Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 3131142 . G A CCDS31729.1:NM_003213.3:c.856Gaa>Aaa_NP_003204.2:p.286E>K Homo sapiens TEA domain transcription factor 4 (TEAD4), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6ge3 1 Q15561 100.0 3e-166 X-RAY
 2018-09-19 GLU A:71 A:286 123.0 0.647 H -59.1 -37.5 123.0 0.647 0.0 HOH
 2.858
 OE1
 O
6gec 1 Q15561 100.0 3e-166 X-RAY
 2018-09-19 GLU A:71 A:286 118.0 0.621 H -64.0 -34.5 118.0 0.621 0.0 HOH
 3.002
 OE1
 O
6ge5 1 Q15561 99.54 1e-165 X-RAY
 2018-09-19 GLU A:71 A:286 119.0 0.626 H -63.0 -37.0 119.0 0.626 0.0 HOH
 3.088
 OE1
 O
6geg 1 Q15561 99.54 1e-165 X-RAY
 2018-09-19 GLU A:71 A:286 120.0 0.632 H -63.7 -34.2 120.0 0.632 0.0 HOH
 2.997
 OE1
 O
6gek 1 Q15561 99.54 1e-165 X-RAY
 2018-09-19 GLU A:71 A:286 121.0 0.637 H -71.4 -31.2 121.0 0.637 0.0 HOH
 3.171
 OE2
 O
GLU C:71 B:286 121.0 0.637 H -68.5 -20.7 NA NA NA
6hik 1 Q15561 99.54 2e-165 X-RAY
 2019-04-03 GLU A:71 A:286 121.0 0.637 H -62.3 -38.0 121.0 0.637 0.0 HOH
 2.691
 O
 O
6ge4 1 Q15561 99.54 2e-165 X-RAY
 2018-09-19 GLU A:71 A:286 123.0 0.647 H -64.7 -34.3 123.0 0.647 0.0 HOH
 3.075
 OE1
 O
6gee 1 Q15561 99.54 2e-165 X-RAY
 2018-09-19 GLU A:71 A:286 120.0 0.632 H -66.3 -33.5 120.0 0.632 0.0 HOH
 2.734
 OE1
 O
5oaq 1 Q15561 100.0 5e-165 X-RAY
 2017-10-11 GLU A:72 A:286 120.0 0.632 H -62.6 -38.3 120.0 0.632 0.0 HOH
 3.608
 O
 O
6q2x 1 Q15561 100.0 5e-165 X-RAY
 2019-07-03 GLU A:72 A:286 116.0 0.611 H -66.4 -35.3 116.0 0.611 0.0 HOH
 4.167
 OE2
 O
6q36 1 Q15561 100.0 5e-165 X-RAY
 2019-07-03 GLU A:72 A:286 127.0 0.668 H -69.2 -34.7 127.0 0.668 0.0 HOH
 6.009
 C
 O
GLU B:72 B:286 128.0 0.674 H -67.7 -37.4 128.0 0.674 0.0 HOH
 2.870
 O
 O
6ge6 1 Q15561 99.09 1e-164 X-RAY
 2018-09-19 GLU A:71 A:286 120.0 0.632 H -64.0 -36.8 120.0 0.632 0.0 HOH
 3.646
 O
 O
6gei 1 Q15561 99.09 1e-164 X-RAY
 2018-09-19 GLU A:71 A:286 122.0 0.642 H -64.7 -34.8 122.0 0.642 0.0 HOH
 4.263
 OE2
 O
6sen 1 Q15561 99.54 5e-164 X-RAY
 2019-11-20 GLU A:72 A:286 114.0 0.6 H -61.8 -34.7 114.0 0.6 0.0 HOH
 2.587
 OE2
 O
GLU B:72 B:286 109.0 0.574 H -62.9 -27.4 NA NA NA
6seo 1 Q15561 99.54 5e-164 X-RAY
 2019-11-20 GLU A:72 A:286 129.0 0.679 H -63.6 -23.2 129.0 0.679 0.0 HOH
 6.011
 C
 O
4ln0 1 Q62296 96.35 3e-161 X-RAY
 2014-02-26 GLU A:74 A:279 71.0 NA H -62.1 -29.6 71.0 NA NA
GLU B:74 B:279 125.0 0.658 H -63.4 -30.0 125.0 0.658 0.0
6l9f 1 Q62296 96.35 3e-161 X-RAY
