Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr12 | 6128388 | . | C | A | CCDS8539.1:NM_000552.3:c.4196cGc>cTc_NP_000543.2:p.1399R>L | Homo sapiens von Willebrand factor (VWF), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 5bv8 | 1 | P04275 | 99.11 | 3e-149 |
X-RAY |
2015-12-23 | ARG | A:174 | A:1399 | 135.0 | NA | H | -62.9 | -39.2 | 135.0 | NA | NA |
HOH |
2.826 |
O |
O |
||
| 7f49 | 1 | P04275 | 99.05 | 2e-140 |
X-RAY |
2021-07-07 | ARG | A:141 | A:636 | 176.0 | 0.782 | H | -67.2 | -36.4 | 176.0 | 0.782 | 0.0 |
OMG A2M OMC OMC OMU A2M A2M OMG A2M A2M OMC A2M OMU OMG GOL HOH |
9.530 7.142 5.506 3.251 2.950 2.779 8.110 4.890 6.850 4.272 8.192 5.491 7.428 8.814 8.068 2.753 |
N N NH1 NH1 NH1 O NH2 NH2 NE NE CB CD CD CD NH1 NE |
O3' OP2 O3' OP2 OP2 N6 C8 N2 CM' C2 OP2 N6 O4 O6 O3 O |
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| 1uex | 3 | P04275 | 99.52 | 3e-140 |
X-RAY |
2003-09-30 | ARG | C:140 | C:636 | 133.0 | 0.591 | H | -60.1 | -32.7 | 122.0 | 0.542 | 0.049 |
A:2134244:0.049 |
HOH |
8.570 |
O |
O |
|
| 3hxo | 1 | P04275 | 99.52 | 3e-140 |
X-RAY |
2009-11-17 | ARG | A:140 | A:636 | 138.0 | 0.613 | H | -75.2 | -31.7 | 138.0 | 0.613 | 0.0 |
DA DG DT DG DC DC DT DT HOH |
7.733 7.185 5.773 7.551 8.301 9.734 8.725 8.015 2.869 |
CD CG CG CG CD CD N N O |
C2 O3' OP1 C2' C5' O2 C7 C7 O |
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| 3hxq | 1 | P04275 | 99.52 | 3e-140 |
X-RAY |
2009-11-17 | ARG | A:140 | A:636 | 157.0 | 0.698 | H | -47.3 | -48.8 | 157.0 | 0.698 | 0.0 |
DA DG DT DG DC DC DC DT DT HOH |
6.495 4.104 2.772 2.885 4.069 9.145 9.012 8.787 7.737 4.916 |
CD NH1 NH1 NH2 NH2 NH2 NE N N N |
C2 O3' OP1 O3' OP1 OP2 O2 C7 O4 O |
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| 7eow | 1 | P04275 | 100.0 | 7e-140 |
X-RAY |
2021-07-07 | ARG | A:163 | A:163 | 185.0 | 0.822 | H | -59.6 | -39.8 | 185.0 | 0.822 | 0.0 |
HOH |
2.682 |
O |
O |
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| 1auq | 1 | P04275 | 99.52 | 1e-139 |
X-RAY |
1998-10-14 | ARG | A:139 | A:636 | 161.0 | 0.716 | H | -62.9 | -42.7 | 161.0 | 0.716 | 0.0 |
HOH |
3.176 |
O |
O |
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| 1u0n | 1 | P04275 | 99.52 | 1e-139 |
X-RAY |
2005-04-19 | ARG | A:139 | A:636 | 172.0 | 0.764 | H | -52.6 | -42.5 | 70.0 | 0.311 | 0.453 |
B:P22029:0.44 C:P22030:0.018 |
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| 1m10 | 1 | P04275 | 99.04 | 7e-139 |
X-RAY |
2002-08-28 | ARG | A:139 | A:636 | 136.0 | 0.604 | H | -44.9 | -61.0 | 136.0 | 0.604 | 0.0 | ||||||
| 7a6o | 1 | L8E853 | 99.51 | 5e-137 |
X-RAY |
2021-03-03 | ARG | A:138 | AAA:1399 | 176.0 | 0.782 | H | -56.1 | -54.5 | 176.0 | 0.782 | 0.0 |
HOH |
2.662 |
HG3 |
O |
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| 1ijb | 1 | P04275 | 99.01 | 4e-134 |
X-RAY |
2002-07-10 | ARG | A:137 | A:636 | 174.0 | 0.773 | H | -66.9 | -37.2 | 174.0 | 0.773 | 0.0 |
