Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 50452740 . G A CCDS8796.1:NM_020039.3:c.191cGt>cAt_NP_064423.2:p.64R>H Homo sapiens acid sensing ion channel subunit 1 (ASIC1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7rnn 2 P78348 91.46 0.0 EM
 2021-08-11 ARG B:64 D:64 46.0 0.204 H -62.8 -39.7 46.0 0.204 0.0
6ave 1 Q1XA76 82.06 0.0 EM
 2018-03-21 ARG A:65 A:65 68.0 0.302 H -76.5 -29.6 13.0 0.058 0.244 C:Q1XA76:0.244
ARG B:65 B:65 71.0 0.316 H -76.6 -29.5 13.0 0.058 0.258 A:Q1XA76:0.258
ARG C:65 C:65 67.0 0.298 H -76.5 -29.5 13.0 0.058 0.24 B:Q1XA76:0.24
6vtk 1 Q1XA76 82.06 0.0 EM
 2020-03-11 ARG A:65 A:65 65.0 0.289 H -90.5 -28.7 15.0 0.067 0.222 B:Q1XA76:0.222
ARG B:65 C:65 65.0 0.289 H -90.5 -28.7 15.0 0.067 0.222 C:Q1XA76:0.222
ARG C:65 B:65 65.0 0.289 H -90.5 -28.7 14.0 0.062 0.227 A:Q1XA76:0.227
6vtl 1 Q1XA76 82.06 0.0 EM
 2020-03-11 ARG A:65 A:65 73.0 0.324 H -72.3 -22.8 15.0 0.067 0.257 B:Q1XA76:0.258
ARG B:65 C:65 72.0 0.32 H -72.3 -22.9 14.0 0.062 0.258 C:Q1XA76:0.258
ARG C:65 B:65 72.0 0.32 H -72.3 -22.9 14.0 0.062 0.258 A:Q1XA76:0.258
7cfs 1 P78348 91.05 0.0 EM
 2020-10-21 ARG A:73 A:64 69.0 0.307 T -103.8 -7.2 22.0 0.098 0.209 B:P78348:0.209
 Y01
NA
 8.045
6.188
 O
NH2
 CAK
NA
ARG B:73 B:64 67.0 0.298 T -103.8 -7.2 22.0 0.098 0.2 C:P78348:0.2
 NA
Y01
 6.203
7.978
 NH2
O
 NA
CAD
ARG C:73 C:64 69.0 0.307 T -103.9 -7.2 22.0 0.098 0.209 A:P78348:0.209
 NA
Y01
 6.213
7.966
 NH2
O
 NA
CAK
7cft 1 P78348 91.05 0.0 EM
 2020-10-21 ARG A:73 A:64 85.0 0.378 H -84.0 -16.4 37.0 0.164 0.214 C:P78348:0.213
ARG B:73 B:64 83.0 0.369 H -83.9 -16.4 33.0 0.147 0.222 A:P78348:0.222
ARG C:73 C:64 85.0 0.378 H -84.0 -16.4 37.0 0.164 0.214 B:P78348:0.213
6l6i 1 P78348 90.0 0.0 X-RAY
 2020-11-04 ARG A:54 A:64 90.0 0.4 H -66.0 -26.6 26.0 0.116 0.284 C:P78348:0.284
ARG B:54 B:64 44.0 0.196 H -61.7 -28.0 20.0 0.089 0.107 A:P78348:0.107
ARG C:54 C:64 101.0 0.449 H -66.1 -21.0 40.0 0.178 0.271 B:P78348:0.271
6l6n 1 P78348 90.0 0.0 X-RAY
 2021-01-13 ARG A:54 A:64 117.0 0.52 H -86.3 2.1 117.0 0.52 0.0
ARG B:54 B:64 126.0 0.56 H -87.4 3.1 126.0 0.56 0.0
ARG C:54 C:64 112.0 0.498 H -83.3 -0.9 112.0 0.498 0.0
4nyk 1 Q1XA76 81.29 0.0 X-RAY
 2014-02-12 ARG A:69 A:65 66.0 0.293 H -63.8 -20.5 13.0 0.058 0.235 A:Q1XA76:0.236
 HOH
 8.029
 NH1
 O
3ij4 1 Q1XA76 81.29 0.0 X-RAY
 2009-11-10 ARG A:64 A:65 67.0 0.298 H -73.3 -21.4 12.0 0.053 0.245 A:Q1XA76:0.244
 CS
CS
CS
CS
CS
CS
HOH
 6.643
8.100
6.643
8.100
6.643
8.100
8.178
 NH2
CD
NH2
CD
NH2
CD
NH1
 CS
CS
CS
CS
CS
CS
O
4fz0 1 Q1XA76 81.89 0.0 X-RAY
 2012-08-01 ARG A:52 A:65 28.0 NA H -76.9 -7.3 28.0 NA NA
ARG B:52 B:65 17.0 NA H -65.5 -25.2 17.0 NA NA
ARG C:52 C:65 96.0 0.427 H -60.2 -47.0 76.0 0.338 0.089 A:Q1XA76:0.089
4fz1 1 Q1XA76 81.89 0.0 X-RAY
 2012-08-01 ARG A:52 A:65 30.0 NA H -54.0 -29.2 30.0 NA NA
4ntw 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 ARG A:52 A:65 75.0 0.333 H -57.8 -34.2 75.0 0.333 0.0 NA
HOH
 6.292
7.535
 NH1
O
 NA
O
