Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr12 | 3129871 | . | G | A | CCDS31729.1:NM_003213.3:c.655Gtg>Atg_NP_003204.2:p.219V>M | Homo sapiens TEA domain transcription factor 4 (TEAD4), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6ge3 | 1 | Q15561 | 100.0 | 3e-166 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 2.0 | 0.013 | S | -81.5 | 79.7 | 2.0 | 0.013 | 0.0 |
HOH |
2.885 |
N |
O |
||
| 6gec | 1 | Q15561 | 100.0 | 3e-166 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 2.0 | 0.013 | S | -85.3 | 80.2 | 2.0 | 0.013 | 0.0 |
HOH |
2.899 |
N |
O |
||
| 6ge5 | 1 | Q15561 | 99.54 | 1e-165 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 1.0 | 0.006 | S | -80.7 | 80.1 | 1.0 | 0.006 | 0.0 |
HOH |
3.080 |
N |
O |
||
| 6geg | 1 | Q15561 | 99.54 | 1e-165 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 2.0 | 0.013 | S | -80.7 | 78.4 | 2.0 | 0.013 | 0.0 |
HOH |
2.869 |
N |
O |
||
| 6gek | 1 | Q15561 | 99.54 | 1e-165 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 2.0 | 0.013 | S | -84.1 | 89.7 | 2.0 | 0.013 | 0.0 |
HOH |
3.076 |
N |
O |
||
| VAL | C:4 | B:219 | 2.0 | 0.013 | S | -80.1 | 90.4 | NA | NA | NA | |||||||||||||
| 6hik | 1 | Q15561 | 99.54 | 2e-165 |
X-RAY |
2019-04-03 | VAL | A:4 | A:219 | 0.0 | 0.0 | E | -120.3 | 140.2 | 0.0 | 0.0 | 0.0 |
PO4 HOH |
9.051 3.747 |
N CA |
O3 O |
||
| 6ge4 | 1 | Q15561 | 99.54 | 2e-165 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 2.0 | 0.013 | S | -82.3 | 77.9 | 2.0 | 0.013 | 0.0 |
HOH |
2.743 |
N |
O |
||
| 6gee | 1 | Q15561 | 99.54 | 2e-165 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 1.0 | 0.006 | S | -81.1 | 88.4 | 1.0 | 0.006 | 0.0 |
HOH |
2.806 |
N |
O |
||
| 5oaq | 1 | Q15561 | 100.0 | 5e-165 |
X-RAY |
2017-10-11 | VAL | A:5 | A:219 | 2.0 | 0.013 | S | -85.8 | 81.2 | 2.0 | 0.013 | 0.0 |
HOH |
2.877 |
N |
O |
||
| 6q2x | 1 | Q15561 | 100.0 | 5e-165 |
X-RAY |
2019-07-03 | VAL | A:5 | A:219 | 2.0 | 0.013 | S | -83.1 | 79.7 | 2.0 | 0.013 | 0.0 |
HOH |
2.906 |
N |
O |
||
| 6q36 | 1 | Q15561 | 100.0 | 5e-165 |
X-RAY |
2019-07-03 | VAL | A:5 | A:219 | 2.0 | 0.013 | S | -77.8 | 81.2 | 2.0 | 0.013 | 0.0 |
HOH |
2.959 |
N |
O |
||
| VAL | B:5 | B:219 | 2.0 | 0.013 | S | -79.2 | 83.2 | 2.0 | 0.013 | 0.0 |
PO4 HOH |
9.073 3.154 |
CG2 N |
O3 O |
|||||||||