HOH |
2.746 |
O |
O |
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| 1ijk | 1 | P04275 | 99.01 | 4e-134 |
X-RAY |
2002-07-10 | ARG | A:137 | A:636 | 128.0 | 0.569 | H | -51.2 | -45.2 | 39.0 | 0.173 | 0.396 |
B:P22029:0.396 |
HOH |
2.765 |
N |
O |
|
| 1sq0 | 1 | P04275 | 99.01 | 5e-134 |
X-RAY |
2004-04-13 | ARG | A:141 | A:636 | 149.0 | 0.662 | H | -58.3 | -48.4 | 131.0 | 0.582 | 0.08 |
B:P07359:0.08 |
HOH |
2.599 |
NH1 |
O |
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| 4c2a | 1 | P04275 | 98.48 | 3e-130 |
X-RAY |
2014-01-08 | ARG | A:137 | A:1399 | 186.0 | 0.827 | H | -56.1 | -39.1 | 186.0 | 0.827 | 0.0 |
HOH |
2.742 |
O |
O |
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| 1oak | 3 | P04275 | 99.49 | 1e-128 |
X-RAY |
1998-10-21 | ARG | C:130 | A:636 | 172.0 | 0.764 | H | -65.9 | -32.8 | 51.0 | 0.227 | 0.537 |
B:1890294:0.191 A:1890296:0.467 |
HOH |
3.267 |
NE |
O |
|
| 1fns | 3 | P04275 | 98.97 | 2e-128 |
X-RAY |
2000-10-18 | ARG | C:130 | A:636 | 182.0 | 0.809 | H | -72.3 | -37.4 | 56.0 | 0.249 | 0.56 |
A:None:0.484 B:None:0.2 |
HOH |
2.841 |
NE |
O |
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| 4c29 | 1 | P04275 | 98.48 | 4e-128 |
X-RAY |
2014-01-08 | ARG | A:137 | A:1399 | 140.0 | 0.622 | H | -61.7 | -39.5 | 140.0 | 0.622 | 0.0 |
PEG HOH |
9.117 4.665 |
N N |
O4 O |
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| ARG | B:137 | B:1399 | 142.0 | 0.631 | H | -65.2 | -37.3 | NA | NA | NA | |||||||||||||
| 4c2b | 1 | P04275 | 98.48 | 4e-128 |
X-RAY |
2014-01-08 | ARG | A:137 | A:1399 | 165.0 | 0.733 | H | -64.1 | -34.5 | 165.0 | 0.733 | 0.0 |
HOH |
9.222 |
N |
O |
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| ARG | C:137 | C:1399 | 183.0 | 0.813 | H | -65.2 | -33.6 | NA | NA | NA | |||||||||||||
| ARG | E:137 | E:1399 | 137.0 | 0.609 | H | -67.7 | -30.1 | NA | NA | NA | |||||||||||||
| ARG | G:137 | G:1399 | 134.0 | 0.596 | H | -63.1 | -32.6 | NA | NA | NA | |||||||||||||
| 1u0o | 3 | Q8CIZ8 | 87.02 | 2e-119 |
X-RAY |
2005-04-19 | ARG | C:139 | C:636 | 175.0 | 0.778 | H | -62.0 | -32.4 | 64.0 | 0.284 | 0.494 |
A:P22029:0.493 |
HOH |
9.482 |
N |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p04275-f1 | 1 | P04275 | 99.93 | 0.0 | ARG | A:1399 | A:1399 | 174.0 | 0.773 | -123.0 | 4.8 | ||
| af-p04275-f2 | 1 | P04275 | 99.93 | 0.0 | ARG | A:1199 | A:1199 | 175.0 | 0.778 | H | -65.4 | -40.6 | |
| af-p04275-f3 | 1 | P04275 | 99.93 | 0.0 | ARG | A:999 | A:999 | 167.0 | 0.742 | H | -65.3 | -41.9 | |
| af-p04275-f6 | 1 | P04275 | 100.0 | 0.0 | ARG | A:399 | A:399 | 170.0 | 0.756 | H | -65.5 | -41.0 | |
| af-p04275-f5 | 1 | P04275 | 99.93 | 0.0 | ARG | A:599 | A:599 | 179.0 | 0.796 | H | -66.0 | -39.9 | |
| af-p04275-f7 | 1 | P04275 | 100.0 | 0.0 | ARG | A:199 | A:199 | 176.0 | 0.782 | H | -67.8 | -37.3 | |
| af-p04275-f4 | 1 | P04275 | 99.93 | 0.0 | ARG | A:799 | A:799 | 84.0 | 0.373 | H | -64.0 | -43.1 | |