Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 50452691 . C A CCDS8796.1:NM_020039.3:c.142Ctg>Atg_NP_064423.2:p.48L>M Homo sapiens acid sensing ion channel subunit 1 (ASIC1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7rnn 2 P78348 91.46 0.0 EM
 2021-08-11 LEU B:48 D:48 66.0 NA H -64.6 -42.2 66.0 NA NA
6ave 1 Q1XA76 82.06 0.0 EM
 2018-03-21 LEU A:49 A:49 126.0 0.741 H -69.9 -36.9 126.0 0.741 0.0
LEU B:49 B:49 127.0 0.747 H -69.8 -37.0 127.0 0.747 0.0
LEU C:49 C:49 126.0 0.741 H -69.9 -36.9 126.0 0.741 0.0
6vtk 1 Q1XA76 82.06 0.0 EM
 2020-03-11 LEU A:49 A:49 119.0 0.7 H -77.3 -26.3 119.0 0.7 0.0
LEU B:49 C:49 119.0 0.7 H -77.2 -26.3 119.0 0.7 0.0
LEU C:49 B:49 119.0 0.7 H -77.2 -26.3 119.0 0.7 0.0
6vtl 1 Q1XA76 82.06 0.0 EM
 2020-03-11 LEU A:49 A:49 133.0 0.782 H -71.4 -40.0 133.0 0.782 0.0
LEU B:49 C:49 132.0 0.776 H -71.3 -40.1 132.0 0.776 0.0
LEU C:49 B:49 132.0 0.776 H -71.3 -40.1 132.0 0.776 0.0
7cfs 1 P78348 91.05 0.0 EM
 2020-10-21 LEU A:57 A:48 72.0 NA H -100.2 -27.7 72.0 NA NA
LEU B:57 B:48 73.0 NA H -100.2 -27.7 73.0 NA NA
LEU C:57 C:48 72.0 NA H -100.2 -27.7 72.0 NA NA
7cft 1 P78348 91.05 0.0 EM
 2020-10-21 LEU A:57 A:48 179.0 1.0 360.0 -28.4 172.0 1.0 0.0 C:P78348:0.041
LEU B:57 B:48 185.0 1.0 360.0 -28.4 178.0 1.0 0.0 A:P78348:0.041
LEU C:57 C:48 183.0 1.0 360.0 -28.4 177.0 1.0 0.0 B:P78348:0.035
6l6i 1 P78348 90.0 0.0 X-RAY
 2020-11-04 LEU A:38 A:48 108.0 0.635 H -69.5 -40.4 108.0 0.635 0.0
LEU B:38 B:48 137.0 0.806 H -57.4 -47.4 137.0 0.806 0.0
LEU C:38 C:48 126.0 0.741 H -58.3 -47.5 126.0 0.741 0.0
6l6n 1 P78348 90.0 0.0 X-RAY
 2021-01-13 LEU A:38 A:48 87.0 0.512 T -88.5 -28.4 87.0 0.512 0.0
LEU B:38 B:48 134.0 0.788 -95.8 4.4 134.0 0.788 0.0
LEU C:38 C:48 143.0 0.841 -92.0 -4.0 143.0 0.841 0.0
4nyk 1 Q1XA76 81.29 0.0 X-RAY
 2014-02-12 LEU A:53 A:49 64.0 NA H -69.9 -39.7 64.0 NA NA HOH
 5.378
 C
 O
3ij4 1 Q1XA76 81.29 0.0 X-RAY
 2009-11-10 LEU A:48 A:49 164.0 0.965 T -74.6 -40.1 164.0 0.965 0.0 HOH
 5.035
 N
 O
4fz0 1 Q1XA76 81.89 0.0 X-RAY
 2012-08-01 LEU A:36 NA:NA DO NA DO DO DO NA NA NA
LEU B:36 B:49 66.0 NA H -66.2 -30.2 66.0 NA NA
LEU C:36 C:49 126.0 0.741 H -91.8 -9.0 126.0 0.741 0.0
4fz1 1 Q1XA76 81.89 0.0 X-RAY
 2012-08-01 LEU A:36 A:49 55.0 NA H -60.1 -66.9 55.0 NA NA