| 6ge6 | 1 | Q15561 | 99.09 | 1e-164 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 1.0 | 0.006 | E | -122.4 | 130.4 | 1.0 | 0.006 | 0.0 |
PO4 HOH |
8.765 6.840 |
N C |
O3 O |
||
| 6gei | 1 | Q15561 | 99.09 | 1e-164 |
X-RAY |
2018-09-19 | VAL | A:4 | A:219 | 0.0 | 0.0 | E | -135.0 | 122.7 | 0.0 | 0.0 | 0.0 |
PO4 HOH |
8.902 3.259 |
N CA |
O3 O |
||
| 6sen | 1 | Q15561 | 99.54 | 5e-164 |
X-RAY |
2019-11-20 | VAL | A:5 | A:219 | 2.0 | 0.013 | E | -84.6 | 85.7 | 2.0 | 0.013 | 0.0 |
SO4 HOH |
9.407 2.805 |
CG2 N |
O4 O |
||
| VAL | B:5 | B:219 | 1.0 | 0.006 | S | -88.2 | 93.0 | NA | NA | NA | |||||||||||||
| 6seo | 1 | Q15561 | 99.54 | 5e-164 |
X-RAY |
2019-11-20 | VAL | A:5 | A:219 | 2.0 | 0.013 | E | -87.0 | 82.1 | 2.0 | 0.013 | 0.0 |
HOH |
7.493 |
CA |
O |
||
| 4ln0 | 1 | Q62296 | 96.35 | 3e-161 |
X-RAY |
2014-02-26 | ILE | A:7 | A:212 | 0.0 | 0.0 | S | -82.5 | 88.6 | 0.0 | 0.0 | 0.0 |
HOH |
9.492 |
CG1 |
O |
||
| ILE | B:7 | B:212 | 5.0 | 0.029 | -83.9 | 91.6 | 5.0 | 0.029 | 0.0 | ||||||||||||||
| 6l9f | 1 | Q62296 | 96.35 | 3e-161 |
X-RAY |
2019-12-11 | ILE | A:7 | A:212 | 5.0 | 0.029 | S | -79.1 | 83.8 | 5.0 | 0.029 | 0.0 |
HOH |
3.139 |
N |
O |
||
| ILE | C:7 | B:212 | 0.0 | 0.0 | S | -78.9 | 95.6 | NA | NA | NA | |||||||||||||
| 6sba | 1 | Q62296 | 96.35 | 9e-161 |
X-RAY |
2020-09-30 | ILE | A:6 | A:212 | 2.0 | 0.011 | E | -88.3 | 90.8 | 2.0 | 0.011 | 0.0 |
HOH |
2.042 |
H |
O |
||
| 3jua | 1 | Q62296 | 96.33 | 2e-160 |
X-RAY |
2010-02-23 | ILE | A:5 | A:212 | 3.0 | 0.017 | S | -87.1 | 84.7 | 3.0 | 0.017 | 0.0 |
HOH |
5.861 |
N |
O |
||
| ILE | C:5 | C:212 | 1.0 | 0.006 | S | -87.3 | 96.1 | NA | NA | NA | |||||||||||||
| ILE | E:5 | E:212 | 6.0 | 0.034 | S | -83.7 | 51.7 | NA | NA | NA | |||||||||||||
| ILE | G:5 | G:212 | 0.0 | 0.0 | S | -82.8 | 50.8 | NA | NA | NA | |||||||||||||
| 5xjd | 1 | Q62296 | 96.33 | 2e-160 |
X-RAY |
2018-01-24 | ILE | A:5 | A:212 | 0.0 | 0.0 | S | -81.7 | 90.1 | 0.0 | 0.0 | 0.0 |
HOH |
5.948 |
N |
O |
||
| ILE | B:5 | B:212 | 0.0 | 0.0 | S | -78.4 | 91.5 | 0.0 | 0.0 | 0.0 |
HOH |
4.874 |
O |
O |
|||||||||
| 5gn0 | 1 | Q62296 | 96.33 | 4e-160 |
X-RAY |
2017-05-31 | ILE | A:10 | A:212 | 0.0 | 0.0 | S | -87.2 | 97.2 | 0.0 | 0.0 | 0.0 |
HOH |
9.138 |
CD1 |
O |
||
| ILE | B:10 | B:212 | 0.0 | 0.0 | S | -83.5 | 79.7 | NA | NA | NA | |||||||||||||
