Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 3131098 . A C CCDS31729.1:NM_003213.3:c.812tAt>tCt_NP_003204.2:p.271Y>S Homo sapiens TEA domain transcription factor 4 (TEAD4), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6ge3 1 Q15561 100.0 3e-166 X-RAY
 2018-09-19 TYR A:56 A:271 39.0 0.17 G -51.4 -36.5 39.0 0.17 0.0 GOL
HOH
 6.487
2.629
 O
OH
 O2
O
6gec 1 Q15561 100.0 3e-166 X-RAY
 2018-09-19 TYR A:56 A:271 38.0 0.165 G -54.3 -35.4 38.0 0.165 0.0 HOH
 2.615
 O
 O
6ge5 1 Q15561 99.54 1e-165 X-RAY
 2018-09-19 TYR A:56 A:271 36.0 0.157 G -56.4 -34.7 36.0 0.157 0.0 HOH
 2.596
 OH
 O
6geg 1 Q15561 99.54 1e-165 X-RAY
 2018-09-19 TYR A:56 A:271 33.0 0.143 G -53.9 -40.4 33.0 0.143 0.0 HOH
 2.526
 OH
 O
6gek 1 Q15561 99.54 1e-165 X-RAY
 2018-09-19 TYR A:56 A:271 29.0 0.126 G -57.3 -46.1 29.0 0.126 0.0 HOH
 2.651
 OH
 O
TYR C:56 B:271 32.0 0.139 G -56.0 -38.8 NA NA NA
6hik 1 Q15561 99.54 2e-165 X-RAY
 2019-04-03 TYR A:56 A:271 39.0 0.17 G -54.7 -36.9 39.0 0.17 0.0 HOH
 2.644
 OH
 O
6ge4 1 Q15561 99.54 2e-165 X-RAY
 2018-09-19 TYR A:56 A:271 38.0 0.165 G -51.5 -41.5 38.0 0.165 0.0 HOH
 2.595
 O
 O
6gee 1 Q15561 99.54 2e-165 X-RAY
 2018-09-19 TYR A:56 A:271 35.0 0.152 G -54.5 -34.0 35.0 0.152 0.0 HOH
 2.613
 O
 O
5oaq 1 Q15561 100.0 5e-165 X-RAY
 2017-10-11 TYR A:57 A:271 34.0 0.148 G -52.3 -31.6 34.0 0.148 0.0 GOL
HOH
 6.582
2.495
 O
OH
 O2
O
6q2x 1 Q15561 100.0 5e-165 X-RAY
 2019-07-03 TYR A:57 A:271 34.0 0.148 G -46.8 -39.2 34.0 0.148 0.0 GOL
HOH
 6.479
2.447
 O
OH
 O2
O
6q36 1 Q15561 100.0 5e-165 X-RAY
 2019-07-03 TYR A:57 A:271 35.0 0.152 G -52.0 -38.3 35.0 0.152 0.0 HOH
 3.286
 N
 O
TYR B:57 B:271 32.0 0.139 G -47.5 -40.4 32.0 0.139 0.0 HOH
 3.827
 CB
 O
6ge6 1 Q15561 99.09 1e-164 X-RAY
 2018-09-19 TYR A:56 A:271 36.0 0.157 G -56.7 -36.8 36.0 0.157 0.0 HOH
 2.682
 OH
 O
6gei 1 Q15561 99.09 1e-164 X-RAY
 2018-09-19 TYR A:56 A:271 40.0 0.174 G -55.7 -34.5 40.0 0.174 0.0 HOH
 2.673
 O
 O
6sen 1 Q15561 99.54 5e-164 X-RAY
 2019-11-20 TYR A:57 A:271 117.0 0.509 G -46.1 -46.6 117.0 0.509 0.0 HOH
 3.990
 O
 O
TYR B:57 B:271 40.0 0.174 G -43.0 -51.6 NA NA NA
6seo 1 Q15561 99.54 5e-164 X-RAY
 2019-11-20 TYR A:57 A:271 37.0 0.161 G -34.6 -52.4 37.0 0.161 0.0 HOH
 9.844
 O
 O
4ln0 1 Q62296 96.35 3e-161 X-RAY
 2014-02-26 TYR A:59 A:264 35.0 0.152 G -51.3 -41.3 35.0 0.152 0.0 HOH
 8.344
 O
 O
TYR B:59 B:264 47.0 0.204 G -46.3 -40.6 47.0 0.204 0.0 GOL
 9.197
 N
 O2
6l9f 1 Q62296 96.35 3e-161 X-RAY
