Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128308 . G A CCDS8539.1:NM_000552.3:c.4276Cgc>Tgc_NP_000543.2:p.1426R>C Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 ARG A:201 A:1426 71.0 NA H -64.2 -36.6 71.0 NA NA HOH
 2.765
 O
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 ARG A:168 A:663 133.0 0.591 H -64.0 -42.9 133.0 0.591 0.0 OMG
OMG
A2M
HOH
 8.838
7.388
8.039
3.672
 NH1
NH1
O
CB
 O3'
OP1
OP1
O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 ARG C:167 C:663 128.0 0.569 H -62.8 -40.8 27.0 0.12 0.449 B:2134245:0.449
 HOH
 8.434
 O
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:167 A:663 122.0 0.542 H -67.0 -29.1 122.0 0.542 0.0 DC
DC
DT
HOH
 7.775
9.819
8.154
3.136
 CG
CB
CB
NH1
 O2
O3'
OP2
O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:167 A:663 160.0 0.711 H -61.5 -38.2 160.0 0.711 0.0 DC
DC
DT
HOH
 6.882
7.768
7.849
3.519
 NH1
NH1
NH1
CG
 O2
OP2
OP2
O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 ARG A:190 A:190 131.0 0.582 H -65.7 -36.3 131.0 0.582 0.0 HOH
 3.680
 CB
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 ARG A:166 A:663 116.0 0.516 H -70.3 -31.1 116.0 0.516 0.0 HOH
 7.408
 O
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 ARG A:166 A:663 105.0 0.467 H -67.1 -30.0 41.0 0.182 0.285 B:P22029:0.093
C:P22030:0.253
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 ARG A:166 A:663 102.0 0.453 H -78.6 -46.5 102.0 0.453 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 ARG A:165 AAA:1426 123.0 0.547 H -67.5 -43.9 123.0 0.547 0.0 HOH
 2.240
 HH22
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:164 A:663 121.0 0.538 H -64.3 -38.4 121.0 0.538 0.0 HOH
 2.697
 O
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:164 A:663 159.0 0.707 H -62.0 -56.2 76.0 0.338 0.369 C:P22030:0.369
B:P22029:0.013
 HOH
 6.670
 NH2
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 ARG A:168 A:663 133.0 0.591 H -64.3 -51.8 133.0 0.591 0.0 HOH
 3.917
 NE
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 ARG A:164 A:1426 142.0 0.631 H -67.5 -39.0 142.0 0.631 0.0 HOH
 3.761
 CB
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 ARG C:157 A:663 138.0 0.613 H -66.4 -42.5 138.0 0.613 0.0 HOH
 2.997
 NH2
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 ARG C:157 A:663 118.0 0.524 H -69.2 -36.7 118.0 0.524 0.0 HOH
 2.750
 O
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:164 A:1426 121.0 0.538 H -67.2 -36.9 121.0 0.538 0.0 PEG
HOH
 9.123
3.220
 N
NH2
 O4
O
ARG B:164 B:1426 126.0 0.56 H -67.2 -37.8 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:164 A:1426 160.0 0.711 H -69.6 -28.7 160.0 0.711 0.0 HOH
 8.573
 N
 O
ARG C:164 C:1426 150.0 0.667 H -68.8 -31.6 NA NA NA
ARG E:164 E:1426 141.0 0.627 H -73.7 -29.1 NA NA NA
ARG G:164 G:1426 139.0 0.618 H -70.4 -29.6 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 ARG C:166 C:663 83.0 0.369 H -63.0 -37.3 83.0 0.369 0.0 HOH
 7.048
 C
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f2 1 P04275 99.93 0.0 ARG A:1226 A:1226 160.0 0.711 H -61.5 -26.9
af-p04275-f3 1 P04275 99.93 0.0 ARG A:1026 A:1026 158.0 0.702 H -62.5 -27.4
af-p04275-f6 1 P04275 100.0 0.0 ARG A:426 A:426 156.0 0.693 H -62.2 -27.3
af-p04275-f5 1 P04275 99.93 0.0 ARG A:626 A:626 158.0 0.702 H -61.5 -26.8
af-p04275-f8 1 P04275 100.0 0.0 ARG A:26 A:26 154.0 0.684 H -64.5 -21.7
af-p04275-f7 1 P04275 100.0 0.0 ARG A:226 A:226 157.0 0.698 H -64.4 -12.5
af-p04275-f4 1 P04275 99.93 0.0 ARG A:826 A:826 161.0 0.716 H -62.5 -28.3