Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128311 . T A CCDS8539.1:NM_000552.3:c.4273Atc>Ttc_NP_000543.2:p.1425I>F Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 ILE A:200 A:1425 1.0 0.006 H -64.1 -44.1 1.0 0.006 0.0 HOH
 4.440
 CG2
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 ILE A:167 A:662 2.0 0.011 H -58.9 -47.6 2.0 0.011 0.0 OMG
HOH
 9.307
4.304
 N
CG2
 OP1
O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 ILE C:166 C:662 6.0 0.034 H -62.2 -47.6 0.0 0.0 0.034 B:2134245:0.034
 HOH
 8.563
 O
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ILE A:166 A:662 0.0 0.0 H -57.1 -49.7 0.0 0.0 0.0 DC
DC
DT
HOH
 7.232
9.150
9.032
6.441
 N
N
N
CG2
 O2
O2
O4
O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ILE A:166 A:662 2.0 0.011 H -57.0 -55.2 2.0 0.011 0.0 DC
DC
DT
HOH
 7.328
9.666
8.988
5.076
 N
N
N
CG2
 O2
O2
O4
O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 ILE A:189 A:189 0.0 0.0 H -60.9 -45.7 0.0 0.0 0.0 HOH
 5.865
 CD1
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 ILE A:165 A:662 0.0 0.0 H -59.2 -41.4 0.0 0.0 0.0 HOH
 7.389
 O
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 ILE A:165 A:662 3.0 0.017 H -57.0 -47.6 3.0 0.017 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 ILE A:165 A:662 0.0 0.0 H -73.1 -30.1 0.0 0.0 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 ILE A:164 AAA:1425 1.0 0.006 H -54.4 -45.7 1.0 0.006 0.0 HOH
 4.913
 HD13
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ILE A:163 A:662 0.0 0.0 H -58.9 -45.0 0.0 0.0 0.0 HOH
 5.431
 O
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ILE A:163 A:662 4.0 0.023 H -55.8 -45.4 4.0 0.023 0.0 HOH
 7.198
 CG1
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 ILE A:167 A:662 6.0 0.034 H -63.2 -41.9 6.0 0.034 0.0 HOH
 4.328
 CG2
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 ILE A:163 A:1425 4.0 0.023 H -63.0 -43.7 4.0 0.023 0.0 HOH
 5.981
 N
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 ILE C:156 A:662 2.0 0.011 H -68.7 -45.5 2.0 0.011 0.0 HOH
 4.378
 CG2
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 ILE C:156 A:662 0.0 0.0 H -62.5 -45.4 0.0 0.0 0.0 HOH
 5.425
 O
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ILE A:163 A:1425 6.0 0.034 H -61.3 -46.4 6.0 0.034 0.0 PEG
HOH
 7.572
5.662
 N
CD1
 O4
O
ILE B:163 B:1425 6.0 0.034 H -60.3 -46.1 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ILE A:163 A:1425 9.0 0.051 H -69.0 -46.3 9.0 0.051 0.0 HOH
 7.209
 N
 O
ILE C:163 C:1425 5.0 0.029 H -64.0 -44.4 NA NA NA
ILE E:163 E:1425 7.0 0.04 H -62.7 -43.2 NA NA NA
ILE G:163 G:1425 8.0 0.046 H -65.7 -48.4 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 ILE C:165 C:662 4.0 0.023 H -69.6 -39.7 4.0 0.023 0.0 HOH
 9.588
 C
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f2 1 P04275 99.93 0.0 ILE A:1225 A:1225 2.0 0.011 H -54.6 -52.2
af-p04275-f3 1 P04275 99.93 0.0 ILE A:1025 A:1025 2.0 0.011 H -54.8 -50.9
af-p04275-f6 1 P04275 100.0 0.0 ILE A:425 A:425 3.0 0.017 H -54.6 -52.3
af-p04275-f5 1 P04275 99.93 0.0 ILE A:625 A:625 3.0 0.017 H -55.0 -51.7
af-p04275-f8 1 P04275 100.0 0.0 ILE A:25 A:25 18.0 0.103 H -59.0 -51.9
af-p04275-f7 1 P04275 100.0 0.0 ILE A:225 A:225 3.0 0.017 H -53.8 -54.2
af-p04275-f4 1 P04275 99.93 0.0 ILE A:825 A:825 3.0 0.017 H -55.3 -51.1