Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr12 | 6128401 | . | G | A | CCDS8539.1:NM_000552.3:c.4183Cgg>Tgg_NP_000543.2:p.1395R>W | Homo sapiens von Willebrand factor (VWF), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 5bv8 | 1 | P04275 | 99.11 | 3e-149 |
X-RAY |
2015-12-23 | ARG | A:170 | A:1395 | 220.0 | 0.978 | T | -53.3 | -36.9 | 220.0 | 0.978 | 0.0 |
HOH |
2.708 |
O |
O |
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| 7f49 | 1 | P04275 | 99.05 | 2e-140 |
X-RAY |
2021-07-07 | ARG | A:137 | A:632 | 217.0 | 0.964 | T | -39.0 | -51.2 | 217.0 | 0.964 | 0.0 |
OMG OMG OMG A2M OMC OMC OMU A2M OMC A2M OMU OMG OMU OMC GOL HOH |
9.995 8.818 8.034 6.959 5.710 7.359 7.583 6.003 3.964 2.827 2.915 4.897 7.131 9.079 7.970 2.961 |
CD N O O O NH1 O CB CB NH2 NH2 NH1 NH1 NH1 NH1 NH1 |
OP2 OP2 N7 OP2 N4 N4 O4 O3' C5' OP2 OP2 N7 O4 N4 O3 O |
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| 1uex | 3 | P04275 | 99.52 | 3e-140 |
X-RAY |
2003-09-30 | ARG | C:136 | C:632 | 203.0 | 0.902 | S | -56.9 | -52.4 | 117.0 | 0.52 | 0.382 |
A:2134244:0.382 |
HOH |
2.998 |
NH2 |
O |
|
| 3hxo | 1 | P04275 | 99.52 | 3e-140 |
X-RAY |
2009-11-17 | ARG | A:136 | A:632 | 213.0 | 0.947 | G | -58.1 | -46.2 | 213.0 | 0.947 | 0.0 |
DG DC DA DG DT DG DC DG DT DG DC DG DT DC HOH |
8.724 3.043 3.011 6.012 8.269 9.084 5.975 2.855 3.146 4.894 4.829 8.558 5.357 8.436 2.917 |
NH1 NH1 NH2 NH2 C NH2 NH2 NH2 NE NH1 NH1 N N N O |
C2' O2 C6 N1 OP2 N2 O2 O3' OP1 C5' OP2 O6 O4 N4 O |
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| 3hxq | 1 | P04275 | 99.52 | 3e-140 |
X-RAY |
2009-11-17 | ARG | A:136 | A:632 | 210.0 | 0.933 | T | -33.1 | -66.5 | 210.0 | 0.933 | 0.0 |
DG DC DA DG DT DG DC DG DT DG DC DG DG DC DT DC HOH |
8.158 2.591 2.887 5.890 8.650 8.986 6.702 2.815 2.959 3.994 4.712 9.633 8.485 9.961 5.210 7.921 2.772 |
NH2 NH2 NH1 NH1 C NH1 NH1 NH1 NH1 NH2 NH2 CG N N N CG O |
C2' O2 C6 N2 OP2 N3 O2 O3' OP1 C5' OP2 OP2 O6 O2 O4 N4 O |
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| 7eow | 1 | P04275 | 100.0 | 7e-140 |
X-RAY |
2021-07-07 | ARG | A:159 | A:159 | 201.0 | 0.893 | T | -55.1 | -39.7 | 201.0 | 0.893 | 0.0 |
HOH |
2.432 |
NH2 |
O |
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| 1auq | 1 | P04275 | 99.52 | 1e-139 |
X-RAY |
1998-10-14 | ARG | A:135 | A:632 | 188.0 | 0.836 | T | -54.9 | -39.1 | 188.0 | 0.836 | 0.0 |
HOH |
3.552 |
N |
O |
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| 1u0n | 1 | P04275 | 99.52 | 1e-139 |
X-RAY |
2005-04-19 | ARG | A:135 | A:632 | 193.0 | 0.858 | G | -54.9 | -26.9 | 76.0 | 0.338 | 0.52 |
C:P22030:0.431 D:P07359:0.151 |
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| 1m10 | 1 | P04275 | 99.04 | 7e-139 |
X-RAY |
2002-08-28 | ARG | A:135 | A:632 | 213.0 | 0.947 | G | -43.2 | -44.5 | 165.0 | 0.733 | 0.214 |
B:P07359:0.213 |
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| 7a6o | 1 | L8E853 | 99.51 | 5e-137 |
X-RAY |
2021-03-03 | ARG | A:134 | AAA:1395 | 204.0 | 0.907 | T | -47.0 | -53.6 | 204.0 | 0.907 | 0.0 |
HOH |
1.342 |
HH22 |
O |
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| 1ijb | 1 | P04275 | 99.01 | 4e-134 |
