Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128464 . G A CCDS8539.1:NM_000552.3:c.4120Cgc>Tgc_NP_000543.2:p.1374R>C Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 ARG A:149 A:1374 11.0 0.049 -124.9 71.1 11.0 0.049 0.0 HOH
 2.767
 O
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 ARG A:116 A:611 15.0 0.067 -125.7 65.5 15.0 0.067 0.0 HOH
 2.707
 O
 O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 ARG C:115 C:611 15.0 0.067 -129.8 58.4 15.0 0.067 0.0 HOH
 4.287
 CG
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:115 A:611 8.0 0.036 -137.0 72.7 8.0 0.036 0.0 HOH
 2.836
 NE
 O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:115 A:611 10.0 0.044 -151.0 89.9 10.0 0.044 0.0 HOH
 6.890
 NH2
 O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 ARG A:138 A:138 16.0 0.071 -123.7 80.7 16.0 0.071 0.0 HOH
 2.500
 O
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 ARG A:114 A:611 10.0 0.044 -136.3 71.7 10.0 0.044 0.0 HOH
 2.535
 O
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 ARG A:114 A:611 18.0 0.08 -118.3 56.7 17.0 0.076 0.004 D:P07359:0.004
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 ARG A:114 A:611 37.0 0.164 S -95.0 87.0 23.0 0.102 0.062 B:P07359:0.062
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 ARG A:113 AAA:1374 12.0 0.053 -123.6 73.5 12.0 0.053 0.0 HOH
 2.489
 HB2
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:112 A:611 7.0 0.031 -133.6 76.8 7.0 0.031 0.0 HOH
 2.622
 O
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:112 A:611 16.0 0.071 -142.7 56.0 16.0 0.071 0.0 HOH
 5.456
 N
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 ARG A:116 A:611 57.0 0.253 -157.8 66.7 37.0 0.164 0.089 B:P07359:0.089
 HOH
 4.104
 NH2
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 ARG A:112 A:1374 63.0 0.28 -125.1 80.1 23.0 0.102 0.178 B:P07359:0.178
 HOH
 2.529
 NH1
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 ARG C:105 A:611 12.0 0.053 -127.6 70.6 12.0 0.053 0.0 HOH
 2.709
 O
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 ARG C:105 A:611 15.0 0.067 -125.3 86.2 15.0 0.067 0.0 HOH
 2.908
 O
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:112 A:1374 9.0 0.04 -131.2 73.5 9.0 0.04 0.0 HOH
 2.337
 O
 O
ARG B:112 B:1374 11.0 0.049 -129.9 74.4 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:112 A:1374 17.0 0.076 -127.7 82.8 16.0 0.071 0.005 B:P07359:0.004
 HOH
 4.135
 CG
 O
ARG C:112 C:1374 15.0 0.067 -123.9 83.3 NA NA NA
ARG E:112 E:1374 17.0 0.076 -127.2 86.5 NA NA NA
ARG G:112 G:1374 16.0 0.071 -127.3 86.3 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 ARG C:114 C:611 11.0 0.049 -121.8 66.0 11.0 0.049 0.0 HOH
 5.861
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f1 1 P04275 99.93 0.0 ARG A:1374 A:1374 30.0 0.133 -179.3 71.8
af-p04275-f2 1 P04275 99.93 0.0 ARG A:1174 A:1174 16.0 0.071 -128.7 69.9
af-p04275-f3 1 P04275 99.93 0.0 ARG A:974 A:974 14.0 0.062 -132.5 68.7
af-p04275-f6 1 P04275 100.0 0.0 ARG A:374 A:374 11.0 0.049 -138.9 70.6
af-p04275-f5 1 P04275 99.93 0.0 ARG A:574 A:574 14.0 0.062 -125.6 70.0
af-p04275-f7 1 P04275 100.0 0.0 ARG A:174 A:174 16.0 0.071 -115.3 71.6
af-p04275-f4 1 P04275 99.93 0.0 ARG A:774 A:774 16.0 0.071 -129.0 72.0