 2019-12-11 TYR A:59 A:264 34.0 0.148 G -54.2 -44.6 34.0 0.148 0.0 HOH
 7.603
 C
 O
TYR C:59 B:264 30.0 0.13 G -59.7 -33.1 NA NA NA
6sba 1 Q62296 96.35 9e-161 X-RAY
 2020-09-30 TYR A:58 A:264 91.0 0.396 G -53.2 -49.4 91.0 0.396 0.0 GOL
HOH
 8.733
3.053
 N
OH
 H11
O
3jua 1 Q62296 96.33 2e-160 X-RAY
 2010-02-23 TYR A:57 A:264 23.0 0.1 G -43.8 -40.0 23.0 0.1 0.0 HOH
 7.071
 CE1
 O
TYR C:57 C:264 31.0 0.135 G -58.0 -44.7 NA NA NA
TYR E:57 E:264 23.0 0.1 G -55.3 -37.0 NA NA NA
TYR G:57 G:264 51.0 0.222 G -55.5 -41.6 NA NA NA
5xjd 1 Q62296 96.33 2e-160 X-RAY
 2018-01-24 TYR A:57 A:264 24.0 0.104 G -52.8 -41.1 24.0 0.104 0.0
TYR B:57 B:264 33.0 0.143 G -53.2 -34.3 33.0 0.143 0.0 HOH
 3.766
 CD1
 O
5gn0 1 Q62296 96.33 4e-160 X-RAY
 2017-05-31 TYR A:62 A:264 49.0 0.213 G -61.2 -34.2 49.0 0.213 0.0 HOH
 7.794
 OH
 O
TYR B:62 B:264 39.0 0.17 G -61.8 -35.6 NA NA NA
TYR C:62 C:264 40.0 0.174 G -64.3 -34.8 NA NA NA
TYR D:62 D:264 35.0 0.152 G -61.8 -29.3 NA NA NA
5z2q 3 Q62296 96.31 1e-159 X-RAY
 2018-01-31 TYR C:64 A:264 37.0 0.161 G -58.4 -35.7 NA NA NA
5z2q 4 Q62296 96.31 2e-159 X-RAY
 2018-01-31 TYR D:66 B:264 44.0 0.191 G -50.4 -39.9 44.0 0.191 0.0
7cmm 1 P28347 81.45 8e-139 X-RAY
 2021-02-03 TYR A:67 A:263 29.0 0.126 T -63.0 -45.4 29.0 0.126 0.0
TYR B:67 B:263 53.0 0.23 G -55.6 -40.5 NA NA NA
TYR C:67 C:263 74.0 0.322 T -63.4 -48.4 NA NA NA
TYR D:67 D:263 43.0 0.187 G -57.0 -38.7 NA NA NA
4re1 1 P28347 81.28 2e-137 X-RAY
 2014-11-19 TYR A:57 A:248 36.0 0.157 G -47.4 -36.3 36.0 0.157 0.0 HOH
 6.797
 CE1
 O
TYR B:57 B:248 44.0 0.191 G -46.0 -37.5 NA NA NA
6hil 1 P28347 81.65 4e-137 X-RAY
 2019-04-03 TYR A:56 A:248 27.0 0.117 G -59.1 -36.3 27.0 0.117 0.0 HOH
 8.310
 OH
 O
TYR C:56 D:248 18.0 0.078 G -51.6 -45.5 NA NA NA
TYR E:56 B:248 22.0 0.096 G -56.6 -36.0 NA NA NA
TYR G:56 C:248 34.0 0.148 G -51.5 -42.0 NA NA NA
3kys 1 P28347 81.65 4e-137 X-RAY
 2010-02-23 TYR A:56 A:248 30.0 0.13 G -75.3 -21.6 30.0 0.13 0.0
TYR C:56 C:248 24.0 0.104 G -46.4 -37.0 NA NA NA
6im5 1 P28347 81.36 2e-136 X-RAY
 2019-02-06 TYR A:70 A:263 39.0 0.17 G -55.4 -36.9 39.0 0.17 0.0 HOH
 3.277
 N
 O
TYR B:70 B:263 32.0 0.139 G -56.5 -37.3 NA NA NA
7li5 1 E9PKB7 81.94 6e-136 X-RAY
 2022-02-02 TYR A:59 A:263 42.0 0.183 G -59.2 -38.9 42.0 0.183 0.0 HOH
 2.729
 OH
 O
TYR B:59 B:263 100.0 0.435 G -51.2 -51.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15561-f1 1 Q15561 100.0 0.0 TYR A:271 A:271 40.0 0.174 G -57.6 -39.4