| ILE | C:10 | C:212 | 0.0 | 0.0 | S | -85.9 | 74.8 | NA | NA | NA | |||||||||||||
| ILE | D:10 | D:212 | 0.0 | 0.0 | S | -85.0 | 85.6 | NA | NA | NA | |||||||||||||
| 5z2q | 3 | Q62296 | 96.31 | 1e-159 |
X-RAY |
2018-01-31 | ILE | C:12 | A:212 | 0.0 | 0.0 | S | -59.0 | 95.3 | NA | NA | NA | ||||||
| 5z2q | 4 | Q62296 | 96.31 | 2e-159 |
X-RAY |
2018-01-31 | ILE | D:14 | B:212 | 0.0 | 0.0 | S | -72.5 | 96.9 | 0.0 | 0.0 | 0.0 |
PO4 |
9.156 |
CD1 |
O2 |
||
| 7cmm | 1 | P28347 | 81.45 | 8e-139 |
X-RAY |
2021-02-03 | ILE | A:15 | A:211 | 4.0 | 0.023 | 53.0 | 62.3 | 4.0 | 0.023 | 0.0 | |||||||
| ILE | B:15 | B:211 | 3.0 | 0.017 | 54.5 | 54.8 | NA | NA | NA | ||||||||||||||
| ILE | C:15 | C:211 | 0.0 | 0.0 | 55.2 | 60.3 | NA | NA | NA | ||||||||||||||
| ILE | D:15 | D:211 | 2.0 | 0.011 | 52.3 | 56.2 | NA | NA | NA | ||||||||||||||
| 4re1 | 1 | P28347 | 81.28 | 2e-137 |
X-RAY |
2014-11-19 | ILE | A:5 | A:196 | 2.0 | 0.011 | S | -89.7 | 97.5 | 2.0 | 0.011 | 0.0 |
CL HOH |
9.500 2.724 |
CD1 N |
CL O |
||
| ILE | B:5 | B:196 | 2.0 | 0.011 | S | -89.6 | 103.5 | NA | NA | NA | |||||||||||||
| 6hil | 1 | P28347 | 81.65 | 4e-137 |
X-RAY |
2019-04-03 | ILE | A:4 | A:196 | 48.0 | 0.274 | 360.0 | 122.0 | 48.0 | 0.274 | 0.0 |
HOH |
2.463 |
O |
O |
|||
| ILE | C:4 | D:196 | 34.0 | 0.194 | 360.0 | 126.0 | NA | NA | NA | ||||||||||||||
| ILE | E:4 | B:196 | 34.0 | 0.194 | 360.0 | 124.0 | NA | NA | NA | ||||||||||||||
| ILE | G:4 | C:196 | 32.0 | 0.183 | 360.0 | 114.2 | NA | NA | NA | ||||||||||||||
| 3kys | 1 | P28347 | 81.65 | 4e-137 |
X-RAY |
2010-02-23 | ILE | A:4 | A:196 | 25.0 | 0.143 | -86.4 | 130.1 | 25.0 | 0.143 | 0.0 | |||||||
| ILE | C:4 | C:196 | 0.0 | 0.0 | E | -124.5 | 132.1 | NA | NA | NA | |||||||||||||
| 6im5 | 1 | P28347 | 81.36 | 2e-136 |
X-RAY |
2019-02-06 | ILE | A:18 | A:211 | 31.0 | NA | 360.0 | 103.9 | 31.0 | NA | NA |
PO4 HOH |
9.402 2.781 |
N N |
O4 O |
|||
| ILE | B:18 | B:211 | 30.0 | NA | 360.0 | 98.2 | NA | NA | NA | ||||||||||||||
| 7li5 | 1 | E9PKB7 | 81.94 | 6e-136 |
X-RAY |
2022-02-02 | ILE | A:7 | A:211 | 35.0 | 0.2 | -70.4 | -44.6 | 35.0 | 0.2 | 0.0 |
HOH |
4.706 |
CD1 |
O |
|||
| ILE | B:7 | B:211 | 31.0 | 0.177 | -82.8 | -19.3 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q15561-f1 | 1 | Q15561 | 100.0 | 0.0 | VAL | A:219 | A:219 | 0.0 | 0.0 | S | -76.9 | 75.4 | |