4ntw 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 LEU A:36 A:49 115.0 0.676 H -57.5 -50.4 115.0 0.676 0.0
4ntx 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 LEU A:36 A:49 68.0 NA H -71.1 -47.4 68.0 NA NA HOH
 9.455
 CB
 O
4nty 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 LEU A:36 A:49 78.0 NA H -86.6 4.7 78.0 NA NA
6cmc 1 Q1XA76 81.89 0.0 X-RAY
 2018-08-08 LEU A:36 A:49 67.0 NA H -69.4 -39.7 67.0 NA NA
5wku 1 Q1XA76 81.52 0.0 X-RAY
 2018-03-14 LEU A:25 A:49 133.0 0.782 H -64.8 -40.2 133.0 0.782 0.0
LEU B:25 C:49 126.0 0.741 H -65.2 -37.4 126.0 0.741 0.0
LEU C:25 B:49 122.0 0.718 H -66.4 -40.4 122.0 0.718 0.0
5wkv 1 Q1XA76 81.52 0.0 X-RAY
 2018-03-14 LEU A:25 A:49 132.0 0.776 H -64.9 -40.4 132.0 0.776 0.0
LEU B:25 C:49 126.0 0.741 H -65.0 -37.6 126.0 0.741 0.0
LEU C:25 B:49 124.0 0.729 H -66.5 -40.7 124.0 0.729 0.0
5wkx 1 Q1XA76 81.52 0.0 X-RAY
 2018-08-08 LEU A:25 A:49 132.0 0.776 H -64.8 -40.2 132.0 0.776 0.0
LEU B:25 C:49 126.0 0.741 H -65.2 -37.4 126.0 0.741 0.0
LEU C:25 B:49 120.0 0.706 H -66.4 -40.4 120.0 0.706 0.0
5wky 1 Q1XA76 81.52 0.0 X-RAY
 2018-08-08 LEU A:25 A:49 133.0 0.782 H -64.8 -40.3 133.0 0.782 0.0
LEU B:25 C:49 125.0 0.735 H -65.2 -37.4 125.0 0.735 0.0
LEU C:25 B:49 121.0 0.712 H -66.4 -40.4 121.0 0.712 0.0
2qts 1 Q1XA76 81.48 0.0 X-RAY
 2007-09-25 LEU A:24 A:49 127.0 0.747 H -76.1 -40.3 127.0 0.747 0.0
LEU B:24 B:49 99.0 0.582 H -76.9 -31.6 99.0 0.582 0.0
LEU C:24 C:49 121.0 0.712 H -68.8 -42.0 121.0 0.712 0.0
LEU D:24 D:49 90.0 0.529 H -67.5 -20.8 NA NA NA
LEU E:24 E:49 74.0 0.435 H -76.4 -20.3 NA NA NA
LEU F:24 F:49 123.0 0.724 H -66.7 -39.1 NA NA NA
6x9h 1 Q1XA76 81.48 0.0 X-RAY
 2020-12-30 LEU A:24 A:49 122.0 0.718 H -66.9 -42.4 122.0 0.718 0.0
LEU B:24 B:49 118.0 0.694 H -57.4 -57.9 118.0 0.694 0.0
LEU C:24 C:49 162.0 0.953 -66.7 -49.2 162.0 0.953 0.0
3s3w 1 Q1XA76 81.48 0.0 X-RAY
 2012-05-23 LEU A:45 A:49 146.0 0.859 T -71.1 -27.4 146.0 0.859 0.0
LEU B:45 NA:NA DO NA DO DO DO NA NA NA
LEU C:45 C:49 118.0 0.694 H -62.8 -41.3 112.0 0.659 0.035 B:Q1XA76:0.035
3s3x 1 Q1XA76 81.48 0.0 X-RAY
 2012-05-23 LEU A:45 A:49 123.0 0.724 H -92.5 -14.5 123.0 0.724 0.0
LEU B:45 B:49 189.0 1.0 360.0 -36.6 189.0 1.0 0.0
LEU C:45 NA:NA DO NA DO DO DO NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p78348-f1 1 P78348 91.99 0.0 LEU A:48 A:48 122.0 0.718 H -64.5 -44.9