Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128383 . C A CCDS8539.1:NM_000552.3:c.4201Gtc>Ttc_NP_000543.2:p.1401V>F Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 VAL A:176 A:1401 1.0 0.006 H -62.6 -39.5 1.0 0.006 0.0 HOH
 2.882
 O
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 VAL A:143 A:638 1.0 0.006 H -61.2 -45.2 1.0 0.006 0.0 A2M
OMC
OMC
A2M
OMG
HOH
 9.124
8.860
9.405
5.944
9.672
2.828
 CB
CB
C
C
O
O
 OP1
OP2
OP2
N6
O6
O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 VAL C:142 C:638 1.0 0.006 H -58.4 -38.6 1.0 0.006 0.0 HOH
 3.297
 O
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 VAL A:142 A:638 1.0 0.006 H -56.2 -48.7 1.0 0.006 0.0 DT
DT
HOH
 9.170
8.762
2.896
 N
CG2
O
 OP1
O4
O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 VAL A:142 A:638 2.0 0.013 H -60.5 -46.4 2.0 0.013 0.0 DT
DT
HOH
 9.976
8.155
6.121
 N
CG2
C
 OP2
O4
O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 VAL A:165 A:165 0.0 0.0 H -62.7 -39.4 0.0 0.0 0.0 HOH
 2.824
 O
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 VAL A:141 A:638 1.0 0.006 H -69.8 -37.3 1.0 0.006 0.0 HOH
 2.766
 O
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 VAL A:141 A:638 3.0 0.019 H -56.3 -30.1 3.0 0.019 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 VAL A:141 A:638 2.0 0.013 H -57.5 -36.3 2.0 0.013 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 VAL A:140 AAA:1401 0.0 0.0 H -71.4 -34.8 0.0 0.0 0.0 HOH
 2.804
 HG13
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 VAL A:139 A:638 1.0 0.006 H -66.3 -40.5 1.0 0.006 0.0 HOH
 3.006
 O
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 VAL A:139 A:638 1.0 0.006 H -65.1 -36.1 1.0 0.006 0.0 HOH
 2.606
 O
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 VAL A:143 A:638 2.0 0.013 H -60.5 -39.6 2.0 0.013 0.0 HOH
 3.052
 O
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 VAL A:139 A:1401 1.0 0.006 H -66.4 -40.0 1.0 0.006 0.0 HOH
 2.744
 O
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 VAL C:132 A:638 1.0 0.006 H -68.5 -34.2 1.0 0.006 0.0 HOH
 2.953
 O
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 VAL C:132 A:638 1.0 0.006 H -62.4 -39.7 1.0 0.006 0.0 HOH
 3.001
 O
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 VAL A:139 A:1401 2.0 0.013 H -65.1 -42.5 2.0 0.013 0.0 PEG
HOH
 8.508
4.870
 CG2
O
 O4
O
VAL B:139 B:1401 1.0 0.006 H -65.1 -41.1 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 VAL A:139 A:1401 2.0 0.013 H -74.6 -46.4 2.0 0.013 0.0 HOH
 8.493
 CG2
 O
VAL C:139 C:1401 4.0 0.026 H -66.7 -45.7 NA NA NA
VAL E:139 E:1401 1.0 0.006 H -73.7 -25.2 NA NA NA
VAL G:139 G:1401 5.0 0.032 H -70.1 -40.1 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 VAL C:141 C:638 0.0 0.0 H -69.2 -34.0 0.0 0.0 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f2 1 P04275 99.93 0.0 VAL A:1201 A:1201 3.0 0.019 H -61.6 -41.5
af-p04275-f3 1 P04275 99.93 0.0 VAL A:1001 A:1001 3.0 0.019 H -61.6 -41.2
af-p04275-f6 1 P04275 100.0 0.0 VAL A:401 A:401 3.0 0.019 H -61.8 -40.3
af-p04275-f5 1 P04275 99.93 0.0 VAL A:601 A:601 3.0 0.019 H -61.4 -41.3
af-p04275-f8 1 P04275 100.0 0.0 VAL A:1 A:1 81.0 0.523 360.0 -48.5
af-p04275-f7 1 P04275 100.0 0.0 VAL A:201 A:201 4.0 0.026 H -61.0 -41.7
af-p04275-f4 1 P04275 99.93 0.0 VAL A:801 A:801 5.0 0.032 H -63.1 -40.5