Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 50452781 . G A CCDS8796.1:NM_020039.3:c.232Gac>Aac_NP_064423.2:p.78D>N Homo sapiens acid sensing ion channel subunit 1 (ASIC1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7rnn 2 P78348 91.46 0.0 EM
 2021-08-11 ASP B:78 D:78 84.0 0.56 E -149.9 158.9 84.0 0.56 0.0
6ave 1 Q1XA76 82.06 0.0 EM
 2018-03-21 ASP A:79 A:79 73.0 0.487 E -148.2 158.3 43.0 0.287 0.2 B:Q1XA76:0.2
ASP B:79 B:79 71.0 0.473 E -148.1 158.3 44.0 0.293 0.18 C:Q1XA76:0.18
ASP C:79 C:79 71.0 0.473 E -148.2 158.2 42.0 0.28 0.193 A:Q1XA76:0.193
6vtk 1 Q1XA76 82.06 0.0 EM
 2020-03-11 ASP A:79 A:79 71.0 0.473 E -93.3 136.7 35.0 0.233 0.24 C:Q1XA76:0.24
ASP B:79 C:79 72.0 0.48 E -93.3 136.7 36.0 0.24 0.24 A:Q1XA76:0.24
ASP C:79 B:79 70.0 0.467 E -93.4 136.8 35.0 0.233 0.234 B:Q1XA76:0.233
6vtl 1 Q1XA76 82.06 0.0 EM
 2020-03-11 ASP A:79 A:79 80.0 0.533 E -153.9 152.3 34.0 0.227 0.306 C:Q1XA76:0.307
ASP B:79 C:79 79.0 0.527 E -153.9 152.3 33.0 0.22 0.307 A:Q1XA76:0.307
ASP C:79 B:79 78.0 0.52 E -153.9 152.3 35.0 0.233 0.287 B:Q1XA76:0.287
7cfs 1 P78348 91.05 0.0 EM
 2020-10-21 ASP A:87 A:78 76.0 0.507 E -132.5 163.6 36.0 0.24 0.267 C:P78348:0.267
ASP B:87 B:78 78.0 0.52 E -132.5 163.5 39.0 0.26 0.26 A:P78348:0.26
ASP C:87 C:78 76.0 0.507 E -132.5 163.5 37.0 0.247 0.26 B:P78348:0.26
7cft 1 P78348 91.05 0.0 EM
 2020-10-21 ASP A:87 A:78 69.0 0.46 -115.1 173.3 33.0 0.22 0.24 B:P78348:0.24
ASP B:87 B:78 69.0 0.46 -115.2 173.3 31.0 0.207 0.253 C:P78348:0.253
ASP C:87 C:78 69.0 0.46 -115.1 173.2 32.0 0.213 0.247 A:P78348:0.247
6l6i 1 P78348 90.0 0.0 X-RAY
 2020-11-04 ASP A:68 A:78 81.0 0.54 E -151.2 160.2 24.0 0.16 0.38 B:P78348:0.38
ASP B:68 B:78 80.0 0.533 E -152.0 155.7 28.0 0.187 0.346 C:P78348:0.347
ASP C:68 C:78 96.0 0.64 E -150.8 155.3 42.0 0.28 0.36 A:P78348:0.36
6l6n 1 P78348 90.0 0.0 X-RAY
 2021-01-13 ASP A:68 A:78 95.0 0.633 E -151.1 152.2 25.0 0.167 0.466 B:P78348:0.467
 HOH
 8.843
 N
 O
ASP B:68 B:78 94.0 0.627 E -150.5 153.4 28.0 0.187 0.44 C:P78348:0.44
 HOH
 5.975
 OD2
 O
ASP C:68 C:78 98.0 0.653 E -150.5 154.6 29.0 0.193 0.46 A:P78348:0.46
 HOH
 8.797
 O
 O
4nyk 1 Q1XA76 81.29 0.0 X-RAY
 2014-02-12 ASP A:83 A:79 69.0 0.46 E -126.3 108.6 20.0 0.133 0.327 A:Q1XA76:0.327
 HOH
 2.935
 OD2
 O
3ij4 1 Q1XA76 81.29 0.0 X-RAY
 2009-11-10 ASP A:78 A:79 69.0 0.46 E -127.6 105.3 22.0 0.147 0.313 A:Q1XA76:0.313
 HOH
 2.799
 OD2
 O
4fz0 1 Q1XA76 81.89 0.0 X-RAY
 2012-08-01 ASP A:66 A:79 107.0 0.713 E -147.6 139.0 38.0 0.253 0.46 C:Q1XA76:0.46
 HOH
 6.716
 OD1
 O
ASP B:66 B:79 104.0 0.693 E -147.8 138.8 35.0 0.233 0.46 A:Q1XA76:0.46
 HOH
 8.509
 O
 O
ASP C:66 C:79 103.0 0.687 E -147.2 136.8 35.0 0.233 0.454 B:Q1XA76:0.453
 HOH
 3.311
 OD1
 O
4fz1 1 Q1XA76 81.89 0.0 X-RAY
 2012-08-01 ASP A:66 A:79 104.0 0.693 E -139.2 135.6 61.0 0.407 0.286 A:Q1XA76:0.287
4ntw 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 ASP A:66 A:79 80.0 0.533 E -148.2 137.2 80.0 0.533 0.0 HOH
 3.371
 CB
 O
4ntx 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 ASP A:66 A:79 79.0 0.527 E -154.5 146.6 79.0 0.527 0.0 HOH
