Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128202 . G A CCDS8539.1:NM_000552.3:c.4382gCc>gTc_NP_000543.2:p.1461A>V Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
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auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 ALA A:236 A:1461 4.0 0.035 S -90.7 151.0 4.0 0.035 0.0 HOH
 2.649
 O
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 ALA A:203 A:698 4.0 0.035 S -95.0 146.9 4.0 0.035 0.0 HOH
 5.976
 CA
 O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 ALA C:202 C:698 9.0 0.078 S -91.4 151.7 9.0 0.078 0.0 HOH
 8.698
 C
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ALA A:202 A:698 5.0 0.043 S -105.3 147.9 5.0 0.043 0.0 HOH
 3.853
 C
 O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ALA A:202 A:698 5.0 0.043 S -111.6 149.6 5.0 0.043 0.0 HOH
 5.719
 N
 O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 ALA A:225 A:225 4.0 0.035 S -102.5 149.8 4.0 0.035 0.0 HOH
 5.088
 N
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 ALA A:201 A:698 4.0 0.035 S -71.4 153.2 4.0 0.035 0.0 HOH
 2.642
 O
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 ALA A:201 A:698 10.0 0.087 S -107.6 156.3 10.0 0.087 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 ALA A:201 A:698 11.0 0.096 S -102.6 156.2 11.0 0.096 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 ALA A:200 AAA:1461 6.0 0.052 S -103.1 155.5 6.0 0.052 0.0 HOH
 2.242
 HB2
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ALA A:199 A:698 4.0 0.035 S -81.6 153.1 4.0 0.035 0.0 HOH
 2.753
 O
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ALA A:199 A:698 5.0 0.043 S -103.8 147.5 5.0 0.043 0.0 HOH
 9.028
 O
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 ALA A:203 A:698 8.0 0.07 S -96.1 148.9 8.0 0.07 0.0 HOH
 6.440
 CA
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 ALA A:199 A:1461 10.0 0.087 S -91.1 154.9 10.0 0.087 0.0 HOH
 5.476
 CA
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 ALA C:192 A:698 5.0 0.043 S -111.6 151.2 5.0 0.043 0.0 HOH
 4.254
 O
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 ALA C:192 A:698 4.0 0.035 S -102.6 147.7 4.0 0.035 0.0 HOH
 4.392
 O
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ALA A:199 A:1461 3.0 0.026 S -90.0 143.6 3.0 0.026 0.0 HOH
 7.110
 N
 O
ALA B:199 B:1461 3.0 0.026 S -94.0 143.0 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ALA A:199 A:1461 3.0 0.026 S -98.8 139.3 3.0 0.026 0.0
ALA C:199 C:1461 4.0 0.035 S -106.9 144.0 NA NA NA
ALA E:199 E:1461 3.0 0.026 S -116.5 135.1 NA NA NA
ALA G:199 G:1461 4.0 0.035 S -101.0 133.1 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 ALA C:201 C:698 11.0 0.096 -112.6 144.3 11.0 0.096 0.0 HOH
 4.289
 CA
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f2 1 P04275 99.93 0.0 ALA A:1261 A:1261 8.0 0.07 S -108.3 139.2
af-p04275-f3 1 P04275 99.93 0.0 ALA A:1061 A:1061 8.0 0.07 S -110.6 134.6
af-p04275-f6 1 P04275 100.0 0.0 ALA A:461 A:461 6.0 0.052 S -103.8 133.8
af-p04275-f5 1 P04275 99.93 0.0 ALA A:661 A:661 7.0 0.061 S -107.1 134.3
af-p04275-f8 1 P04275 100.0 0.0 ALA A:61 A:61 65.0 0.565 S -75.6 131.0
af-p04275-f7 1 P04275 100.0 0.0 ALA A:261 A:261 9.0 0.078 S -124.3 140.4
af-p04275-f4 1 P04275 99.93 0.0 ALA A:861 A:861 8.0 0.07 S -116.0 134.9