Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128327 . A C CCDS8539.1:NM_000552.3:c.4257caT>caG_NP_000543.2:p.1419H>Q Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 HIS A:194 A:1419 86.0 0.441 T -87.9 -5.6 86.0 0.441 0.0 HOH
 2.907
 ND1
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 HIS A:161 A:656 82.0 0.421 T -107.8 1.8 82.0 0.421 0.0 HOH
 2.819
 N
 O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 HIS C:160 C:656 80.0 0.41 -103.4 -1.5 79.0 0.405 0.005 B:2134245:0.005
 HOH
 8.262
 C
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 HIS A:160 A:656 77.0 0.395 T -102.4 -4.2 77.0 0.395 0.0 DT
DG
DC
DC
HOH
 9.518
6.008
3.931
8.713
2.993
 CD2
CD2
C
O
N
 C2'
C2'
N4
N3
O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 HIS A:160 A:656 85.0 0.436 T -104.4 1.3 85.0 0.436 0.0 DT
DG
DC
DC
HOH
 9.355
5.676
3.960
9.114
2.865
 ND1
ND1
C
O
N
 C2'
C2'
N4
N3
O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 HIS A:183 A:183 86.0 0.441 T -103.9 6.8 86.0 0.441 0.0 HOH
 2.904
 NE2
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 HIS A:159 A:656 89.0 0.456 T -81.6 -6.5 89.0 0.456 0.0 HOH
 2.917
 N
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 HIS A:159 A:656 83.0 0.426 T -105.3 -13.5 83.0 0.426 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 HIS A:159 A:656 61.0 0.313 T -107.8 13.6 61.0 0.313 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 HIS A:158 AAA:1419 85.0 0.436 T -87.1 -18.4 85.0 0.436 0.0 HOH
 2.027
 HE2
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 HIS A:157 A:656 87.0 0.446 T -88.2 -4.4 87.0 0.446 0.0 HOH
 2.799
 ND1
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 HIS A:157 A:656 76.0 0.39 T -111.4 -7.6 76.0 0.39 0.0 HOH
 2.599
 N
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 HIS A:161 A:656 83.0 0.426 T -105.5 18.0 83.0 0.426 0.0 HOH
 3.136
 N
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 HIS A:157 A:1419 82.0 0.421 T -111.6 11.9 82.0 0.421 0.0 HOH
 3.165
 N
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 HIS C:150 A:656 82.0 0.421 T -112.0 -6.2 82.0 0.421 0.0 HOH
 2.656
 NE2
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 HIS C:150 A:656 81.0 0.415 T -97.3 4.8 81.0 0.415 0.0 HOH
 2.832
 N
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 HIS A:157 A:1419 79.0 0.405 T -104.2 -0.5 79.0 0.405 0.0 PEG
CA
HOH
 9.169
5.090
3.089
 O
CE1
N
 O1
CA
O
HIS B:157 B:1419 79.0 0.405 T -104.8 -0.4 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 HIS A:157 A:1419 94.0 0.482 T -90.9 5.1 94.0 0.482 0.0 SO4
HOH
 3.405
3.398
 NE2
O
 O3
O
HIS C:157 C:1419 89.0 0.456 T -93.1 -4.2 NA NA NA
HIS E:157 E:1419 90.0 0.462 T -92.7 -3.2 NA NA NA
HIS G:157 G:1419 93.0 0.477 T -89.6 9.9 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 HIS C:159 C:656 112.0 0.574 S -57.1 0.1 112.0 0.574 0.0 HOH
 7.299
 ND1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f2 1 P04275 99.93 0.0 HIS A:1219 A:1219 88.0 0.451 T -96.3 -5.1
af-p04275-f3 1 P04275 99.93 0.0 HIS A:1019 A:1019 96.0 0.492 T -95.0 -4.0
af-p04275-f6 1 P04275 100.0 0.0 HIS A:419 A:419 92.0 0.472 T -97.7 -4.2
af-p04275-f5 1 P04275 99.93 0.0 HIS A:619 A:619 97.0 0.497 T -96.9 -3.6
af-p04275-f8 1 P04275 100.0 0.0 HIS A:19 A:19 180.0 0.923 T -100.4 2.1
af-p04275-f7 1 P04275 100.0 0.0 HIS A:219 A:219 96.0 0.492 T -105.8 -9.9
af-p04275-f4 1 P04275 99.93 0.0 HIS A:819 A:819 95.0 0.487 T -96.1 -3.3