20 EM
 2021-09-22 SER A:20 A:20 111.0 0.965 S -73.5 -74.4 51.0 0.443 0.522 G:P10997:0.243
I:P10997:0.27
SER B:20 B:20 113.0 0.983 57.1 41.3 54.0 0.47 0.513 H:P10997:0.191
J:P10997:0.322
SER C:20 C:20 109.0 0.948 S -73.5 -74.4 79.0 0.687 0.261 E:P10997:0.261
SER D:20 D:20 112.0 0.974 57.2 41.3 74.0 0.643 0.331 F:P10997:0.33
SER E:20 E:20 109.0 0.948 S -73.5 -74.5 50.0 0.435 0.513 C:P10997:0.252
G:P10997:0.261
SER F:20 F:20 112.0 0.974 57.2 41.3 55.0 0.478 0.496 H:P10997:0.313
D:P10997:0.183
SER G:20 G:20 110.0 0.957 S -73.5 -74.4 50.0 0.435 0.522 A:P10997:0.261
E:P10997:0.261
SER H:20 H:20 111.0 0.965 57.2 41.3 53.0 0.461 0.504 F:P10997:0.191
B:P10997:0.313
SER I:20 I:20 108.0 0.939 S -73.5 -74.4 79.0 0.687 0.252 A:P10997:0.252
SER J:20 J:20 112.0 0.974 57.2 41.3 90.0 0.783 0.191 B:P10997:0.191
3g7v 1 P0AEX9,P10997 100.0 1e-19 X-RAY
 2009-06-23 SER A:391 A:390 99.0 0.861 H -66.9 -33.2 99.0 0.861 0.0 SO4
GOL
HOH
 3.413
4.913
2.620
 N
CA
O
 O3
C1
O
SER B:391 B:390 94.0 0.817 H -64.5 -33.8 94.0 0.817 0.0 SO4
SO4
GOL
HOH
 9.709
3.381
3.688
2.637
 N
OG
CA
O
 O4
O2
C3
O
SER C:391 C:390 106.0 0.922 H -59.6 -40.1 NA NA NA
SER D:391 D:390 106.0 0.922 H -64.3 -40.2 NA NA NA
5mgq 1 P10997 100.0 4e-19 NMR
 2017-03-29 SER A:20 A:20 68.0 0.591 T -60.9 -5.9 68.0 0.591 0.0
6zrf 1 P10997 100.0 4e-19 EM
 2020-09-30 SER A:20 A:20 103.0 0.896 S -117.6 -57.8 70.0 0.609 0.287 B:P10997:0.287
SER B:20 C:20 101.0 0.878 S -117.6 -57.8 32.0 0.278 0.6 C:P10997:0.287
A:P10997:0.313
SER C:20 E:20 101.0 0.878 S -117.5 -57.8 33.0 0.287 0.591 D:P10997:0.296
B:P10997:0.304
SER D:20 G:20 100.0 0.87 S -117.5 -57.8 32.0 0.278 0.592 C:P10997:0.296
E:P10997:0.296
SER E:20 I:20 102.0 0.887 S -117.5 -57.9 34.0 0.296 0.591 F:P10997:0.296
D:P10997:0.287
SER F:20 K:20 102.0 0.887 S -117.6 -57.8 68.0 0.591 0.296 E:P10997:0.296
SER G:20 B:20 101.0 0.878 S -117.6 -57.8 68.0 0.591 0.287 H:P10997:0.287
SER H:20 D:20 102.0 0.887 S -117.5 -57.8 32.0 0.278 0.609 G:P10997:0.313
I:P10997:0.296
SER I:20 F:20 103.0 0.896 S -117.6 -57.8 34.0 0.296 0.6 H:P10997:0.304
J:P10997:0.296
SER J:20 H:20 103.0 0.896 S -117.6 -57.7 33.0 0.287 0.609 I:P10997:0.304
K:P10997:0.296
SER K:20 J:20 100.0 0.87 S -117.6 -57.8 32.0 0.278 0.592 L:P10997:0.261
J:P10997:0.322
SER L:20 L:20 101.0 0.878 S -117.6 -57.8 69.0 0.6 0.278 K:P10997:0.278
6zrq 1 P10997 97.22 2e-18 EM
 2020-09-30 GLY A:20 A:20 83.0 1.0 S 88.7 -2.8 64.0 0.853 0.147 C:P10997:0.253
GLY B:20 B:20 83.0 1.0 S 88.6 -2.7 65.0 0.867 0.133 D:P10997:0.24
GLY C:20 C:20 82.0 1.0 S 88.6 -2.7 43.0 0.573 0.427 A:P10997:0.28
E:P10997:0.253
GLY D:20 D:20 84.0 1.0 S 88.6 -2.6 43.0 0.573 0.427 F:P10997:0.24
B:P10997:0.307
GLY E:20 E:20 83.0 1.0 S 88.6 -2.7 43.0 0.573 0.427 C:P10997:0.28
G:P10997:0.253
GLY F:20 F:20 84.0 1.0 S 88.6 -2.7 44.0 0.587 0.413 H:P10997:0.24
D:P10997:0.293
GLY G:20 G:20 83.0 1.0 S 88.6 -2.7 44.0 0.587 0.413 I:P10997:0.227
E:P10997:0.28
GLY H:20 H:20 83.0 1.0 S 88.6 -2.7 43.0 0.573 0.427 F:P10997:0.293
