Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128275 . C A CCDS8539.1:NM_000552.3:c.4309Gcc>Tcc_NP_000543.2:p.1437A>S Homo sapiens von Willebrand factor (VWF), mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 ALA A:212 A:1437 15.0 0.13 -94.7 147.0 15.0 0.13 0.0 HOH
 2.830
 O
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 ALA A:179 A:674 19.0 0.165 -89.6 143.4 19.0 0.165 0.0 HOH
 3.991
 O
 O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 ALA C:178 C:674 11.0 0.096 -98.3 156.9 4.0 0.035 0.061 B:2134245:0.061
 HOH
 5.001
 N
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ALA A:178 A:674 5.0 0.043 -101.9 153.6 5.0 0.043 0.0 HOH
 3.192
 O
 O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ALA A:178 A:674 16.0 0.139 -125.7 150.9 16.0 0.139 0.0 HOH
 3.317
 O
 O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 ALA A:201 A:201 12.0 0.104 -111.6 148.5 12.0 0.104 0.0 HOH
 6.197
 N
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 ALA A:177 A:674 15.0 0.13 -95.3 148.8 15.0 0.13 0.0 HOH
 5.447
 N
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 ALA A:177 A:674 14.0 0.122 -124.1 151.3 14.0 0.122 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 ALA A:177 A:674 11.0 0.096 -94.5 171.1 11.0 0.096 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 ALA A:176 AAA:1437 11.0 0.096 -113.2 151.2 11.0 0.096 0.0 HOH
 4.987
 HB3
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ALA A:175 A:674 12.0 0.104 -96.2 148.8 12.0 0.104 0.0 HOH
 2.629
 O
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ALA A:175 A:674 17.0 0.148 -96.6 146.0 17.0 0.148 0.0 HOH
 3.987
 O
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 ALA A:179 A:674 14.0 0.122 -112.6 160.5 14.0 0.122 0.0 HOH
 2.646
 O
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 ALA A:175 A:1437 20.0 0.174 -104.3 147.8 20.0 0.174 0.0 HOH
 4.588
 O
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 ALA C:168 A:674 14.0 0.122 -104.2 143.2 14.0 0.122 0.0 HOH
 3.602
 O
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 ALA C:168 A:674 11.0 0.096 -100.0 149.0 11.0 0.096 0.0 HOH
 2.932
 O
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ALA A:175 A:1437 14.0 0.122 -98.0 136.7 14.0 0.122 0.0 HOH
 2.973
 O
 O
ALA B:175 B:1437 12.0 0.104 -96.9 138.3 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ALA A:175 A:1437 19.0 0.165 -108.2 155.9 19.0 0.165 0.0
ALA C:175 C:1437 18.0 0.157 -115.2 153.1 NA NA NA
ALA E:175 E:1437 22.0 0.191 -108.1 153.5 NA NA NA
ALA G:175 G:1437 18.0 0.157 -118.6 147.0 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 ALA C:177 C:674 18.0 0.157 -128.8 164.2 18.0 0.157 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f2 1 P04275 99.93 0.0 ALA A:1237 A:1237 16.0 0.139 -89.2 147.7
af-p04275-f3 1 P04275 99.93 0.0 ALA A:1037 A:1037 17.0 0.148 -89.9 147.3
af-p04275-f6 1 P04275 100.0 0.0 ALA A:437 A:437 17.0 0.148 -87.7 143.9
af-p04275-f5 1 P04275 99.93 0.0 ALA A:637 A:637 19.0 0.165 -91.3 146.0
af-p04275-f8 1 P04275 100.0 0.0 ALA A:37 A:37 21.0 0.183 -90.0 141.5
af-p04275-f7 1 P04275 100.0 0.0 ALA A:237 A:237 20.0 0.174 -89.8 146.7
af-p04275-f4 1 P04275 99.93 0.0 ALA A:837 A:837 17.0 0.148 -90.4 148.2