4ntx 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 ARG A:52 A:65 70.0 0.311 H -61.5 -31.8 70.0 0.311 0.0 NA
AMR
HOH
 7.049
8.371
7.371
 NH1
NE
O
 NA
N6
O
4nty 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 ARG A:52 A:65 67.0 0.298 H -85.1 -38.6 67.0 0.298 0.0 CS
HOH
 7.457
9.652
 NH1
O
 CS
O
6cmc 1 Q1XA76 81.89 0.0 X-RAY
 2018-08-08 ARG A:52 A:65 64.0 0.284 H -63.8 -21.0 10.0 0.044 0.24 A:Q1XA76:0.24
5wku 1 Q1XA76 81.52 0.0 X-RAY
 2018-03-14 ARG A:41 A:65 70.0 0.311 H -62.7 -34.4 13.0 0.058 0.253 B:Q1XA76:0.253
ARG B:41 C:65 69.0 0.307 H -64.9 -31.8 14.0 0.062 0.245 C:Q1XA76:0.244
ARG C:41 B:65 72.0 0.32 H -63.6 -34.3 15.0 0.067 0.253 A:Q1XA76:0.253
5wkv 1 Q1XA76 81.52 0.0 X-RAY
 2018-03-14 ARG A:41 A:65 70.0 0.311 H -62.7 -34.5 13.0 0.058 0.253 B:Q1XA76:0.253
ARG B:41 C:65 70.0 0.311 H -64.2 -32.2 13.0 0.058 0.253 C:Q1XA76:0.253
 CL
 9.661
 NH1
 CL
ARG C:41 B:65 70.0 0.311 H -63.1 -34.3 14.0 0.062 0.249 A:Q1XA76:0.249
5wkx 1 Q1XA76 81.52 0.0 X-RAY
 2018-08-08 ARG A:41 A:65 71.0 0.316 H -62.7 -34.4 13.0 0.058 0.258 B:Q1XA76:0.258
ARG B:41 C:65 67.0 0.298 H -64.9 -31.9 14.0 0.062 0.236 C:Q1XA76:0.236
ARG C:41 B:65 72.0 0.32 H -63.7 -34.3 14.0 0.062 0.258 A:Q1XA76:0.258
5wky 1 Q1XA76 81.52 0.0 X-RAY
 2018-08-08 ARG A:41 A:65 69.0 0.307 H -62.6 -34.4 13.0 0.058 0.249 B:Q1XA76:0.249
ARG B:41 C:65 68.0 0.302 H -64.9 -31.8 14.0 0.062 0.24 C:Q1XA76:0.24
ARG C:41 B:65 71.0 0.316 H -63.6 -34.4 15.0 0.067 0.249 A:Q1XA76:0.249
2qts 1 Q1XA76 81.48 0.0 X-RAY
 2007-09-25 ARG A:40 A:65 58.0 0.258 H -66.3 -34.2 58.0 0.258 0.0 GLC
GLC
HOH
 3.537
6.813
6.760
 CD
NH2
CG
 O1
O2
O
ARG B:40 B:65 72.0 0.32 H -73.6 -28.3 66.0 0.293 0.027 A:Q1XA76:0.027
 GLC
GLC
GLC
GLC
GLC
HOH
 7.516
3.328
4.770
2.916
9.852
3.308
 CD
CD
N
NH1
NH2
CG
 O4
O3
O3
O3
O2
O
ARG C:40 C:65 91.0 0.404 H -85.6 -22.4 57.0 0.253 0.151 B:Q1XA76:0.151
 GLC
GLC
GLC
GLC
HOH
 5.462
5.999
3.079
5.925
3.252
 NH2
NH1
NE
CG
NH1
 O3
C1
O2
C1
O
ARG D:40 D:65 64.0 0.284 H -73.2 -31.3 NA NA NA
ARG E:40 E:65 112.0 0.498 H -73.8 -14.5 NA NA NA
ARG F:40 F:65 91.0 0.404 H -80.1 -10.4 NA NA NA
6x9h 1 Q1XA76 81.48 0.0 X-RAY
 2020-12-30 ARG A:40 A:65 69.0 0.307 H -71.4 -16.9 13.0 0.058 0.249 B:Q1XA76:0.249
 NA
 7.065
 NH2
 NA
ARG B:40 B:65 68.0 0.302 H -71.2 -19.3 17.0 0.076 0.226 C:Q1XA76:0.227
 NA
 7.060
 NH2
 NA
ARG C:40 C:65 70.0 0.311 H -70.8 -19.0 15.0 0.067 0.244 A:Q1XA76:0.244
 NA
 7.029
 NH2
 NA
3s3w 1 Q1XA76 81.48 0.0 X-RAY
 2012-05-23 ARG A:61 A:65 78.0 0.347 H -65.1 -42.8 51.0 0.227 0.12 C:Q1XA76:0.12
ARG B:61 B:65 92.0 0.409 H -69.0 -39.5 51.0 0.227 0.182 A:Q1XA76:0.182
ARG C:61 C:65 59.0 0.262 H -76.8 -60.8 34.0 0.151 0.111 B:Q1XA76:0.111
3s3x 1 Q1XA76 81.48 0.0 X-RAY
 2012-05-23 ARG A:61 A:65 107.0 0.476 H -105.1 -16.3 57.0 0.253 0.223 C:Q1XA76:0.222
ARG B:61 B:65 103.0 0.458 H -68.7 -23.5 94.0 0.418 0.04 A:Q1XA76:0.04
ARG C:61 C:65 121.0 0.538 H -47.0 -47.1 121.0 0.538 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p78348-f1 1 P78348 91.99 0.0 ARG A:64 A:64 71.0 0.316 H -65.5 -38.9