 3.443
 CB
 O
4nty 1 Q1XA76 81.89 0.0 X-RAY
 2014-02-19 ASP A:66 A:79 79.0 0.527 E -164.0 138.3 45.0 0.3 0.227 A:Q1XA76:0.227
 HOH
 7.790
 OD2
 O
6cmc 1 Q1XA76 81.89 0.0 X-RAY
 2018-08-08 ASP A:66 A:79 70.0 0.467 E -126.5 108.2 23.0 0.153 0.314 A:Q1XA76:0.313
5wku 1 Q1XA76 81.52 0.0 X-RAY
 2018-03-14 ASP A:55 A:79 86.0 0.573 E -147.9 155.4 27.0 0.18 0.393 C:Q1XA76:0.393
 CL
 8.563
 OD2
 CL
ASP B:55 C:79 80.0 0.533 E -146.7 156.6 37.0 0.247 0.286 A:Q1XA76:0.287
 NAG
CL
 9.870
8.029
 CB
OD2
 O6
CL
ASP C:55 B:79 82.0 0.547 E -146.8 156.3 30.0 0.2 0.347 B:Q1XA76:0.347
 CL
 8.893
 OD2
 CL
5wkv 1 Q1XA76 81.52 0.0 X-RAY
 2018-03-14 ASP A:55 A:79 83.0 0.553 E -147.6 155.1 24.0 0.16 0.393 C:Q1XA76:0.393
 CL
CA
 8.156
9.525
 OD2
O
 CL
CA
ASP B:55 C:79 80.0 0.533 E -146.2 156.0 37.0 0.247 0.286 A:Q1XA76:0.287
 CA
 9.417
 O
 CA
ASP C:55 B:79 80.0 0.533 E -146.4 156.0 31.0 0.207 0.326 B:Q1XA76:0.327
 CL
CA
 9.814
9.722
 OD2
O
 CL
CA
5wkx 1 Q1XA76 81.52 0.0 X-RAY
 2018-08-08 ASP A:55 A:79 85.0 0.567 E -147.9 155.3 26.0 0.173 0.394 C:Q1XA76:0.393
 CL
 8.563
 OD2
 CL
ASP B:55 C:79 79.0 0.527 E -146.7 156.6 38.0 0.253 0.274 A:Q1XA76:0.273
 NAG
CL
 9.871
8.029
 CB
OD2
 O6
CL
ASP C:55 B:79 81.0 0.54 E -146.8 156.3 29.0 0.193 0.347 B:Q1XA76:0.347
 CL
 8.893
 OD2
 CL
5wky 1 Q1XA76 81.52 0.0 X-RAY
 2018-08-08 ASP A:55 A:79 86.0 0.573 E -147.9 155.4 28.0 0.187 0.386 C:Q1XA76:0.387
 CL
 8.564
 OD2
 CL
ASP B:55 C:79 82.0 0.547 E -146.7 156.6 38.0 0.253 0.294 A:Q1XA76:0.293
 NAG
CL
 9.871
8.028
 CB
OD2
 O6
CL
ASP C:55 B:79 81.0 0.54 E -146.8 156.4 30.0 0.2 0.34 B:Q1XA76:0.34
 CL
 8.893
 OD2
 CL
2qts 1 Q1XA76 81.48 0.0 X-RAY
 2007-09-25 ASP A:54 A:79 104.0 0.693 E -160.9 139.8 32.0 0.213 0.48 B:Q1XA76:0.48
 HOH
 2.424
 OD2
 O
ASP B:54 B:79 103.0 0.687 E -158.5 142.4 31.0 0.207 0.48 C:Q1XA76:0.48
 HOH
 2.507
 OD2
 O
ASP C:54 C:79 107.0 0.713 E -153.4 133.7 35.0 0.233 0.48 A:Q1XA76:0.48
 HOH
 2.553
 OD2
 O
ASP D:54 D:79 105.0 0.7 E -160.8 137.4 NA NA NA
ASP E:54 E:79 104.0 0.693 E -158.6 139.3 NA NA NA
ASP F:54 F:79 103.0 0.687 E -159.3 138.2 NA NA NA
6x9h 1 Q1XA76 81.48 0.0 X-RAY
 2020-12-30 ASP A:54 A:79 79.0 0.527 E -147.2 153.8 28.0 0.187 0.34 C:Q1XA76:0.34
ASP B:54 B:79 79.0 0.527 E -146.9 157.4 24.0 0.16 0.367 A:Q1XA76:0.367
ASP C:54 C:79 82.0 0.547 E -151.1 157.4 14.0 0.093 0.454 B:Q1XA76:0.453
3s3w 1 Q1XA76 81.48 0.0 X-RAY
 2012-05-23 ASP A:75 A:79 109.0 0.727 E -156.2 141.5 29.0 0.193 0.534 B:Q1XA76:0.533
 HOH
 2.444
 OD1
 O
ASP B:75 B:79 107.0 0.713 E -156.2 141.2 29.0 0.193 0.52 C:Q1XA76:0.52
 HOH
 4.108
 N
 O
ASP C:75 C:79 108.0 0.72 E -156.5 141.1 29.0 0.193 0.527 A:Q1XA76:0.527
 HOH
 4.587
 OD1
 O
3s3x 1 Q1XA76 81.48 0.0 X-RAY
 2012-05-23 ASP A:75 A:79 100.0 0.667 E -163.1 108.4 40.0 0.267 0.4 B:Q1XA76:0.4
 K
 8.884
 N
 K
ASP B:75 B:79 100.0 0.667 E -163.2 108.3 42.0 0.28 0.387 C:Q1XA76:0.387
 K
 8.845
 N
 K
ASP C:75 C:79 100.0 0.667 E -163.3 108.2 40.0 0.267 0.4 A:Q1XA76:0.4
 K
 8.983
 N
 K

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p78348-f1 1 P78348 91.99 0.0 ASP A:78 A:78 63.0 0.42 E -143.3 136.7