J:P10997:0.24
GLY I:20 I:20 83.0 1.0 S 88.6 -2.6 43.0 0.573 0.427 G:P10997:0.307
K:P10997:0.227
GLY J:20 J:20 83.0 1.0 S 88.6 -2.7 43.0 0.573 0.427 H:P10997:0.293
L:P10997:0.253
GLY K:20 K:20 82.0 1.0 S 88.6 -2.7 60.0 0.8 0.2 I:P10997:0.293
GLY L:20 L:20 82.0 1.0 S 88.7 -2.7 61.0 0.813 0.187 J:P10997:0.28
6zrr 1 P10997 97.22 2e-18 EM
 2020-09-30 GLY A:20 A:20 84.0 1.0 S 87.8 -3.1 65.0 0.867 0.133 D:P10997:0.253
GLY B:20 B:20 83.0 1.0 S 87.8 -3.0 40.0 0.533 0.467 F:P10997:0.107
C:P10997:0.347
E:P10997:0.24
GLY C:20 C:20 48.0 0.64 -82.5 173.3 42.0 0.56 0.08 F:P10997:0.08
GLY D:20 D:20 84.0 1.0 S 87.8 -3.0 45.0 0.6 0.4 G:P10997:0.24
A:P10997:0.28
GLY E:20 E:20 83.0 1.0 S 87.8 -3.1 21.0 0.28 0.72 F:P10997:0.347
H:P10997:0.213
C:P10997:0.093
I:P10997:0.107
B:P10997:0.293
GLY F:20 F:20 49.0 0.653 -82.5 173.2 18.0 0.24 0.413 C:P10997:0.347
I:P10997:0.08
GLY G:20 G:20 84.0 1.0 S 87.7 -3.0 45.0 0.6 0.4 D:P10997:0.267
J:P10997:0.24
GLY H:20 H:20 83.0 1.0 S 87.8 -3.0 20.0 0.267 0.733 F:P10997:0.093
L:P10997:0.107
I:P10997:0.347
E:P10997:0.293
K:P10997:0.213
GLY I:20 I:20 50.0 0.667 -82.5 173.2 18.0 0.24 0.427 F:P10997:0.347
L:P10997:0.08
GLY J:20 J:20 84.0 1.0 S 87.8 -3.0 44.0 0.587 0.413 G:P10997:0.28
M:P10997:0.253
GLY K:20 K:20 83.0 1.0 S 87.8 -3.0 21.0 0.28 0.72 O:P10997:0.107
H:P10997:0.293
L:P10997:0.347
I:P10997:0.093
N:P10997:0.213
GLY L:20 L:20 50.0 0.667 -82.6 173.2 17.0 0.227 0.44 O:P10997:0.08
I:P10997:0.36
GLY M:20 M:20 82.0 1.0 S 87.7 -3.0 43.0 0.573 0.427 J:P10997:0.267
P:P10997:0.24
GLY N:20 N:20 82.0 1.0 S 87.8 -3.0 20.0 0.267 0.733 O:P10997:0.347
Q:P10997:0.227
L:P10997:0.107
R:P10997:0.107
K:P10997:0.293
GLY O:20 O:20 49.0 0.653 -82.5 173.2 17.0 0.227 0.426 L:P10997:0.347
R:P10997:0.08
GLY P:20 P:20 82.0 1.0 S 87.8 -3.0 62.0 0.827 0.173 M:P10997:0.267
GLY Q:20 Q:20 82.0 1.0 S 87.8 -3.0 36.0 0.48 0.52 O:P10997:0.093
R:P10997:0.347
N:P10997:0.28
GLY R:20 R:20 49.0 0.653 -82.5 173.2 24.0 0.32 0.333 O:P10997:0.333
7bg0 1 P0AEX9,P10997 86.11 1e-14 X-RAY
 2021-08-04 SER A:391 A:416 93.0 0.809 -57.5 132.6 93.0 0.809 0.0
SER B:391 NA:NA DO NA DO DO DO NA NA NA
SER C:391 NA:NA DO NA DO DO DO NA NA NA
SER D:391 E:416 104.0 0.904 -57.8 136.0 NA NA NA
3g7w 1 P0AEX9,P10997 100.0 6e-09 X-RAY
 2009-06-23 SER A:391 A:390 65.0 0.565 -69.1 -41.3 65.0 0.565 0.0 SO4
SO4
SO4
HOH
 6.126
9.841
4.561
2.957
 N
CA
N
N
 O1
O1
O2
O
5knz 1 P10997 90.91 1.0 ELECTRON CRYSTALLOGRAPHY
 2016-12-21 GLY A:2 A:20 67.0 0.893 -101.7 -107.5 19.0 0.253 0.64 A:P10997:0.267
A:P10997:0.373
5ko0 1 P10997 100.0 1.0 ELECTRON CRYSTALLOGRAPHY
 2016-12-21 SER A:6 A:20 115.0 1.0 -141.5 152.0 46.0 0.4 0.6 B:P10997:0.409
B:P10997:0.191
 SCN
HOH
 6.953
3.154
 C
O
 C
O
SER B:6 B:20 101.0 0.878 -150.7 154.8 21.0 0.183 0.695 A:P10997:0.243
A:P10997:0.452
 SCN
SCN
HOH
 6.264
5.889
3.757
 N
O
N
 N
S
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p10997-f1 1 P10997 100.0 1e-61 SER A:53 A:53 77.0 0.67 H -55.1 -39.9