 2019-12-11 GLU A:74 A:279 85.0 NA H -58.0 -42.4 85.0 NA NA HOH
 5.849
 C
 O
GLU C:74 B:279 142.0 0.747 H -57.0 -32.0 NA NA NA
6sba 1 Q62296 96.35 9e-161 X-RAY
 2020-09-30 GLU A:73 A:279 95.0 0.5 H -67.2 -32.4 95.0 0.5 0.0 HOH
 2.626
 OE1
 O
3jua 1 Q62296 96.33 2e-160 X-RAY
 2010-02-23 GLU A:72 A:279 136.0 0.716 H -48.7 -38.5 136.0 0.716 0.0 HOH
 6.201
 C
 O
GLU C:72 C:279 130.0 0.684 H -67.6 -7.0 NA NA NA
GLU E:72 E:279 128.0 0.674 H -67.8 -10.9 NA NA NA
GLU G:72 G:279 160.0 0.842 H -85.2 -25.0 NA NA NA
5xjd 1 Q62296 96.33 2e-160 X-RAY
 2018-01-24 GLU A:72 A:279 120.0 0.632 H -66.1 -36.6 120.0 0.632 0.0 HOH
 7.719
 C
 O
GLU B:72 B:279 117.0 0.616 H -65.1 -37.2 117.0 0.616 0.0 HOH
 5.902
 C
 O
5gn0 1 Q62296 96.33 4e-160 X-RAY
 2017-05-31 GLU A:77 A:279 116.0 0.611 H -62.1 -34.3 116.0 0.611 0.0 HOH
 3.697
 OE2
 O
GLU B:77 B:279 131.0 0.689 H -62.7 -47.5 NA NA NA
GLU C:77 C:279 131.0 0.689 H -64.2 -46.3 NA NA NA
GLU D:77 D:279 142.0 0.747 H -65.4 -51.3 NA NA NA
5z2q 3 Q62296 96.31 1e-159 X-RAY
 2018-01-31 GLU C:79 A:279 133.0 0.7 H -65.0 -25.1 NA NA NA
5z2q 4 Q62296 96.31 2e-159 X-RAY
 2018-01-31 GLU D:81 B:279 159.0 0.837 H -57.5 -33.1 159.0 0.837 0.0
7cmm 1 P28347 81.45 8e-139 X-RAY
 2021-02-03 GLY A:82 A:278 68.0 0.907 H -62.1 -41.7 68.0 0.907 0.0
GLY B:82 B:278 65.0 0.867 H -68.9 -22.4 NA NA NA
GLY C:82 C:278 69.0 0.92 H -60.9 -39.8 NA NA NA
GLY D:82 D:278 63.0 0.84 H -67.3 -23.1 NA NA NA
4re1 1 P28347 81.28 2e-137 X-RAY
 2014-11-19 GLY A:72 A:263 57.0 0.76 H -70.4 -39.9 57.0 0.76 0.0 HOH
 6.048
 C
 O
GLY B:72 B:263 63.0 0.84 H -68.9 -38.1 NA NA NA
6hil 1 P28347 81.65 4e-137 X-RAY
 2019-04-03 GLY A:71 A:263 66.0 0.88 H -73.2 -44.0 66.0 0.88 0.0 HOH
 4.386
 O
 O
GLY C:71 D:263 54.0 0.72 H -65.0 -41.5 NA NA NA
GLY E:71 B:263 55.0 0.733 H -63.4 -53.2 NA NA NA
GLY G:71 C:263 56.0 0.747 H -56.3 -57.3 NA NA NA
3kys 1 P28347 81.65 4e-137 X-RAY
 2010-02-23 GLY A:71 A:263 68.0 0.907 H -82.1 -23.0 68.0 0.907 0.0 HOH
 5.382
 C
 O
GLY C:71 C:263 69.0 0.92 H -61.1 -42.2 NA NA NA
6im5 1 P28347 81.36 2e-136 X-RAY
 2019-02-06 GLY A:85 A:278 58.0 0.773 H -59.5 -37.9 58.0 0.773 0.0 HOH
 2.856
 O
 O
GLY B:85 B:278 56.0 0.747 H -59.8 -32.0 NA NA NA
7li5 1 E9PKB7 81.94 6e-136 X-RAY
 2022-02-02 GLY A:74 A:278 58.0 0.773 H -60.4 -35.1 58.0 0.773 0.0 HOH
 3.304
 O
 O
GLY B:74 B:278 56.0 0.747 H -59.5 -34.6 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15561-f1 1 Q15561 100.0 0.0 GLU A:286 A:286 105.0 0.553 H -69.8 -27.4