X-RAY |
2002-07-10 | ARG | A:133 | A:632 | 218.0 | 0.969 | T | -51.4 | -41.5 | 218.0 | 0.969 | 0.0 |
HOH |
2.773 |
O |
O |
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| 1ijk | 1 | P04275 | 99.01 | 4e-134 |
X-RAY |
2002-07-10 | ARG | A:133 | A:632 | 178.0 | 0.791 | T | -51.6 | -52.4 | 102.0 | 0.453 | 0.338 |
C:P22030:0.262 B:P22029:0.138 |
HOH |
2.895 |
O |
O |
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| 1sq0 | 1 | P04275 | 99.01 | 5e-134 |
X-RAY |
2004-04-13 | ARG | A:137 | A:632 | 205.0 | 0.911 | T | -60.9 | -34.1 | 163.0 | 0.724 | 0.187 |
B:P07359:0.187 |
HOH |
2.935 |
O |
O |
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| 4c2a | 1 | P04275 | 98.48 | 3e-130 |
X-RAY |
2014-01-08 | ARG | A:133 | A:1395 | 202.0 | 0.898 | T | -62.7 | -41.6 | 168.0 | 0.747 | 0.151 |
B:P07359:0.151 |
HOH |
2.865 |
O |
O |
|
| 1oak | 3 | P04275 | 99.49 | 1e-128 |
X-RAY |
1998-10-21 | ARG | C:126 | A:632 | 212.0 | 0.942 | T | -41.6 | -45.9 | 13.0 | 0.058 | 0.884 |
B:1890294:0.729 A:1890296:0.329 |
HOH |
2.506 |
NH2 |
O |
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| 1fns | 3 | P04275 | 98.97 | 2e-128 |
X-RAY |
2000-10-18 | ARG | C:126 | A:632 | 217.0 | 0.964 | T | -48.0 | -42.1 | 16.0 | 0.071 | 0.893 |
A:None:0.329 B:None:0.72 |
HOH |
2.836 |
NH1 |
O |
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| 4c29 | 1 | P04275 | 98.48 | 4e-128 |
X-RAY |
2014-01-08 | ARG | A:133 | A:1395 | 208.0 | 0.924 | T | -57.3 | -41.2 | 208.0 | 0.924 | 0.0 |
PEG HOH |
6.299 3.068 |
N O |
O4 O |
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| ARG | B:133 | B:1395 | 216.0 | 0.96 | T | -55.9 | -40.3 | NA | NA | NA | |||||||||||||
| 4c2b | 1 | P04275 | 98.48 | 4e-128 |
X-RAY |
2014-01-08 | ARG | A:133 | A:1395 | 210.0 | 0.933 | S | -82.5 | -52.9 | 193.0 | 0.858 | 0.075 |
B:P07359:0.076 |
HOH |
6.444 |
N |
O |
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| ARG | C:133 | C:1395 | 201.0 | 0.893 | S | -80.9 | -49.8 | NA | NA | NA | |||||||||||||
| ARG | E:133 | E:1395 | 198.0 | 0.88 | S | -66.7 | -48.5 | NA | NA | NA | |||||||||||||
| ARG | G:133 | G:1395 | 202.0 | 0.898 | S | -88.3 | -36.6 | NA | NA | NA | |||||||||||||
| 1u0o | 3 | Q8CIZ8 | 87.02 | 2e-119 |
X-RAY |
2005-04-19 | ARG | C:135 | C:632 | 194.0 | 0.862 | T | -68.9 | -4.7 | 45.0 | 0.2 | 0.662 |
B:P22030:0.547 A:P22029:0.156 |
HOH |
7.728 |
NH2 |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p04275-f1 | 1 | P04275 | 99.93 | 0.0 | ARG | A:1395 | A:1395 | 211.0 | 0.938 | G | -70.9 | -24.2 | |
| af-p04275-f2 | 1 | P04275 | 99.93 | 0.0 | ARG | A:1195 | A:1195 | 217.0 | 0.964 | G | -54.7 | -35.9 | |
| af-p04275-f3 | 1 | P04275 | 99.93 | 0.0 | ARG | A:995 | A:995 | 211.0 | 0.938 | G | -56.3 | -37.0 | |
| af-p04275-f6 | 1 | P04275 | 100.0 | 0.0 | ARG | A:395 | A:395 | 212.0 | 0.942 | G | -56.2 | -36.9 | |
| af-p04275-f5 | 1 | P04275 | 99.93 | 0.0 | ARG | A:595 | A:595 | 205.0 | 0.911 | G | -57.9 | -36.3 | |
| af-p04275-f7 | 1 | P04275 | 100.0 | 0.0 | ARG | A:195 | A:195 | 212.0 | 0.942 | G | -56.6 | -33.8 | |
| af-p04275-f4 | 1 | P04275 | 99.93 | 0.0 | ARG | A:795 | A:795 | 196.0 | 0.871 | G | -58.0 | -38.8 | |